Antp

Summary

Gene Symbol: Antp
Description: Antennapedia
Alias: ANT-C, ANT-P, ANTC, ANTP, Ant, AntP, AntP1, Antp P1, Antp P2, Antp1, Aus, BG:DS07700.1, CG1028, DMANTPE1, DRO15DC96Z, DmAntp, Dmel\CG1028, Scx, antp, l(3)84Ba, CG1028 gene product from transcript CG1028-RG, Antp-PD, Antp-PE, Antp-PF, Antp-PG, Antp-PH, Antp-PI, Antp-PJ, Antp-PK, Antp-PL, Antp-PM, Antp-PN, Aus, CG1028-PD, CG1028-PE, CG1028-PF, CG1028-PG, CG1028-PH, CG1028-PI, CG1028-PJ, CG1028-PK, CG1028-PL, CG1028-PM, CG1028-PN, Dm-Antennapedia, Sex comb extra, Sex combs extra, antenapedia, antennapaedia, antennapedia, antennapedia P1, antennapedia P2, atennapedia, humeral, nasobemia
Species: fruit fly

Top Publications

  1. ncbi Structure of a DNA-bound Ultrabithorax-Extradenticle homeodomain complex
    J M Passner
    Structural Biology Program, Department of Physiology and Biophysics, Mount Sinai School of Medicine, New York, New York 10029, USA
    Nature 397:714-9. 1999
  2. ncbi Hox proteins: sculpting body parts by activating localized cell death
    Claudio R Alonso
    Laboratory for Development and Evolution, Department of Zoology, University of Cambridge, Downing Street, CB2 3EJ, Cambridge, UK
    Curr Biol 12:R776-8. 2002
  3. ncbi Caveolin-1 gene disruption promotes mammary tumorigenesis and dramatically enhances lung metastasis in vivo. Role of Cav-1 in cell invasiveness and matrix metalloproteinase (MMP-2/9) secretion
    Terence M Williams
    Department of Molecular Pharmacology and Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Biol Chem 279:51630-46. 2004
  4. pmc Spatial distribution of Antennapedia transcripts during Drosophila development
    M Levine
    EMBO J 2:2037-46. 1983
  5. ncbi Homeotic gene Antennapedia mRNA contains 5'-noncoding sequences that confer translational initiation by internal ribosome binding
    S K Oh
    Department of Biochemistry, University of Colorado Health Sciences Center, Denver 80262
    Genes Dev 6:1643-53. 1992
  6. ncbi A conserved sequence motif in Polycomb-response elements
    J Mihaly
    Mol Cell 1:1065-6. 1998
  7. ncbi A pulse of the Drosophila Hox protein Abdominal-A schedules the end of neural proliferation via neuroblast apoptosis
    Bruno C Bello
    Medical Research Council, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, United Kingdom
    Neuron 37:209-19. 2003
  8. ncbi Identification of target genes of the homeotic gene Antennapedia by enhancer detection
    J T Wagner-Bernholz
    Biozentrum, University of Basel, Switzerland
    Genes Dev 5:2467-80. 1991
  9. ncbi Direct regulation of the muscle-identity gene apterous by a Hox protein in the somatic mesoderm
    M Capovilla
    Institut de Biologie Moleculaire et Cellulaire, UPR 9022 du CNRS, 67084 Strasbourg, France
    Development 128:1221-30. 2001
  10. ncbi Multiplex detection of RNA expression in Drosophila embryos
    Dave Kosman
    Section of Cell and Developmental Biology, University of California San Diego, La Jolla, CA 92093, USA
    Science 305:846. 2004

Research Grants

  1. Quantitative genomics of sexual dimorphism
    Sergey Nuzhdin; Fiscal Year: 2005
  2. SPECIFICITY IN HOMEOTIC RESPONSE ELEMENTS
    William McGinnis; Fiscal Year: 2005
  3. Regulation of epidermal barrier wound repair
    WILLIAM JAMES MCGINNIS; Fiscal Year: 2010
  4. TRANSCRIPTIONAL COACTIVATORS IN ENDOCRINE REGULATION
    Richard Goodman; Fiscal Year: 2003
  5. DISSECTION OF ONCOGENIC PATHWAYS USING DROSOPHILA
    Richard Mann; Fiscal Year: 2004
  6. Genetic Transfer in the Evolution of Infectious Disease
    Rob DeSalle; Fiscal Year: 2005
  7. RECEPTORS AND SIGNALING IN NEUROENDOCRINE SYSTEMS
    Richard Goodman; Fiscal Year: 2006
  8. Integrated Approcahes to Find Hox-regulated DNA Elements
    Richard Mann; Fiscal Year: 2008
  9. Identification of gene targets for morphine and other drugs of abuse
    Richard Goodman; Fiscal Year: 2009
  10. Regulation of MeCP2 by CREB-induced microRNAs
    Richard H Goodman; Fiscal Year: 2010

Detail Information

Publications145 found, 100 shown here

  1. ncbi Structure of a DNA-bound Ultrabithorax-Extradenticle homeodomain complex
    J M Passner
    Structural Biology Program, Department of Physiology and Biophysics, Mount Sinai School of Medicine, New York, New York 10029, USA
    Nature 397:714-9. 1999
    ..Together, these protein-DNA and protein-protein interactions define the general principles by which homeotic proteins interact with Extradenticle (or Pbx1) to affect development along the anterior-posterior axis of animals...
  2. ncbi Hox proteins: sculpting body parts by activating localized cell death
    Claudio R Alonso
    Laboratory for Development and Evolution, Department of Zoology, University of Cambridge, Downing Street, CB2 3EJ, Cambridge, UK
    Curr Biol 12:R776-8. 2002
    ..A recent study reveals that the Drosophila Hox protein Deformed directly activates the cell-death-promoting gene reaper to maintain the boundaries between distinct head segments...
  3. ncbi Caveolin-1 gene disruption promotes mammary tumorigenesis and dramatically enhances lung metastasis in vivo. Role of Cav-1 in cell invasiveness and matrix metalloproteinase (MMP-2/9) secretion
    Terence M Williams
    Department of Molecular Pharmacology and Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Biol Chem 279:51630-46. 2004
    ..These results demonstrate, for the first time, that caveolin-1 is a potent suppressor of mammary tumor growth and metastasis using novel in vivo animal model approaches...
  4. pmc Spatial distribution of Antennapedia transcripts during Drosophila development
    M Levine
    EMBO J 2:2037-46. 1983
    We have localized transcripts specified by the homeotic Antennapedia (Antp) locus within serial tissue sections of Drosophila embryos and larvae by in situ hybridization. As a hybridization probe we used a 2...
  5. ncbi Homeotic gene Antennapedia mRNA contains 5'-noncoding sequences that confer translational initiation by internal ribosome binding
    S K Oh
    Department of Biochemistry, University of Colorado Health Sciences Center, Denver 80262
    Genes Dev 6:1643-53. 1992
    The Antennapedia (Antp) homeotic gene of Drosophila melanogaster has two promoters, P1 and P2...
  6. ncbi A conserved sequence motif in Polycomb-response elements
    J Mihaly
    Mol Cell 1:1065-6. 1998
  7. ncbi A pulse of the Drosophila Hox protein Abdominal-A schedules the end of neural proliferation via neuroblast apoptosis
    Bruno C Bello
    Medical Research Council, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, United Kingdom
    Neuron 37:209-19. 2003
    ..These studies identify a mechanism linking the Hox axial patterning system to neural proliferation, and this involves temporal regulation of precursor cell death rather than the cell cycle...
  8. ncbi Identification of target genes of the homeotic gene Antennapedia by enhancer detection
    J T Wagner-Bernholz
    Biozentrum, University of Basel, Switzerland
    Genes Dev 5:2467-80. 1991
    Localized expression of the homeotic gene Antennapedia (Antp) in Drosophila melanogaster is required for normal development of the thoracic segments...
  9. ncbi Direct regulation of the muscle-identity gene apterous by a Hox protein in the somatic mesoderm
    M Capovilla
    Institut de Biologie Moleculaire et Cellulaire, UPR 9022 du CNRS, 67084 Strasbourg, France
    Development 128:1221-30. 2001
    ..We show that the product of the Hox gene Antennapedia is present in the somatic mesoderm of the second and third thoracic segments...
  10. ncbi Multiplex detection of RNA expression in Drosophila embryos
    Dave Kosman
    Section of Cell and Developmental Biology, University of California San Diego, La Jolla, CA 92093, USA
    Science 305:846. 2004
    ....
  11. ncbi The DNA binding specificity of Ultrabithorax is modulated by cooperative interactions with extradenticle, another homeoprotein
    S K Chan
    Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032
    Cell 78:603-15. 1994
    The Ultrabithorax (Ubx) and Antennapedia (Antp) genes of Drosophila encode homeodomain proteins that have very similar DNA binding specificities in vitro but specify the development of different segmental patterns in vivo...
  12. pmc Hematopoiesis at the onset of metamorphosis: terminal differentiation and dissociation of the Drosophila lymph gland
    Melina Grigorian
    Department of Molecular Cell and Developmental Biology, University of California Los Angeles, USA
    Dev Genes Evol 221:121-31. 2011
    ..Cells of the secondary lobes undergo a rapid phase of proliferation that lasts until 8 h APF, followed by expression of Pxn and dispersal. These hemocytes do not express P1, indicating that they disperse prior to full maturation...
  13. ncbi Escherichia coli K1 internalization via caveolae requires caveolin-1 and protein kinase Calpha interaction in human brain microvascular endothelial cells
    Sunil K Sukumaran
    Division of Infectious Diseases, Children s Hospital, and the Keck School of Medicine, University of Southern California, Los Angeles, California 90027, USA
    J Biol Chem 277:50716-24. 2002
    ..of HBMEC with a cell-permeable peptide that represents the scaffolding domain, which was coupled to an antennapedia motif of a Drosophila transcription factor significantly blocked the interaction of caveolin-1 with phospho-..
  14. ncbi The Drosophila homeotic gene moira regulates expression of engrailed and HOM genes in imaginal tissues
    B J Brizuela
    Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Mech Dev 65:209-20. 1997
    ..We show that moira is required for the function of multiple homeotic genes of the Antennapedia and bithorax complexes (HOM genes) in most imaginal tissues and that the requirement for moira function is at ..
  15. ncbi Hox protein mutation and macroevolution of the insect body plan
    Matthew Ronshaugen
    Section of Cell and Developmental Biology, Universith of California San Diego, Jolla, CA 92093, USA
    Nature 415:914-7. 2002
    ..Here we show that naturally selected alteration of the Ubx protein is linked to the evolutionary transition to hexapod limb pattern...
  16. ncbi Drosophila midgut morphogenesis requires the function of the segmentation gene odd-paired
    D M Cimbora
    Department of Human Genetics, Howard Hughes Medical Institute, University of Utah, Salt Lake City 84112, USA
    Dev Biol 169:580-95. 1995
    ..proceeds, interruptions are less frequently observed; however, one interruption, coincident with the Antennapedia expression and variability of Ultrabithorax expression in opa mutants...
  17. ncbi Muscles in the Drosophila second thoracic segment are patterned independently of autonomous homeotic gene function
    S Roy
    National Centre for Biological Sciences, Tata Institute of Fundamental Research, P O Box 1234, IISc Campus, Bangalore, 560012, India
    Curr Biol 7:222-7. 1997
    ..Here, we have examined the roles of homeotic genes in the patterning of the somatic muscles of the thoracic segments of Drosophila...
  18. ncbi Caveolin-1 expression enhances endothelial capillary tubule formation
    Jun Liu
    Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Biol Chem 277:10661-8. 2002
    ....
  19. pmc Exploiting transcription factor binding site clustering to identify cis-regulatory modules involved in pattern formation in the Drosophila genome
    Benjamin P Berman
    Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 99:757-62. 2002
    ..We tested one of the newly identified clusters, mapping upstream of the gap gene giant (gt), and show that it acts as an enhancer that recapitulates the posterior expression pattern of gt...
  20. ncbi Unraveling cis-regulatory mechanisms at the abdominal-A and Abdominal-B genes in the Drosophila bithorax complex
    Omar S Akbari
    Biology Department M S 314, University of Nevada, Reno, 1664 N Virginia Street, Reno, NV 89557, USA
    Dev Biol 293:294-304. 2006
    ..The hope is that these studies of gene regulation at the BX-C in the humble fruit fly will provide clues as to how vast intergenic regions contribute to the incredible complexity of gene regulation in other species, including humans...
  21. ncbi Hox genes and the regulation of movement in Drosophila
    Richa Dixit
    National Centre for Biological Sciences, Tata Institute of Fundamental Research, Bangalore 560065, India
    Dev Neurobiol 68:309-16. 2008
    ..By loss and gain of function experiments we show that particular Hox gene functions are necessary and sufficient to dictate the formation of a neuromuscular network that orchestrates the movements of peristaltic locomotion...
  22. ncbi Mouse Hox-2.2 specifies thoracic segmental identity in Drosophila embryos and larvae
    J Malicki
    Department of Human Genetics, Yale University, New Haven, Connecticut 06511
    Cell 63:961-7. 1990
    The mouse genome has a number of homeobox genes that are structurally similar to the Drosophila Antenapedia (Antp) gene. We find that one of the mouse Antp-like genes, Hox-2...
  23. pmc Dosage-dependent modifiers of polycomb and antennapedia mutations in Drosophila
    J A Kennison
    Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, Bethesda, MD 20892
    Proc Natl Acad Sci U S A 85:8136-40. 1988
    Two genes known to control the determination of segmental identity in Drosophila melanogaster are polycomb and antennapedia. To identify additional genes involved in the determination of segmental identity, we have isolated dominant ..
  24. ncbi Redesigning the body plan of Drosophila by ectopic expression of the homoeotic gene Antennapedia
    S Schneuwly
    Nature 325:816-8. 1987
    Genetic and molecular studies on the expression of Antennapedia (Antp) have suggested that this gene specifies mainly the second thoracic segment...
  25. ncbi Specification of anteroposterior cell fates in Caenorhabditis elegans by Drosophila Hox proteins
    C P Hunter
    Department of Biochemistry and Biophysics, University of California, San Francisco 94143 0554, USA
    Nature 377:229-32. 1995
    b>Antennapedia class homeobox (Hox) genes specify cell fates in successive anteroposterior body domains in vertebrates, insects and nematodes...
  26. ncbi Functional analysis of the mouse homeobox gene HoxB9 in Drosophila development
    J Malicki
    Department of Genetics, Yale University, New Haven, CT 06511
    Mech Dev 42:139-50. 1993
    ..effects produced by ectopically expressed Abdominal-B, but are also similar to the transformations induced by Antennapedia and mouse HoxB6 (Hox-2...
  27. ncbi Trans-regulation of thoracic homeotic selector genes of the Antennapedia and bithorax complexes by the trithorax group genes: absent, small, and homeotic discs 1 and 2
    D Lajeunesse
    Department of Biology, Johns Hopkins University, Baltimore, MD 21218, USA
    Mech Dev 53:123-39. 1995
    ..trithorax group appear to be required for the maintenance of expression of the homeotic selector genes of the Antennapedia and bithorax complexes...
  28. ncbi Homeotic gene action in embryonic brain development of Drosophila
    F Hirth
    Institute of Zoology, University of Basel, Basel, Switzerland
    Development 125:1579-89. 1998
    ..Our findings demonstrate that the action of the homeotic genes labial and Deformed are required for neuronal differentiation in the developing brain of Drosophila...
  29. ncbi The ground state of the ventral appendage in Drosophila
    F Casares
    Department of Biochemistry and Molecular Biophysics, Columbia University, 701 West 168 Street, New York, NY 10032, USA
    Science 293:1477-80. 2001
    ..These results raise the possibility that, during evolution, leglike appendages could have developed without selector gene activity...
  30. ncbi Functional equivalence of Hox gene products in the specification of the tritocerebrum during embryonic brain development of Drosophila
    F Hirth
    Institute of Zoology, Biocenter Pharmacenter, University of Basel, Klingelbergstrasse 50, CH 4056 Basel, Switzerland
    Development 128:4781-8. 2001
    ..This suggests that in embryonic brain development, differences in Hox gene action rely mainly on cis-acting regulatory elements and not on Hox protein specificity...
  31. ncbi Function of the Trithorax-like gene during Drosophila development
    Fernando Bejarano
    Centro de Biologia Molecular, CSIC UAM, Universidad Autonoma de Madrid, 28049 Madrid, Spain
    Dev Biol 268:327-41. 2004
    ..We also suggest that GAGA factor may not have a dual activator/repressor function. Rather, Trithorax-like mutations may produce dual loss of activation and loss of repression effects...
  32. ncbi Getting a molecular grasp on Hox contextual activity
    Samir Merabet
    Laboratoire de Genetique et Physiologie du Developpement, IBDM, CNRS, Universite de la Mediterranee, Parc Scientifique de Luminy, Case 907, 13288 Marseille Cedex 09, France
    Trends Genet 21:477-80. 2005
    ..A recent study identified novel Hox molecular partners, whose properties set a conceptual framework to understand how Hox proteins use and integrate contextual information...
  33. ncbi Tarsus determination in Drosophila melanogaster
    Anthony Percival-Smith
    Department of Biology, University of Western Ontario, London, Canada
    Genome 48:712-21. 2005
    Arista versus tarsus determination is well investigated in Drosophila, yet it remains unresolved whether Antennapedia (ANTP) cell autonomously or noncell autonomously determines tarsus identity and whether Sex combs reduced (SCR) is the ..
  34. ncbi Histone replacement marks the boundaries of cis-regulatory domains
    Yoshiko Mito
    Basic Sciences Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA
    Science 315:1408-11. 2007
    ..Our results suggest the existence of a continuous process that disrupts nucleosomes and maintains accessibility of cis-regulatory elements...
  35. pmc Multi-step control of muscle diversity by Hox proteins in the Drosophila embryo
    Jonathan Enriquez
    Centre de Biologie du Developpement, UMR 5547 CNRS UPS, IFR 109 Institut d Exploration Fonctionnelle des Génomes, 31062 Toulouse Cedex 9, France
    Development 137:457-66. 2010
    ..Differential control of col transcription by the Antennapedia and Ultrabithorax/Abdominal-A paralogs is mediated by separate cis-regulatory modules (CRMs)...
  36. ncbi Homeobox genes and axial patterning
    W McGinnis
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06511
    Cell 68:283-302. 1992
  37. ncbi Homeotic genes have specific functional roles in the establishment of the Drosophila embryonic peripheral nervous system
    J G Heuer
    Howard Hughes Medical Institute, Department of Biology, Indiana University, Bloomington 47405
    Development 115:35-47. 1992
    ..The PNS was examined in embryos homozygous for mutations in the homeotic genes Sex combs reduced (Scr), Antennapedia (Antp), Ultrabithorax (Ubx), abdominal-A (abd-A) and Abdominal-B (Abd-B) with antibodies that label specific ..
  38. pmc The homeotic gene Sex combs reduced of Drosophila melanogaster is differentially regulated in the embryonic and imaginal stages of development
    A M Pattatucci
    Howard Hughes Medical Institute, Indiana University, Bloomington 47405
    Genetics 129:443-61. 1991
    The Sex combs reduced (Scr) locus is unique among the genes contained within the Antennapedia complex (ANT-C) of Drosophila melanogaster in that it directs functions that are required for both cephalic and thoracic development in the ..
  39. pmc A functional and structural analysis of the Sex combs reduced locus of Drosophila melanogaster
    A M Pattatucci
    Howard Hughes Medical Institute, Indiana University, Bloomington 47405
    Genetics 129:423-41. 1991
    ....
  40. ncbi The specificities of Sex combs reduced and Antennapedia are defined by a distinct portion of each protein that includes the homeodomain
    G Gibson
    Department of Cell Biology, Biozentrum, Basel, Switzerland
    Cell 62:1087-103. 1990
    The sequence requirements for distinguishing the functional specificities of two homeodomain proteins, Antennapedia and Sex combs reduced, involved in the specification of segmental identities in Drosophila, have been determined...
  41. ncbi Different patterns of transcription from the two Antennapedia promoters during Drosophila embryogenesis
    J R Bermingham
    Howard Hughes Medical Institute, University of Colorado, Boulder 80309 0347
    Development 109:553-66. 1990
    ..The homeotic gene Antennapedia (Antp), a member of the Antennapedia Complex, is required for the correct differentiation of thoracic segments ..
  42. ncbi Mutations in the Drosophila gene extradenticle affect the way specific homeo domain proteins regulate segmental identity
    M Peifer
    Department of Biology, Princeton University, New Jersey 08544 1003
    Genes Dev 4:1209-23. 1990
    ..Segmental identity in Drosophila is mediated by the products of the Antennapedia and bithorax complexes...
  43. pmc The relationship between the functional complexity and the molecular organization of the Antennapedia locus of Drosophila melanogaster
    M K Abbott
    Genetics 114:919-42. 1986
    ..the loss of Antp+ function in the development of the adult thorax causes specific portions of the leg, wing and humeral imaginal discs to develop abnormally...
  44. ncbi A homologous protein-coding sequence in Drosophila homeotic genes and its conservation in other metazoans
    W McGinnis
    Cell 37:403-8. 1984
    The homeotic genes of the bithorax complex (BX-C) and the Antennapedia complex (ANT-C) of Drosophila appear to specify the developmental fate of segments or parts of segments of the fly...
  45. ncbi Homeotic response elements are tightly linked to tissue-specific elements in a transcriptional enhancer of the teashirt gene
    A McCormick
    Department of Developmental Biology, Howard Hughes Medical Institute, Stanford University School of Medicine, CA 94305 5427, USA
    Development 121:2799-812. 1995
    ..Sites where Antennapedia (Antp) and Ultrabithorax (Ubx) proteins bind in vitro were mapped within evolutionarily conserved sequences...
  46. ncbi Control of Drosophila adult pattern by extradenticle
    S González-Crespo
    Centro de Biologia Molecular, Universidad Autonoma de Madrid, Spain
    Development 121:2117-25. 1995
    ..produced by known homeotic mutations such as Ultrabithorax (Ubx), labial (lab), spineless-aristapedia (ssa) or Antennapedia (Antp). In other regions, the lack of exd causes novel homeotic transformations producing ectopic eyes and legs...
  47. ncbi Homeotic genes and the regulation and evolution of insect wing number
    S B Carroll
    Howard Hughes Medical Institute, Madison, Wisconsin, USA
    Nature 375:58-61. 1995
    ....
  48. ncbi Regulation of a decapentaplegic midgut enhancer by homeotic proteins
    J R Manak
    Department of Developmental Biology, Howard Hughes Medical Institute, Stanford University School of Medicine, California 94305 5427
    Development 120:3605-19. 1994
    ..The enhancer is activated ectopically in the visceral mesoderm by ubiquitous expression of Ubx or Antennapedia but not by Sex combs reduced protein. Ectopic expression of abd-A represses the enhancer...
  49. ncbi Ectopic expression and function of the Antp and Scr homeotic genes: the N terminus of the homeodomain is critical to functional specificity
    W Zeng
    Department of Developmental Biology, Stanford University School of Medicine, California 94305 5427
    Development 118:339-52. 1993
    ..The two Drosophila homeotic proteins encoded by Antennapedia and Sex combs reduced determine cell fates in the epidermis and internal tissues of the posterior head and ..
  50. ncbi Homeotic genes of Drosophila
    G Morata
    Centro de Biologia Molecular CSIC UAM, Facultad de Ciencias, Universidad Autonoma de Madrid, Spain
    Curr Opin Genet Dev 3:606-14. 1993
    ..Comparison between Drosophila and other species suggests a common functional organization of homeotic complexes in the animal kingdom...
  51. ncbi Gene inactivation in Drosophila mediated by the Polycomb gene product or by position-effect variegation does not involve major changes in the accessibility of the chromatin fibre
    J Schlossherr
    Institut fur Genetik, Universitat Koln, Germany
    Mol Gen Genet 243:453-62. 1994
    ..These results favour models in which the inactivation is achieved by sequestration of the silenced region in a particular nuclear compartment rather than by a chromatin packaging model...
  52. ncbi Ectopic decapentaplegic in the Drosophila midgut alters the expression of five homeotic genes, dpp, and wingless, causing specific morphological defects
    K Staehling-Hampton
    McArdle Laboratory for Cancer Research, University of Wisconsin, Madison 53706
    Dev Biol 164:502-12. 1994
    ..Ectopic dpp in the visceral mesoderm caused changes in the gene expression of Sex combs reduced, Antennapedia, Ultrabithorax (Ubx), and abdominal-A (abd-A) and disrupted the formation of the gastric caeca and the first ..
  53. ncbi Early tagma-specific commitment of Drosophila CNS progenitor NB1-1
    A Prokop
    Institut für Genetik Zellbiologie, Mainz, Germany
    Development 120:2567-78. 1994
    ..At that stage antibody stainings reveal both proteins to be present in NB1-1 during normal development. Possible mechanisms conferring the early tagma-specific determination are discussed...
  54. ncbi The mouse Hox-1.3 gene is functionally equivalent to the Drosophila Sex combs reduced gene
    J J Zhao
    Brookdale Center for Molecular Biology, Mount Sinai School of Medicine, New York, New York 10029 6574
    Genes Dev 7:343-54. 1993
    ..3. The results suggest that mouse Hox-1.3 cannot only substitute functionally for Drosophila Scr in the determination of external structures but also can participate in the regulatory hierarchy of insect organogenesis...
  55. pmc Cell-type-specific mechanisms of transcriptional repression by the homeotic gene products UBX and ABD-A in Drosophila embryos
    B Appel
    Department of Human Genetics, Howard Hughes Medical Institute, University of Utah, Salt Lake City 84112
    EMBO J 12:1099-109. 1993
    ..Ultrabithorax (Ubx) and abdominal-A (abd-A) genes within a negatively regulated target, the P2 promoter of the Antennapedia (Antp) gene...
  56. ncbi The segment identity functions of Ultrabithorax are contained within its homeo domain and carboxy-terminal sequences
    S K Chan
    Department of Biochemistry and Molecular Biophysics, Columbia University College of Physicians and Surgeons, New York, New York 10032
    Genes Dev 7:796-811. 1993
    ..the structural differences that distinguish two Drosophila homeotic selector proteins, Ultrabithorax (Ubx) and Antennapedia (Antp), have been investigated...
  57. ncbi Extra specificity from extradenticle: the partnership between HOX and PBX/EXD homeodomain proteins
    R S Mann
    Department of Biochemistry and Molecular Biophysics, Columbia University, NY 10032, USA
    Trends Genet 12:258-62. 1996
    ....
  58. ncbi Nuclear translocation of extradenticle requires homothorax, which encodes an extradenticle-related homeodomain protein
    G E Rieckhof
    Department of Biochemistry and Molecular Biophysics, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Cell 91:171-83. 1997
    ..These data suggest a novel and evolutionarily conserved mechanism for regulating HOX activity in which a direct protein-protein interaction between EXD and HTH results in EXD's nuclear translocation...
  59. ncbi Control of antennal versus leg development in Drosophila
    F Casares
    Department of Biochemistry and Molecular Biophysics, Center for Neurobiology and Behavior, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Nature 392:723-6. 1998
    ..antennae and legs are homologous structures that differ from each other as a result of the Hox gene Antennapedia (Antp), which promotes leg identities by repressing unknown antennal-determining genes...
  60. ncbi Homeotic regulation of segment-specific differences in neuroblast numbers and proliferation in the Drosophila central nervous system
    A Prokop
    Institut für Genetik Zellbiologie, Becherweg 32, D 55128 Mainz, Germany
    Mech Dev 74:99-110. 1998
    ....
  61. ncbi Functional dominance among Hox genes: repression dominates activation in the regulation of Dpp
    M Capovilla
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Development 125:4949-57. 1998
    ..Thus, these results suggest that other cases of Hox competition and functional dominance may also be understood in terms of competition for target gene regulation in which repression dominates over activation...
  62. ncbi TGF-beta family signal transduction in Drosophila development: from Mad to Smads
    L A Raftery
    Cutaneous Biology Research Center, Massachusetts General Hospital Harvard Medical School, Building 149 13th Street, Charlestown, Massachusetts, 02129, USA
    Dev Biol 210:251-68. 1999
    ..Identification of more ligand sequences and demonstration of a functional Drosophila activin-like signal transduction pathway suggest that all TGF-beta signal transduction pathways are present in flies...
  63. pmc Activity regulation of Hox proteins, a mechanism for altering functional specificity in development and evolution
    X Li
    Department of Biology, University of California at San Diego, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 96:6802-7. 1999
    The closely related Hox transcription factors Ultrabithorax (Ubx) and Antennapedia (Antp) respectively direct first abdominal (A1) and second thoracic (T2) segment identities in Drosophila...
  64. pmc The control of trunk Hox specificity and activity by Extradenticle
    H D Ryoo
    Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032, USA
    Genes Dev 13:1704-16. 1999
    ..This element, fkh[250(con)], is activated by Scr, Antennapedia (Antp), and Ultrabithorax (Ubx) but repressed by abdominal-A (abd-A)...
  65. ncbi Functions for Drosophila brachyenteron and forkhead in mesoderm specification and cell signalling
    T Kusch
    Institut fur Genetik, Universitat zu Koln, Weyertal 121, D 50931 Köln, Germany
    Development 126:3991-4003. 1999
    ..We propose that the functions of brachyenteron in mesodermal development of Drosophila are comparable to the roles of the vertebrate Brachyury genes during gastrulation...
  66. pmc Transvection and silencing of the Scr homeotic gene of Drosophila melanogaster
    Jeffrey W Southworth
    Section on Drosophila Gene Regulation, Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 2785, USA
    Genetics 161:733-46. 2002
    ..This allele, which is associated with an insertion near the Antennapedia P1 promoter, inactivates the Antennapedia P1 and P2 promoters in cis and derepresses the Scr promoters both in ..
  67. ncbi Hox gene cross-regulatory interactions in the embryonic brain of Drosophila
    Simon G Sprecher
    Institute of Zoology, Biocenter Pharmacenter University of Basel, Klingelbergstr 50, CH 4056 Basel, Switzerland
    Mech Dev 121:527-36. 2004
    ..65 kb brain-specific labial-enhancer element. A functional analysis of Antennapedia and Ultrabithorax protein domains shows that the transcriptional repression of labial requires homeodomain-DNA ..
  68. ncbi Drosophila cardiac tube organogenesis requires multiple phases of Hox activity
    Laurent Perrin
    Laboratoire de Genetique et Physiologie du Developpement, UMR 6545 CNRS Université, IBDM CNRS Université de la Méditerranée, Marseille Cedex 09, 13288 France
    Dev Biol 272:419-31. 2004
    ..The three Hox genes of the Bithorax Complex as well as Antennapedia (Antp) have been shown to be expressed in the posterior cardiac tube, while no Hox gene is expressed in the ..
  69. ncbi Direct integration of Hox and segmentation gene inputs during Drosophila development
    Brian Gebelein
    Department of Biochemistry and Molecular Biophysics and Center for Neurobiology and Behavior, Columbia University, 701 West 168th Street, HHSC 1104, New York, New York 10032, USA
    Nature 431:653-9. 2004
    ..Our results suggest that these two classes of proteins may collaborate to directly control gene expression at many downstream target genes...
  70. ncbi A critical role for cyclin E in cell fate determination in the central nervous system of Drosophila melanogaster
    Christian Berger
    Institute for Genetics, University of Mainz, D 55099 Mainz, Germany
    Nat Cell Biol 7:56-62. 2005
    ..However, other components of the cell cycle seem to have a minor role in this process, suggesting a critical role for CycE in regulating cell fate in segment-specific neural lineages...
  71. pmc The role of histone H2Av variant replacement and histone H4 acetylation in the establishment of Drosophila heterochromatin
    Jyothishmathi Swaminathan
    Department of Biology, Johns Hopkins University, Baltimore, Maryland 21218, USA
    Genes Dev 19:65-76. 2005
    ....
  72. ncbi Recognition of distinct target sites by a unique Labial/Extradenticle/Homothorax complex
    Andreas Ebner
    Biozentrum der Universitat Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
    Development 132:1591-600. 2005
    ..Thus Lab, and most probably other Hox proteins, selects different DNA sequences in regulating downstream target genes. These observations have implications with regard to the current model of Hox-binding selectivity...
  73. ncbi Cofactor-interaction motifs and the cooption of a homeotic Hox protein into the segmentation pathway of Drosophila melanogaster
    Ulrike Löhr
    Abteilung Molekulare Entwicklungsbiologie, Max Planck Institut fur biophysikalische Chemie, Am Fassberg 11, 37077 Gottingen, Germany
    Curr Biol 15:643-9. 2005
    ..Strengthening the Ftz/Ftz-F1 interaction led to degeneration of the YPWM and loss of homeotic activity. Thus, small changes in protein sequence can result in a qualitative switch in function during evolution...
  74. ncbi Evolutionarily conserved domains required for activation and repression functions of the Drosophila Hox protein Ultrabithorax
    Ella Tour
    Section in Cell and Developmental Biology, Division of Biology, University of California, San Diego, La Jolla, CA 92093, USA
    Development 132:5271-81. 2005
    ..These results suggest that the N-terminal region containing the SSYF motif has been conserved in many Hox proteins for its role in transcriptional activation...
  75. pmc Localization of the Antennapedia protein in Drosophila embryos and imaginal discs
    J Wirz
    Biozentrum, University of Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
    EMBO J 5:3327-34. 1986
    Antibodies have been raised against a fusion protein containing the 3' region of the coding sequence of the Antennapedia (Antp) gene fused to beta-galactosidase...
  76. pmc A Hedgehog- and Antennapedia-dependent niche maintains Drosophila haematopoietic precursors
    Lolitika Mandal
    Department of Molecular, Cell and Developmental Biology, Molecular Biology Institute, Mattel Children s Hospital at UCLA, University of California, Los Angeles, Los Angeles, California 90095, USA
    Nature 446:320-4. 2007
    ..Here we show that the PSC is specified early in the embryo by the homeotic gene Antennapedia (Antp) and expresses the signalling molecule Hedgehog...
  77. ncbi The rise and fall of Hox gene clusters
    Denis Duboule
    National Research Centre Frontiers in Genetics, Department of Zoology and Animal Biology, University of Geneva, Sciences III, Switzerland
    Development 134:2549-60. 2007
    ..By integrating these parameters, general conclusions emerge that can help solve the aforementioned dilemma...
  78. pmc Comparing active and repressed expression states of genes controlled by the Polycomb/Trithorax group proteins
    Christian Beisel
    Zentrum für Molekulare Biologie der Universität Heidelberg ZMBH, Im Neuenheimer Feld 282, D 69120 Heidelberg, Germany
    Proc Natl Acad Sci U S A 104:16615-20. 2007
    ..PcG/TrxG proteins, as well as histone modifications in active and repressed genes across the two homeotic complexes ANT-C and BX-C...
  79. pmc A unique Extradenticle recruitment mode in the Drosophila Hox protein Ultrabithorax
    Samir Merabet
    Institut de Biologie du Developpement de Marseille Luminy, Centre National de la Recherche Scientifique, Universite de la Mediterranee, Parc Scientifique de Luminy, 13288 Marseille Cedex 09, France
    Proc Natl Acad Sci U S A 104:16946-51. 2007
    ....
  80. pmc A single Hox locus in Drosophila produces functional microRNAs from opposite DNA strands
    Alexander Stark
    Broad Institute of Massachussetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02141, USA
    Genes Dev 22:8-13. 2008
    ..We also report sense/antisense miRNAs in mouse and find antisense transcripts close to many miRNAs in both flies and mammals, suggesting that additional sense/antisense pairs exist...
  81. doi The YPWM motif links Antennapedia to the basal transcriptional machinery
    Frederic Prince
    Biozentrum, University of Basel, Klingelberstrasse 70, CH 4056 Basel, Switzerland
    Development 135:1669-79. 2008
    ..In our study, we investigated the importance of the Antennapedia (Antp) YPWM motif for homeotic transformations in adult Drosophila...
  82. pmc The Drosophila gap gene giant has an anterior segment identity function mediated through disconnected and teashirt
    Lisa R Sanders
    Department of Genetics, North Carolina State University, Raleigh, NC 27695, USA
    Genetics 179:441-53. 2008
    ..However, the homeosis does not occur through altered expression of the Hom-C genes but through changes in the regulation of disco and tsh...
  83. doi The nuclear organization of Polycomb/Trithorax group response elements in larval tissues of Drosophila melanogaster
    Elena Fedorova
    Department Biologie II, Ludwig Maximilians Universitat Munchen, Grosshaderner Str 2, 82152, Planegg Martinsried, Germany
    Chromosome Res 16:649-73. 2008
    ....
  84. doi Antagonistic roles for Ultrabithorax and Antennapedia in regulating segment-specific apoptosis of differentiated motoneurons in the Drosophila embryonic central nervous system
    Ana Rogulja-Ortmann
    Institute of Genetics, University of Mainz, 55099 Mainz, Germany
    Development 135:3435-45. 2008
    ..We report here that the Hox genes Ultrabithorax (Ubx) and Antennapedia (Antp) regulate segment-specific survival of differentiated motoneurons in the ventral nerve cord of Drosophila ..
  85. ncbi Multiple roles for Hox genes in segment-specific shaping of CNS lineages
    Ana Rogulja-Ortmann
    Institute of Genetics, University of Mainz, Mainz, Germany
    Fly (Austin) 2:316-9. 2008
    ....
  86. pmc Functional anatomy of polycomb and trithorax chromatin landscapes in Drosophila embryos
    Bernd Schuettengruber
    Institut de Genetique Humaine, CNRS, Montpellier, France
    PLoS Biol 7:e13. 2009
    ..Furthermore, several DNA sequence features discriminate between PcG- and TRX-N-bound regions, indicating that underlying DNA sequence contains critical information to drive PREs and TREs towards silencing or activation...
  87. doi Abdominal-A mediated repression of Cyclin E expression during cell-fate specification in the Drosophila central nervous system
    Ramakrishnan Kannan
    Center for Cellular and Molecular Biology, Hyderabad, India
    Mech Dev 127:137-45. 2010
    ..Furthermore, our data suggest a complex network to regulate CycE expression where AbdA functions as a key regulator...
  88. pmc Hematopoietic stem cells in Drosophila
    Svetlana Minakhina
    Rutgers University, Department of Molecular Biology and Biochemistry, Waksman Institute, 190 Frelinghuysen Road, Piscataway, NJ 08854, USA
    Development 137:27-31. 2010
    ..Zfrp8/PDCD2 is likely to have similar functions in hematopoietic stem cell maintenance in vertebrates...
  89. pmc Segment-specific neuronal subtype specification by the integration of anteroposterior and temporal cues
    Daniel Karlsson
    Department of Clinical and Experimental Medicine, Linkoping University, Linkoping, Sweden
    PLoS Biol 8:e1000368. 2010
    ..This study reveals a surprisingly restricted, yet multifaceted, function of both anteroposterior and temporal cues with respect to lineage control and cell fate specification...
  90. doi Developmental RNA processing of 3'UTRs in Hox mRNAs as a context-dependent mechanism modulating visibility to microRNAs
    Stefan Thomsen
    John Maynard Smith Building, School of Life Sciences, University of Sussex, Brighton, UK
    Development 137:2951-60. 2010
    ....
  91. pmc Serpent, suppressor of hairless and U-shaped are crucial regulators of hedgehog niche expression and prohemocyte maintenance during Drosophila larval hematopoiesis
    Yumiko Tokusumi
    Department of Biological Sciences, University of Notre Dame, 147 Galvin Life Sciences Hall, Notre Dame, IN 46556, USA
    Development 137:3561-8. 2010
    ....
  92. pmc Insights into Hox protein function from a large scale combinatorial analysis of protein domains
    Samir Merabet
    Institut de Biologie du Developpement de Marseille Luminy, UMR6216 CNRS, Parc Scientifique de Luminy, Case 907, Marseille, France
    PLoS Genet 7:e1002302. 2011
    ....
  93. pmc Cofactor binding evokes latent differences in DNA binding specificity between Hox proteins
    Matthew Slattery
    Department of Biochemistry and Molecular Biophysics, Columbia University, 701 West 168 th Street, HHSC 1104, New York, NY 10032, USA
    Cell 147:1270-82. 2011
    ..Together, these data suggest that emergent DNA recognition properties revealed by interactions with cofactors contribute to transcription factor specificities in vivo...
  94. pmc Structural relationships among genes that control development: sequence homology between the Antennapedia, Ultrabithorax, and fushi tarazu loci of Drosophila
    M P Scott
    Proc Natl Acad Sci U S A 81:4115-9. 1984
    ..These clusters, the bithorax complex (BX-C) and the Antennapedia complex (ANT-C), both contain multiple homoeotic loci: mutations in each locus cause a transformation of one ..
  95. pmc DSP1, an HMG-like protein, is involved in the regulation of homeotic genes
    M Decoville
    Centre de Biophysique Moleculaire, CNRS UPR 4301, conventionnée avec l Université d Orléans, 45071 Orleans, France
    Genetics 157:237-44. 2001
    ..We propose that DSP1 protein is a chromatin remodeling factor, acting as a trx-G or a Pc-G protein depending on the considered function...
  96. pmc Glutamate receptors of Drosophila melanogaster: cloning of a kainate-selective subunit expressed in the central nervous system
    A Ultsch
    Abteilung Neurochemie, Max Planck Institut für Hirnforschung, Frankfurt Main, Federal Repoublic of Germany
    Proc Natl Acad Sci U S A 89:10484-8. 1992
    ..DGluR-I transcripts are differentially expressed during Drosophila development and, in late embryogenesis, accumulate in the central nervous system...
  97. ncbi The prospero gene encodes a divergent homeodomain protein that controls neuronal identity in Drosophila
    Q Chu-LaGraff
    Department of Cell and Structural Biology, University of Illinois, Urbana 61801
    Dev Suppl . 1991
    ..These data are consistent with a model in which pros controls neuroblast cell lineages by regulating gene expression...
  98. ncbi Homeodomain proteins and the regulation of gene expression
    M Affolter
    Biozentrum, University of Basel, Switzerland
    Curr Opin Cell Biol 2:485-95. 1990
  99. ncbi What determines the specificity of action of Drosophila homeodomain proteins?
    S Hayashi
    National Institute of Genetics, Shizuoka ken, Japan
    Cell 63:883-94. 1990
  100. ncbi The structure of the Antennapedia homeodomain determined by NMR spectroscopy in solution: comparison with prokaryotic repressors
    Y Q Qian
    Institut für Molekularbiologie und Biophysik Eidgenössische Technische Hochschule Hönggerberg, Zurich, Switzerland
    Cell 59:573-80. 1989
    The structure of the Antennapedia homeodomain from Drosophila melanogaster was determined by nuclear magnetic resonance spectroscopy in solution...
  101. pmc Identification of homeotic target genes in Drosophila melanogaster including nervy, a proto-oncogene homologue
    P G Feinstein
    Center for Neurobiology and Behavior, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Genetics 140:573-86. 1995
    ..These results illustrate potentially general rules about the homeotic control of target gene expression and suggest that subtractive hybridization can be used to isolate interesting homeotic target genes...

Research Grants11

  1. Quantitative genomics of sexual dimorphism
    Sergey Nuzhdin; Fiscal Year: 2005
    ..We expect our results to have a profound impact on our understanding of the evolution of sexual dimorphism, and the role that sexual differentiation plays in the generation of phenotypic diversity. ..
  2. SPECIFICITY IN HOMEOTIC RESPONSE ELEMENTS
    William McGinnis; Fiscal Year: 2005
    ..We will apply microarrays to test whether this combination of transcription factors regulates a common group of "skeletal" and/or "collagen and cross-linking" genes in Drosophila and other animals. ..
  3. Regulation of epidermal barrier wound repair
    WILLIAM JAMES MCGINNIS; Fiscal Year: 2010
    ..abstract_text> ..
  4. TRANSCRIPTIONAL COACTIVATORS IN ENDOCRINE REGULATION
    Richard Goodman; Fiscal Year: 2003
    ..Finally, we will characterize the ability of the "CREB binding domain" of CBP to interact with other transcription factors activated or inhibited by Ser/Thr phosphorylation. ..
  5. DISSECTION OF ONCOGENIC PATHWAYS USING DROSOPHILA
    Richard Mann; Fiscal Year: 2004
    ..The use of Drosophila genetics is proposed to help make connections between genetic functions that cannot be easily identified in mammalian experimental systems. ..
  6. Genetic Transfer in the Evolution of Infectious Disease
    Rob DeSalle; Fiscal Year: 2005
    ....
  7. RECEPTORS AND SIGNALING IN NEUROENDOCRINE SYSTEMS
    Richard Goodman; Fiscal Year: 2006
    ..Core laboratories for cell culture, protein chemistry, and administration are designed to allow the proposed studies to be performed in an efficient and cost-effective manner. ..
  8. Integrated Approcahes to Find Hox-regulated DNA Elements
    Richard Mann; Fiscal Year: 2008
    ..Once these methods are worked out, they will be applicable to a wide variety of problems in biology. [unreadable] [unreadable]..
  9. Identification of gene targets for morphine and other drugs of abuse
    Richard Goodman; Fiscal Year: 2009
    ..The concept that CREB signaling induces mediators of translational arrest has profound implications for the understanding of drug action. ..
  10. Regulation of MeCP2 by CREB-induced microRNAs
    Richard H Goodman; Fiscal Year: 2010
    ..The studies described in this proposal address a completely novel mechanism of gene regulation that has implications for the understanding of MeCP2 biology and neural development in general. ..