amn

Summary

Gene Symbol: amn
Description: amnesiac
Alias: Amn, Anm, CG11937, Dmel\CG11937, Drm-amn, EP(X)1442, PACAP, PACAP-38, PACAP-like, PACAP38, PACAP38-like, Pacap38, chpd, CG11937 gene product from transcript CG11937-RA, CG11937-PA, amn-PA, cheap date, cheapdate, pituitary adenylyl cyclase-activating polypeptide, pituitary adenylyl cyclase-activating polypeptide-like
Species: fruit fly

Top Publications

  1. ncbi The Drosophila memory mutant amnesiac
    W G Quinn
    Nature 277:212-4. 1979
  2. ncbi Classical conditioning and retention in normal and mutant Drosophila melanogaster
    T Tully
    J Comp Physiol A 157:263-77. 1985
  3. ncbi Loss of calcium/calmodulin responsiveness in adenylate cyclase of rutabaga, a Drosophila learning mutant
    M S Livingstone
    Cell 37:205-15. 1984
  4. pmc Reward learning in normal and mutant Drosophila
    B L Tempel
    Proc Natl Acad Sci U S A 80:1482-6. 1983
  5. ncbi A neuropeptide gene defined by the Drosophila memory mutant amnesiac
    M B Feany
    Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA
    Science 268:869-73. 1995
  6. ncbi Genetic dissection of consolidated memory in Drosophila
    T Tully
    Cold Spring Harbor Laboratory, New York 11724
    Cell 79:35-47. 1994
  7. pmc Radish, a Drosophila mutant deficient in consolidated memory
    E Folkers
    Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge 02139
    Proc Natl Acad Sci U S A 90:8123-7. 1993
  8. ncbi Gene discovery in Drosophila: new insights for learning and memory
    J Dubnau
    Cold Spring Harbor Laboratory, New York 11724, USA
    Annu Rev Neurosci 21:407-44. 1998
  9. ncbi Ethanol intoxication in Drosophila: Genetic and pharmacological evidence for regulation by the cAMP signaling pathway
    M S Moore
    Gallo Center and Department of Neurology, University of California, San Francisco, 94110, USA
    Cell 93:997-1007. 1998
  10. ncbi Developmental expression of an amn(+) transgene rescues the mutant memory defect of amnesiac adults
    J DeZazzo
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
    J Neurosci 19:8740-6. 1999

Research Grants

  1. Connectivity in the Nematode Nervous System
    Scott Emmons; Fiscal Year: 2002
  2. Regulated Gene Expression and Drosophila Behavior
    Ronald Davis; Fiscal Year: 2003
  3. GENETIC ANALYSIS OF MORPHOGENESIS IN A NEMATODE
    Scott Emmons; Fiscal Year: 2005
  4. NEUROGENETICS OF DROSOPHILA REPRODUCTION
    LESLIE GRIFFITH; Fiscal Year: 2007
  5. NEURON DIFFERENTIATION IN C ELEGANS
    Scott Emmons; Fiscal Year: 2002
  6. Molecular Neurobiology of Behavioral Rhythms
    Jeffrey Hall; Fiscal Year: 2006
  7. GENETIC INTERFERENCE WITH MEMORY CONSOLIDATION
    Edward Korzus; Fiscal Year: 2003
  8. Functional Anatomy of Learning and Memory in Drosophila
    JOSHUA DUBNAU; Fiscal Year: 2008

Scientific Experts

Detail Information

Publications101 found, 100 shown here

  1. ncbi The Drosophila memory mutant amnesiac
    W G Quinn
    Nature 277:212-4. 1979
  2. ncbi Classical conditioning and retention in normal and mutant Drosophila melanogaster
    T Tully
    J Comp Physiol A 157:263-77. 1985
    ..After this, the rates of decay slowed sharply; conditioned avoidance still was measureable at least three hours after training...
  3. ncbi Loss of calcium/calmodulin responsiveness in adenylate cyclase of rutabaga, a Drosophila learning mutant
    M S Livingstone
    Cell 37:205-15. 1984
    ..The mutation possibly affects the catalytic subunit directly. We postulate that there is at least one other type of adenylate cyclase activity that is unaffected by the mutation and insensitive to calcium/calmodulin...
  4. pmc Reward learning in normal and mutant Drosophila
    B L Tempel
    Proc Natl Acad Sci U S A 80:1482-6. 1983
    ..In this situation, the expression of learning is approximately the sum of that obtained by using either reinforcement alone. After such training, memory decays at two distinct rates, each characteristic of one type of reinforcement...
  5. ncbi A neuropeptide gene defined by the Drosophila memory mutant amnesiac
    M B Feany
    Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA
    Science 268:869-73. 1995
    ..One suppressor mutation that was recovered mapped in the amnesiac (amn) gene. Cloning of the locus revealed that amn encodes a previously uncharacterized neuropeptide gene...
  6. ncbi Genetic dissection of consolidated memory in Drosophila
    T Tully
    Cold Spring Harbor Laboratory, New York 11724
    Cell 79:35-47. 1994
    ..LTM showed no appreciable decay over 7 days, was sensitive to CXM, and was not disrupted by the radish mutation...
  7. pmc Radish, a Drosophila mutant deficient in consolidated memory
    E Folkers
    Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge 02139
    Proc Natl Acad Sci U S A 90:8123-7. 1993
    ..The mutant shows normal locomotor activity and normal sensitivity to the odor cues and electric-shock reinforcement used in the learning tests. The radish gene maps within a 180-kb interval in the 11D-E region of the X chromosome...
  8. ncbi Gene discovery in Drosophila: new insights for learning and memory
    J Dubnau
    Cold Spring Harbor Laboratory, New York 11724, USA
    Annu Rev Neurosci 21:407-44. 1998
    ..Second, because core cellular mechanisms of simple forms of learning are evolutionarily conserved, biological pathways discovered in invertebrates are likely to be conserved in vertebrate systems as well...
  9. ncbi Ethanol intoxication in Drosophila: Genetic and pharmacological evidence for regulation by the cAMP signaling pathway
    M S Moore
    Gallo Center and Department of Neurology, University of California, San Francisco, 94110, USA
    Cell 93:997-1007. 1998
    ..Using an inebriometer to measure ethanol-induced loss of postural control, we identified cheapdate, a mutant with enhanced sensitivity to ethanol...
  10. ncbi Developmental expression of an amn(+) transgene rescues the mutant memory defect of amnesiac adults
    J DeZazzo
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
    J Neurosci 19:8740-6. 1999
    ..protein, which includes regions homologous to vertebrate pituitary adenylyl cyclase-activating peptide (PACAP; Feany and Quinn, 1995)...
  11. ncbi Type II cAMP-dependent protein kinase-deficient Drosophila are viable but show developmental, circadian, and drug response phenotypes
    S K Park
    Department of Biology, University of Virginia, Charlottesville, Virginia 22903, USA
    J Biol Chem 275:20588-96. 2000
    ..These findings implicate type II PKA activity in these processes in Drosophila and imply a common role for PKA signaling in regulating responsiveness to cocaine and alcohol...
  12. ncbi The amnesiac gene product is expressed in two neurons in the Drosophila brain that are critical for memory
    S Waddell
    Center for Learning and Memory Department of Brain and Cognitive Sciences Department of Biology Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Cell 103:805-13. 2000
    ..The predicted amnesiac gene product, AMN, is an apparent preproneuropeptide, and previous studies suggest that it stimulates cAMP synthesis...
  13. ncbi Mushroom body memoir: from maps to models
    Martin Heisenberg
    Biozentrum der Universität Würzburg, Am Hubland, D 97074 Wurzburg, Germany
    Nat Rev Neurosci 4:266-75. 2003
  14. ncbi Aging specifically impairs amnesiac-dependent memory in Drosophila
    Takuya Tamura
    Tokyo Metropolitan Institute for Neuroscience, Fuchu, Tokyo 183 8526, Japan
    Neuron 40:1003-11. 2003
    ..we demonstrate that age-related defects in olfactory memory are identical to those of the MTM mutant amnesiac (amn). Furthermore, amn flies do not exhibit an age-dependent decrease in memory, in contrast to other memory mutants...
  15. ncbi Exclusive consolidated memory phases in Drosophila
    Guillaume Isabel
    Developpement, Evolution, Plasticité du Système Nerveux, CNRS, 1 Avenue de la Terrasse, 91190 Gifsur Yvette, France
    Science 304:1024-7. 2004
    ..We propose that ARM acts as a gating mechanism that ensures that LTM is formed only after repetitive and spaced training...
  16. ncbi Modulation of L-type calcium channels in Drosophila via a pituitary adenylyl cyclase-activating polypeptide (PACAP)-mediated pathway
    Anindya Bhattacharya
    Department of Pharmacology and Toxicology, State University of New York at Buffalo, Buffalo, New York 14214 3000, USA
    J Biol Chem 279:37291-7. 2004
    ..present data suggesting the possible role of a neuropeptide, pituitary adenylyl cyclase-activating polypeptide (PACAP), in this modulation...
  17. ncbi Diverse odor-conditioned memories require uniquely timed dorsal paired medial neuron output
    Alex C Keene
    Department of Neurobiology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA
    Neuron 44:521-33. 2004
    ..The amn gene encodes a homolog of vertebrate pituitary adenylate cyclase-activating peptide (PACAP), and it is strongly expressed in dorsal paired medial (DPM) neurons...
  18. ncbi Drosophila DPM neurons form a delayed and branch-specific memory trace after olfactory classical conditioning
    Dinghui Yu
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Cell 123:945-57. 2005
    ..DPM neurons are therefore "odor generalists" and form a delayed, branch-specific, and amnesiac-dependent memory trace that may guide behavior after acquisition...
  19. ncbi Drosophila dorsal paired medial neurons provide a general mechanism for memory consolidation
    Alex C Keene
    Department of Neurobiology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, Massachusetts 01605, USA
    Curr Biol 16:1524-30. 2006
    ..Here we show that stable reward-odor memory is also DPM neuron dependent. DPM neuron expression of amnesiac (amn) in amn mutant flies restores wild-type memory...
  20. pmc Drosophila alpha/beta mushroom body neurons form a branch-specific, long-term cellular memory trace after spaced olfactory conditioning
    Dinghui Yu
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Neuron 52:845-55. 2006
    ....
  21. ncbi The Drosophila DCO mutation suppresses age-related memory impairment without affecting lifespan
    Daisuke Yamazaki
    Tokyo Metropolitan Institute for Neuroscience, Fuchu, Tokyo 183 8526, Japan
    Nat Neurosci 10:478-84. 2007
    ..In Drosophila AMI consists of a specific reduction in memory dependent on the amnesiac (amn) gene. amn encodes putative neuropeptides that have been proposed to regulate cAMP levels in mushroom bodies...
  22. ncbi Attention-like processes in Drosophila require short-term memory genes
    Bruno van Swinderen
    Neurosciences Institute, 10640 John Jay Hopkins Drive, San Diego, CA 92121, USA
    Science 315:1590-3. 2007
    ..These processes were modulated by genes involved in short-term memory formation, namely dunce and rutabaga. Attention defects in these mutants were associated with distinct optomotor effects in behavioral assays...
  23. doi Neuronal assemblies of the Drosophila mushroom body
    Nobuaki K Tanaka
    Institute of Molecular and Cellular Biosciences, The University of Tokyo, Tokyo 113 0032, Japan
    J Comp Neurol 508:711-55. 2008
    ..Structural differences between lobes are also discussed...
  24. doi amnesiac regulates sleep onset and maintenance in Drosophila melanogaster
    Weijie Liu
    State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Road, Chaoyang District, Beijing 100101, China
    Biochem Biophys Res Commun 372:798-803. 2008
    ..gene, encodes a neuropeptide that is homologous with vertebrate pituitary adenylate cyclase-activating peptide (PACAP), is expressed in dorsal paired medial (DPM) neurons and is required for the middle-term memory (MTM) in flies...
  25. doi cAMP signalling in mushroom bodies modulates temperature preference behaviour in Drosophila
    Sung Tae Hong
    Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Guseong Dong, Yusong gu, Daejeon, 305 701, Korea
    Nature 454:771-5. 2008
    ..Preferred temperatures were affected by the level of cAMP and PKA activity in the MBs in various PKA pathway mutants...
  26. doi Concentric zones, cell migration and neuronal circuits in the Drosophila visual center
    Eri Hasegawa
    Frontier Science Organization, Kanazawa University, 13 1 Takaramachi Kanazawa shi, Ishikawa, Japan
    Development 138:983-93. 2011
    ..Thus, genes that show the concentric zones may form a genetic hierarchy to establish neuronal circuits in the medulla...
  27. doi arouser reveals a role for synapse number in the regulation of ethanol sensitivity
    Mark Eddison
    Department of Anatomy, University of California San Francisco, San Francisco, CA 94158, USA
    Neuron 70:979-90. 2011
    ..We thus show that a developmental abnormality affecting synapse number and ethanol sensitivity is not permanent and can be reversed by manipulating the environment of the adult fly...
  28. pmc Serotonin-mushroom body circuit modulating the formation of anesthesia-resistant memory in Drosophila
    Pei Tseng Lee
    Department of Life Science, National Tsing Hua University, Hsinchu 30013, Taiwan
    Proc Natl Acad Sci U S A 108:13794-9. 2011
    ..Thus, in addition to the Amnesiac peptide required for anesthesia-sensitive memory formation, the two DPM neurons also release 5HT acting on MB neurons for ARM formation...
  29. pmc Distinct traces for appetitive versus aversive olfactory memories in DPM neurons of Drosophila
    Isaac Cervantes-Sandoval
    Department of Neuroscience, The Scripps Research Institute Florida, Jupiter, FL 33410, USA
    Curr Biol 22:1247-52. 2012
    ..These results indicate that the persistence and breadth of the DPM neuron memory trace influences the duration of behavioral memory...
  30. ncbi Neuropeptides, adenylyl cyclase, and memory storage
    E Kandel
    Howard Hughes Medical Institute, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    Science 268:825-6. 1995
  31. ncbi Physiology and biochemistry of Drosophila learning mutants
    R L Davis
    Department of Cell Biology, Baylor College of Medicine, Houston, Texas, USA
    Physiol Rev 76:299-317. 1996
    ..An appendix describing the currently used paradigms to test Drosophila behavior is included...
  32. ncbi A return to genetic dissection of memory in Drosophila
    T Tully
    Cold Spring Harbor Laboratory, New York 11724, USA
    Cold Spring Harb Symp Quant Biol 61:207-18. 1996
  33. pmc Data transferability from model organisms to human beings: insights from the functional genomics of the flightless region of Drosophila
    R Maleszka
    Research School of Biological Sciences, Australian National University, Canberra ACT 2600, Australia
    Proc Natl Acad Sci U S A 95:3731-6. 1998
    ....
  34. ncbi Vision affects mushroom bodies and central complex in Drosophila melanogaster
    M Barth
    Theodor Boveri Institut für Biowissenschaften Lehrstuhl für Genetik, Wurzburg, Germany
    Learn Mem 4:219-29. 1997
    ..This stimulating effect of crowding is not observed in any of the cAMP mutants, including rutabaga1...
  35. ncbi Behavioral functions of the insect mushroom bodies
    T Zars
    Theodor Boveri Institut für Biowissenschaften, Lehrstuhl für Genetik und Neurobiologie, Am Hubland, Biozentrum, D 97074, Wurzburg, Germany
    Curr Opin Neurobiol 10:790-5. 2000
    ..In addition, the mushroom bodies are necessary for context generalization in visual learning and for regulating the transition from walking to rest...
  36. ncbi The Drosophila Mutant tetanic Interacts with a Gene Complex Including the Structural Locus of K+ Channels and Shows Altered Dephosphorylation and Learning
    S Orgad
    Neurobiology Department, The Weizmann Institute for Science, Rehovot, Israel
    Eur J Neurosci 1:367-373. 1989
    ..The functional relationships between phosphorylation, K+ currents, phosphatase activity and modulation of synaptic activity during learning and memory are discussed in the light of their possible genetic links...
  37. ncbi The spatial code for odors is changed by conditioning
    Elissa A Hallem
    Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06520 USA
    Neuron 42:359-61. 2004
  38. pmc Sequential learning of pheromonal cues modulates memory consolidation in trainer-specific associative courtship conditioning
    Aki Ejima
    Department of Biology and Volen Center for Complex Systems, Brandeis University MS008, 415 South Street, Waltham, MA 02454 9110, USA
    Curr Biol 15:194-206. 2005
    ..In more natural settings, however, animals can have multiple salient experiences that need to be remembered and prioritized. The mechanisms by which animals deal with multiple experiences are incompletely understood...
  39. pmc The genetic basis of alcoholism: multiple phenotypes, many genes, complex networks
    Tatiana V Morozova
    Department of Biology, Box 7617, North Carolina State University, Raleigh, NC 27695, USA
    Genome Biol 13:239. 2012
    ..Alcoholism is a significant public health problem. A picture of the genetic architecture underlying alcohol-related phenotypes is emerging from genome-wide association studies and work on genetically tractable model organisms...
  40. pmc Healthy aging - insights from Drosophila
    Konstantin G Iliadi
    Program in Developmental and Stem Cell Biology, The Hospital for Sick Children Toronto, ON, Canada
    Front Physiol 3:106. 2012
    ....
  41. pmc Contribution of visual and circadian neural circuits to memory for prolonged mating induced by rivals
    Woo Jae Kim
    Howard Hughes Medical Institute, Departments of Physiology, Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA, USA
    Nat Neurosci 15:876-83. 2012
    ..Our study thus delineates parts of the molecular and cellular basis for LMD, a plastic social behavior elicited by visual cues...
  42. pmc Female contact modulates male aggression via a sexually dimorphic GABAergic circuit in Drosophila
    Quan Yuan
    1 Department of Physiology and Howard Hughes Medical Institute, University of California at San Francisco, San Francisco, California, USA 2 3
    Nat Neurosci 17:81-8. 2014
    ..We propose that the GABAergic inhibition represents a critical cellular mechanism that enables prior experience to modulate aggression. ..
  43. pmc Functional neuroanatomy of Drosophila olfactory memory formation
    Tugba Guven-Ozkan
    Department of Neuroscience, The Scripps Research Institute Florida, Jupiter, Florida 33458, USA
    Learn Mem 21:519-26. 2014
    ..Despite this progress, a complete and unified model that details the pathway from acquisition to memory expression remains elusive. ..
  44. pmc A novel paradigm for nonassociative long-term memory in Drosophila: predator-induced changes in oviposition behavior
    Balint Z Kacsoh
    Department of Genetics, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire 03755
    Genetics 199:1143-57. 2015
    ....
  45. pmc A single pair of neurons modulates egg-laying decisions in Drosophila
    Chia Lin Wu
    Department of Biochemistry, College of Medicine, Chang Gung University, Taoyuan, Taiwan Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan Department of Medical Research, Chang Gung Memorial Hospital, Taoyuan, Taiwan
    PLoS ONE 10:e0121335. 2015
    ..In the present study, we found that amnesiac (amn) mutant flies show significant defects in egg-laying decisions, and such defects can be reversed by expressing the ..
  46. ncbi Odour avoidance learning in the larva of Drosophila melanogaster
    Sukant Khurana
    Tata Institute of Fundamental Research, National Centre for Biological Sciences, Bangalore 560 065, India
    J Biosci 34:621-31. 2009
    ..The same method of analysis when applied to learning mutants dunce, amnesiac, rutabaga and radish reveals memory deficits characteristic of the mutant strains...
  47. doi Epigenetic silencing of core histone genes by HERS in Drosophila
    Saya Ito
    Institute of Molecular and Cellular Biosciences, University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    Mol Cell 45:494-504. 2012
    ..These findings illustrate a salient molecular switch linking epigenetic gene silencing to cell cycle-dependent histone production...
  48. ncbi The Drosophila dunce locus: learning and memory genes in the fly
    R L Davis
    Department of Cell Biology, Baylor College of Medicine, Houston, TX 77030
    Trends Genet 7:224-9. 1991
    ..In addition, the recent cloning and characterization of dunce counterparts from mammals has revealed that these too may participate in animal behavior and, in particular, in the regulation of mood...
  49. ncbi Genetic dissection of memory formation in Drosophila melanogaster
    T Tully
    Department of Biology, Brandeis University, Waltham, Massachusetts 02254
    Cold Spring Harb Symp Quant Biol 55:203-11. 1990
  50. ncbi Deletion mapping of the Drosophila memory mutant amnesiac
    T Tully
    J Neurogenet 3:33-47. 1986
    ..conditioning procedure, two deficiency chromosomes, mal8 and mal12, produced amnesiac-like memory deficits in Df/amn flies but not in Df/ + controls...
  51. ncbi Chemically reinforced conditioned courtship in Drosophila: responses of wild-type and the dunce, amnesiac and don giovanni mutants
    S L Ackerman
    J Neurogenet 3:111-23. 1986
    ..Courtship-depressing effects of cis-vaccenyl alcohol, which can be recovered from fertilized females, were confirmed, but no evidence for its role as a negative reinforcer of male courtship was obtained...
  52. ncbi Wiring by fly: the neuromuscular system of the Drosophila embryo
    M Bate
    Department of Zoology, University of Cambridge, England
    Neuron 15:513-25. 1995
  53. ncbi Flies, genes, learning, and memory
    R J Greenspan
    Department of Biology, New York University, New York 10003, USA
    Neuron 15:747-50. 1995
  54. ncbi Dissection of memory formation: from behavioral pharmacology to molecular genetics
    J DeZazzo
    Cold Spring Harbor Laboratory, Harbor, NY 11724, USA
    Trends Neurosci 18:212-8. 1995
    ..These studies support the application of reverse-genetic strategies, including the use of temporally specific agonists and antagonists, to advance the functional dissection of memory formation...
  55. ncbi Drosophila mushroom body subdomains: innate or learned representations of odor preference and sexual orientation?
    J S de Belle
    Max Planck Institut für biologische Kybernetik, Tubingen, Federal Republic of Germany
    Neuron 15:245-7. 1995
  56. ncbi Mediation of PACAP-like neuropeptide transmission by coactivation of Ras/Raf and cAMP signal transduction pathways in Drosophila
    Y Zhong
    Cold Spring Harbor Laboratory, New York 11724, USA
    Nature 375:588-92. 1995
    ..Thus the Ras/Raf pathway also appears to be essential for G-protein-coupled neurotransmission...
  57. ncbi Progress in understanding the Drosophila dnc locus
    A Nighorn
    Department of Cell Biology, Baylor College of Medicine, Houston, TX 77030
    Comp Biochem Physiol Biochem Mol Biol 108:1-9. 1994
    ..This paper reviews the recent developments in the understanding of the structure and function of the gene identified by the first and best-characterized of these mutants, the Drosophila dunce mutant...
  58. ncbi The mating of a fly
    J C Hall
    Department of Biology, Brandeis University, Waltham, MA 02254 9110
    Science 264:1702-14. 1994
    ..Further behavioral mutations seemed originally to be courtship-specific, turned out not to have that property, and have led to a broadened perspective on the nature and action of Drosophila's sex-determination genes...
  59. ncbi Mushroom bodies and Drosophila learning
    R L Davis
    Center for Learning and Memory, Cold Spring Harbor Laboratory, New York 11724
    Neuron 11:1-14. 1993
  60. ncbi CREB and the formation of long-term memory
    J C Yin
    Cold Spring Harbor Laboratory, New York 11724, USA
    Curr Opin Neurobiol 6:264-8. 1996
    ..These results have led to the recent hypothesis that CREB is pivotal in the switch from short-term (protein synthesis independent) to long-term (protein synthesis dependent) memory...
  61. ncbi Biochemistry of insect learning: lessons from bees and flies
    V H Meller
    Department of Cell Biology and Neurology, Baylor College of Medicine, Houston, TX 77030, USA
    Insect Biochem Mol Biol 26:327-35. 1996
    ..In spite of similarities, temporal, and possibly biochemical aspects of learning differ markedly between these organisms...
  62. pmc Discovery of genes involved with learning and memory: an experimental synthesis of Hirschian and Benzerian perspectives
    T Tully
    Cold Spring Harbor Laboratory, NY 11724, USA
    Proc Natl Acad Sci U S A 93:13460-7. 1996
    ..In addition, more specific conclusions will be obtained from reverse-genetic experiments, in which gene disruptions are restricted in time and/or space...
  63. ncbi Modulation of Drosophila heartbeat by neurotransmitters
    E Johnson
    Department of Zoology, University of Maine, Orono 04469, USA
    J Comp Physiol B 167:89-97. 1997
    ..Dopamine-N-acetyltransferase, which is on the catabolic route to dopamine, serotonin, and octopamine, has no effect. hypoactiveC reduces the rate of the heart, but its mechanism of action is unknown...
  64. ncbi Drosophila learning and memory: recent progress and new approaches
    M P Belvin
    Cold Spring Harbor Laboratory, NY 11724, USA
    Bioessays 19:1083-9. 1997
    ....
  65. ncbi Genetic approaches to neuroethology
    M Heisenberg
    Biozentrum, Lehrstuhl fur Genetik, Wurzburg, Germany
    Bioessays 19:1065-73. 1997
    ..The 'graininess' of a functional model of the brain, therefore, is defined by the independent regulatory units of the genes rather than by the genes themselves...
  66. ncbi The fruit fly: a model organism to study the genetics of alcohol abuse and addiction?
    H J Bellen
    Howard Hughes Medical Institute, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Cell 93:909-12. 1998
  67. ncbi Genetic lesions in Drosophila behavioural mutants
    G O Pflugfelder
    Theodor Boveri Institut Biozentrum, Lehrstuhl fur Genetik, Universität Würzburg Am Hubland, Germany
    Behav Brain Res 95:3-15. 1998
    ..Various mutagens are reviewed as to their suitability in inducing selective regulatory mutations...
  68. ncbi Abnormal mushroom body plasticity in the Drosophila memory mutant amnesiac
    R Hitier
    Institut Alfred Fessard, CNRS, Gif sur Yvette, France
    Neuroreport 9:2717-9. 1998
    ..Independent of the plasticity effect, the calyces are on average slightly bigger than wild type in amnesiac and smaller in rutabaga flies...
  69. ncbi Altered outward K(+) currents in Drosophila larval neurons of memory mutants rutabaga and amnesiac
    D Yu
    Laboratory of Visual Information Processing, Department of Neurobiology, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, People s Republic of China
    J Neurobiol 40:158-70. 1999
    ..adenosine monophosphate (cAMP) analog 8-bromo-cAMP in both Drosophila memory mutants rutabaga (rut) and amnesiac (amn) was significantly larger than that (50%) in wild type...
  70. ncbi Genes to remember
    C M Alberini
    Department of Neuroscience, Brown University, Providence, RI 02912, USA
    J Exp Biol 202:2887-91. 1999
    ..Here, we review the studies showing that conserved molecules and biological mechanisms are engaged in simple and complex forms of memory...
  71. ncbi Functional anatomy: from molecule to memory
    J Dubnau
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
    Curr Biol 11:R240-3. 2001
    ..Blockade of synaptic transmission in the amnesiac-expressing cells disrupts memory, but not learning, suggesting presynaptic and postsynaptic sites for memory formation...
  72. ncbi Synchronized neural activity in the Drosophila memory centers and its modulation by amnesiac
    P Rosay
    IBLS Division of Molecular Genetics, Anderson College Complex, University of Glasgow, G11 6NU, Scotland, Glasgow, United Kingdom
    Neuron 30:759-70. 2001
    ..It is also sensitive to pharmacological agents specific for several classes of ion channel and for acetylcholine and GABA receptors. A role in memory consolidation involving transcriptionally mediated synaptic strengthening is proposed...
  73. ncbi Molecular biology and anatomy of Drosophila olfactory associative learning
    G Roman
    Department of Molecular and Cellular Biology and Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston 77030, USA
    Bioessays 23:571-81. 2001
    ..In this review, we discuss the nature of the behavioral tasks, the molecules, and the neuronal circuits involved in olfactory learning in Drosophila...
  74. ncbi Neurobiology. Learning how a fruit fly forgets
    S Waddell
    Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Science 293:1271-2. 2001
  75. pmc Control of Drosophila perineurial glial growth by interacting neurotransmitter-mediated signaling pathways
    J Yager
    Department of Biochemistry and Cell Biology, MS 140, Rice University, Houston, TX 77005, USA
    Proc Natl Acad Sci U S A 98:10445-50. 2001
    ..transporter; eag, which encodes a potassium channel; push, which encodes a large, Zn(2+)-finger-containing protein; amn, which encodes a putative neuropeptide related to the pituitary adenylate cyclase activator peptide; and NF1, the ..
  76. ncbi What can we teach Drosophila? What can they teach us?
    S Waddell
    Dept of Neurobiology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Trends Genet 17:719-26. 2001
    ....
  77. ncbi Learning in simple systems
    B D Burrell
    Department of Biological Sciences, 1392 Lilly Hall of Life Sciences, West Lafayette, IN 47907 1392, USA
    Curr Opin Neurobiol 11:757-64. 2001
    ..Some pathways contribute to a single stage of memory formation, whereas others impact on multiple stages of memory development. Distinct cellular pathways may also act in series or in parallel during various stages of memory formation...
  78. ncbi The genetics of cognitive processes: candidate genes in humans and animals
    K I Morley
    Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane, Australia
    Behav Genet 31:511-31. 2001
    ..This survey confirms that many genes are associated with cognitive variation and highlights the potential importance of animal models in the study of human cognition...
  79. ncbi Higher brain functions of PACAP and a homologous Drosophila memory gene amnesiac: insights from knockouts and mutants
    Hitoshi Hashimoto
    Laboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, 1 6 Yamadaoka, Suita, Osaka 565 0871, Japan
    Biochem Biophys Res Commun 297:427-31. 2002
    ..Pituitary adenylate cyclase-activating polypeptide (PACAP) functions as a neuromodulator and neurotransmitter and regulates a variety of physiological processes...
  80. ncbi Functional dissection of neuroanatomical loci regulating ethanol sensitivity in Drosophila
    Aylin R Rodan
    Department of Anatomy, University of California, San Francisco, California 94143 0452, USA
    J Neurosci 22:9490-501. 2002
    ..We conclude that the regulation of ethanol-induced behaviors by PKA involves complex interactions among groups of cells that mediate either increased or reduced sensitivity to the acute intoxicating effects of ethanol...
  81. ncbi High-resolution analysis of ethanol-induced locomotor stimulation in Drosophila
    Fred W Wolf
    Department of Anatomy, University of California at San Francisco, San Francisco, California 94143, USA
    J Neurosci 22:11035-44. 2002
    ..The effects of ethanol on locomotion are comparable in flies and mammals, suggesting that Drosophila is a suitable model system to study the underlying mechanisms...
  82. ncbi Genetic basis of male sexual behavior
    Scott W Emmons
    Department of Molecular Genetics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA
    J Neurobiol 54:93-110. 2003
    ..It can also help us to gain an appreciation of how behavior is encoded by genes and their regulatory sequences...
  83. ncbi Drugs, flies, and videotape: the effects of ethanol and cocaine on Drosophila locomotion
    Adrian Rothenfluh
    Department of Anatomy, University of California at San Francisco, 513 Parnassus Avenue, 94143 0452, USA
    Curr Opin Neurobiol 12:639-45. 2002
    ..Surprising similarities between flies and mammals have begun to emerge at the behavioral, neurochemical and molecular levels...
  84. ncbi Courtship lite: a personal history of reproductive behavioral neurogenetics in Drosophila
    Jeffrey C Hall
    Department of Biology, Brandeis University, Waltham, Massachusetts 02454 9110, USA
    J Neurogenet 16:135-63. 2002
  85. ncbi Operant visual learning and memory in Drosophila mutants dunce, amnesiac and radish
    Z F Gong
    Laboratory of Visual Information Processing, Institute of Biophysics, Academia Sinica, 15 Datun Road, Chaoyang District, Beijing, People s Republic of China
    J Insect Physiol 44:1149-1158. 1998
    ..These results lend support to the argument that there are certain common molecular mechanisms underlying learning and memory through different tasks and the previous multi-phase model of visual memory is modified in a genetic way...
  86. ncbi The relation of transcription to memory formation
    Edward Korzus
    University of California San Diego, Department of Neurosciences, 9500 Gilman Drive M C 0986, La Jolla, CA 92093 0986, USA
    Acta Biochim Pol 50:775-82. 2003
    ..Transcription seems to play essential role in memory formation but the mechanisms for activation of transcription and downstream processes during memory consolidation remain unclear...
  87. ncbi Olfactory learning
    Ronald L Davis
    Department of Molecular and Cellular Biology, Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX 77030, USA
    Neuron 44:31-48. 2004
    ..Molecular genetic studies of olfactory learning in Drosophila have revealed numerous molecules that function within the third order olfactory neurons for normal olfactory learning...
  88. ncbi Diverse mechanisms to remember various odors
    Thomas Preat
    Developpement, Evolution et Plasticité du Système Nerveux, CNRS, Gif, 91190, France
    Neuron 44:404-5. 2004
    ..DPM neurons are required during acquisition of some odors and during memory consolidation of others. These findings reveal a surprising level of complexity for the formation of olfactory memories in Drosophila...
  89. pmc A clock gene, period, plays a key role in long-term memory formation in Drosophila
    Takaomi Sakai
    Gunma University Graduate School of Medicine, 3 39 22 Showa machi, Maebashi 371 8511, Japan
    Proc Natl Acad Sci U S A 101:16058-63. 2004
    ..In contrast, mutations in other clock genes (timeless, dClock, and cycle) did not affect LTM formation. Thus, independent of the core oscillator of circadian clock, per plays a key role in LTM formation...
  90. ncbi Genetic modules and networks for behavior: lessons from Drosophila
    Robert R H Anholt
    WM Keck Center for Behavioral Biology and Departments of Zoology and Genetics, North Carolina State University, Raleigh, NC 27695 7617, USA
    Bioessays 26:1299-306. 2004
    ..Such networks are exquisitely sensitive to genetic background and sex effects. This review describes how Drosophila can serve as a model for uncovering fundamental principles of the genetic architecture of behavior...
  91. ncbi Unconventional sex: fresh approaches to courtship learning
    Jennifer E Mehren
    Department of Biology and Volen Center for Complex Systems, Brandeis University MS008, 415 South Street, Waltham, Massachusetts 02454 9110, USA
    Curr Opin Neurobiol 14:745-50. 2004
    ..Advances in transgenic tools and developments in behavioral assays have increased the power of studying courtship learning in the fruit fly...
  92. ncbi Induction of cAMP response element-binding protein-dependent medium-term memory by appetitive gustatory reinforcement in Drosophila larvae
    Ken Honjo
    Graduate School of Life and Environmental Sciences, University of Tsukuba, Tsukuba 305 8572, Japan
    J Neurosci 25:7905-13. 2005
    ..Moreover, we also show that synaptic output of larval mushroom body neurons is required for retrieval but not for acquisition and retention of the larval memory, including the CREB-dependent component...
  93. ncbi Ras activity in the Drosophila prothoracic gland regulates body size and developmental rate via ecdysone release
    Philip E Caldwell
    Department of Biochemistry and Cell Biology, Rice University, Houston, Texas 77251, USA
    Curr Biol 15:1785-95. 2005
    ..Because all growth occurs during the larval stages, final body size depends on both the larval growth rate and the duration of each larval stage, which in turn might be regulated by the timing of ecdysone release...
  94. ncbi Watching the fly brain learn
    Leslie C Griffith
    Department of Biology and National Center for Behavioral Genomics, Brandeis University, 415 South Street, Waltham, Massachusetts 02454, USA
    Neuron 49:171-4. 2006
    ..These findings provide important new insight into the circuitry of learning in Drosophila...
  95. doi Distinctive neuronal networks and biochemical pathways for appetitive and aversive memory in Drosophila larvae
    Ken Honjo
    Graduate School of Life and Environmental Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan
    J Neurosci 29:852-62. 2009
    ..These results as a whole suggest that the genetically programmed memory circuitries might provide predisposition in the efficacy of inducing longer-lived memory components in associative learning...
  96. doi Mutations affecting the cAMP transduction pathway disrupt the centrophobism behavior
    Sebastien Lebreton
    Bases Neurales des Comportements chez la Drosophile Laboratoire de Neurobiologie Cellulaire et Moléculaire NBCM, CNRS, Gif sur Yvette, France
    J Neurogenet 23:225-34. 2009
    ..Here, we report that disturbing this pathway by using different mutants, such as dnc, rut, PKA, or amn, lead to centrophobism defect...
  97. pmc Genetic effects in Drosophila on the potency of diverse general anesthetics: a distinctive pattern of altered sensitivity
    Joseph L Campbell
    Laboratory of Molecular Biology, National Institute of Mental Health, Bethesda, MD 20892 3736, USA
    J Neurogenet 23:412-21. 2009
    ..Intriguingly, P element insertions that co-map with several NEP loci have been shown to alter the fly's response to cocaine and ethanol, suggesting that common genetic elements are involved in the response to all three drugs...
  98. pmc The amnesiac gene is involved in the regulation of thermal nociception in Drosophila melanogaster
    Benjamin T Aldrich
    Department of Anesthesia, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    J Neurogenet 24:33-41. 2010
    ..The amnesiac gene (amn), which encodes a putative neuropeptide precursor, is important for stabilizing olfactory memory, and is involved ..
  99. ncbi Decreased odor avoidance after electric shock in Drosophila mutants biases learning and memory tests
    T Preat
    Institut Alfred Fessard, Centre National de la Recherche Scientifique, 91190 Gif sur Yvette, France
    J Neurosci 18:8534-8. 1998
    ..In contrast, the Dnc phosphodiesterase accumulated in the mushroom bodies would be involved specifically in memory formation...
  100. ncbi The nature of Drosophila melanogaster
    C J Reaume
    Department of Biology, University of Toronto at Mississauga, 3359 Mississauga Road, Mississauga, Ontario, Canada, L5L1C6
    Curr Biol 16:R623-8. 2006

Research Grants8

  1. Connectivity in the Nematode Nervous System
    Scott Emmons; Fiscal Year: 2002
    ..The preanal ganglion circuitry provides a unique opportunity to explore the development and function of a defined set of synapses during postembryonic life in a system which is not essential for survival in this hermaphroditic species. ..
  2. Regulated Gene Expression and Drosophila Behavior
    Ronald Davis; Fiscal Year: 2003
    ..The techniques proposed here offer a general method for turning on gene activity both spatially and temporally in Drosophila. ..
  3. GENETIC ANALYSIS OF MORPHOGENESIS IN A NEMATODE
    Scott Emmons; Fiscal Year: 2005
    ..This research will contribute to understanding a fundamental aspect of animal development, and thus help towards progress in overcoming diseases that arise as a result of developmental abnormalities. ..
  4. NEUROGENETICS OF DROSOPHILA REPRODUCTION
    LESLIE GRIFFITH; Fiscal Year: 2007
    ..melanogaster ..
  5. NEURON DIFFERENTIATION IN C ELEGANS
    Scott Emmons; Fiscal Year: 2002
    ..3) screen for mutants (including ts alleles) in which TH::GFP expression is lost and characterize the corresponding genes molecularly. (4) identify genes involved in the axon connectivity of DA neurons. ..
  6. Molecular Neurobiology of Behavioral Rhythms
    Jeffrey Hall; Fiscal Year: 2006
    ..of chronobiology in this model system may provide insights into the nature of certain rhythm-related disorders of humans, some of which are associated with genetic variations of Drosophila clock gene orthologs [unreadable] [unreadable]..
  7. GENETIC INTERFERENCE WITH MEMORY CONSOLIDATION
    Edward Korzus; Fiscal Year: 2003
    ..A newly created mouse model will provide the unique approach to study memory consolidation at molecular, cellular and cognitive level. ..
  8. Functional Anatomy of Learning and Memory in Drosophila
    JOSHUA DUBNAU; Fiscal Year: 2008
    ..As a result, an understanding of the "logic" of how information is processed in relatively simple nervous systems can greatly inform future investigations of human cognition. ..