Acp70A

Summary

Gene Symbol: Acp70A
Description: Accessory gland peptide 70A
Alias: ACP, Acp-70A, Acp70, Acp70a, CG17673, Dmel\CG17673, DrmSP, PapB, Spg70, Acp70A-PA, CG17673-PA, DrmSP, Paragonial-peptide-B, Sex peptide, Sex-Peptide, accessory gland peptide 70A, accessory protein 70A, sex peptide gene in 70, sexpeptide
Species: fruit fly

Top Publications

  1. pmc Control of the postmating behavioral switch in Drosophila females by internal sensory neurons
    Chung Hui Yang
    Howard Hughes Medical Institute, Department of Physiology, University of California, San Francisco, San Francisco, CA 94143, USA
    Neuron 61:519-26. 2009
  2. pmc A network of interactions among seminal proteins underlies the long-term postmating response in Drosophila
    K Ravi Ram
    Department of Molecular Biology and Genetics, Biotechnology Building, Cornell University, Ithaca, NY 14853, USA
    Proc Natl Acad Sci U S A 106:15384-9. 2009
  3. ncbi Sex-peptides: seminal peptides of the Drosophila male
    E Kubli
    Zoological Institute, University Zurich Irchel, Winterthurerstrasse 190, 8057, Zurich, Switzerland
    Cell Mol Life Sci 60:1689-704. 2003
  4. doi Sensory neurons in the Drosophila genital tract regulate female reproductive behavior
    Martin Häsemeyer
    Research Institute of Molecular Pathology IMP, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Neuron 61:511-8. 2009
  5. pmc The sex peptide of Drosophila melanogaster: female post-mating responses analyzed by using RNA interference
    Tracey Chapman
    Department of Biology, Darwin Building, and Wolfson Institute for Biomedical Research, Cruciform Building, University College London, Gower Street, London WC1E 6BT, UK
    Proc Natl Acad Sci U S A 100:9923-8. 2003
  6. ncbi A male accessory gland peptide that regulates reproductive behavior of female D. melanogaster
    P S Chen
    Institute of Zoology, University of Zurich, Switzerland
    Cell 54:291-8. 1988
  7. pmc Sex-peptide is the molecular basis of the sperm effect in Drosophila melanogaster
    Huanfa Liu
    Zoological Institute, University of Zurich Irchel, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Proc Natl Acad Sci U S A 100:9929-33. 2003
  8. pmc Drosophila female sexual behavior induced by sterile males showing copulation complementation
    L Xue
    Institute for Molecular Biology, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Proc Natl Acad Sci U S A 97:3272-5. 2000
  9. pmc Sex peptide is required for the efficient release of stored sperm in mated Drosophila females
    Frank W Avila
    Department of Biology, Gustavus Adolphus College, St Peter, MN 56082, USA
    Genetics 186:595-600. 2010
  10. pmc Allocrine modulation of feeding behavior by the Sex Peptide of Drosophila
    Gil B Carvalho
    Division of Biology 156 29 and 216 76, California Institute of Technology, Pasadena, 91125, USA
    Curr Biol 16:692-6. 2006

Scientific Experts

Detail Information

Publications76

  1. pmc Control of the postmating behavioral switch in Drosophila females by internal sensory neurons
    Chung Hui Yang
    Howard Hughes Medical Institute, Department of Physiology, University of California, San Francisco, San Francisco, CA 94143, USA
    Neuron 61:519-26. 2009
    ..in the receptivity and egg-laying behavior in Drosophila females, primarily due to a peptide pheromone called sex peptide which is transferred with the sperm into the female reproductive tract during copulation...
  2. pmc A network of interactions among seminal proteins underlies the long-term postmating response in Drosophila
    K Ravi Ram
    Department of Molecular Biology and Genetics, Biotechnology Building, Cornell University, Ithaca, NY 14853, USA
    Proc Natl Acad Sci U S A 106:15384-9. 2009
    ..Drosophila seminal fluid also contains a "sex peptide" (SP, Acp70A) that plays a major role in regulating egg production and mating behavior in females for several ..
  3. ncbi Sex-peptides: seminal peptides of the Drosophila male
    E Kubli
    Zoological Institute, University Zurich Irchel, Winterthurerstrasse 190, 8057, Zurich, Switzerland
    Cell Mol Life Sci 60:1689-704. 2003
    ..Sps bind to sperm. Together with sperm they are responsible for the persistence of the two post-mating responses. But Sps are the molecular basis of the sperm effect; sperm is merely the carrier...
  4. doi Sensory neurons in the Drosophila genital tract regulate female reproductive behavior
    Martin Häsemeyer
    Research Institute of Molecular Pathology IMP, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Neuron 61:511-8. 2009
    ..In Drosophila melanogaster, changes in female behavior upon mating are triggered by the sex peptide (SP), a small peptide present in the male's seminal fluid...
  5. pmc The sex peptide of Drosophila melanogaster: female post-mating responses analyzed by using RNA interference
    Tracey Chapman
    Department of Biology, Darwin Building, and Wolfson Institute for Biomedical Research, Cruciform Building, University College London, Gower Street, London WC1E 6BT, UK
    Proc Natl Acad Sci U S A 100:9923-8. 2003
    ..Injection of the seminal fluid sex peptide (SP) induces both responses in virgin females, but only for 1-2 days...
  6. ncbi A male accessory gland peptide that regulates reproductive behavior of female D. melanogaster
    P S Chen
    Institute of Zoology, University of Zurich, Switzerland
    Cell 54:291-8. 1988
    ..The precursor peptide is encoded by a short mRNA that accumulates exclusively in the male accessory gland. The gene has been localized by in situ hybridization to polytene chromosomes at 70A...
  7. pmc Sex-peptide is the molecular basis of the sperm effect in Drosophila melanogaster
    Huanfa Liu
    Zoological Institute, University of Zurich Irchel, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Proc Natl Acad Sci U S A 100:9929-33. 2003
    ..The second conclusion is supported by the finding that SP binds to sperm. The 36-aa-encoding SP gene is the first small Drosophila gene knocked out with the method of homologous recombination...
  8. pmc Drosophila female sexual behavior induced by sterile males showing copulation complementation
    L Xue
    Institute for Molecular Biology, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Proc Natl Acad Sci U S A 97:3272-5. 2000
    ..Our observations may have important implications for the role of sexual behavior in evolution and for the treatment of male sexual dysfunction in humans...
  9. pmc Sex peptide is required for the efficient release of stored sperm in mated Drosophila females
    Frank W Avila
    Department of Biology, Gustavus Adolphus College, St Peter, MN 56082, USA
    Genetics 186:595-600. 2010
    The Drosophila seminal fluid protein (SFP) sex peptide (SP) elicits numerous post-mating responses, including increased egg laying and decreased sexual receptivity, in the mated female...
  10. pmc Allocrine modulation of feeding behavior by the Sex Peptide of Drosophila
    Gil B Carvalho
    Division of Biology 156 29 and 216 76, California Institute of Technology, Pasadena, 91125, USA
    Curr Biol 16:692-6. 2006
    ..Remarkably, this change is abolished if the males lack a single, small seminal protein, the Sex Peptide (SP)...
  11. doi Female nutritional status determines the magnitude and sign of responses to a male ejaculate signal in Drosophila melanogaster
    C Fricke
    School of Biological Sciences, University of East Anglia, Norwich, UK
    J Evol Biol 23:157-65. 2010
    ..adult female nutrition on the response of female Drosophila melanogaster to a specific ejaculate component, the sex peptide (SP), which is of interest because of its effects on female egg laying, sexual receptivity, feeding rate, ..
  12. doi Mating-increases trypsin in female Drosophila hemolymph
    Noam Pilpel
    Department of Entomology, The Hebrew University of Jerusalem, Rehovot, Israel
    Insect Biochem Mol Biol 38:320-30. 2008
    ..To test this hypothesis we examined the fate of one Acp, Drosophila melanogaster Sex Peptide (Acp70A, DrmSP), which possesses several putative serine-protease cleavage sites, in hemolymph of unmated and ..
  13. ncbi Ectopic expression of sex-peptide in a variety of tissues in Drosophila females using the P[GAL4] enhancer-trap system
    S Nakayama
    Department of Biology, Tokyo Metropolitan University, Japan
    Mol Gen Genet 254:449-55. 1997
    ..Western blot analysis of head, thorax, and abdominal extracts revealed that the biological activity was correlated with expression in the head fraction...
  14. ncbi Seminal fluid-mediated fitness traits in Drosophila
    T Chapman
    The Galton Laboratory, Department of Biology, University College, London, Wolfson House, 4 Stephenson Way, London, NW1 2HE, UK
    Heredity (Edinb) 87:511-21. 2001
    ..In this review I address these issues by bringing together evidence for the function, evolution, diversification, and maintenance of variation in, seminal fluid-mediated traits...
  15. pmc Probing the function of Drosophila melanogaster accessory glands by directed cell ablation
    J M Kalb
    Section of Genetics and Development, Cornell University, Ithaca, NY 14853 2703
    Proc Natl Acad Sci U S A 90:8093-7. 1993
    ..These transgenic strains that express diphtheria toxins of different strengths in accessory-gland main cells will be useful in further defining the role of these cells...
  16. ncbi The hydroxyproline motif of male sex peptide elicits the innate immune response in Drosophila females
    Elena V Domanitskaya
    Zoologisches Institut Universität Zürich Irchel, Zurich, Switzerland
    FEBS J 274:5659-68. 2007
    ..In Drosophila melanogaster females, sex peptide (SP) is the major seminal agent eliciting oviposition and reduction of receptivity...
  17. ncbi The gifts that keep on giving: physiological functions and evolutionary dynamics of male seminal proteins in Drosophila
    M F Wolfner
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853 2703, USA
    Heredity (Edinb) 88:85-93. 2002
    ..An apparent prohormonal Acp, ovulin (Acp26Aa) stimulates ovulation in mated Drosophila females...
  18. pmc Proteomics reveals novel Drosophila seminal fluid proteins transferred at mating
    Geoffrey D Findlay
    Department of Genome Sciences, University of Washington, Seattle, Washington, USA
    PLoS Biol 6:e178. 2008
    ....
  19. pmc Feeding, fecundity and lifespan in female Drosophila melanogaster
    Andrew I Barnes
    Research Department of Genetics, Evolution and Environment, University College London, Darwin Building, Gower Street, London WC1E 6BT, UK
    Proc Biol Sci 275:1675-83. 2008
    ..In Drosophila melanogaster, these effects can be mediated by an ejaculate 'sex peptide' (SP), which, in addition, contributes significantly to the cost of mating in females...
  20. ncbi Gradual release of sperm bound sex-peptide controls female postmating behavior in Drosophila
    Jing Peng
    Zoological Institute, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Curr Biol 15:207-13. 2005
    ..In Drosophila melanogaster, sex-peptide (SP) elicits short- and long-term PMR, but only the latter in the presence of stored sperm (sperm effect)...
  21. ncbi Ductus ejaculatorius peptide 99B (DUP99B), a novel Drosophila melanogaster sex-peptide pheromone
    Philippe Saudan
    Zoologisches Institut Universität Zürich Irchel, Zurich, Switzerland
    Eur J Biochem 269:989-97. 2002
    ..The C-terminal parts of mature DUP99B and D. melanogaster sex-peptide (ACP70A) are highly homologous...
  22. ncbi Tokens of love: functions and regulation of Drosophila male accessory gland products
    M F Wolfner
    Section of Genetics and Development, Cornell University, Ithaca, NY 14853 2703, USA
    Insect Biochem Mol Biol 27:179-92. 1997
    ..Further dissection of accessory gland function has defined several molecules that cause these effects. A "sex peptide" and a prohormone-like molecule (Accessory gland protein 26Aa) stimulate the female's egg-laying rate; the sex ..
  23. pmc Associations between sperm competition and natural variation in male reproductive genes on the third chromosome of Drosophila melanogaster
    Anthony C Fiumera
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853, USA
    Genetics 176:1245-60. 2007
    ..Several associations were consistent with previous findings [Acp70A with the male's influence on the female's refractoriness to remating (refractory), Esterase-6 with a male's ..
  24. ncbi Sex peptide causes mating costs in female Drosophila melanogaster
    Stuart Wigby
    Department of Biology, University College London, Darwin Building, Gower Street, London, WC1E 6BT, United Kingdom
    Curr Biol 15:316-21. 2005
    ..We demonstrate here that a single Acp, the sex peptide (SP or Acp70A), which decreases female receptivity and stimulates egg production in the first matings of virgin ..
  25. ncbi Ectopic expression of sex peptide alters reproductive behavior of female D. melanogaster
    T Aigaki
    Department of Experimental Biology, Tokyo Metropolitan Institute of Gerontology, Japan
    Neuron 7:557-63. 1991
    b>Sex peptide, a secreted component of the male accessory glands, has been shown to induce behavioral and physiological changes in mated Drosophila...
  26. ncbi Control of oocyte maturation in sexually mature Drosophila females
    M Soller
    Zoologisches Institut, Universitat Zurich Irchel, Winterthurerstrasse 190, Zurich, CH 8057, Switzerland
    Dev Biol 208:337-51. 1999
    ..Since juvenile hormone analogue does not elicit increased oviposition and reduced receptivity, Sex-Peptide must have an additional, separate effect on these two postmating responses...
  27. ncbi Sex-peptide activates juvenile hormone biosynthesis in the Drosophila melanogaster corpus allatum
    P Moshitzky
    Department of Entomology, Hebrew University, Rehovot, Israel
    Arch Insect Biochem Physiol 32:363-74. 1996
    ..Our results suggest that the CA is a direct target for SP in vivo and that sexual maturity is established separately for the two post-mating reactions...
  28. ncbi Drosophila sex-peptide stimulates female innate immune system after mating via the Toll and Imd pathways
    Jing Peng
    Zoological Institute, University of Zurich Irchel, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Curr Biol 15:1690-4. 2005
    ..Mating may physically damage females and pathogens may be transferred. Thus, endogenous stimulation of AMP transcription by SP at mating might be considered as a preventive step to encounter putative immunogenic attacks...
  29. ncbi Mating and sex peptide stimulate the accumulation of yolk in oocytes of Drosophila melanogaster
    M Soller
    Zoologisches Institut Universität Zürich Irchel, Switzerland
    Eur J Biochem 243:732-8. 1997
    ..Central to the control of receptivity and oviposition in Drosophila melanogaster is the sex peptide (SP), a 36-amino-acid peptide sex pheromone synthesized in the male accessory glands and transferred to the ..
  30. pmc Female Drosophila melanogaster suffer reduced defense against infection due to seminal fluid components
    Sarah M Short
    Field of Genetics and Development, Cornell University Ithaca, NY 14853, USA
    J Insect Physiol 58:1192-201. 2012
    ..on male transfer of sperm and seminal fluid proteins, including the accessory gland protein known as "sex peptide." However, the effect of these male factors is dependent on the presence of the female germline...
  31. ncbi Defective transfer of seminal-fluid materials during matings of semi-fertile fruitless mutants in Drosophila
    Adriana Villella
    Department of Biology, MS 008, Brandeis University, Waltham, MA 02454 9110, USA
    J Comp Physiol A Neuroethol Sens Neural Behav Physiol 192:1253-69. 2006
    ..fruitless (fru) mutant genotypes, we examined the transfer of seminal fluid using a transgene that encodes the Sex Peptide (SP) oligopeptide fused to Green Fluorescent Protein (GFP)...
  32. doi The benefits of male ejaculate sex peptide transfer in Drosophila melanogaster
    C Fricke
    School of Biological Sciences, University of East Anglia, Norwich, UK
    J Evol Biol 22:275-86. 2009
    ..Here, we measured the fitness benefits to males of ejaculate sex peptide (SP) transfer...
  33. pmc The Drosophila melanogaster seminal fluid protease "seminase" regulates proteolytic and post-mating reproductive processes
    Brooke A LaFlamme
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY, USA
    PLoS Genet 8:e1002435. 2012
    ..phenotypes of females mated to CG10586 knockdown males are similar to those of females that fail to store sex peptide, an important elicitor of long-term post-mating responses, and indicate a role for CG10586 in regulating sex ..
  34. pmc The homeodomain protein defective proventriculus is essential for male accessory gland development to enhance fecundity in Drosophila
    Ryunosuke Minami
    Graduate School of Natural Science and Technology, Okayama University, Okayama, Japan
    PLoS ONE 7:e32302. 2012
    ..A well-known accessory gland protein, sex peptide, is secreted from the main cells and induces female postmating response to increase progeny production, whereas ..
  35. doi Functional impact of silencing the Helicoverpa armigera sex-peptide receptor on female reproductive behaviour
    O Hanin
    Department of Entomology, Hebrew University, Rehovot, Israel
    Insect Mol Biol 21:161-7. 2012
    ..of this receptor in brains and pheromone glands of mated females, thereby implicating a regulatory role for sex peptide in the reproductive behaviour of H. armigera...
  36. pmc Protein-specific manipulation of ejaculate composition in response to female mating status in Drosophila melanogaster
    Laura K Sirot
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA
    Proc Natl Acad Sci U S A 108:9922-6. 2011
    ..In contrast, the levels of a key receptivity-inhibiting Sfp (sex peptide) were the same in M and V females...
  37. pmc The genetic basis for male x female interactions underlying variation in reproductive phenotypes of Drosophila
    Clement Y Chow
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853 2703, USA
    Genetics 186:1355-65. 2010
    ..Encoded on these chromosomes are, respectively, sex peptide (SP) and sex peptide receptor (SPR), the only pair of physically interacting male Acp and female receptor known...
  38. pmc The effect of sex peptide and calorie intake on fecundity in female Drosophila melanogaster
    Blanka Rogina
    Department of Genetics and Developmental Biology, School of Medicine, University of Connecticut Health Center, Farmington, CT, USA
    ScientificWorldJournal 9:1178-89. 2009
    ..b>Sex peptide (SP) is one of the Acps that initiates many changes, including an increase in egg production...
  39. pmc Enteric neurons and systemic signals couple nutritional and reproductive status with intestinal homeostasis
    Paola Cognigni
    Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, UK
    Cell Metab 13:92-104. 2011
    ..modulating appetite, a vasopressin-like system essential for fluid homeostasis, and enteric neurons mediating sex peptide-induced changes in intestinal physiology...
  40. ncbi Common functional elements of Drosophila melanogaster seminal peptides involved in reproduction of Drosophila melanogaster and Helicoverpa armigera females
    Y Fan
    Department of Entomology, The Hebrew University, P O Box 12, 76100, Rehovot, Israel
    Insect Biochem Mol Biol 30:805-12. 2000
    b>Sex peptide (SP) and Ductus ejaculatorius peptide (Dup) 99B are synthesized in the retrogonadal complex of adult male Drosophila melanogaster, and are transferred in the male seminal fluid to the female genital tract during mating...
  41. pmc MIPs are ancestral ligands for the sex peptide receptor
    Young Joon Kim
    Research Institute of Molecular Pathology, A 1030 Vienna, Austria
    Proc Natl Acad Sci U S A 107:6520-5. 2010
    ..In Drosophila melanogaster, postmating behaviors are triggered by sex peptide (SP), which is produced in the male seminal fluid and transferred to female during copulation...
  42. pmc Neural circuitry underlying Drosophila female postmating behavioral responses
    Carolina Rezaval
    Department of Physiology, Anatomy and Genetics, University of Oxford, Sherrington Building, Parks Road, Oxford OX1 3PT, UK
    Curr Biol 22:1155-65. 2012
    ..Transfer of male sex peptide (SP) during copulation mediates these postmating responses via sensory neurons that coexpress the sex-..
  43. pmc Seminal fluid protein allocation and male reproductive success
    Stuart Wigby
    Department of Genetics, Evolution and Environment, University College London, Darwin Building, Gower Street, London WC1E 6BT, UK
    Curr Biol 19:751-7. 2009
    ..When males were exposed to a competitor male, matings were longer and more of two key Sfps, sex peptide [8] and ovulin [9], were transferred, indicating strategic allocation of Sfps...
  44. pmc YA is needed for proper nuclear organization to transition between meiosis and mitosis in Drosophila
    Katharine L Sackton
    Dept of Molecular Biology and Genetics, Cornell University, Ithaca NY 14853, USA
    BMC Dev Biol 9:43. 2009
    ..After egg activation, YA enters nuclei and interacts with chromatin and the nuclear lamina. This study was designed to define more precisely the events prior to the first cleavage division that are dependent upon YA...
  45. doi Variation in sex peptide expression in D. melanogaster
    D T Smith
    Centre for Ecology and Conservation, University of Exeter, Cornwall Campus, Penryn, Cornwall, UK
    Genet Res (Camb) 91:237-42. 2009
    Male Drosophila melanogaster transfers many accessory-gland proteins to females during copulation. Sex peptide (SP) is one of these and one of its main effects is to decrease female remating propensity...
  46. doi NMR studies of the solution conformation of the sex peptide from Drosophila melanogaster
    Kerstin Moehle
    Chemistry Department, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    FEBS Lett 585:1197-202. 2011
    The insect sex peptide (SP) elicits a variety of biological responses upon transfer to the mated female...
  47. ncbi One-tube direct PCR from whole Drosophila melanogaster adults
    A Czank
    Zoologisches Institut, Universitat Zurich, Switzerland
    Trends Genet 12:457. 1996
  48. doi Myoinhibiting peptides are the ancestral ligands of the promiscuous Drosophila sex peptide receptor
    Jeroen Poels
    Animal Physiology and Neurobiology, Katholieke Universiteit Leuven, Naamsestraat 59, Leuven, Belgium
    Cell Mol Life Sci 67:3511-22. 2010
    Male insects change behaviors of female partners by co-transferring accessory gland proteins (Acps) like sex peptide (SP), with their sperm...
  49. doi Sex peptide receptor and neuronal TOR/S6K signaling modulate nutrient balancing in Drosophila
    Carlos Ribeiro
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Curr Biol 20:1000-5. 2010
    ..is a critical modulator of this decision-making process in females and that it relies on the action of the sex peptide receptor in internal ppk(+) sensory neurons...
  50. ncbi The developments between gametogenesis and fertilization: ovulation and female sperm storage in Drosophila melanogaster
    Margaret C Bloch Qazi
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA
    Dev Biol 256:195-211. 2003
    ..melanogaster, both processes are triggered by male factors during and after mating, including sperm and seminal fluid proteins. Therefore, an interplay of male and female factors coordinates the gametes for fertilization...
  51. pmc Molecular population genetics of male accessory gland proteins in Drosophila
    D J Begun
    Section of Integrative Biology and Institute for Cellular and Molecular Biology, University of Texas, Austin, Texas 78712, USA
    Genetics 156:1879-88. 2000
    ..In addition to the already-reported departures of Acp26A, Acp29AB, and Acp70A from neutrality, our data reject neutrality at Acp29AB and Acp36DE in the direction of excess replacements in ..
  52. pmc The role of male accessory gland protein Acp36DE in sperm competition in Drosophila melanogaster
    T Chapman
    Department of Biology, University College London, UK
    Proc Biol Sci 267:1097-105. 2000
    ..Our results indicate that mutations in genes that affect sperm storage can drastically affect the outcome of sperm competition...
  53. ncbi Binding sites of Drosophila melanogaster sex peptide pheromones
    M Ottiger
    Zoologisches Institut Universität Zürich Irchel, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    J Neurobiol 44:57-71. 2000
    Drosophila melanogaster sex peptide (SP) and Ductus ejaculatorius peptide (DUP99B) are male pheromones transferred in the seminal fluid to the female during copulation. Both reduce sexual receptivity and stimulate oviposition in females...
  54. ncbi The sex-peptide
    E Kubli
    Zoologisches Institut, Universitat Zurich Irchel, Switzerland
    Bioessays 14:779-84. 1992
    ..The sex-peptide, therefore, can be considered as a pheromone. In this review, I shall limit my discussion to Drosophila melanogaster...
  55. pmc Unusual haplotype structure at the proximal breakpoint of In(2L)t in a natural population of Drosophila melanogaster
    P Andolfatto
    Committee on Genetics, University of Chicago, Chicago, Illinois 60637, USA
    Genetics 153:1297-311. 1999
    ..Certain features of our data suggest that the unusual pattern in standard chromosomes is the product of selection rather than demography...
  56. ncbi Ovulation stimulating substances in Drosophila biarmipes males: their origin, genetic variation in the response of females, and molecular characterization
    M Imamura
    Department of Biology, Tokyo Metropolitan University, Japan
    Insect Biochem Mol Biol 28:365-72. 1998
    ..Its C-terminal region has a striking similarity to the sex-peptide of D. melanogaster, but the N-terminal region was entirely different. Evolutionary implications of these findings are discussed...
  57. ncbi Ovulation and the suppression of mating in Drosophila melanogaster females: behavioral basis
    Y Fuyama
    Department of Biology, Tokyo Metropolitan University, Japan
    Behav Genet 27:483-8. 1997
    ..Courtship behavior by mutant males defective in olfaction or learning suggested that females are capable of repelling males by emitting a volatile pheromone(s) with an inhibitory effect on male courtship...
  58. pmc Evolutionary history of the sex-peptide (Acp70A) gene region in Drosophila melanogaster
    S Cirera
    Departament de Genetica, Facultat de Biologia, Universitat de Barcelona, Spain
    Genetics 147:189-97. 1997
    ..Of all the accessory gland peptides (Acp's) involved in these two responses, the sex-peptide (coded by the Acp70A gene) is among the best characterized at the functional level. A 1...
  59. ncbi The accessory gland proteins in male Drosophila: structural, reproductive, and evolutionary aspects
    P S Chen
    Institute of Zoology, University of Zurich, Switzerland
    Experientia 52:503-10. 1996
    ..The most prominent feature is the species-specific variability. However, the analysis of the sex peptide in D...
  60. ncbi Genetic evidence that ovulation reduces sexual receptivity in Drosophila melanogaster females
    Y Fuyama
    Department of Biology, Tokyo Metropolitan University, Japan
    Behav Genet 25:581-7. 1995
    ..Essentially the same was found with the females that were ectopically expressing the sex-peptide gene. The results indicate that ovulation induced by the sex-peptide has an effect of reducing the sexual receptivity of mated females...
  61. ncbi Drosophila suzukii contains a peptide homologous to the Drosophila melanogaster sex-peptide and functional in both species
    T Schmidt
    Zoological Institute, University Zurich Irchel, Switzerland
    Insect Biochem Mol Biol 23:571-9. 1993
    ..The D. melanogaster and the D. suzuki sex-peptides elicit rejection behaviour in the presence of males and an increased egg laying in virgin females of both species...
  62. ncbi The Drosophila melanogaster X-linked mfs(1)6E locus is required for production of normal seminal fluid by the male accessory glands
    P P Lopez
    Centro de Investigaciones Biologicas, Velazquez 144, Madrid, 28006, Spain
    Exp Cell Res 267:1-12. 2001
    ..Mutant male accessory glands show notable abnormalities, connected with glandular secretion as well as qualitative and quantitative differences in their protein content...
  63. ncbi Mushroom bodies and post-mating behaviors of Drosophila melanogaster females
    I Fleischmann
    Zoologisches Institut, Universitat Zurich Irchel, Switzerland
    J Neurogenet 15:117-44. 2001
    ..Central to these changes is Sex peptide (SP), a male peptide transferred into the female during copulation...
  64. ncbi Enhanced cost of mating in female sterile mutants of Drosophila melanogaster
    Morio Ueyama
    Department of Biology, Tokyo Metropolitan University, Hachioji
    Genes Genet Syst 78:29-36. 2003
    ..Even more extreme shortening of life spans were observed when the sex peptide gene (Acp70A) was expressed in homozygous otu females, though they were virgin, indicating that the shortening ..
  65. ncbi Sexual behavior: a seminal peptide stimulates appetites
    Alex Wong
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853, USA
    Curr Biol 16:R256-7. 2006
    ..These findings contribute significantly to our understanding of mating behaviors and resource allocation, and may provide insights useful for controlling the reproduction of insect pests...
  66. ncbi Widely distributed Drosophila G-protein-coupled receptor (CG7887) is activated by endogenous tachykinin-related peptides
    Ryan T Birse
    Department of Zoology, Stockholm University, SE 10691 Stockholm, Sweden
    J Neurobiol 66:33-46. 2006
    ..Our findings suggest that DTKR is a DTK receptor in Drosophila and that this ligand-receptor system plays multiple functional roles...
  67. ncbi Reproductive biology: direct delivery of costly sex peptides
    Matthew J G Gage
    School of Biological Sciences, University of East Anglia, Norwich NR4 7TJ, UK
    Curr Biol 15:R124-6. 2005
    ..Two new studies demonstrate, first, how an influential male sex peptide in Drosophila is delivered to the female bound directly onto sperm cells, and second, that its subsequent ..
  68. ncbi Pheromone perception and behavior in Drosophila
    Hubert Amrein
    Duke University Medical Center, Department of Molecular Genetics and Microbiology, Durham, North Carolina 27710, USA
    Curr Opin Neurobiol 14:435-42. 2004
    ..These advances have made it possible to make specific manipulations of pheromone pathways for further investigation...
  69. ncbi The presence of Drosophila melanogaster sex peptide-like immunoreactivity in the accessory glands of male Helicoverpa armigera
    Vidya K Nagalakshmi
    Department of Entomology, The Hebrew University, P O Box 12, Rehovot 76100, Israel
    J Insect Physiol 50:241-8. 2004
    In this study a highly specific polyclonal antibody to DrmSP was produced and used to develop and standardize a sensitive direct ELISA. Structure-activity studies revealed that the antiserum is specific to the N-terminal of DrmSP...
  70. ncbi Quantitative trait loci affecting natural variation in Drosophila longevity
    Gretchen L Geiger-Thornsberry
    Department of Genetics, Box 7614, North Carolina State University, Raleigh 27695, USA
    Mech Ageing Dev 125:179-89. 2004
    ..Quantitative complementation tests are therefore useful for identifying QTL contributing to segregating genetic variation in life span in nature...
  71. ncbi Population genetics of accessory gland proteins and sexual behavior in Drosophila melanogaster populations from Evolution Canyon
    Tami M Panhuis
    Department of Biology, University of California, Riverside, California 92521, USA
    Evolution 57:2785-91. 2003
    ..We sequenced six different Acp genes from isofemale lines from the south-facing slope (11 lines) and north-facing slope (nine lines) of Evolution ..
  72. ncbi Drosophila CG8422 encodes a functional diuretic hormone receptor
    Erik C Johnson
    Department of Anatomy and Neurobiology, Washington University School of Medicine, Saint Louis, MO 63110, USA
    J Exp Biol 207:743-8. 2004
    ..The identification of a Drosophila receptor for the DH neuropeptide provides a basis for genetic analysis of this critical factor's roles in maintaining physiological homeostasis...
  73. ncbi The sex-peptide DUP99B is expressed in the male ejaculatory duct and in the cardia of both sexes
    Albana Rexhepaj
    Zoologisches Institut Universität Zürich Irchel, Zurich, Switzerland
    Eur J Biochem 270:4306-14. 2003
    ..However, sex-peptide seems to play the major role in eliciting the postmating responses, while DUP99B may have specialized for other, as yet unknown, functions...
  74. ncbi Sex-peptides bind to two molecularly different targets in Drosophila melanogaster females
    Zhaobing Ding
    Zoologisches Institut Universität Zürich Irchel, Winterthurerstrasse190, CH 8057 Zurich, Switzerland
    J Neurobiol 55:372-84. 2003
    ..Our results suggest that binding of SP in the nervous system is responsible for eliciting the postmating responses, whereas binding in the genital tract reflects the presence of a peptide transporter...
  75. ncbi The mating of a fly
    J C Hall
    Department of Biology, Brandeis University, Waltham, MA 02254 9110
    Science 264:1702-14. 1994
    ..Further behavioral mutations seemed originally to be courtship-specific, turned out not to have that property, and have led to a broadened perspective on the nature and action of Drosophila's sex-determination genes...

Research Grants48

  1. Comparative Genomics of Seminal Fluid Proteins
    ANTHONY FIUMERA; Fiscal Year: 2005
    ..Finally, I will then determine the functional conservation of Acps using transgenic D. melanogaster expressing heterospecific accessory gland proteins. ..
  2. Molecular Genetics of Pronuclear Functions in Drosphila
    MARIANA WOLFNER; Fiscal Year: 2005
    ..Such modulation could mediate the rapid, concerted changes in egg physiology that occur at that time. ..
  3. ACTIONS OF SEMINAL PROTEINS IN MATED DROSOPHILA FEMALES
    MARIANA WOLFNER; Fiscal Year: 2009
    ..In addition to their relevance to reproductive mechanisms in a range of organisms including mammals, we anticipate that our findings will have practical applications in the control of insect vectors of human disease. ..
  4. Molecular genetics of egg activation and pronuclear function in Drosophila
    MARIANA FEDERICA WOLFNER; Fiscal Year: 2010
    ..Thus, we exploit the powerful genetics of Drosophila to elucidate efficiently the molecules and gene pathways needed to start development in humans. ..
  5. ACTIONS OF SEMINAL PROTEINS IN MATED DROSOPHILA FEMALES
    MARIANA FEDERICA WOLFNER; Fiscal Year: 2010
    ..Despite their importance, the functions of these proteins are not well understood. We use Drosophila's "Acp" seminal proteins as a model to investigate the mechanisms by which seminal proteins affect females...
  6. Molecular genetics of egg activation and pronuclear function in Drosophila
    MARIANA WOLFNER; Fiscal Year: 2007
    ..Thus, we exploit the powerful genetics of Drosophila to elucidate efficiently the molecules and gene pathways needed to start development in humans. ..
  7. ACTIONS OF SEMINAL PROTEINS IN MATED DROSOPHILA FEMALES
    MARIANA WOLFNER; Fiscal Year: 2003
    ..Analyzing these mutants, and ectopic expression of Acps, will identify new Acps that regulate ovulation, sperm storage or proteolysis. ..
  8. MOLECULAR GENETICS OF PRONUCLEAR FUNCTIONS IN DROSOPHILA
    MARIANA WOLFNER; Fiscal Year: 1993
    ..Simultaneously, they will permit the first genetic dissection of a non-lamin nuclear envelope component, and its developmental function, in an animal...
  9. ACTIONS OF SEMINAL PROTEINS IN MATED DROSOPHILA FEMALES
    MARIANA WOLFNER; Fiscal Year: 2007
    ..In addition to their relevance to reproductive mechanisms in a range of organisms including mammals, we anticipate that our findings will have practical applications in the control of insect vectors of human disease. ..
  10. MOLECULAR GENETICS OF PRONUCLEAR FUNCTIONS IN DROSOPHILA
    MARIANA WOLFNER; Fiscal Year: 2001
    ..Finally, we will elucidate the developmental controls that permit YA to enter nuclei upon egg activation, and the signals that target YA to the nuclear lamina. ..
  11. Molecular Genetics of Caloric Restriction in Aging Flies
    Blanka Rogina; Fiscal Year: 2009
    ..abstract_text> ..
  12. Molecular Genetics of Caloric Restriction in Aging Flies
    Blanka Rogina; Fiscal Year: 2010
    ..It will reveal how reduced caloric intake affects metabolism and life span, and provide the foundation for the development of new therapies for the treatments of age-associated diseases in humans. ..
  13. Genomic analysis of adaptation in Drosophila
    David J Begun; Fiscal Year: 2010
    ..These approaches could eventually be used in human populations. ..
  14. Natural variation in Drosophila female postmating traits
    DAVID BEGUN; Fiscal Year: 2007
    ..abstract_text> ..