Acp26Aa

Summary

Gene Symbol: Acp26Aa
Description: Accessory gland protein 26Aa
Alias: Acp, Acp26A, Acp26Aab, Acp26a, CG8982, Dmel\CG8982, Mst26A, Mst26Aa, Ovulin, msP355a, mst 355a, mst355a, ovulin, CG8982 gene product from transcript CG8982-RA, Acp26Aa-PA, CG8982-PA, accessory gland peptide 26Aa, accessory gland protein 26Aa, accessory gland-specific peptide 26Aa, accessory protein 26A, ovulin
Species: fruit fly

Top Publications

  1. ncbi Fates and targets of male accessory gland proteins in mated female Drosophila melanogaster
    K Ravi Ram
    Department of Molecular Biology and Genetics, Biotechnology Building, Cornell University, Ithaca, NY 14853, USA
    Insect Biochem Mol Biol 35:1059-71. 2005
  2. ncbi The Drosophila seminal fluid protein Acp26Aa stimulates release of oocytes by the ovary
    Y Heifetz
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA
    Curr Biol 10:99-102. 2000
  3. pmc The Acp26Aa seminal fluid protein is a modulator of early egg hatchability in Drosophila melanogaster
    T Chapman
    The Galton Laboratory, Department of Biology, University College London, Wolfson House, 4 Stephenson Way, London NW1 2HE, UK
    Proc Biol Sci 268:1647-54. 2001
  4. ncbi Seminal fluid-mediated fitness traits in Drosophila
    T Chapman
    The Galton Laboratory, Department of Biology, University College, London, Wolfson House, 4 Stephenson Way, London, NW1 2HE, UK
    Heredity (Edinb) 87:511-21. 2001
  5. ncbi The gifts that keep on giving: physiological functions and evolutionary dynamics of male seminal proteins in Drosophila
    M F Wolfner
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853 2703, USA
    Heredity (Edinb) 88:85-93. 2002
  6. pmc Sex-peptide is the molecular basis of the sperm effect in Drosophila melanogaster
    Huanfa Liu
    Zoological Institute, University of Zurich Irchel, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Proc Natl Acad Sci U S A 100:9929-33. 2003
  7. ncbi Sex-peptides: seminal peptides of the Drosophila male
    E Kubli
    Zoological Institute, University Zurich Irchel, Winterthurerstrasse 190, 8057, Zurich, Switzerland
    Cell Mol Life Sci 60:1689-704. 2003
  8. pmc Two cleavage products of the Drosophila accessory gland protein ovulin can independently induce ovulation
    Yael Heifetz
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA
    Proc Natl Acad Sci U S A 102:743-8. 2005
  9. ncbi Gradual release of sperm bound sex-peptide controls female postmating behavior in Drosophila
    Jing Peng
    Zoological Institute, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Curr Biol 15:207-13. 2005
  10. ncbi Structure, cell-specific expression, and mating-induced regulation of a Drosophila melanogaster male accessory gland gene
    A J Dibenedetto
    Section of Genetics and Development, Cornell University, Ithaca, New York 14853 2703
    Dev Biol 139:134-48. 1990

Research Grants

Scientific Experts

Detail Information

Publications71

  1. ncbi Fates and targets of male accessory gland proteins in mated female Drosophila melanogaster
    K Ravi Ram
    Department of Molecular Biology and Genetics, Biotechnology Building, Cornell University, Ithaca, NY 14853, USA
    Insect Biochem Mol Biol 35:1059-71. 2005
    ..Each Acp has multiple targets and is unique in its pattern of localization...
  2. ncbi The Drosophila seminal fluid protein Acp26Aa stimulates release of oocytes by the ovary
    Y Heifetz
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA
    Curr Biol 10:99-102. 2000
    ..We found that the prohormone-like molecule Acp26Aa [5] [10] stimulates the first step in egg-laying - release of oocytes by the ovary...
  3. pmc The Acp26Aa seminal fluid protein is a modulator of early egg hatchability in Drosophila melanogaster
    T Chapman
    The Galton Laboratory, Department of Biology, University College London, Wolfson House, 4 Stephenson Way, London NW1 2HE, UK
    Proc Biol Sci 268:1647-54. 2001
    ..Two Acps that modulate egg production are Acp26Aa (ovulin) and Acp70A (the sex peptide)...
  4. ncbi Seminal fluid-mediated fitness traits in Drosophila
    T Chapman
    The Galton Laboratory, Department of Biology, University College, London, Wolfson House, 4 Stephenson Way, London, NW1 2HE, UK
    Heredity (Edinb) 87:511-21. 2001
    ..In this review I address these issues by bringing together evidence for the function, evolution, diversification, and maintenance of variation in, seminal fluid-mediated traits...
  5. ncbi The gifts that keep on giving: physiological functions and evolutionary dynamics of male seminal proteins in Drosophila
    M F Wolfner
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853 2703, USA
    Heredity (Edinb) 88:85-93. 2002
    ..An apparent prohormonal Acp, ovulin (Acp26Aa) stimulates ovulation in mated Drosophila females...
  6. pmc Sex-peptide is the molecular basis of the sperm effect in Drosophila melanogaster
    Huanfa Liu
    Zoological Institute, University of Zurich Irchel, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Proc Natl Acad Sci U S A 100:9929-33. 2003
    ..Three seminal fluid peptides elicit postmating responses: ovulin, sex-peptide (SP), and DUP99B...
  7. ncbi Sex-peptides: seminal peptides of the Drosophila male
    E Kubli
    Zoological Institute, University Zurich Irchel, Winterthurerstrasse 190, 8057, Zurich, Switzerland
    Cell Mol Life Sci 60:1689-704. 2003
    ..Sps bind to sperm. Together with sperm they are responsible for the persistence of the two post-mating responses. But Sps are the molecular basis of the sperm effect; sperm is merely the carrier...
  8. pmc Two cleavage products of the Drosophila accessory gland protein ovulin can independently induce ovulation
    Yael Heifetz
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA
    Proc Natl Acad Sci U S A 102:743-8. 2005
    ..One seminal-fluid protein, ovulin (Acp26Aa), stimulates an early step in the egg-laying process, the release of oocytes by the ovary...
  9. ncbi Gradual release of sperm bound sex-peptide controls female postmating behavior in Drosophila
    Jing Peng
    Zoological Institute, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Curr Biol 15:207-13. 2005
    ..In Drosophila melanogaster, sex-peptide (SP) elicits short- and long-term PMR, but only the latter in the presence of stored sperm (sperm effect)...
  10. ncbi Structure, cell-specific expression, and mating-induced regulation of a Drosophila melanogaster male accessory gland gene
    A J Dibenedetto
    Section of Genetics and Development, Cornell University, Ithaca, New York 14853 2703
    Dev Biol 139:134-48. 1990
    ..The mating-stimulated synthesis of the mst 316-lacZ fusion protein, and by inference of the native gene product, appears to be due at least in part to increased transcript levels...
  11. pmc Predicted seminal astacin-like protease is required for processing of reproductive proteins in Drosophila melanogaster
    Kristipati Ravi Ram
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA
    Proc Natl Acad Sci U S A 103:18674-9. 2006
    ..in seminal fluid, is necessary to process two other seminal proteins: the ovulation hormone ovulin (Acp26Aa) and the sperm storage protein Acp36DE...
  12. pmc Evidence for structural constraint on ovulin, a rapidly evolving Drosophila melanogaster seminal protein
    Alex Wong
    Department of Molecular Biology and Genetics, Biotechnology Building Room 423, Cornell University, Ithaca, NY 14853, USA
    Proc Natl Acad Sci U S A 103:18644-9. 2006
    The egg-laying hormone ovulin (Acp26Aa) is among the most rapidly evolving proteins in the Drosophila genome...
  13. pmc Seminal proteins but not sperm induce morphological changes in the Drosophila melanogaster female reproductive tract during sperm storage
    Erika M Adams
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA
    J Insect Physiol 53:319-31. 2007
    ..events, we identified morphological changes that take place during sperm storage in females mated to wild-type, Acp-deficient or sperm-deficient males. A reproducible set of morphological changes occurs in a wild-type mating...
  14. pmc Targeted gene deletion and phenotypic analysis of the Drosophila melanogaster seminal fluid protease inhibitor Acp62F
    Jacob L Mueller
    School of Biological Sciences, University of East Anglia, Norwich NR4 7TJ, United Kingdom
    Genetics 178:1605-14. 2008
    ..In addition, the processing of at least one seminal protein, the ovulation hormone ovulin, is slower in the absence of Acp62F.
  15. pmc The Drosophila melanogaster seminal fluid protease "seminase" regulates proteolytic and post-mating reproductive processes
    Brooke A LaFlamme
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY, USA
    PLoS Genet 8:e1002435. 2012
    ..These results point to an important role for proteolysis among insect SFPs and suggest that protease cascades may be a mechanism for precise temporal regulation of multiple post-mating responses in females...
  16. pmc A novel function for the Hox gene Abd-B in the male accessory gland regulates the long-term female post-mating response in Drosophila
    Dragan Gligorov
    Department of Genetics and Evolution and NCCR Frontiers in Genetics, University of Geneva, Geneva, Switzerland
    PLoS Genet 9:e1003395. 2013
    ..in the secondary cells contributes to glycosylation of at least three accessory gland proteins: ovulin (Acp26Aa), CG1656, and CG1652...
  17. pmc A Drosophila protease cascade member, seminal metalloprotease-1, is activated stepwise by male factors and requires female factors for full activity
    Brooke A LaFlamme
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853
    Genetics 196:1117-29. 2014
    ..In addition, we find that expression of Semp1 in virgin females demonstrates that females can activate this protease on their own, resulting in activity that is complete but substantially delayed. ..
  18. pmc Mated Drosophila melanogaster females require a seminal fluid protein, Acp36DE, to store sperm efficiently
    D M Neubaum
    Department of Molecular Biology, Cornell University, Ithaca, New York 14853 2703, USA
    Genetics 153:845-57. 1999
    ..Acp36DE associates tightly with sperm. Our results indicate that Acp36DE is essential for the initial storage of sperm, and that it may also influence the arrangement and retention of stored sperm...
  19. ncbi Synthesis of two Drosophila male accessory gland proteins and their fate after transfer to the female during mating
    S A Monsma
    Section of Genetics and Development, Cornell University, Ithaca, New York 14853 2703
    Dev Biol 142:465-75. 1990
    ..msP 355a is subject to rapid and specific cleavage within the female genital tract, but not in the hemolymph; msP 355b is not cleaved in either the female genital tract or the hemolymph...
  20. pmc A Drosophila seminal fluid protein, Acp26Aa, stimulates egg laying in females for 1 day after mating
    L A Herndon
    Section of Genetics and Development, Cornell University, Ithaca, NY 14853 2703, USA
    Proc Natl Acad Sci U S A 92:10114-8. 1995
    ..This molecule, Acp26Aa, has structural features of a prohormone and contains a region with amino acid similarity to the egg-laying ..
  21. ncbi Male and female cooperate in the prohormone-like processing of a Drosophila melanogaster seminal fluid protein
    M Park
    Section of Biochemistry, Molecular and Cell Biology, Cornell University, Ithaca, New York 14853 2703, USA
    Dev Biol 171:694-702. 1995
    b>Acp26Aa is a Drosophila seminal fluid protein that plays a role in the elevation of egg-laying by the mated female and has structural features of a prohormone...
  22. pmc Probing the function of Drosophila melanogaster accessory glands by directed cell ablation
    J M Kalb
    Section of Genetics and Development, Cornell University, Ithaca, NY 14853 2703
    Proc Natl Acad Sci U S A 90:8093-7. 1993
    ..These transgenic strains that express diphtheria toxins of different strengths in accessory-gland main cells will be useful in further defining the role of these cells...
  23. ncbi The accessory gland proteins in male Drosophila: structural, reproductive, and evolutionary aspects
    P S Chen
    Institute of Zoology, University of Zurich, Switzerland
    Experientia 52:503-10. 1996
    ..Thus, genes encoding the accessory gland proteins are apparently under strong evolutionary selection...
  24. ncbi Tokens of love: functions and regulation of Drosophila male accessory gland products
    M F Wolfner
    Section of Genetics and Development, Cornell University, Ithaca, NY 14853 2703, USA
    Insect Biochem Mol Biol 27:179-92. 1997
    ..A "sex peptide" and a prohormone-like molecule (Accessory gland protein 26Aa) stimulate the female's egg-laying rate; the sex peptide also depresses her receptivity to mating...
  25. pmc Different forces drive the evolution of the Acp26Aa and Acp26Ab accessory gland genes in the Drosophila melanogaster species complex
    M Aguade
    Departament de Genetica, Facultat de Biologia, Universitat de Barcelona, 08071 Barcelona, Spain
    Genetics 150:1079-89. 1998
    The Acp26Aa and Acp26Ab genes that code for male accessory gland proteins are tandemly arranged in the species of the Drosophila melanogaster complex. An approximately 1...
  26. pmc The Drosophila melanogaster seminal fluid protein Acp62F is a protease inhibitor that is toxic upon ectopic expression
    Oliver Lung
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853, USA
    Genetics 160:211-24. 2002
    ..We report here that of eight Drosophila seminal fluid proteins (Acps) and one non-Acp tested, only Acp62F is toxic when ectopically expressed...
  27. pmc Characterizing male-female interactions using natural genetic variation in Drosophila melanogaster
    MICHAEL REINHART
    From the Department of Biological Sciences, Binghamton University, Binghamton, NY Reinhart, Carney, and Fiumera and the Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY Clark
    J Hered 106:67-79. 2015
    ..genes that had consistent effects across the different females including a derived, high fitness allele in Acp26Aa that may be the target of adaptive evolution...
  28. pmc Integrated 3D view of postmating responses by the Drosophila melanogaster female reproductive tract, obtained by micro-computed tomography scanning
    Alexandra L Mattei
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853
    Proc Natl Acad Sci U S A 112:8475-80. 2015
    ..The 3D reconstructions provided by high-resolution micro-CT scans reveal how male and female molecules and anatomy interface to carry out and coordinate mating-dependent changes in the female's reproductive physiology. ..
  29. pmc Oh, the places they'll go: Female sperm storage and sperm precedence in Drosophila melanogaster
    Sandra L Schnakenberg
    Center for Genomics and Systems Biology Department of Biology New York University New York, NY USA
    Spermatogenesis 2:224-235. 2012
    ..In this review, we describe male and female factors, as well as their interactions, involved in female sperm storage and differential male fertilization success...
  30. pmc Two rapidly evolving genes contribute to male fitness in Drosophila
    Josephine A Reinhardt
    Department of Biology, The University of North Carolina at Chapel Hill, CB 3280, Coker Hall, Chapel Hill, NC, 27599 3280, USA
    J Mol Evol 77:246-59. 2013
    ..Together these data provide a clear case where a lack of sequence conservation does not imply a lack of conservation of expression or function. ..
  31. pmc Identification of Drosophila-based endpoints for the assessment and understanding of xenobiotic-mediated male reproductive adversities
    Snigdha Misra
    Embryotoxicology, CSIR Indian Institute of Toxicology Research, Mahatma Gandhi Marg, Lucknow 226001, UP, India Academy of Scientific and Innovative Research AcSIR, Lucknow 226001, UP, India
    Toxicol Sci 141:278-91. 2014
    ....
  32. pmc The RED domain of Paired is specifically required for Drosophila accessory gland maturation
    Li Li
    Institute of Intervention Vessel, Shanghai 10th People s Hospital, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Science and Technology, Tongji University, 1239 Siping Road, Shanghai 200092, People s Republic of China
    Open Biol 5:140179. 2015
    ..We found that the RED domain is specifically required for the expression of Acp26Aa and sex peptide in male accessory glands, and the induction of female post-mating response...
  33. pmc Effects of atrazine exposure on male reproductive performance in Drosophila melanogaster
    Andrea Vogel
    Department of Biological Sciences, Binghamton University, Binghamton, NY 13902, USA Electronic address
    J Insect Physiol 72:14-21. 2015
    ..Exposure upregulated expression of one male reproductive gene, ovulin, but had no effect on expression of another, sex peptide...
  34. pmc Induction of excessive endoplasmic reticulum stress in the Drosophila male accessory gland results in infertility
    Clement Y Chow
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York, United States of America
    PLoS ONE 10:e0119386. 2015
    ..The induction of strong ER stress in the insect male AG may provide a simple way for studying or manipulating male fertility, as it eliminates AG function while preserving sperm production. ..
  35. pmc Evolutionary EST analysis identifies rapidly evolving male reproductive proteins in Drosophila
    W J Swanson
    Department of Molecular Biology and Genetics, Biotechnology Building, Cornell University, Ithaca, NY 14853 2703, USA
    Proc Natl Acad Sci U S A 98:7375-9. 2001
    ..The evolutionary EST approach applied here to identify putative targets of adaptive evolution is readily applicable to other tissues and organisms...
  36. pmc Feeding, fecundity and lifespan in female Drosophila melanogaster
    Andrew I Barnes
    Research Department of Genetics, Evolution and Environment, University College London, Darwin Building, Gower Street, London WC1E 6BT, UK
    Proc Biol Sci 275:1675-83. 2008
    ..We conclude that female mating costs are not the result of over-feeding, but may be due to other, potentially more direct, effects of ejaculate molecules...
  37. pmc Widespread polymorphism in the positions of stop codons in Drosophila melanogaster
    Yuh Chwen G Lee
    Department of Evolution and Ecology, The University of California at Davis, CA, USA
    Genome Biol Evol 4:533-49. 2012
    ..melanogaster and Drosophila simulans, and high-frequency alleles that cause extreme changes in gene length. SCPs likely have an important role in the evolution of these genes...
  38. doi Using blocks of linked single nucleotide polymorphisms as highly polymorphic genetic markers for parentage analysis
    Beatrix Jones
    Centre for Mathematical Biology, Massey University, Private Bag 102 904, North Shore Mail Centre, Auckland 0745, New Zealand, Institute of Information and Mathematical Sciences, Massey University, Private Bag 102 904, North Shore Mail Centre, Auckland 0745, New Zealand, Dana Farber Cancer Research Center, Boston, MA 02115, USA, Department of Biological Sciences, Binghamton University, PO Box 6000, Binghamton, NY 13902, USA
    Mol Ecol Resour 9:487-97. 2009
    ....
  39. doi Perceived sperm competition intensity influences seminal fluid protein production prior to courtship and mating
    Kenneth M Fedorka
    University of Central Florida, Department of Biology, 4000 Central Florida Blvd, Orlando, FL 32816, USA
    Evolution 65:584-90. 2011
    ..Our data suggest that perceived competition in the pre-mating environment places a significant influence on Sfp allocation, which may be a general trend in promiscuous animal systems with internal fertilization...
  40. pmc Hitchhiking under positive Darwinian selection
    J C Fay
    Committee on Genetics, University of Chicago, Chicago, Illinois 60637, USA
    Genetics 155:1405-13. 2000
    ..Application of the H test to published surveys of Drosophila variation reveals an excess of high frequency variants that are likely to have been influenced by positive selection...
  41. pmc A role for Acp29AB, a predicted seminal fluid lectin, in female sperm storage in Drosophila melanogaster
    Alex Wong
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 13902, USA
    Genetics 180:921-31. 2008
    ..Moreover, Acp29AB's effects on sperm storage and sperm competition may explain previously documented evidence for positive selection on the Acp29AB locus...
  42. pmc Seminal fluid protein allocation and male reproductive success
    Stuart Wigby
    Department of Genetics, Evolution and Environment, University College London, Darwin Building, Gower Street, London WC1E 6BT, UK
    Curr Biol 19:751-7. 2009
    ..When males were exposed to a competitor male, matings were longer and more of two key Sfps, sex peptide [8] and ovulin [9], were transferred, indicating strategic allocation of Sfps...
  43. pmc Immortal coils: conserved dimerization motifs of the Drosophila ovulation prohormone ovulin
    Alex Wong
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA
    Insect Biochem Mol Biol 40:303-10. 2010
    ..Here we address this question by focusing on ovulin, a prohormone that induces ovulation in Drosophila melanogaster females after mating...
  44. doi NMR studies of the solution conformation of the sex peptide from Drosophila melanogaster
    Kerstin Moehle
    Chemistry Department, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    FEBS Lett 585:1197-202. 2011
    ..The C-terminal disulfide-bonded loop populates helical turns or nascent helical structure. Overall, the results reveal a rather flexible peptide that lacks a compact folded structure in solution...
  45. pmc Protein-specific manipulation of ejaculate composition in response to female mating status in Drosophila melanogaster
    Laura K Sirot
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA
    Proc Natl Acad Sci U S A 108:9922-6. 2011
    ..The levels of a fecundity-stimulating Sfp (ovulin) were significantly lower in M females relative to V females, at the same time point shortly after the end of ..
  46. ncbi Structure and expression of a Drosophila male accessory gland gene whose product resembles a peptide pheromone precursor
    S A Monsma
    Section of Biochemistry, Molecular, and Cell Biology, Cornell University, Ithaca, New York 14853
    Genes Dev 2:1063-73. 1988
    ..The predicted sequence of one protein has features of a peptide hormone precursor, and a region in which 11 of 17 amino acids are identical to egg-laying hormone (ELH) of the California sea hare, Aplysia californica...
  47. pmc Molecular population genetics of male accessory gland proteins in Drosophila
    D J Begun
    Section of Integrative Biology and Institute for Cellular and Molecular Biology, University of Texas, Austin, Texas 78712, USA
    Genetics 156:1879-88. 2000
    ..In addition to the already-reported departures of Acp26A, Acp29AB, and Acp70A from neutrality, our data reject neutrality at Acp29AB and Acp36DE in the direction of excess ..
  48. ncbi Drosophila seminal fluid proteins enter the circulatory system of the mated female fly by crossing the posterior vaginal wall
    O Lung
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA
    Insect Biochem Mol Biol 29:1043-52. 1999
    ..kinetics of transfer and localization in mated females of two seminal fluid proteins that enter the hemolymph (Acp26Aa and Acp62F) and one that does not (Acp36DE)...
  49. pmc Polymorphism and divergence in the Mst26A male accessory gland gene region in Drosophila
    M Aguade
    Departament de Genetica, Facultat de Biologia, Universitat de Barcelona, Spain
    Genetics 132:755-70. 1992
    ..The Mst26Aa and Mst26Ab transcription units are tandemly arranged in a approximately 1...
  50. pmc Linkage disequilibrium as a signature of selective sweeps
    Yuseob Kim
    Department of Biological Statistics and Computational Biology, Cornell University, Ithaca, New York 14853, USA
    Genetics 167:1513-24. 2004
    ..However, the improvement made by including LD is rather small, suggesting that most of the relevant information regarding selective sweeps is captured by the spatial distribution and marginal allele frequencies of polymorphisms...
  51. ncbi Nuclear entry of the Drosophila melanogaster nuclear lamina protein YA correlates with developmentally regulated changes in its phosphorylation state
    J Yu
    Section of Genetics and Development, Cornell University, Ithaca, New York, 14853 2703, USA
    Dev Biol 210:124-34. 1999
    ..A model for developmental regulation of the nuclear entry of YA is proposed and implications for understanding Drosophila egg activation are discussed...
  52. ncbi Adaptive hitchhiking effects on genome variability
    P Andolfatto
    Institute of Cell, Animal and Population Biology, University of Edinburgh, Ashworth Labs, King s Buildings, Edinburgh EH9 3JT, UK
    Curr Opin Genet Dev 11:635-41. 2001
    ..Accounting for the effects of population structure and history poses a challenge for future investigations...
  53. ncbi Testing the neutral theory of molecular evolution with genomic data from Drosophila
    Justin C Fay
    Committee on Genetics, University of Chicago, Chicago, Illinois 60637, USA
    Nature 415:1024-6. 2002
    ..A higher A/S ratio of divergence than of polymorphism is also observed in other species, which suggests a rate of adaptive evolution that is far higher than permitted by the neutral theory of molecular evolution...
  54. ncbi Positive selection driving the evolution of a gene of male reproduction, Acp26Aa, of Drosophila: II. Divergence versus polymorphism
    S C Tsaur
    Department of Ecology and Evolution, University of Chicago, Illinois 60637, USA
    Mol Biol Evol 15:1040-6. 1998
    The evolution of the gene for a male ejaculatory protein, Acp26Aa, has been shown to be driven by positive selection when nonsibling species in the Drosophila melanogaster subgroup are compared...
  55. pmc Evidence of a high rate of selective sweeps in African Drosophila melanogaster
    Sylvain Mousset
    Laboratoire d Ecologie, Ecole Pratique des Hautes Etudes, Universite Pierre et Marie Curie, 75005 Paris, France
    Genetics 163:599-609. 2003
    ..Four loci [Acp26Aa, Fbp2, Vha68-1, and Su(H)] were previously found to deviate from a neutral mutation-drift equilibrium as a ..
  56. ncbi The developments between gametogenesis and fertilization: ovulation and female sperm storage in Drosophila melanogaster
    Margaret C Bloch Qazi
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA
    Dev Biol 256:195-211. 2003
    ..melanogaster, both processes are triggered by male factors during and after mating, including sperm and seminal fluid proteins. Therefore, an interplay of male and female factors coordinates the gametes for fertilization...
  57. ncbi Positive selection and the molecular evolution of a gene of male reproduction, Acp26Aa of Drosophila
    S C Tsaur
    Department of Ecology and Evolution, University of Chicago, IIIinois 60637, USA
    Mol Biol Evol 14:544-9. 1997
    The gene for a male ejaculatory protein, Acp26Aa, in four sibling species of the Drosophila melanogaster subgroup has previously been shown to have a nonsynonymous rate (Ka) of nucleotide substitution that is indistinguishable from the ..
  58. ncbi New reproductive anomalies in fruitless-mutant Drosophila males: extreme lengthening of mating durations and infertility correlated with defective serotonergic innervation of reproductive organs
    G Lee
    Department of Biology, Brandeis University, Waltham, Massachusetts 02454, USA
    J Neurobiol 47:121-49. 2001
    ....
  59. ncbi Population genetics of accessory gland proteins and sexual behavior in Drosophila melanogaster populations from Evolution Canyon
    Tami M Panhuis
    Department of Biology, University of California, Riverside, California 92521, USA
    Evolution 57:2785-91. 2003
    ..We sequenced six different Acp genes from isofemale lines from the south-facing slope (11 lines) and north-facing slope (nine lines) of Evolution ..
  60. ncbi Quantitative trait loci affecting natural variation in Drosophila longevity
    Gretchen L Geiger-Thornsberry
    Department of Genetics, Box 7614, North Carolina State University, Raleigh 27695, USA
    Mech Ageing Dev 125:179-89. 2004
    ..Quantitative complementation tests are therefore useful for identifying QTL contributing to segregating genetic variation in life span in nature...
  61. ncbi A putative helical cytokine functioning in innate immune signalling in Drosophila melanogaster
    D Malagoli
    Department of Animal Biology, University of Modena and Reggio Emilia, Via Campi 213 D, 41100 Modena, Italy
    Biochim Biophys Acta 1770:974-8. 2007
    ..These observations suggest the involvement of helical cytokines in the innate immune response of invertebrates...
  62. pmc Sperm competitive ability in Drosophila melanogaster associated with variation in male reproductive proteins
    Anthony C Fiumera
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853, USA
    Genetics 169:243-57. 2005
    ..The latter case is consistent with antagonistic pleiotropy and may serve as a mechanism maintaining genetic variation...
  63. ncbi Inversion polymorphisms and nucleotide variability in Drosophila
    P Andolfatto
    Institute of Cell, Animal and Population Biology, University of Edinburgh, Edinburgh, EH9 3JT, UK
    Genet Res 77:1-8. 2001
  64. ncbi Detecting non-neutral heterogeneity across a region of DNA sequence in the ratio of polymorphism to divergence
    J H McDonald
    Department of Biology, University of Delaware, Newark 19716, USA
    Mol Biol Evol 13:253-60. 1996
    ..By simulating neutral evolution and comparing the observed number of runs to the simulations, a statistical test is possible which does not require any a priori decisions about subdivision...
  65. ncbi Reproductive biology: direct delivery of costly sex peptides
    Matthew J G Gage
    School of Biological Sciences, University of East Anglia, Norwich NR4 7TJ, UK
    Curr Biol 15:R124-6. 2005
    ..Two new studies demonstrate, first, how an influential male sex peptide in Drosophila is delivered to the female bound directly onto sperm cells, and second, that its subsequent release has significant reproductive costs for females...
  66. pmc Distinguishing between selective sweeps and demography using DNA polymorphism data
    Jeffrey D Jensen
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853, USA
    Genetics 170:1401-10. 2005
    ....
  67. ncbi Sex in Drosophila mauritiana: a very high level of amino acid polymorphism in a male reproductive protein gene, Acp26Aa
    S C Tsaur
    Department of Ecology and Evolution, University of Chicago, Illinois 60637, USA
    Mol Biol Evol 18:22-6. 2001
    ..The accessory gland protein gene (Acp26Aa) of Drosophila is one such example...
  68. ncbi Differences in the pattern of evolution in six physically linked genes of Drosophila melanogaster
    Martina Zurovcov√°
    Institute of Entomology, Czech Academy of Sciences and Faculty of Biological Sciences, University of South Bohemia, Branisovska 31, 370 05 Ceske Budejovice, Czech Republic
    Gene 381:24-33. 2006
    We describe DNA sequence polymorphisms at six loci (Acp26Aa, Acp26Ab, Acp29AB, Idgf1, Idgf3 and Ddc), all on the second chromosome of Drosophila melanogaster in one natural European population...
  69. ncbi Two tightly-linked Drosophila male accessory gland transcripts with the same developmental expression derive from independent transcription units
    M Park
    Section of Genetics and Development, Cornell University, Ithaca, NY 14853 2703
    Mech Dev 48:51-7. 1994
    b>Acp26Aa and Acp26Ab are Drosophila male accessory gland transcripts that are tightly linked and transcribed from the same DNA strand...
  70. pmc Variation in sperm displacement and its association with accessory gland protein loci in Drosophila melanogaster
    A G Clark
    Department of Biology, Pennsylvania State University, University Park 16802
    Genetics 139:189-201. 1995
    ..Significant associations were found between particular Acp alleles at four different loci (Acp26Aa/Ab, Acp29B, Acp36DE and Acp53E) and the ability of males to resist displacement by subsequent sperm...
  71. ncbi The Drosophila melanogaster X-linked mfs(1)6E locus is required for production of normal seminal fluid by the male accessory glands
    P P Lopez
    Centro de Investigaciones Biologicas, Velazquez 144, Madrid, 28006, Spain
    Exp Cell Res 267:1-12. 2001
    ..Mutant male accessory glands show notable abnormalities, connected with glandular secretion as well as qualitative and quantitative differences in their protein content...

Research Grants2

  1. Molecular genetics of egg activation and pronuclear function in Drosophila
    MARIANA FEDERICA WOLFNER; Fiscal Year: 2010
    ..Thus, we exploit the powerful genetics of Drosophila to elucidate efficiently the molecules and gene pathways needed to start development in humans. ..
  2. Natural variation in Drosophila female postmating traits
    DAVID BEGUN; Fiscal Year: 2008
    ..abstract_text> ..