Abl

Summary

Gene Symbol: Abl
Description: Abl tyrosine kinase
Alias: 4674, ABL, Abl1, AblK, Ableson, Am ABL, C-abl, CG4032, D-Abl, D-abl, D-ash, DAbl, DROTKABL3, Dabl, Dash, Ddash/abl, Dmel\CG4032, Dsrc7, abl, abl1, c-abl, cAbl, dAbl, l(3)04674, l(3)73Ba, l(3)c-abl, CG4032 gene product from transcript CG4032-RJ, Abl oncogene, Abl-PA, Abl-PB, Abl-PC, Abl-PD, Abl-PE, Abl-PF, Abl-PG, Abl-PH, Abl-PI, Abl-PJ, CG4032-PA, CG4032-PB, CG4032-PC, CG4032-PD, CG4032-PE, CG4032-PF, CG4032-PG, CG4032-PH, CG4032-PI, CG4032-PJ, D-abelson, abelson, abelson kinase, abelson tyrosine kinase, abl kinase
Species: fruit fly

Top Publications

  1. ncbi Spatial control of the actin cytoskeleton in Drosophila epithelial cells
    B Baum
    Department of Genetics, Howard Hughes Medical Institute, Harvard Medical School, 200 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nat Cell Biol 3:883-90. 2001
  2. ncbi The tyrosine kinase Abl and its substrate enabled collaborate with the receptor phosphatase Dlar to control motor axon guidance
    Z Wills
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Neuron 22:301-12. 1999
  3. ncbi The first oncogene in Drosophila melanogaster
    K H Baek
    Division of Pediatric Oncology, Dana Farber Cancer Institute, Harvard Medical School, 44 Binney Street, Boston, MA, USA
    Mutat Res 436:131-6. 1999
  4. ncbi Stop or go in the target zone
    S Kunes
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Neuron 22:639-40. 1999
  5. ncbi Cycling, stressed-out and nervous: cellular functions of c-Abl
    R A Van Etten
    Center for Blood Research, Dept of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Trends Cell Biol 9:179-86. 1999
  6. ncbi Increased levels of the Drosophila Abelson tyrosine kinase in nerves and muscles: subcellular localization and mutant phenotypes imply a role in cell-cell interactions
    R L Bennett
    McArdle Laboratory for Cancer Research, University of Wisconsin, Madison 53706
    Development 116:953-66. 1992
  7. ncbi A novel tyrosine kinase-independent function of Drosophila abl correlates with proper subcellular localization
    M Henkemeyer
    McArdle Laboratory for Cancer Research, University of Wisconsin, Madison 53706
    Cell 63:949-60. 1990
  8. ncbi Genetic suppression of mutations in the Drosophila abl proto-oncogene homolog
    F B Gertler
    McArdle Laboratory for Cancer Research, University of Wisconsin, Madison 53706
    Science 248:857-60. 1990
  9. ncbi Genetic analysis of a Drosophila neural cell adhesion molecule: interaction of fasciclin I and Abelson tyrosine kinase mutations
    T Elkins
    Howard Hughes Medical Institute, University of California, Berkeley 94720
    Cell 60:565-75. 1990
  10. ncbi Drosophila abl tyrosine kinase in embryonic CNS axons: a role in axonogenesis is revealed through dosage-sensitive interactions with disabled
    F B Gertler
    McArdle Laboratory for Cancer Research, University of Wisconsin, Madison 53706
    Cell 58:103-13. 1989

Research Grants

  1. REGULATION OF NEUROGENESIS IN THE DROSOPHILA CNS
    Krishna Bhat; Fiscal Year: 2002
  2. Niemann Pick C disease in Drosophila
    Krishna Bhat; Fiscal Year: 2007
  3. NEUROTROPHIN RECEPTOR INTERACTIONS
    Mark Bothwell; Fiscal Year: 2004
  4. Amyloid Precursor Protein Signaling
    Mark Bothwell; Fiscal Year: 2006
  5. Nogo Receptor Signaling and Function
    Mark Bothwell; Fiscal Year: 2007

Scientific Experts

  • L M Machesky
  • E C Liebl
  • P J Woodring
  • Krishna Bhat
  • Lindsay K MacDougall
  • Eric C Lai
  • P Martin
  • Richard A Van Etten
  • Mary Packard
  • Bader Al-Anzi
  • S M Ahern Djamali
  • Akira Chiba
  • Mark Bothwell
  • Bharatkumar N Patel
  • A W Stoker
  • K H Baek
  • U Tepass
  • B Baum
  • D S Rice
  • Jeong K Song
  • Julie Gates
  • Mark Peifer
  • Tzu Yang Lin
  • Wenjun Xiong
  • Joy N Dorsten
  • Edward Giniger
  • F M Hoffmann
  • D Van Vactor
  • Mark F A VanBerkum
  • Chiu Hui Huang
  • Donald T Fox
  • J L Juang
  • Anita Hsouna
  • Jaskirat Singh
  • Jyh Lyh Juang
  • Jana Slováková
  • Masako Tamada
  • David Van Vactor
  • S M Ahern-Djamali
  • Irina Kuzina
  • Lalima L Madan
  • Ilaria Rebay
  • Marek Mlodzik
  • J Singh
  • L A Lowery
  • Maximiliane Hilger
  • Hung Hsiang Yu
  • Hsueh Yen Ku
  • Stephanie H Nowotarski
  • Catarina C F Homem
  • Tzu Ching Meng
  • Marco Muda
  • Gracie L Andrews
  • James P Mahaffey
  • Ying Che Chang
  • Rong Long Pan
  • Ruth I Johnson
  • Carolyn A Worby
  • Z Wills
  • Traci L Stevens
  • Catherine Pawson
  • C S Goodman
  • Edward M Rogers
  • Mark A Seeger
  • H Lin
  • Peter A Kolodziej
  • J Bateman
  • Maarten Leyssen
  • Wenjun Li
  • MaryAnn Martin
  • David J Forsthoefel
  • Gaspar Jekely
  • A R Comer
  • Mark Emerson
  • Haeryun Lee
  • Elizabeth E Grevengoed
  • Jannette Rusch
  • Daniel Crowner
  • Zachary Wills
  • James C Clemens
  • Jack E Dixon
  • Nancy Simonson-Leff
  • F B Gertler
  • Andreas Prokop
  • Natalia Sánchez-Soriano
  • Ana Carmena
  • Dene L Farrell
  • Jennifer A Zallen
  • E E Grevengoed
  • Stephan Speicher

Detail Information

Publications106 found, 100 shown here

  1. ncbi Spatial control of the actin cytoskeleton in Drosophila epithelial cells
    B Baum
    Department of Genetics, Howard Hughes Medical Institute, Harvard Medical School, 200 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nat Cell Biol 3:883-90. 2001
    ..The Abl tyrosine kinase also collaborates in this process...
  2. ncbi The tyrosine kinase Abl and its substrate enabled collaborate with the receptor phosphatase Dlar to control motor axon guidance
    Z Wills
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Neuron 22:301-12. 1999
    ..We now demonstrate that the Drosophila Abl tyrosine kinase functions in the intersegmental nerve b (ISNb) motor choice point pathway as an antagonist of the ..
  3. ncbi The first oncogene in Drosophila melanogaster
    K H Baek
    Division of Pediatric Oncology, Dana Farber Cancer Institute, Harvard Medical School, 44 Binney Street, Boston, MA, USA
    Mutat Res 436:131-6. 1999
    ....
  4. ncbi Stop or go in the target zone
    S Kunes
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Neuron 22:639-40. 1999
  5. ncbi Cycling, stressed-out and nervous: cellular functions of c-Abl
    R A Van Etten
    Center for Blood Research, Dept of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Trends Cell Biol 9:179-86. 1999
    ..biochemical and genetic approaches have converged to shed new light on the mechanism of regulation of c-Abl kinase activity and the multiple roles of c-Abl in cellular physiology...
  6. ncbi Increased levels of the Drosophila Abelson tyrosine kinase in nerves and muscles: subcellular localization and mutant phenotypes imply a role in cell-cell interactions
    R L Bennett
    McArdle Laboratory for Cancer Research, University of Wisconsin, Madison 53706
    Development 116:953-66. 1992
    Mutations in the Drosophila Abelson tyrosine kinase have pleiotropic effects late in development that lead to pupal lethality or adults with a reduced life span, reduced fecundity and rough eyes...
  7. ncbi A novel tyrosine kinase-independent function of Drosophila abl correlates with proper subcellular localization
    M Henkemeyer
    McArdle Laboratory for Cancer Research, University of Wisconsin, Madison 53706
    Cell 63:949-60. 1990
  8. ncbi Genetic suppression of mutations in the Drosophila abl proto-oncogene homolog
    F B Gertler
    McArdle Laboratory for Cancer Research, University of Wisconsin, Madison 53706
    Science 248:857-60. 1990
    The Drosophila abelson (abl) gene encodes the homolog of the mammalian c-abl cytoplasmic tyrosine kinase and is an essential gene for the development of viable adult flies...
  9. ncbi Genetic analysis of a Drosophila neural cell adhesion molecule: interaction of fasciclin I and Abelson tyrosine kinase mutations
    T Elkins
    Howard Hughes Medical Institute, University of California, Berkeley 94720
    Cell 60:565-75. 1990
    ..The Drosophila Abelson (abl) proto-oncogene homolog encodes a cytoplasmic tyrosine kinase that is expressed during embryogenesis ..
  10. ncbi Drosophila abl tyrosine kinase in embryonic CNS axons: a role in axonogenesis is revealed through dosage-sensitive interactions with disabled
    F B Gertler
    McArdle Laboratory for Cancer Research, University of Wisconsin, Madison 53706
    Cell 58:103-13. 1989
    During Drosophila embryogenesis, the Abelson tyrosine kinase (abl) is localized in the axons of the central nervous system (CNS)...
  11. pmc DNA sequence, structure, and tyrosine kinase activity of the Drosophila melanogaster Abelson proto-oncogene homolog
    M J Henkemeyer
    McArdle Laboratory for Cancer Research, University of Wisconsin, Madison 53706
    Mol Cell Biol 8:843-53. 1988
    We report our molecular characterization of the Drosophila melanogaster Abelson gene (abl), a gene in which recessive loss-of-function mutations result in lethality at the pupal stage of development...
  12. ncbi enabled, a dosage-sensitive suppressor of mutations in the Drosophila Abl tyrosine kinase, encodes an Abl substrate with SH3 domain-binding properties
    F B Gertler
    McArdle Laboratory for Cancer Research, University of Wisconsin Medical School, Madison 53706
    Genes Dev 9:521-33. 1995
    ..ena protein contains proline-rich motifs and binds to Abl and Src SH3 domains, ena is also a substrate for the Abl kinase; tyrosine phosphorylation of ena is increased when it is coexpressed in cells with human or Drosophila Abl and ..
  13. ncbi Abl tyrosine kinase in signal transduction and cell-cycle regulation
    J Y Wang
    Department of Biology and Center for Molecular Genetics, University of California, San Diego 92093 0116
    Curr Opin Genet Dev 3:35-43. 1993
    Although the biological function of the c-Abl tyrosine kinase remains unsolved, potentially productive avenues towards the elucidation of that function have been identified by recent progress...
  14. pmc Genetic interactions between the Drosophila Abelson (Abl) tyrosine kinase and failed axon connections (fax), a novel protein in axon bundles
    K K Hill
    McArdle Laboratory for Cancer Research, University of Wisconsin Medical School, Madison 53706, USA
    Genetics 141:595-606. 1995
    Mutations in the failed axon connections (fax) gene have been identified as dominant genetic enhancers of the Abl mutant phenotype. These mutations in fax all result in defective or absent protein product...
  15. pmc Phosphorylation of Enabled by the Drosophila Abelson tyrosine kinase regulates the in vivo function and protein-protein interactions of Enabled
    A R Comer
    McArdle Laboratory for Cancer Research and Laboratory of Genetics, University of Wisconsin Madison, 53706, USA
    Mol Cell Biol 18:152-60. 1998
    ..Mutations in Drosophila ena were discovered as dominant genetic suppressors of mutations in the Abelson tyrosine kinase (Abl), suggesting that Ena and Abl function in the same pathway or process...
  16. ncbi Systematic gain-of-function genetics in Drosophila
    P Rørth
    Department of Embryology, Carnegie Institution of Washington, 115 West University Parkway, Baltimore, MD 21210, USA
    Development 125:1049-57. 1998
    ..These studies demonstrate the ability of the modular misexpression system to identify developmentally important genes and suggest that it will be generally useful for genetic interaction screens...
  17. ncbi Midline Fasciclin: a Drosophila Fasciclin-I-related membrane protein localized to the CNS midline cells and trachea
    S Hu
    Department of Biology, University of California, Los Angeles 90024, USA
    J Neurobiol 35:77-93. 1998
    ..However, embryos mutant for both midline fasciclin and the abelson nonreceptor tyrosine kinase, show more severe defects in axonogenesis that resemble fasciclin I abelson double ..
  18. ncbi A role for Abl in Notch signaling
    E Giniger
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Neuron 20:667-81. 1998
    b>Abl is an axonal tyrosine kinase that has yet to be clearly linked to a receptor; Notch is a receptor for which the signaling pathway remains incompletely understood...
  19. ncbi Roles of Armadillo, a Drosophila catenin, during central nervous system development
    J Loureiro
    Department of Biology, University of North Carolina, Chapel Hill 27599 3280, USA
    Curr Biol 8:622-32. 1998
    ..Wingless/Wnt signaling also directs certain cell fates in the central nervous system (CNS), and cadherins and catenins are thought to function together during neural development...
  20. ncbi Dominant effects of the bcr-abl oncogene on Drosophila morphogenesis
    F J Fogerty
    Department of Medicine, University of Wisconsin Comprehensive Cancer Center, Madison 53706, USA
    Oncogene 18:219-32. 1999
    ..Enabled, previously identified as a suppressor of the abl mutant phenotype and substrate for Drosophila Abl kinase, had markedly increased phosphotyrosine levels in Bcr-Abl expressing Drosophila, indicating that it is a ..
  21. ncbi Profilin and the Abl tyrosine kinase are required for motor axon outgrowth in the Drosophila embryo
    Z Wills
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Neuron 22:291-9. 1999
    ..Profilin associates with members of the Enabled family of proteins, suggesting that Profilin might link Abl function to the cytoskeleton...
  22. pmc Identification of profilin and src homology 3 domains as binding partners for Drosophila enabled
    S M Ahern-Djamali
    McArdle Laboratory for Cancer Research and Laboratory of Genetics, University of Wisconsin Medical School, 1400 University Avenue, Madison, WI 53706, USA
    Proc Natl Acad Sci U S A 96:4977-82. 1999
    Drosophila Enabled (Ena) was first identified as a genetic suppressor of mutations in the Abelson tyrosine kinase and subsequently was shown to be a member of the Ena/vasodilator-stimulated phosphoprotein family of proteins...
  23. ncbi Dosage-sensitive, reciprocal genetic interactions between the Abl tyrosine kinase and the putative GEF trio reveal trio's role in axon pathfinding
    E C Liebl
    Department of Biology, Denison University, Granville, Ohio 43023, USA
    Neuron 26:107-18. 2000
    The Abelson tyrosine kinase (Abl) is integrated into signal transduction networks regulating axon outgrowth. We have identified the Drosophila trio gene through a mutation that exacerbates the Abl mutant phenotype...
  24. ncbi Repulsive axon guidance: Abelson and Enabled play opposing roles downstream of the roundabout receptor
    G J Bashaw
    Department of Molecular and Cell Biology, University of California, Berkeley 94720, USA
    Cell 101:703-15. 2000
    ..Here, we present genetic and biochemical evidence that the Abelson (Abl) tyrosine kinase and its substrate Enabled (Ena) play direct and opposing roles in Robo signal transduction...
  25. pmc Modulation of the F-actin cytoskeleton by c-Abl tyrosine kinase in cell spreading and neurite extension
    Pamela J Woodring
    The Salk Institute, La Jolla, CA 92037 1099, USA
    J Cell Biol 156:879-92. 2002
    ..The c-Abl kinase is activated by physiological signals that also regulate the actin cytoskeleton...
  26. ncbi A Drosophila homolog of cyclase-associated proteins collaborates with the Abl tyrosine kinase to control midline axon pathfinding
    Zachary Wills
    Department of Cell Biology and Program in Neuroscience, Harvard Medical School, Boston, MA 02115, USA
    Neuron 36:611-22. 2002
    ..a homolog of the adenylyl cyclase-associated protein that binds and regulates actin in yeast, associates with Abl in Drosophila cells, suggesting a functional relationship in vivo...
  27. ncbi Notch steers Drosophila ISNb motor axons by regulating the Abl signaling pathway
    Daniel Crowner
    Division of Basic Sciences and Program in Developmental Biology, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue, North, Seattle, WA 98109, USA
    Curr Biol 13:967-72. 2003
    ..ISNb axons, Notch interacts genetically with multiple components of a signal transduction pathway that includes the Abl tyrosine kinase and its affiliated accessory proteins...
  28. ncbi Interactions between the secreted protein Amalgam, its transmembrane receptor Neurotactin and the Abelson tyrosine kinase affect axon pathfinding
    Eric C Liebl
    Department of Biology, Denison University, Granville, OH 43023, USA
    Development 130:3217-26. 2003
    Two novel dosage-sensitive modifiers of the Abelson tyrosine kinase (Abl) mutant phenotype have been identified...
  29. pmc Balancing different types of actin polymerization at distinct sites: roles for Abelson kinase and Enabled
    Elizabeth E Grevengoed
    University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 3280, USA
    J Cell Biol 163:1267-79. 2003
    The proto-oncogenic kinase Abelson (Abl) regulates actin in response to cell signaling. Drosophila Abl is required in the nervous system, and also in epithelial cells, where it regulates adherens junction stability and actin organization...
  30. ncbi The Abelson tyrosine kinase, the Trio GEF and Enabled interact with the Netrin receptor Frazzled in Drosophila
    David J Forsthoefel
    The Ohio State University, Department of Molecular Genetics and Center for Molecular Neurobiology, Columbus, OH 43210, USA
    Development 132:1983-94. 2005
    The attractive Netrin receptor Frazzled (Fra), and the signaling molecules Abelson tyrosine kinase (Abl), the guanine nucleotide-exchange factor Trio, and the Abl substrate Enabled (Ena), all regulate axon pathfinding at the Drosophila ..
  31. ncbi Abelson, enabled, and p120 catenin exert distinct effects on dendritic morphogenesis in Drosophila
    Wenjun Li
    Gladstone Institute of Neurological Disease, San Francisco, California, USA
    Dev Dyn 234:512-22. 2005
    ..both loss-of-function and gain-of-function analyses in vivo, we show here that the nonreceptor tyrosine kinase Abelson (Abl), an important regulator of cytoskeleton dynamics, inhibits dendritic branching of dendritic arborization (..
  32. pmc Amyloid precursor protein promotes post-developmental neurite arborization in the Drosophila brain
    Maarten Leyssen
    Laboratory of Neurogenetics, Department of Human Genetics, Flanders Interuniversity Institute for Biotechnology VIB and University of Leuven, School of Medicine, Leuven, Belgium
    EMBO J 24:2944-55. 2005
    ..arborization, which depends critically on a conserved motif in the C-terminus and requires interaction with the Abelson (Abl) tyrosine kinase...
  33. ncbi Abelson kinase (Abl) and RhoGEF2 regulate actin organization during cell constriction in Drosophila
    Donald T Fox
    Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 3280, USA
    Development 134:567-78. 2007
    ..Here, we report the identification of Abelson kinase (Abl) as a novel ventral furrow regulator...
  34. ncbi Enabled plays key roles in embryonic epithelial morphogenesis in Drosophila
    Julie Gates
    Lineberger Comprehensive Cancer Center and Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Development 134:2027-39. 2007
    ..We also explored filopodial regulation in cultured Drosophila cells and embryos. These data provide new insights into developmental and mechanistic roles of this important actin regulator...
  35. ncbi Frazzled regulation of myosin II activity in the Drosophila embryonic CNS
    Joy N Dorsten
    Department of Biological Sciences, Wayne State University, Detroit, MI 48202, USA
    Dev Biol 308:120-32. 2007
    ..b>Abelson tyrosine kinase may also help regulate myosin II activity...
  36. ncbi The involvement of Abl and PTP61F in the regulation of Abi protein localization and stability and lamella formation in Drosophila S2 cells
    Chiu Hui Huang
    Division of Molecular and Genomic Medicine, National Health Research Institutes, Zhunan, Miaoli 35053, Taiwan
    J Biol Chem 282:32442-52. 2007
    ..Abi (Abl interactor protein) functions as a substrate adaptor protein for Abl and a core member of the WAVE complex, ..
  37. pmc Using Bcr-Abl to examine mechanisms by which abl kinase regulates morphogenesis in Drosophila
    Traci L Stevens
    Department of Biology and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 3280, USA
    Mol Biol Cell 19:378-93. 2008
    ..Here, we explore the role of regulation of Abl kinase activity during development...
  38. pmc The receptor protein tyrosine phosphatase PTP69D antagonizes Abl tyrosine kinase to guide axons in Drosophila
    Jeong K Song
    Axon Guidance and Neural Connectivity Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bldg 37 Room 1016, 37 Convent Drive, Bethesda, MD 20892, USA
    Mech Dev 125:247-56. 2008
    During Drosophila embryogenesis, both the cytoplasmic Abelson tyrosine kinase (Abl) and the membrane bound tyrosine phosphatase PTP69D are required for proper guidance of CNS and motor axons...
  39. doi Tyrosine phosphoproteomics and identification of substrates of protein tyrosine phosphatase dPTP61F in Drosophila S2 cells by mass spectrometry-based substrate trapping strategy
    Ying Che Chang
    Institute of Biochemical Sciences, College of Life Sciences, National Taiwan University, Taipei 106, Taiwan
    J Proteome Res 7:1055-66. 2008
    ..were confirmed as tyrosine phosphorylated proteins, including a receptor PTK PDGF/VEGF receptor, a cytosolic PTK Abl, and several components of SCAR/WAVE complex, which may work in coordination to control actin dynamics...
  40. pmc Dscam guides embryonic axons by Netrin-dependent and -independent functions
    Gracie L Andrews
    Department of Biology MS 314, University of Nevada, Reno, NV 89557, USA
    Development 135:3839-48. 2008
    ..These functions in axon guidance have implications for the pathogenesis of Down Syndrome...
  41. pmc Organization of F-actin via concerted regulation of Kette by PTP61F and dAbl
    Hsueh Yen Ku
    Institute of Biological Chemistry, Academia Sinica, 128 Academia Road, Section 2, Taipei 11529, Taiwan
    Mol Cell Biol 29:3623-32. 2009
    ..of actin polymerization, as a substrate for Drosophila protein tyrosine phosphatase PTP61F, as well as for dAbl tyrosine kinase. We further show that dAbl is a direct substrate for PTP61F...
  42. pmc Enabled and Capping protein play important roles in shaping cell behavior during Drosophila oogenesis
    Julie Gates
    Lineberger Comprehensive Cancer Center and Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Dev Biol 333:90-107. 2009
    ..Enabled appears to be negatively regulated during oogenesis by Abelson kinase. We also explored the function of Capping protein...
  43. doi Abi plays an opposing role to Abl in Drosophila axonogenesis and synaptogenesis
    Tzu Yang Lin
    Division of Molecular and Genomic Medicine, National Health Research Institutes, Zhunan, Miaoli 35053, Taiwan
    Development 136:3099-107. 2009
    Abl tyrosine kinase (Abl) regulates axon guidance by modulating actin dynamics. Abelson interacting protein (Abi), originally identified as a kinase substrate of Abl, also plays a key role in actin dynamics, yet its role with respect to ..
  44. pmc The Drosophila immunoglobulin gene turtle encodes guidance molecules involved in axon pathfinding
    Bader Al-Anzi
    Division of Biology 156 29, California Institute of Technology, Pasadena, CA 91125, USA
    Neural Dev 4:31. 2009
    ..However, a large number of commissural axons successfully cross the midline even in the complete absence of netrin signaling, indicating the presence of a yet unidentified midline attractant...
  45. pmc In the absence of frazzled over-expression of Abelson tyrosine kinase disrupts commissure formation and causes axons to leave the embryonic CNS
    Joy N Dorsten
    Department of Biological Sciences, Wayne State University, Detroit, Michigan, United States of America
    PLoS ONE 5:e9822. 2010
    ..nerve cord, the formation of commissures require both the chemoattractive Netrin receptor Frazzled (Fra) and the Abelson (Abl) cytoplasmic tyrosine kinase...
  46. pmc Drosophila Abelson kinase mediates cell invasion and proliferation through two distinct MAPK pathways
    J Singh
    Department of Developmental and Regenerative Biology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Oncogene 29:4033-45. 2010
    The Abelson (Abl) family of non-receptor tyrosine kinases has an important role in cell morphogenesis, motility, and proliferation...
  47. pmc Parallel genetic and proteomic screens identify Msps as a CLASP-Abl pathway interactor in Drosophila
    L A Lowery
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genetics 185:1311-25. 2010
    ..Here, we report that Msps is a strong modifier of CLASP and Abl in the retina...
  48. pmc Abelson family kinases regulate Frizzled planar cell polarity signaling via Dsh phosphorylation
    Jaskirat Singh
    Department of Developmental and Regenerative Biology, Mount Sinai School of Medicine, New York, New York 10029, USA
    Genes Dev 24:2157-68. 2010
    b>Abelson (Abl) family tyrosine kinases have been implicated in cell morphogenesis, adhesion, motility, and oncogenesis...
  49. pmc Disabled is a bona fide component of the Abl signaling network
    Jeong K Song
    Axon Guidance and Neural Connectivity Unit, Basic Neuroscience Program, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Development 137:3719-27. 2010
    b>Abl is an essential regulator of cell migration and morphogenesis in both vertebrates and invertebrates...
  50. pmc How Notch establishes longitudinal axon connections between successive segments of the Drosophila CNS
    Irina Kuzina
    National Institute of Neurological Disorders and Stroke and National Human Genome Research Institute NIH, Bethesda, MD 20892, USA
    Development 138:1839-49. 2011
    ..non-canonical signaling pathway in the pioneer growth cones themselves, promoting their motility by suppressing Abl signaling to stimulate filopodial growth while presumably reducing substratum adhesion...
  51. pmc Abl regulates planar polarized junctional dynamics through β-catenin tyrosine phosphorylation
    Masako Tamada
    Howard Hughes Medical Institute and Developmental Biology Program, Sloan Kettering Institute, 1275 York Avenue, New York, NY 10065, USA
    Dev Cell 22:309-19. 2012
    ..The Abl tyrosine kinase is concentrated at specific planar junctions and is necessary for polarized β-catenin localization ..
  52. ncbi Abelson tyrosine kinase is required to transduce midline repulsive cues
    Anita Hsouna
    Department of Biological Sciences, Wayne State University, 5047 Gullen Mall, Detroit, Michigan 48202, USA
    J Neurobiol 57:15-30. 2003
    ..The cytoplasmic Abelson tyrosine kinase participate in several signaling pathways that orchestrate both growth cone advance and steering in ..
  53. ncbi The Drosophila Abelson proto-oncogene homolog: identification of mutant alleles that have pleiotropic effects late in development
    M J Henkemeyer
    McArdle Laboratory for Cancer Research, University of Wisconsin, Madison 53706
    Cell 51:821-8. 1987
    The Abelson gene in Drosophila (abl) consists of ten exons extending over 26 kb of genomic DNA...
  54. pmc Abelson kinase regulates epithelial morphogenesis in Drosophila
    E E Grevengoed
    Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 3280, USA
    J Cell Biol 155:1185-98. 2001
    Activation of the nonreceptor tyrosine kinase Abelson (Abl) contributes to the development of leukemia, but the complex roles of Abl in normal development are not fully understood...
  55. pmc latheo, a new gene involved in associative learning and memory in Drosophila melanogaster, identified from P element mutagenesis
    S Boynton
    Department of Biology, Brandeis University, Waltham, Massachusetts 02254
    Genetics 131:655-72. 1992
    ..Flies heterozygous for latheoP1 and one of two EMS lethal alleles or one lethal excision allele also show the behavioral deficits, thereby demonstrating that the behavioral and lethal phenotypes co-map to the same locus...
  56. ncbi Regulators of endocytosis maintain localized receptor tyrosine kinase signaling in guided migration
    Gaspar Jekely
    Developmental Biology Program, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Dev Cell 9:197-207. 2005
    ..Cbl and Sprint both regulate early steps of RTK endocytosis. Thus, a physiological role of RTK endocytosis is to ensure localized intracellular response to guidance cues by stimulating spatial restriction of signaling...
  57. pmc Systems-wide analysis of a phosphatase knock-down by quantitative proteomics and phosphoproteomics
    Maximiliane Hilger
    Proteomics and Signal Transduction, Max Planck Institute for Biochemistry, Am Klopferspitz 18, D 82152 Martinsried, Germany
    Mol Cell Proteomics 8:1908-20. 2009
    ..Our analysis highlights a connection of Ptp61F to cytoskeletal regulation through GTPase regulating proteins and focal adhesion components...
  58. doi The actin-binding protein Canoe/AF-6 forms a complex with Robo and is required for Slit-Robo signaling during axon pathfinding at the CNS midline
    Jana Slováková
    Instituto de Neurociencias, CSIC UMH, 03550 Sant Joan d Alacant, Spain
    J Neurosci 32:10035-44. 2012
    ..Our data argue that Cno is a novel regulator of the Slit-Robo signaling pathway, crucial for regulating the subcellular localization of Robo and for transducing its signaling to the actin cytoskeleton during axon guidance at the midline...
  59. pmc Modulation of catalytic activity in multi-domain protein tyrosine phosphatases
    Lalima L Madan
    Molecular Biophysics Unit, Indian Institute of Science, Bangalore, India
    PLoS ONE 6:e24766. 2011
    ....
  60. ncbi Signal transduction in the control of cell growth and development
    T Pawson
    Samuel Lunenfeld Research Institute, Mt Sinai Hospital, Toronto, Ontario, Canada
    Trends Genet 7:343-5. 1991
  61. ncbi Drosophila src family proteins
    S C Wadsworth
    Worcester Foundation for Experimental Biology, Shrewsbury, MA 61545
    Comp Biochem Physiol B 97:403-6. 1990
  62. pmc Fasciclin II controls proneural gene expression in Drosophila
    L Garcia-Alonso
    Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley 94720, USA
    Proc Natl Acad Sci U S A 92:10501-5. 1995
    ..Mutations in the Abelson tyrosine kinase gene show dominant interactions with fasII mutations, suggesting that Abl and Fas II function in a ..
  63. pmc A genetic analysis of the Drosophila closely linked interacting genes bulge, argos and soba
    T Wemmer
    Institut fur Entwicklungsbiologie, Universitat zu Koln, Germany
    Genetics 140:629-41. 1995
    ..In addition, we have identified one allele of a new gene, clown, which like soba suppresses the eye phenotypes associated with hs-argos and bulgeDominant. clown maps on chromosome 3 at the cytological position 68CD...
  64. ncbi Dosage-sensitive modifiers of Drosophila abl tyrosine kinase function: prospero, a regulator of axonal outgrowth, and disabled, a novel tyrosine kinase substrate
    F B Gertler
    McArdle Laboratory for Cancer Research, University of Wisconsin, Madison 53706
    Genes Dev 7:441-53. 1993
    In the absence of the Drosophila abl protein-tyrosine kinase (PTK), loss-of-function mutations in either disabled or prospero have dominant phenotypic effects on embryonic development...
  65. ncbi From growth cone to synapse: the life history of the RP3 motor neuron
    K Broadie
    Department of Zoology, University of Cambridge, UK
    Dev Suppl . 1993
    ..Genetic analysis has revealed mutations in a number of different genes which affect specific aspects of RP3 development from axon outgrowth to synapse formation...
  66. ncbi To cross or not to cross: a genetic analysis of guidance at the midline
    G Tear
    Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley 94720
    Perspect Dev Neurobiol 1:183-94. 1993
    ..These phenotypes suggest that these two genes encode important components for growth cone guidance at the midline...
  67. ncbi Genetic and molecular dissection of axon pathfinding in the Drosophila nervous system
    M A Seeger
    Program in Molecular and Cell Biology, Oklahoma Medical Research Foundation, Oklahoma City 73104 5073
    Curr Opin Neurobiol 4:56-62. 1994
    ....
  68. ncbi Embryonic development of the Drosophila brain: formation of commissural and descending pathways
    S Therianos
    Laboratory of Neurobiology, Institute of Zoology, University of Basel, Switzerland
    Development 121:3849-60. 1995
    ....
  69. ncbi Intermittent divergence of the protein tyrosine kinase family during animal evolution
    H Suga
    Department of Biophysics, Faculty of Science, Kyoto University, Japan
    FEBS Lett 412:540-6. 1997
    ..These results strongly suggest that the PTKs diverged intermittently, but not gradually, during animal evolution...
  70. pmc Transmembrane glycoprotein gp150 is a substrate for receptor tyrosine phosphatase DPTP10D in Drosophila cells
    S J Fashena
    Division of Biology, California Institute of Technology, Pasadena 91125, USA
    Mol Cell Biol 17:6859-67. 1997
    ..Phosphotyrosines on gp150 might function as binding sites for downstream signaling molecules, thereby initiating a signaling cascade that could be modulated in vivo by RPTPs such as DPTP10D...
  71. pmc Disabled is a putative adaptor protein that functions during signaling by the sevenless receptor tyrosine kinase
    N Le
    Department of Biological Sciences, Stanford University, Stanford, California 94305 5020, USA
    Mol Cell Biol 18:4844-54. 1998
    ..Taken together, these results indicate that DAB is a novel component of the SEV signaling pathway...
  72. ncbi Drosophila abelson interacting protein (dAbi) is a positive regulator of abelson tyrosine kinase activity
    J L Juang
    National Health Research Institute, 128 Yen Chiu Yuan Road, Sec 2, Taipei, Taiwan
    Oncogene 18:5138-47. 1999
    ..We report a new member of this gene family, a Drosophila Abi (dAbi) that is a substrate for Abl kinase and that co-immunoprecipitates with Abl if the Abi SH3 domain is intact...
  73. ncbi Trio quartet in D. (melanogaster)
    L Luo
    Department of Biological Sciences, Stanford University, California 94305, USA
    Neuron 26:1-2. 2000
  74. ncbi Putting on the brakes: a negative regulatory function for Ena/VASP proteins in cell migration
    L M Machesky
    School of Biosciences, Division of Molecular and Cell Biology, University of Birmingham, United Kingdom
    Cell 101:685-8. 2000
  75. ncbi Four-jointed interacts with dachs, abelson and enabled and feeds back onto the Notch pathway to affect growth and segmentation in the Drosophila leg
    G R Buckles
    Department of Biology, Texas A and M University, College Station, TX 77843 3258, USA
    Development 128:3533-42. 2001
    ..We also show that four-jointed interacts with abelson, enabled and dachs, which leads us to suggest that one target of four-jointed signaling is the actin cytoskeleton...
  76. ncbi Drosophila Ack targets its substrate, the sorting nexin DSH3PX1, to a protein complex involved in axonal guidance
    Carolyn A Worby
    Life Sciences Institute and Department of Biological Chemistry, University of Michigan, Ann Arbor, Michigan 48109 0606, USA
    J Biol Chem 277:9422-8. 2002
    ..These results suggest that the phosphorylation of DSH3PX1 by DAck targets this sorting nexin to a protein complex that includes Dock, an adaptor protein important for axonal guidance...
  77. ncbi Axon guidance: the cytoplasmic tail
    Bharatkumar N Patel
    Program in Neuroscience, Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Curr Opin Cell Biol 14:221-9. 2002
    ..Recent studies demonstrate a critical role for the cytoplasmic tails of guidance receptors in signalling and also reveal the potential for a great deal of crosstalk between the various receptor-signalling pathways...
  78. pmc Use of double-stranded RNA-mediated interference to determine the substrates of protein tyrosine kinases and phosphatases
    Marco Muda
    Serono Reproductive Biology Institute, Inc, Randolph, MA 02368, U S A
    Biochem J 366:73-7. 2002
    ..The present study illustrates the versatility of RNAi in the identification of the physiological substrates for protein kinases and phosphatases...
  79. ncbi Abi enhances Abl-mediated CDC2 phosphorylation and inactivation
    Tzu Yang Lin
    Division of Molecular and Genomic Medicine, National Health Research Institutes, Taipei, Taiwan
    J Biomed Sci 11:902-10. 2004
    b>Abelson tyrosine kinase (Abl) is a non-receptor tyrosine kinase which is frequently coupled with adaptor proteins to interact with its substrates for the regulation of cytoskeleton rearrangement, cell growth and apoptosis in response to ..
  80. pmc The Drosophila CD2AP/CIN85 orthologue Cindr regulates junctions and cytoskeleton dynamics during tissue patterning
    Ruth I Johnson
    Department of Developmental and Regenerative Biology, Mount Sinai Medical School, New York, NY 10029, USA
    J Cell Biol 180:1191-204. 2008
    ..Together, these data demonstrate that Cindr is involved in dynamic cell rearrangement in an emerging epithelium...
  81. pmc Formin-dependent synaptic growth: evidence that Dlar signals via Diaphanous to modulate synaptic actin and dynamic pioneer microtubules
    Catherine Pawson
    Department of Biochemistry and Biophysics, Programs in Neuroscience and Cell Biology, University of California, San Francisco, San Francisco, California 94158 2822, USA
    J Neurosci 28:11111-23. 2008
    ....
  82. pmc Endodomain diversity in the Drosophila Dscam and its roles in neuronal morphogenesis
    Hung Hsiang Yu
    Department of Neurobiology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    J Neurosci 29:1904-14. 2009
    ..In sum, Dscam with or without exon 19 in its endodomain is used to govern different stage-specific neuronal morphogenetic processes, possibly due to differences in protein targeting...
  83. pmc Abelson tyrosine kinase is required for Drosophila photoreceptor morphogenesis and retinal epithelial patterning
    Wenjun Xiong
    Ben May Department for Cancer Research, The University of Chicago, Chicago, Illinois, USA
    Dev Dyn 240:1745-55. 2011
    ..In this study we show that the Abelson (Abl) tyrosine kinase localizes to the dynamically remodeling apical-junctional membrane domains of the ..
  84. ncbi Learning about cancer genes through invertebrate genetics
    F M Hoffmann
    McArdle Laboratory for Cancer Research, University of Wisconsin, Madison 53706
    Curr Opin Genet Dev 2:45-52. 1992
    ..Some of the critical molecules involved are homologous to proto-oncogenes and others are likely to be analogous to the products of tumor suppressor genes...
  85. ncbi Drosophila abl and genetic redundancy in signal transduction
    F M Hoffmann
    McArdle Laboratory for Cancer Research, University of Wisconsin, Madison 53706
    Trends Genet 7:351-5. 1991
    Genetic studies on Drosophila Abl and, more recently, on mouse c-Abl and c-Src indicate that the functions of these non-receptor tyrosine kinases may duplicate activities of other molecules within signal transduction pathways...
  86. ncbi A molecular analysis of transformer, a gene in Drosophila melanogaster that controls female sexual differentiation
    M McKeown
    Cell 48:489-99. 1987
    ..These results suggest that tra+ function is regulated at the level of production of the female-specific tra RNA. The fact that a tra transcript is found in males raises interesting possibilities for how tra expression is controlled...
  87. ncbi Nucleotide sequences of the Drosophila src and abl homologs: conservation and variability in the src family oncogenes
    F M Hoffmann
    Cell 35:393-401. 1983
    Two cloned Drosophila sequences, Dash and Dsrc, were previously isolated by hybridization to the viral oncogenes v-abl and v-src...
  88. ncbi Three loci related to the src oncogene and tyrosine-specific protein kinase activity in Drosophila
    M A Simon
    Nature 302:837-9. 1983
    ..It should now be possible to identify the precise locus that encodes a src-specific protein kinase in Drosophila, and to explore the role of c-src in the growth and development of D. melanogaster...
  89. pmc DNA sequences homologous to vertebrate oncogenes are conserved in Drosophila melanogaster
    B Z Shilo
    Proc Natl Acad Sci U S A 78:6789-92. 1981
    ..Five of these probes hybridized to the DNA of Drosophila melanogaster. Abelson leukemia virus probe detected a single homologous DNA fragment in Drosophila DNA...
  90. pmc A Drosophila G-protein alpha subunit, Gf alpha, expressed in a spatially and temporally restricted pattern during Drosophila development
    F Quan
    Vollum Institute for Advanced Biomedical Research, Oregon Health Sciences University, Portland 97201
    Proc Natl Acad Sci U S A 90:4236-40. 1993
    ..The Gf alpha gene has been characterized and mapped to position 73B of the Drosophila genome...
  91. ncbi PY in the fly receptor-like tyrosine phosphatases in axonal pathfinding
    C B Chien
    Max Planck Institut fur Entwicklungsbiologie, Abteilung Physikalische Biologie, Tubingen, Federal Republic of Germany
    Neuron 16:1065-8. 1996
  92. ncbi Low mutation rates of microsatellite loci in Drosophila melanogaster
    M D Schug
    Section of Genetics and Development, Cornell University, Ithaca, New York 14853, USA
    Nat Genet 15:99-102. 1997
    ..3 x 10(-6), a mutation rate considerably lower than reported for various mammals. We propose that the comparatively low mutation rate is primarily a function of short microsatellite repeat lengths in the D. melanogaster genome...
  93. ncbi Genetic analysis of protein tyrosine phosphatases
    D Van Vactor
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Curr Opin Genet Dev 8:112-26. 1998
    ..Finally, very recent studies of other mammalian PTPs suggest that they have critical roles in processes as diverse as hematopoiesis and liver and pituitary development...
  94. pmc Mutations in Drosophila enabled and rescue by human vasodilator-stimulated phosphoprotein (VASP) indicate important functional roles for Ena/VASP homology domain 1 (EVH1) and EVH2 domains
    S M Ahern-Djamali
    McArdle Laboratory for Cancer Research and Laboratory of Genetics University of Wisconsin Medical School, Madison, Wisconsin 53706, USA
    Mol Biol Cell 9:2157-71. 1998
    Drosophila Enabled (Ena) was initially identified as a dominant genetic suppressor of mutations in the Abelson tyrosine kinase and, more recently, as a member of the Ena/human vasodilator-stimulated phosphoprotein (VASP) family of ..
  95. ncbi Genetic analysis of cadherin function in animal morphogenesis
    U Tepass
    Department of Zoology University of Toronto 25 Harbord Street, Toronto, Ontario, M5S 3G5, Canada
    Curr Opin Cell Biol 11:540-8. 1999
    ..Fat-like cadherins are required for epithelial morphogenesis, proliferation control, and epithelial planar polarization...
  96. ncbi Alzheimer's disease: neurodevelopment converges with neurodegeneration
    M Bothwell
    Department of Physiology and Biophysics, University of Washington, Seattle 98195, USA
    Cell 102:271-3. 2000
  97. ncbi Estimation of microsatellite mutation rates in Drosophila melanogaster
    J Fernando Vázquez
    Area de Genetica, Departamento de Biologia Funcional, Universidad de Oviedo, 33071 Oviedo, Spain
    Genet Res 76:323-6. 2000
    ..The average mutation rate was 5.1 x 10(-6), in full agreement with previous estimates from two different sets of mutation accumulation lines...
  98. ncbi The Trio family of guanine-nucleotide-exchange factors: regulators of axon guidance
    J Bateman
    Department of Cell Biology and Program in Neuroscience, Harvard Medical School, Boston, MA 02115, USA
    J Cell Sci 114:1973-80. 2001
    ..Future studies of these mechanisms promise to yield insights not only into neural development but also into the ongoing function and remodeling of the adult nervous system...
  99. ncbi Epithelial fusions in the embryo
    Paul Martin
    Department Anatomy and Developmental Biology, University College London, UK
    Curr Opin Cell Biol 14:569-74. 2002
    ..It is now clear that there are intriguing parallels with more complex morphogenetic tissue movements in vertebrates...
  100. ncbi FASt remodeling of synapses in Drosophila
    Mary Packard
    Department of Neurobiology, University of Massachusetts Medical School, Aaron Lazare Medical Research Building, 364 Plantation Street, Worcester, MA 01605 2324, USA
    Curr Opin Neurobiol 13:527-34. 2003
    ..These studies offer convincing evidence that synaptic cell adhesion brings about both negative and positive forces that stabilize synapses, while maintaining their ability to change in an activity-dependent manner...
  101. ncbi The microtubule plus end tracking protein Orbit/MAST/CLASP acts downstream of the tyrosine kinase Abl in mediating axon guidance
    Haeryun Lee
    Department of Cell Biology, Program in Neuroscience, Dana Farber Cancer Institute Harvard Cancer Center and Harvard Center of Neurodegeneration and Repair, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA
    Neuron 42:913-26. 2004
    ..Using a genetic screen, we identified the microtubule-associated protein Orbit/MAST as a partner of the Abelson (Abl) tyrosine kinase...

Research Grants5

  1. REGULATION OF NEUROGENESIS IN THE DROSOPHILA CNS
    Krishna Bhat; Fiscal Year: 2002
    ..These studies will help understand pathways that govern the lineage elaboration in the Drosophila CNS as well as in other eukaryotic organisms including humans. ..
  2. Niemann Pick C disease in Drosophila
    Krishna Bhat; Fiscal Year: 2007
    ..This work will provide insight into the role of these proteins in neurodegenerative diseases and development. ..
  3. NEUROTROPHIN RECEPTOR INTERACTIONS
    Mark Bothwell; Fiscal Year: 2004
    ..The patterns of developmental expression of P75/NTR, NRH1 and NRH2 will be examined in Xenopus and mice, to assess whether the opportunity for functional interactions exist. ..
  4. Amyloid Precursor Protein Signaling
    Mark Bothwell; Fiscal Year: 2006
    ..Effects of agonistic APP monoclonal antibody, beta-amyloid peptide, LRP, and alpha-2 macroglobulin on APP signaling will be assessed. ..
  5. Nogo Receptor Signaling and Function
    Mark Bothwell; Fiscal Year: 2007
    ..Effects of these manipulations on axonal targeting will be assessed by injecting the fluorescent marker Dil into embryos to allow microscopic imaging of axon trajectories. ..