ygjF

Summary

Gene Symbol: ygjF
Description: G/U mismatch-specific DNA glycosylase
Species: Escherichia coli CFT073

Top Publications

  1. ncbi Novel activity of Escherichia coli mismatch uracil-DNA glycosylase (Mug) excising 8-(hydroxymethyl)-3,N4-ethenocytosine, a potential product resulting from glycidaldehyde reaction
    Bo Hang
    Donner Laboratory, Life Sciences Division, Lawrence Berkeley National Laboratory, University of California, Berkeley, California 94720, USA
    Biochemistry 41:2158-65. 2002
  2. ncbi 1,N(2)-ethenoguanine, a mutagenic DNA adduct, is a primary substrate of Escherichia coli mismatch-specific uracil-DNA glycosylase and human alkylpurine-DNA-N-glycosylase
    Murat Saparbaev
    Groupe Réparation de l ADN, Unité Mixte de Recherche 8532 CNRS, Laboratoire de Biotechnologies et Pharmacologie Génétique Appliquée Ecole Normale Supérieure Cachan, Institut Gustave Roussy, 94805 Villejuif Cedex, France
    J Biol Chem 277:26987-93. 2002
  3. ncbi A new class of uracil-DNA glycosylases related to human thymine-DNA glycosylase
    P Gallinari
    Istituto di Richerche di Biologia Molecolare P Angeletti, Pomezia, Italy
    Nature 383:735-8. 1996
  4. ncbi Repair of the mutagenic DNA oxidation product, 5-formyluracil
    Pingfang Liu
    Department of Biochemistry and Microbiology, School of Medicine, Loma Linda University, Loma Linda, CA 92350, USA
    DNA Repair (Amst) 2:199-210. 2003
  5. ncbi Influence of local duplex stability and N6-methyladenine on uracil recognition by mismatch-specific uracil-DNA glycosylase (Mug)
    Victoria Valinluck
    Department of Biochemistry and Microbiology, School of Medicine, Loma Linda University, Loma Linda, California 92350, USA
    Chem Res Toxicol 15:1595-601. 2002
  6. ncbi Substrate recognition by a family of uracil-DNA glycosylases: UNG, MUG, and TDG
    Pingfang Liu
    Department of Biochemistry and Microbiology, School of Medicine, Loma Linda University, Loma Linda, CA 92350, USA
    Chem Res Toxicol 15:1001-9. 2002
  7. ncbi Escherichia coli DNA glycosylase Mug: a growth-regulated enzyme required for mutation avoidance in stationary-phase cells
    S K Mokkapati
    Department of Chemistry, 463 Chemistry Building, Wayne State University, Detroit, MI 48202, USA
    Mol Microbiol 41:1101-11. 2001
  8. pmc Crystal structure of a thwarted mismatch glycosylase DNA repair complex
    T E Barrett
    Department of Biochemistry and Molecular Biology, University College London, Gower Street, London WC1E 6BT
    EMBO J 18:6599-609. 1999
  9. ncbi The role of the Escherichia coli mug protein in the removal of uracil and 3,N(4)-ethenocytosine from DNA
    E Lutsenko
    Department of Chemistry, Wayne State University, Detroit, Michigan 48202, USA
    J Biol Chem 274:31034-8. 1999
  10. ncbi Thermostable uracil-DNA glycosylase from Thermotoga maritima a member of a novel class of DNA repair enzymes
    M Sandigursky
    Departments of Radiology and Radiation Oncology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA
    Curr Biol 9:531-4. 1999

Research Grants

  1. Enzyme Repair of Excoyclic Adducts
    Bo Hang; Fiscal Year: 2005

Scientific Experts

  • Bo Hang
  • Murat Saparbaev
  • Pingfang Liu
  • Lawrence C Sowers
  • Artur Burdzy
  • T E Barrett
  • Rory J O'Neill
  • Victoria Valinluck
  • J Jiricny
  • S K Mokkapati
  • A S Bhagwat
  • E Lutsenko
  • M Sandigursky
  • R Savva
  • L H Pearl
  • T Brown
  • Erik Zmuda
  • Geoffrey S Baldwin
  • Ashok S Bhagwat
  • Olga V Vorob'eva
  • Hassan Shahbakhti
  • P Gallinari
  • Junichi Ryu
  • A R Fernandez de Henestrosa
  • G L Verdine
  • O D Schärer
  • W A Franklin
  • G Panayotou
  • T Barlow

Detail Information

Publications13

  1. ncbi Novel activity of Escherichia coli mismatch uracil-DNA glycosylase (Mug) excising 8-(hydroxymethyl)-3,N4-ethenocytosine, a potential product resulting from glycidaldehyde reaction
    Bo Hang
    Donner Laboratory, Life Sciences Division, Lawrence Berkeley National Laboratory, University of California, Berkeley, California 94720, USA
    Biochemistry 41:2158-65. 2002
    ..We believe that these findings may have biological and structural implications in defining the role of 8-HM-epsilonC in glycosylase recognition/repair...
  2. ncbi 1,N(2)-ethenoguanine, a mutagenic DNA adduct, is a primary substrate of Escherichia coli mismatch-specific uracil-DNA glycosylase and human alkylpurine-DNA-N-glycosylase
    Murat Saparbaev
    Groupe Réparation de l ADN, Unité Mixte de Recherche 8532 CNRS, Laboratoire de Biotechnologies et Pharmacologie Génétique Appliquée Ecole Normale Supérieure Cachan, Institut Gustave Roussy, 94805 Villejuif Cedex, France
    J Biol Chem 277:26987-93. 2002
    ..Taken together these observations suggest a possible role for these proteins in counteracting the genotoxic effects of 1,N(2)-epsilonG residues in vivo...
  3. ncbi A new class of uracil-DNA glycosylases related to human thymine-DNA glycosylase
    P Gallinari
    Istituto di Richerche di Biologia Molecolare P Angeletti, Pomezia, Italy
    Nature 383:735-8. 1996
    ....
  4. ncbi Repair of the mutagenic DNA oxidation product, 5-formyluracil
    Pingfang Liu
    Department of Biochemistry and Microbiology, School of Medicine, Loma Linda University, Loma Linda, CA 92350, USA
    DNA Repair (Amst) 2:199-210. 2003
    ..The pathways by which this important lesion is repaired in human cells are as yet unexplained, and are likely to be complex...
  5. ncbi Influence of local duplex stability and N6-methyladenine on uracil recognition by mismatch-specific uracil-DNA glycosylase (Mug)
    Victoria Valinluck
    Department of Biochemistry and Microbiology, School of Medicine, Loma Linda University, Loma Linda, California 92350, USA
    Chem Res Toxicol 15:1595-601. 2002
    ....
  6. ncbi Substrate recognition by a family of uracil-DNA glycosylases: UNG, MUG, and TDG
    Pingfang Liu
    Department of Biochemistry and Microbiology, School of Medicine, Loma Linda University, Loma Linda, CA 92350, USA
    Chem Res Toxicol 15:1001-9. 2002
    ..These results provide new insights into the mechanisms of base selection by DNA repair glycosylases...
  7. ncbi Escherichia coli DNA glycosylase Mug: a growth-regulated enzyme required for mutation avoidance in stationary-phase cells
    S K Mokkapati
    Department of Chemistry, 463 Chemistry Building, Wayne State University, Detroit, MI 48202, USA
    Mol Microbiol 41:1101-11. 2001
    ..Thus, Mug joins a very small coterie of DNA repair enzymes whose principal function is to avoid mutations in stationary-phase cells...
  8. pmc Crystal structure of a thwarted mismatch glycosylase DNA repair complex
    T E Barrett
    Department of Biochemistry and Molecular Biology, University College London, Gower Street, London WC1E 6BT
    EMBO J 18:6599-609. 1999
    ....
  9. ncbi The role of the Escherichia coli mug protein in the removal of uracil and 3,N(4)-ethenocytosine from DNA
    E Lutsenko
    Department of Chemistry, Wayne State University, Detroit, Michigan 48202, USA
    J Biol Chem 274:31034-8. 1999
    ..coli that can remove this mutagenic adduct. Thus, the principal role of Mug in E. coli may be to help repair damage to DNA caused by exogenous chemical agents such as chloroacetaldehyde...
  10. ncbi Thermostable uracil-DNA glycosylase from Thermotoga maritima a member of a novel class of DNA repair enzymes
    M Sandigursky
    Departments of Radiology and Radiation Oncology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA
    Curr Biol 9:531-4. 1999
    ..These findings suggest that the T. maritima UDG is a member of a new class of DNA repair enzymes...
  11. pmc 3,N4-ethenocytosine, a highly mutagenic adduct, is a primary substrate for Escherichia coli double-stranded uracil-DNA glycosylase and human mismatch-specific thymine-DNA glycosylase
    M Saparbaev
    Groupe Reparation des lesions Radio et Chimio Induites, UMR 1772, Centre National de la Recherche Scientifique, Institut Gustave Roussy, 94805 Villejuif Cedex, France
    Proc Natl Acad Sci U S A 95:8508-13. 1998
    ..coli dsUDG and hTDG proteins in vitro suggests that these enzymes may be responsible for the repair of this mutagenic lesion in vivo and be important contributors to genetic stability...
  12. ncbi Crystal structure of a G:T/U mismatch-specific DNA glycosylase: mismatch recognition by complementary-strand interactions
    T E Barrett
    Department of Biochemistry and Molecular Biology, University College London, United Kingdom
    Cell 92:117-29. 1998
    ..Details of the MUG structure explain its thymine DNA-glycosylase activity and the specificity for G:U/T mispairs, which derives from direct recognition of guanine on the complementary strand...
  13. ncbi Mismatch uracil glycosylase from Escherichia coli: a general mismatch or a specific DNA glycosylase?
    Rory J O'Neill
    Imperial College London, Department of Biological Sciences, Sir Alexander Flemming Building, South Kensington, London SW7 2AZ, United Kingdom
    J Biol Chem 278:20526-32. 2003
    ..This comparison of different substrates under single turnover conditions provides a rational basis for comparing substrates of MUG and we relate these conclusions to the known crystal structures of the enzyme and its catalytic mechanism...

Research Grants1

  1. Enzyme Repair of Excoyclic Adducts
    Bo Hang; Fiscal Year: 2005
    ..abstract_text> ..