yccA

Summary

Gene Symbol: yccA
Description: Modulator of FtsH protease, inner membrane protein
Alias: ECK0961, JW0953
Species: Escherichia coli str. K-12 substr. MG1655

Top Publications

  1. pmc The E. coli divE mutation, which differentially inhibits synthesis of certain proteins, is in tRNASer1
    F Tamura
    EMBO J 3:1103-7. 1984
  2. ncbi Different pathways for protein degradation by the FtsH/HflKC membrane-embedded protease complex: an implication from the interference by a mutant form of a new substrate protein, YccA
    A Kihara
    Department of Cell Biology, Institute for Virus Research, Kyoto University, Japan
    J Mol Biol 279:175-88. 1998
  3. ncbi FtsH--a single-chain charonin?
    W Schumann
    Institute of Genetics, University of Bayreuth, Germany
    FEMS Microbiol Rev 23:1-11. 1999
  4. pmc Dislocation of membrane proteins in FtsH-mediated proteolysis
    A Kihara
    Institute for Virus Research, Kyoto University, Sakyo ku, Kyoto 606 8507, Japan
    EMBO J 18:2970-81. 1999
  5. pmc Length recognition at the N-terminal tail for the initiation of FtsH-mediated proteolysis
    S Chiba
    Institute for Virus Research, Kyoto University Japan
    EMBO Rep 1:47-52. 2000
  6. ncbi The Cpx stress response system of Escherichia coli senses plasma membrane proteins and controls HtpX, a membrane protease with a cytosolic active site
    Nobuyuki Shimohata
    Institute for Virus Research, Kyoto University, Kyoto 606 8507, Japan
    Genes Cells 7:653-62. 2002
  7. ncbi Global impact of mature biofilm lifestyle on Escherichia coli K-12 gene expression
    Christophe Beloin
    Groupe de Génétique des Biofilms CNRS URA 2172, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
    Mol Microbiol 51:659-74. 2004
  8. ncbi BAX Inhibitor-1, an ancient cell death suppressor in animals and plants with prokaryotic relatives
    R Hückelhoven
    Institute of Phytopathology and Applied Zoology, Justus Liebig University Giessen, Heinrich Buff Ring 26 32, D 35392 Giessen, Germany
    Apoptosis 9:299-307. 2004
  9. pmc Effects of antibiotics and a proto-oncogene homolog on destruction of protein translocator SecY
    Johna van Stelten
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Science 325:753-6. 2009
  10. ncbi Expression of the leuX gene in Escherichia coli. Regulation at transcription and tRNA processing steps
    T Nomura
    Department of Molecular Genetics, National Institute of Genetics, Shizuoka, Japan
    J Mol Biol 197:659-70. 1987

Scientific Experts

  • W Schumann
  • Ralph Hückelhoven
  • Johna van Stelten
  • A Kihara
  • Kaneyoshi Yamamoto
  • Christophe Beloin
  • K Ito
  • Y Akiyama
  • Nobuyuki Shimohata
  • S Chiba
  • Dominique Belin
  • Filo Silva
  • Thomas J Silhavy
  • Akira Ishihama
  • Jean Marc Ghigo
  • Janus A J Haagensen
  • Brigitte Arbeille
  • Søren Molin
  • Gerard Prensier
  • Damien Balestrino
  • Philippe Faure
  • Patricia Latour-Lambert
  • Jaione Valle
  • Mickaël Kzreminski
  • Shinobu Chiba
  • Yoshinori Akiyama
  • Naoya Saikawa
  • Koreaki Ito
  • H Mori
  • E Matsuo
  • T Nomura
  • F Tamura
  • M Ohki
  • A Ishihama
  • N Fujita
  • S Nishimura

Detail Information

Publications12

  1. pmc The E. coli divE mutation, which differentially inhibits synthesis of certain proteins, is in tRNASer1
    F Tamura
    EMBO J 3:1103-7. 1984
    ....
  2. ncbi Different pathways for protein degradation by the FtsH/HflKC membrane-embedded protease complex: an implication from the interference by a mutant form of a new substrate protein, YccA
    A Kihara
    Department of Cell Biology, Institute for Virus Research, Kyoto University, Japan
    J Mol Biol 279:175-88. 1998
    ..coli chromosome. The mutation (yccA11) is an internal deletion within a gene (yccA) known as an open reading frame for a hydrophobic protein with putative seven transmembrane segments...
  3. ncbi FtsH--a single-chain charonin?
    W Schumann
    Institute of Genetics, University of Bayreuth, Germany
    FEMS Microbiol Rev 23:1-11. 1999
    ..Its activity can be modulated by the HflKC proteins, by another membrane protein designated YccA which can transiently associate with both the FtsH and the HflKC proteins, or by small peptides such as CIII ..
  4. pmc Dislocation of membrane proteins in FtsH-mediated proteolysis
    A Kihara
    Institute for Virus Research, Kyoto University, Sakyo ku, Kyoto 606 8507, Japan
    EMBO J 18:2970-81. 1999
    Escherichia coli FtsH degrades several integral membrane proteins, including YccA, having seven transmembrane segments, a cytosolic N-terminus and a periplasmic C-terminus...
  5. pmc Length recognition at the N-terminal tail for the initiation of FtsH-mediated proteolysis
    S Chiba
    Institute for Virus Research, Kyoto University Japan
    EMBO Rep 1:47-52. 2000
    ..b>YccA, a natural substrate of FtsH was found to require the N-terminal tail of 20 amino acid residues or longer to be ..
  6. ncbi The Cpx stress response system of Escherichia coli senses plasma membrane proteins and controls HtpX, a membrane protease with a cytosolic active site
    Nobuyuki Shimohata
    Institute for Virus Research, Kyoto University, Kyoto 606 8507, Japan
    Genes Cells 7:653-62. 2002
    ..The pathway for this transmembrane signalling is mediated by the CpxR-CpxA two-component phospho-relay mechanism...
  7. ncbi Global impact of mature biofilm lifestyle on Escherichia coli K-12 gene expression
    Christophe Beloin
    Groupe de Génétique des Biofilms CNRS URA 2172, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
    Mol Microbiol 51:659-74. 2004
    ..These results constitute a comprehensive analysis of the global transcriptional response triggered in mature E. coli biofilms and provide insights into its physiological signature...
  8. ncbi BAX Inhibitor-1, an ancient cell death suppressor in animals and plants with prokaryotic relatives
    R Hückelhoven
    Institute of Phytopathology and Applied Zoology, Justus Liebig University Giessen, Heinrich Buff Ring 26 32, D 35392 Giessen, Germany
    Apoptosis 9:299-307. 2004
    ..This review focuses on the present understanding about BI-1 and suggests potential directions for further analyses of this increasingly noticed protein...
  9. pmc Effects of antibiotics and a proto-oncogene homolog on destruction of protein translocator SecY
    Johna van Stelten
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Science 325:753-6. 2009
    ..Increasing the amounts or the stability of the membrane protein YccA, a known inhibitor of FtsH, counteracted this destruction...
  10. ncbi Expression of the leuX gene in Escherichia coli. Regulation at transcription and tRNA processing steps
    T Nomura
    Department of Molecular Genetics, National Institute of Genetics, Shizuoka, Japan
    J Mol Biol 197:659-70. 1987
    ....
  11. ncbi Transcriptional response of Escherichia coli to external copper
    Kaneyoshi Yamamoto
    Department of Agricultural Chemistry, Kinki University, Nakamachi 3327 204, Nara 631 8505, Japan
    Mol Microbiol 56:215-27. 2005
    ..e. CueR, CusR, CpxR and YedW regulons. These copper-responsive regulons appear to sense and respond to different concentrations of external copper...