rseA

Summary

Gene Symbol: rseA
Description: anti-RNA polymerase sigma factor SigE
Species: Escherichia coli CFT073

Top Publications

  1. ncbi Analysis of an Escherichia coli mutant strain resistant to the cell-killing function encoded by the gef gene family
    L K Poulsen
    Biotechnological Institute, Technical University of Denmark, Lyngby
    Mol Microbiol 6:895-905. 1992
  2. ncbi Hyperosmotic shock induces the sigma32 and sigmaE stress regulons of Escherichia coli
    A A Bianchi
    Bioengineering, University of Washington, Seattle 98195, USA
    Mol Microbiol 34:1029-38. 1999
  3. pmc Function of the sigma(E) regulon in dead-cell lysis in stationary-phase Escherichia coli
    T Nitta
    Department of Biological Chemistry, Faculty of Agriculture, Yamaguchi University, Japan
    J Bacteriol 182:5231-7. 2000
  4. ncbi degS (hhoB) is an essential Escherichia coli gene whose indispensable function is to provide sigma (E) activity
    B M Alba
    Department of Biochemistry, University of California at San Francisco, San Francisco, California 94143, USA
    Mol Microbiol 40:1323-33. 2001
  5. ncbi RseB binding to the periplasmic domain of RseA modulates the RseA:sigmaE interaction in the cytoplasm and the availability of sigmaE.RNA polymerase
    B Collinet
    Department of Microbiology, Immunology and Molecular Genetics, University of California at Los Angeles, California 90095, USA
    J Biol Chem 275:33898-904. 2000
  6. ncbi Interaction of the conserved region 4.2 of sigma(E) with the RseA anti-sigma factor
    Christina Tam
    Department of Biochemistry and Molecular Biology, The University of Chicago, 920 East 58th Street, Chicago, IL 60637, USA
    J Biol Chem 277:27282-7. 2002
  7. pmc YaeL (EcfE) activates the sigma(E) pathway of stress response through a site-2 cleavage of anti-sigma(E), RseA
    Kazue Kanehara
    Institute for Virus Research, Kyoto University, Kyoto 606 8507, Japan
    Genes Dev 16:2147-55. 2002
  8. pmc DegS and YaeL participate sequentially in the cleavage of RseA to activate the sigma(E)-dependent extracytoplasmic stress response
    Benjamin M Alba
    Department of Biochemistry and Biophysics, University of California at San Francisco, San Francisco, California 94143, USA
    Genes Dev 16:2156-68. 2002
  9. ncbi Phosphorylation-mediated regulation of heat shock response in Escherichia coli
    Gracjana Klein
    Departement de Biochimie Medicale, Centre Medical Universitaire, 1, rue Michel Servet, 1211 Geneve 4, Switzerland
    Mol Microbiol 48:269-85. 2003
  10. pmc Regulation of the alternative sigma factor sigma(E) during initiation, adaptation, and shutoff of the extracytoplasmic heat shock response in Escherichia coli
    Sarah E Ades
    Department of Stomatology, University of California, San Francisco 94143 0512, USA
    J Bacteriol 185:2512-9. 2003

Scientific Experts

  • Sarah E Ades
  • D Missiakas
  • Elizabeth A Campbell
  • Gracjana Klein
  • Carol A Gross
  • Satish Raina
  • Benjamin M Alba
  • Kazue Kanehara
  • Christina Tam
  • B M Alba
  • B Collinet
  • T Nitta
  • A A Bianchi
  • C A Gross
  • S Raina
  • A De Las Penas
  • Sheng Wang
  • Seth A Darst
  • Jonathan L Tupy
  • Meghan M Sharp
  • Tanja M Gruber
  • Claire Dartigalongue
  • Dominique Missiakas
  • Christina Onufryk
  • Koreaki Ito
  • Jennifer A Leeds
  • Gary Lau
  • C Georgopoulos
  • Bruno Collinet
  • Yoshinori Akiyama
  • Chi Zen Lu
  • J C Pelayo
  • H J Zhong
  • K Hiratsu
  • M Yamada
  • C Herrera
  • M Murata
  • H Izu
  • H Yuzawa
  • H Nagamitsu
  • T Chen
  • H Yu
  • F Baneyx
  • H Nashimoto
  • L Connolly
  • M P Mayer
  • M Lemaire
  • M Amemura
  • V Deretic
  • M J Schurr
  • H Shinagawa
  • K Makino
  • L K Poulsen
  • P E March
  • N W Larsen
  • U Varshney
  • P Andersson
  • P T Morrison
  • M Inouye
  • S Molin
  • R Flachmann
  • J Ahnn
  • J H van de Sande
  • A Laufer
  • S T Lovett
  • L E Gilson
  • M Gutlich
  • J Seifert
  • F J Wientjes
  • H E Takiff
  • R Kolodner
  • H G Gassen
  • H Uchida
  • N Kunz
  • T Hutcheon

Detail Information

Publications23

  1. ncbi Analysis of an Escherichia coli mutant strain resistant to the cell-killing function encoded by the gef gene family
    L K Poulsen
    Biotechnological Institute, Technical University of Denmark, Lyngby
    Mol Microbiol 6:895-905. 1992
    ..1 kDa. ORF178 and an upstream frame, ORF190, probably constitute an operon...
  2. ncbi Hyperosmotic shock induces the sigma32 and sigmaE stress regulons of Escherichia coli
    A A Bianchi
    Bioengineering, University of Washington, Seattle 98195, USA
    Mol Microbiol 34:1029-38. 1999
    ..Overproduction of the cytoplasmic domain of the sigmaE anti-sigma factor, RseA, reduced the magnitude of osmotic induction in lambdaphi(P3rpoH:lacZ ) lysogens, but had no effect on the ..
  3. pmc Function of the sigma(E) regulon in dead-cell lysis in stationary-phase Escherichia coli
    T Nitta
    Department of Biological Chemistry, Faculty of Agriculture, Yamaguchi University, Japan
    J Bacteriol 182:5231-7. 2000
    Elevation of active sigma(E) levels in Escherichia coli by either repressing the expression of rseA encoding an anti-sigma(E) factor or cloning rpoE in a multicopy plasmid, led to a large decrease in the number of dead cells and the ..
  4. ncbi degS (hhoB) is an essential Escherichia coli gene whose indispensable function is to provide sigma (E) activity
    B M Alba
    Department of Biochemistry, University of California at San Francisco, San Francisco, California 94143, USA
    Mol Microbiol 40:1323-33. 2001
    ..DegS promotes the destabilization of the sigma (E)-specific anti-sigma factor RseA, thereby releasing sigma (E) to direct gene expression. We demonstrate that degS is an essential E...
  5. ncbi RseB binding to the periplasmic domain of RseA modulates the RseA:sigmaE interaction in the cytoplasm and the availability of sigmaE.RNA polymerase
    B Collinet
    Department of Microbiology, Immunology and Molecular Genetics, University of California at Los Angeles, California 90095, USA
    J Biol Chem 275:33898-904. 2000
    ..The N-terminal domain of RseA sequesters sigmaE in the cytoplasmic membrane, preventing its association with core RNA polymerase...
  6. ncbi Interaction of the conserved region 4.2 of sigma(E) with the RseA anti-sigma factor
    Christina Tam
    Department of Biochemistry and Molecular Biology, The University of Chicago, 920 East 58th Street, Chicago, IL 60637, USA
    J Biol Chem 277:27282-7. 2002
    ..The RseA anti-sigma factor inhibits the activity of Esigma(E) RNA polymerase...
  7. pmc YaeL (EcfE) activates the sigma(E) pathway of stress response through a site-2 cleavage of anti-sigma(E), RseA
    Kazue Kanehara
    Institute for Virus Research, Kyoto University, Kyoto 606 8507, Japan
    Genes Dev 16:2147-55. 2002
    ..Whereas sigma(E) is thought to be activated by regulated cleavage of RseA on the periplasmic side by the DegS protease, we found that a degradation intermediate of RseA consisting of the ..
  8. pmc DegS and YaeL participate sequentially in the cleavage of RseA to activate the sigma(E)-dependent extracytoplasmic stress response
    Benjamin M Alba
    Department of Biochemistry and Biophysics, University of California at San Francisco, San Francisco, California 94143, USA
    Genes Dev 16:2156-68. 2002
    ..The stress signal is transduced across the inner membrane to the cytoplasm via the inner membrane protein RseA, the anti-sigma factor that inhibits the transcriptional activity of sigma(E)...
  9. ncbi Phosphorylation-mediated regulation of heat shock response in Escherichia coli
    Gracjana Klein
    Departement de Biochimie Medicale, Centre Medical Universitaire, 1, rue Michel Servet, 1211 Geneve 4, Switzerland
    Mol Microbiol 48:269-85. 2003
    ..Additionally, we show that the antisigma factor RseA is phosphorylated at the N-terminally located Tyr-38 and that this phosphorylation presumably alters its binding ..
  10. pmc Regulation of the alternative sigma factor sigma(E) during initiation, adaptation, and shutoff of the extracytoplasmic heat shock response in Escherichia coli
    Sarah E Ades
    Department of Stomatology, University of California, San Francisco 94143 0512, USA
    J Bacteriol 185:2512-9. 2003
    ..is communicated to sigma(E) primarily through the regulated proteolysis of the inner membrane anti-sigma factor RseA, as the degradation rate of RseA is correlated with the changes in sigma(E) activity throughout the stress response...
  11. pmc The Escherichia coli sigma(E)-dependent extracytoplasmic stress response is controlled by the regulated proteolysis of an anti-sigma factor
    S E Ades
    Department of Stomatology, University of California at San Francisco, San Francisco, California 94143 USA
    Genes Dev 13:2449-61. 1999
    ..The inner membrane protein RseA is the central regulatory molecule in this signal transduction cascade and acts as a sigma(E)-specific anti-sigma ..
  12. ncbi The sigmaE-mediated response to extracytoplasmic stress in Escherichia coli is transduced by RseA and RseB, two negative regulators of sigmaE
    A De Las Penas
    Department of Bacteriology, University of Wisconsin Madison, 53706, USA
    Mol Microbiol 24:373-85. 1997
    ..Deletion of rseA leads to a 25-fold induction of sigma(E) activity...
  13. ncbi Modulation of the Escherichia coli sigmaE (RpoE) heat-shock transcription-factor activity by the RseA, RseB and RseC proteins
    D Missiakas
    Centre National de Recherche Scientifique, LIDSM, Marseille, France
    Mol Microbiol 24:355-71. 1997
    ..The second gene of this operon, rseA, encodes an anti-sigma(E) activity. This was demonstrated at both the genetic and biochemical levels...
  14. pmc Molecular analysis of the Escherichia coli recO gene
    P T Morrison
    Division of Cellular and Molecular Biology, Dana Farber Cancer Institute, Boston, Massachusetts
    J Bacteriol 171:3641-9. 1989
    ..A combination of primary sequence analysis and secondary structure predictions suggested that recO contains a mononucleotide-binding fold...
  15. ncbi Sequence analysis, expression, and conservation of Escherichia coli uracil DNA glycosylase and its gene (ung)
    U Varshney
    Department of Medical Biochemistry, Faculty of Medicine, University of Calgary, Canada
    J Biol Chem 263:7776-84. 1988
    ..No sequence homologies were seen for Pseudomonas, Clostridium, Micrococcus, and several eukaryotic genomes...
  16. ncbi Molecular biology of pyridine nucleotide biosynthesis in Escherichia coli. Cloning and characterization of quinolinate synthesis genes nadA and nadB
    R Flachmann
    Institut fur Biochemie, Technische Hochschule Darmstadt, Federal Republic of Germany
    Eur J Biochem 175:221-8. 1988
    ..High-copy-number vectors, carrying either gene nadA, nadB or nadA + nadB, increased quinolinate production 1.5-fold, 2.0-fold and 15-fold respectively. Both gene products seem to be equally rate-limiting in quinolinate synthesis...
  17. ncbi Characterization of the lep operon of Escherichia coli. Identification of the promoter and the gene upstream of the signal peptidase I gene
    P E March
    J Biol Chem 260:7206-13. 1985
    ..The DNA sequence immediately downstream of the lep gene contains features consistent with a rho factor-independent transcriptional termination site, indicating that the lep operon encodes only two proteins (lepA and lep)...
  18. pmc A GTP-binding protein of Escherichia coli has homology to yeast RAS proteins
    J Ahnn
    Proc Natl Acad Sci U S A 83:8849-53. 1986
    ..These data indicate that ras-related sequences occur not only in eukaryotes but also in prokaryotes...
  19. ncbi DNA sequencing of the Escherichia coli ribonuclease III gene and its mutations
    H Nashimoto
    Mol Gen Genet 201:25-9. 1985
    ..coli...
  20. pmc The rpoE gene of Escherichia coli, which encodes sigma E, is essential for bacterial growth at high temperature
    K Hiratsu
    Department of Molecular Microbiology, Osaka University, Japan
    J Bacteriol 177:2918-22. 1995
    ..We demonstrate that expression of htrA is completely dependent on the rpoE gene in vivo and that the rpoE gene is essential for bacterial growth at high temperature...
  21. pmc The rpoE gene encoding the sigma E (sigma 24) heat shock sigma factor of Escherichia coli
    S Raina
    Departement de Biochimie Medicale, Centre Medical Universitaire, Geneve, Switzerland
    EMBO J 14:1043-55. 1995
    ..In vivo and in vitro analyses of rpoE transcriptional regulation showed that the rpoE gene is transcribed from two major promoters, one of which is positively regulated by sigma E itself...
  22. ncbi Crystal structure of Escherichia coli sigmaE with the cytoplasmic domain of its anti-sigma RseA
    Elizabeth A Campbell
    Laboratory of Molecular Biophysics, The Rockefeller University, 1230 York Avenue, New York, New York 10021, USA
    Mol Cell 11:1067-78. 2003
    ..Escherichia coli ECF sigma factor sigma(E) in an inhibitory complex with the cytoplasmic domain of its anti-sigma, RseA. Despite extensive sequence variability, the two major domains of sigma(E) are virtually identical in structure to ..
  23. pmc Functional equivalence of Escherichia coli sigma E and Pseudomonas aeruginosa AlgU: E. coli rpoE restores mucoidy and reduces sensitivity to reactive oxygen intermediates in algU mutants of P. aeruginosa
    H Yu
    Department of Microbiology, University of Texas Health Science Center at San Antonio 78284 7758, USA
    J Bacteriol 177:3259-68. 1995
    ..aeruginosa and suggest that elements showing sequence similarity to those known to regulate AlgU activity in P. aeruginosa are also present in other bacteria...