ftsL

Summary

Gene Symbol: ftsL
Description: membrane bound cell division leucine zipper septum protein
Alias: ECK0084, JW0081, mraR, yabD
Species: Escherichia coli str. K-12 substr. MG1655

Top Publications

  1. pmc Mutants, suppressors, and wrinkled colonies: mutant alleles of the cell division gene ftsQ point to functional domains in FtsQ and a role for domain 1C of FtsA in divisome assembly
    Nathan W Goehring
    Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, MA 02115, USA
    J Bacteriol 189:633-45. 2007
  2. pmc YgbQ, a cell division protein in Escherichia coli and Vibrio cholerae, localizes in codependent fashion with FtsL to the division site
    Nienke Buddelmeijer
    Department of Microbiology and Molecular Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 99:6316-21. 2002
  3. pmc Cell division in Escherichia coli: role of FtsL domains in septal localization, function, and oligomerization
    J M Ghigo
    Unité des Membranes Bactériennes, Institut Pasteur CNRS URA 1300, 75724 Paris Cedex 15, France
    J Bacteriol 182:116-29. 2000
  4. pmc Cytokinesis in bacteria
    Jeffery Errington
    Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, United Kingdom
    Microbiol Mol Biol Rev 67:52-65, table of contents. 2003
  5. ncbi Localization of FtsL to the Escherichia coli septal ring
    J M Ghigo
    Unité de Physiologie Cellulaire Institut Pasteur CNRS URA 1300, Paris, France
    Mol Microbiol 31:725-37. 1999
  6. pmc Localization of FtsI (PBP3) to the septal ring requires its membrane anchor, the Z ring, FtsA, FtsQ, and FtsL
    D S Weiss
    Department of Microbiology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Bacteriol 181:508-20. 1999
  7. ncbi Use of a two-hybrid assay to study the assembly of a complex multicomponent protein machinery: bacterial septosome differentiation
    G Di Lallo
    Dipartimento di Biologia, Universita Tor Vergata, Via della Ricerca Scientifica, I 00133 Rome, Italy
    Microbiology 149:3353-9. 2003
  8. pmc Divisome under construction: distinct domains of the small membrane protein FtsB are necessary for interaction with multiple cell division proteins
    Mark D Gonzalez
    Department of Microbiology and Molecular Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
    J Bacteriol 191:2815-25. 2009
  9. ncbi A complex of the Escherichia coli cell division proteins FtsL, FtsB and FtsQ forms independently of its localization to the septal region
    Nienke Buddelmeijer
    Department of Microbiology and Molecular Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
    Mol Microbiol 52:1315-27. 2004
  10. pmc Domain-swapping analysis of FtsI, FtsL, and FtsQ, bitopic membrane proteins essential for cell division in Escherichia coli
    L M Guzman
    Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Bacteriol 179:5094-103. 1997

Research Grants

Scientific Experts

  • David Weiss
  • Jean Marc Ghigo
  • Jeffery Errington
  • Cynthia A Hale
  • G Karimova
  • H Hara
  • Dirk Jan Scheffers
  • M Vicente
  • Dominique Mengin-Lecreulx
  • Jon Beckwith
  • Nathan W Goehring
  • Mark D Gonzalez
  • Nienke Buddelmeijer
  • Mary Jane Tsang
  • Dana Boyd
  • Carine Robichon
  • Dayle K Blencowe
  • Felipe Villanelo
  • Rakesh Sikdar
  • Patricia L Echtenkamp
  • Luciano Paolozzi
  • Lucia Grenga
  • Fusinita van den Ent
  • Silvia Maggi
  • Giuseppe Luzi
  • Patrizia Ghelardini
  • V D'Ulisse
  • Tanneke Den Blaauwen
  • Thessa M F Vinkenvleugel
  • P Ghelardini
  • Mirjam E G Aarsman
  • L Paolozzi
  • M Fagioli
  • G Di Lallo
  • Thomas G Bernhardt
  • J C Chen
  • W D Donachie
  • Andrew P Morby
  • Octavio Monasterio
  • JUAN BRUNET
  • J Beckwith
  • Daniel Ladant
  • Rosalba Lagos
  • Alexis Ordenes
  • Sawsan Al Jubori
  • Esra A Akbay
  • William T Doerrler
  • Michael L Shuler
  • David B Wilson
  • Dmitry Veprintsev
  • M Carrion
  • Daniela Fadda
  • Nanne Nanninga
  • L M Guzman
  • Alice Ind
  • Philip West
  • Jan Lowe
  • Orietta Massidda
  • Ivana Petrovska
  • Martine Nguyen-Distèche
  • Frederico Gueiros-Filho
  • Andre Piette
  • Claudine Fraipont
  • D Barionovi
  • Jonathan Beckwith
  • Nicholas Judson
  • John J Mekalanos
  • M J Gomez
  • J A Ayala
  • S Dongarrá
  • R Merchante-Schubert
  • H K Jung
  • F Ishino
  • M Ueki
  • J J Barondess
  • M Matsuhashi
  • M Wachi
  • M Nakamura
  • J van Heijenoort
  • M Doi
  • I N Maruyama
  • Y Horota
  • J Kato
  • M Ikeda
  • M Carson
  • L M Guzman Verduzco
  • M Soma
  • B Fluoret
  • H Suzuki

Detail Information

Publications44

  1. pmc Mutants, suppressors, and wrinkled colonies: mutant alleles of the cell division gene ftsQ point to functional domains in FtsQ and a role for domain 1C of FtsA in divisome assembly
    Nathan W Goehring
    Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, MA 02115, USA
    J Bacteriol 189:633-45. 2007
    ..One of these proteins, FtsQ, is physically associated with multiple essential division proteins, including FtsK, FtsL, FtsB, FtsW, and FtsI. In this work we performed a genetic analysis of the ftsQ gene...
  2. pmc YgbQ, a cell division protein in Escherichia coli and Vibrio cholerae, localizes in codependent fashion with FtsL to the division site
    Nienke Buddelmeijer
    Department of Microbiology and Molecular Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 99:6316-21. 2002
    ..coli genome designed to find potential interacting partners for cell division protein FtsL. In V...
  3. pmc Cell division in Escherichia coli: role of FtsL domains in septal localization, function, and oligomerization
    J M Ghigo
    Unité des Membranes Bactériennes, Institut Pasteur CNRS URA 1300, 75724 Paris Cedex 15, France
    J Bacteriol 182:116-29. 2000
    In Escherichia coli, nine essential cell division proteins are known to localize to the division septum. FtsL is a 13-kDa bitopic membrane protein with a short cytoplasmic N-terminal domain, a membrane-spanning segment, and a periplasmic ..
  4. pmc Cytokinesis in bacteria
    Jeffery Errington
    Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, United Kingdom
    Microbiol Mol Biol Rev 67:52-65, table of contents. 2003
    ..The functions of most of these proteins are unclear with the exception of at least one penicillin-binding protein, which catalyzes a key step in cell wall synthesis in the division septum...
  5. ncbi Localization of FtsL to the Escherichia coli septal ring
    J M Ghigo
    Unité de Physiologie Cellulaire Institut Pasteur CNRS URA 1300, Paris, France
    Mol Microbiol 31:725-37. 1999
    In Escherichia coli, nine gene products are known to be essential for assembly of the division septum. One of these, FtsL, is a bitopic membrane protein whose precise function is not understood...
  6. pmc Localization of FtsI (PBP3) to the septal ring requires its membrane anchor, the Z ring, FtsA, FtsQ, and FtsL
    D S Weiss
    Department of Microbiology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Bacteriol 181:508-20. 1999
    ..Septal localization depended upon every other division protein tested (FtsZ, FtsA, FtsQ, and FtsL)...
  7. ncbi Use of a two-hybrid assay to study the assembly of a complex multicomponent protein machinery: bacterial septosome differentiation
    G Di Lallo
    Dipartimento di Biologia, Universita Tor Vergata, Via della Ricerca Scientifica, I 00133 Rome, Italy
    Microbiology 149:3353-9. 2003
    The ability of each of the nine Escherichia coli division proteins (FtsZ, FtsA, ZipA, FtsK, FtsQ, FtsL, FtsW, FtsI, FtsN) to interact with itself and with each of the remaining eight proteins was studied in 43 possible combinations of ..
  8. pmc Divisome under construction: distinct domains of the small membrane protein FtsB are necessary for interaction with multiple cell division proteins
    Mark D Gonzalez
    Department of Microbiology and Molecular Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
    J Bacteriol 191:2815-25. 2009
    ..Within the Escherichia coli divisome is a conserved subcomplex of inner membrane proteins, the FtsB/FtsL/FtsQ complex, which is necessary for linking the upstream division proteins, which are predominantly cytoplasmic, ..
  9. ncbi A complex of the Escherichia coli cell division proteins FtsL, FtsB and FtsQ forms independently of its localization to the septal region
    Nienke Buddelmeijer
    Department of Microbiology and Molecular Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
    Mol Microbiol 52:1315-27. 2004
    Three membrane proteins required for cell division in Escherichia coli, FtsQ, FtsL and FtsB, localize to the cell septum...
  10. pmc Domain-swapping analysis of FtsI, FtsL, and FtsQ, bitopic membrane proteins essential for cell division in Escherichia coli
    L M Guzman
    Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Bacteriol 179:5094-103. 1997
    FtsI, FtsL, and FtsQ are three membrane proteins required for assembly of the division septum in the bacterium Escherichia coli. Cells lacking any of these three proteins form long, aseptate filaments that eventually lyse...
  11. pmc Multiple interaction domains in FtsL, a protein component of the widely conserved bacterial FtsLBQ cell division complex
    Mark D Gonzalez
    Department of Microbiology and Molecular Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
    J Bacteriol 192:2757-68. 2010
    ..400 genomes indicates that the overwhelming majority of bacteria possess homologs of the Escherichia coli proteins FtsL, FtsB, and FtsQ, three proteins essential for cell division in that bacterium...
  12. doi Structural and mutational analysis of the cell division protein FtsQ
    Fusinita van den Ent
    MRC LMB, Hills Road, Cambridge CB2 2QH, UK
    Mol Microbiol 68:110-23. 2008
    ..that localize FtsQ need the second beta-strand of the POTRA domain and those that are recruited by FtsQ, like FtsL/FtsB, require the surface formed by the tip of the last alpha-helix and the two C-terminal beta-strands...
  13. pmc Contribution of the FtsQ transmembrane segment to localization to the cell division site
    Dirk Jan Scheffers
    Molecular Microbiology, Institute for Molecular Cell Biology, Vrije Universiteit Amsterdam, De Boelelaan 1085, 1081 HV, Amsterdam, The Netherlands
    J Bacteriol 189:7273-80. 2007
    ..insert into the membrane, whereas another mutant (L29/32R) was correctly assembled and interacted with FtsB and FtsL but failed to localize efficiently to the cell division site...
  14. ncbi Three functional subdomains of the Escherichia coli FtsQ protein are involved in its interaction with the other division proteins
    V D'Ulisse
    Dipartimento di Biologia Università Tor Vergata, Via della Ricerca Scientifica, Roma 00133, Italy
    Microbiology 153:124-38. 2007
    ..for the Escherichia coli divisome assembly, is able to interact with various division proteins, namely FtsI, FtsL, FtsN, FtsB and FtsW...
  15. pmc Interaction network among Escherichia coli membrane proteins involved in cell division as revealed by bacterial two-hybrid analysis
    Gouzel Karimova
    Unité de Biochimie des Interactions Macromoléculaires, Institut Pasteur, 75724 Paris, Cedex 15, France
    J Bacteriol 187:2233-43. 2005
    ..In addition, our study shows that the cAMP-based two-hybrid system is particularly appropriate for analyzing molecular interactions between membrane proteins...
  16. ncbi FtsQ, FtsL and FtsI require FtsK, but not FtsN, for co-localization with FtsZ during Escherichia coli cell division
    J C Chen
    Department of Microbiology and Molecular Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
    Mol Microbiol 42:395-413. 2001
    ..In Escherichia coli, at least nine essential gene products participate directly in septum formation: FtsA, FtsI, FtsL, FtsK, FtsN, FtsQ, FtsW, FtsZ and ZipA...
  17. ncbi Premature targeting of cell division proteins to midcell reveals hierarchies of protein interactions involved in divisome assembly
    Nathan W Goehring
    Department of Microbiology and Molecular Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
    Mol Microbiol 61:33-45. 2006
    ..Based on these observations we present a revised model for assembly of the E. coli division apparatus...
  18. pmc The β-lactam resistance protein Blr, a small membrane polypeptide, is a component of the Escherichia coli cell division machinery
    Gouzel Karimova
    Institut Pasteur, CNRS UMR 3528, Unité de Biochimie des Interactions Macromoléculaires, Departement de Biologie Structurale et Chimie, Paris, France
    J Bacteriol 194:5576-88. 2012
    ..Blr, a short membrane polypeptide of 41 residues, as an interacting partner of the essential cell division protein FtsL. In addition to FtsL, Blr was found to associate with several other divisomal proteins, including FtsI, FtsK, FtsN, ..
  19. pmc A role for the FtsQLB complex in cytokinetic ring activation revealed by an ftsL allele that accelerates division
    Mary Jane Tsang
    Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA, 02115, USA
    Mol Microbiol 95:925-44. 2015
    ..In this report, we study a 'forgotten' allele of ftsL from Escherichia coli, which encodes a conserved division gene of unknown function...
  20. doi Cell cycle progression in Escherichia coli B/r affects transcription of certain genes: Implications for synthetic genome design
    Patricia L Echtenkamp
    School of Chemical and Biomolecular Engineering, Cornell University, Ithaca, New York 14853 5201, USA
    Biotechnol Bioeng 102:902-9. 2009
    ..In conclusion, gene position, with regard to the C period, and gene function are important factors to incorporate into design criteria for synthetic bacterial genomes...
  21. doi The Escherichia coli FtsK functional domains involved in its interaction with its divisome protein partners
    Lucia Grenga
    Laboratorio di Microbiologia Generale, Dipartimento di Biologia, Universita Tor Vergata, Rome, Italy
    FEMS Microbiol Lett 287:163-7. 2008
    ..The ability of FtsK to interact with several cell division proteins, namely FtsZ, FtsQ, FtsL and FtsI, by the two-hybrid assay was already shown by our group...
  22. doi Division protein interaction web: identification of a phylogenetically conserved common interactome between Streptococcus pneumoniae and Escherichia coli
    Silvia Maggi
    Dipartimento di Biologia, Universita Tor Vergata, Roma, Italy
    Microbiology 154:3042-52. 2008
    ..At least nine division proteins, ZapA, FtsZ, FtsA, FtsK, FtsQ/DivIB, FtsB/DivIC, FtsL, FtsI and FtsW, are believed to have a conserved function between these bacteria and thus we may say that a ..
  23. pmc Characterization of YmgF, a 72-residue inner membrane protein that associates with the Escherichia coli cell division machinery
    Gouzel Karimova
    Institut Pasteur, CNRS URA 2185, Unité de Biochimie des Interactions Macromoléculaires, Departement de Biologie Structurale et Chimie, 25 rue du Dr Roux, Paris Cedex 15, France
    J Bacteriol 191:333-46. 2009
    ..coli cell division protein FtsL. Here we report the characterization of YmgF, a 72-residue integral membrane protein of unknown function that was ..
  24. pmc Inefficient Tat-dependent export of periplasmic amidases in an Escherichia coli strain with mutations in two DedA family genes
    Rakesh Sikdar
    Department of Biological Sciences, Louisiana State University, 202 Life Science, Baton Rouge, LA 70803, USA
    J Bacteriol 192:807-18. 2010
    ..Green fluorescent protein fusions to the cell division proteins FtsZ, ZipA, FtsI, FtsL, and FtsQ are correctly localized to new septation sites in BC202...
  25. pmc A model for the Escherichia coli FtsB/FtsL/FtsQ cell division complex
    Felipe Villanelo
    Laboratorio de Biología Estructural y Molecular, Departamento de Biologia, Facultad de Ciencias, Universidad de Chile, Chile
    BMC Struct Biol 11:28. 2011
    ..The proteins involved in connecting both steps in cell division are FtsQ, FtsB and FtsL, and their interaction is a crucial and conserved event in the division of different bacteria...
  26. doi Identification of a novel function for the FtsL cell division protein from Escherichia coli K12
    Dayle K Blencowe
    Sense Proteomic Ltd, The Southern Centre, Unit 15, The Oxford Industrial Park, Mead Road, Yarnton, Oxford OX1 1QU, United Kingdom
    Biochem Biophys Res Commun 411:44-9. 2011
    Analysis of the essential cell division protein FtsL demonstrates the partial conservation of a cysteine-pair within the trans-membrane region which itself is flanked by histidine-pairs in the cytosol and periplasm...
  27. pmc Role of leucine zipper motifs in association of the Escherichia coli cell division proteins FtsL and FtsB
    Carine Robichon
    Institut Pasteur, CNRS URA 2185, Unité de Biochimie des Interactions Macromoléculaires, Departement de Biologie Structurale et Chimie, 28 rue du Dr Roux, 75724 Paris Cedex 15, France
    J Bacteriol 193:4988-92. 2011
    b>FtsL and FtsB are two inner-membrane proteins that are essential constituents of the cell division apparatus of Escherichia coli...
  28. ncbi Bacterial cell division and the septal ring
    David S Weiss
    Department of Microbiology, University of Iowa, Iowa City, IA 52242, USA
    Mol Microbiol 54:588-97. 2004
    ..Finally, two murein hydrolases, AmiC and EnvC, have been shown to localize to the septal ring of Escherichia coli, where they play an important role in separation of daughter cells...
  29. ncbi The order of the ring: assembly of Escherichia coli cell division components
    Miguel Vicente
    Centro Nacional de Biotecnologia, Consejo Superior de Investigaciones Cientificas, Campus de Cantoblanco, C Darwin 3, 28049 Madrid, Spain
    Mol Microbiol 61:5-8. 2006
    ..In addition, back-recruitment of all late proteins except FtsN into the division ring occurs even in the absence of proteins incorporated at earlier stages, i.e. FtsA or FtsQ...
  30. ncbi Maturation of the Escherichia coli divisome occurs in two steps
    Mirjam E G Aarsman
    Molecular Cytology, Swammerdam Institute for Life Sciences, University of Amsterdam, Kruislaan 316, 1098 SM Amsterdam, The Netherlands
    Mol Microbiol 55:1631-45. 2005
    Cell division proteins FtsZ (FtsA, ZipA, ZapA), FtsE/X, FtsK, FtsQ, FtsL/B, FtsW, PBP3, FtsN and AmiC localize at mid cell in Escherichia coli in an interdependent order as listed...
  31. pmc Premature targeting of a cell division protein to midcell allows dissection of divisome assembly in Escherichia coli
    Nathan W Goehring
    Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genes Dev 19:127-37. 2005
    ....
  32. pmc FtsL, an essential cytoplasmic membrane protein involved in cell division in Escherichia coli
    L M Guzman
    Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts 02115
    J Bacteriol 174:7716-28. 1992
    ..This gene, which we named ftsL, was detected through characterization of TnphoA insertions in a plasmid containing this chromosomal region...
  33. pmc ZipA is required for recruitment of FtsK, FtsQ, FtsL, and FtsN to the septal ring in Escherichia coli
    Cynthia A Hale
    Department of Molecular Biology and Microbiology, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106 4960, USA
    J Bacteriol 184:2552-6. 2002
    ..directly bind FtsZ polymers at the prospective division site, followed by the sequential addition of FtsK, FtsQ, FtsL, FtsW, FtsI, and FtsN. Recruitment of FtsK and all downstream components requires the prior localization of FtsA...
  34. ncbi Co-ordinate regulation of the Escherichia coli cell cycle or The cloud of unknowing
    W D Donachie
    Department of Molecular Biology, University of Edinburgh, Kings Buildings, Mayfield Road, Edinburgh, UK
    Mol Microbiol 40:779-85. 2001
    ..A discussion of some aspects of the regulation of chromosome replication, segregation and cell division in Escherichia coli...
  35. ncbi mraW, an essential gene at the dcw cluster of Escherichia coli codes for a cytoplasmic protein with methyltransferase activity
    M Carrion
    Centro de Biología Molecular Severo Ochoa C S I C U A M, Campus de la Universidad Autónoma de Madrid Cantoblanco, 28049 Madrid, Spain
    Biochimie 81:879-88. 1999
    Three new open reading frames, mraZ, mraW and mraR (also called ftsL), were revealed by DNA sequencing immediately upstream of gene pbpB in the dcw cluster of Escherichia coli...
  36. pmc Contribution of the Pmra promoter to expression of genes in the Escherichia coli mra cluster of cell envelope biosynthesis and cell division genes
    D Mengin-Lecreulx
    Laboratoire des Enveloppes Bactériennes, Centre National de la Recherche Scientifique, Universite Paris Sud, 91405 Orsay Cedex, France
    J Bacteriol 180:4406-12. 1998
    ..promoter is required for expression of the first nine genes of the mra cluster: mraZ (orfC), mraW (orfB), ftsL (mraR), ftsI, murE, murF, mraY, murD, and ftsW...
  37. ncbi Regulation of transcription of cell division genes in the Escherichia coli dcw cluster
    M Vicente
    Departamento de Biologia Celular y del Desarrollo, Consejo Superior de Investigaciones Cientificas, Madrid, Spain
    Cell Mol Life Sci 54:317-24. 1998
    ....
  38. pmc A promoter for the first nine genes of the Escherichia coli mra cluster of cell division and cell envelope biosynthesis genes, including ftsI and ftsW
    H Hara
    National Institute of Genetics, Shizuoka ken, Japan
    J Bacteriol 179:5802-11. 1997
    ..Although several potential promoter sequences in this region of the mra cluster have been reported, we conclude that the promoter identified in this study is required for the first nine genes of the cluster to be fully expressed...
  39. ncbi On the process of cellular division in Escherichia coli: nucleotide sequence of the gene for penicillin-binding protein 3
    M Nakamura
    Mol Gen Genet 191:1-9. 1983
    ..PBP-3 synthesized in vitro showed a lower mobility in SDS-gel electrophoresis than that of the authentic PBP-3, suggesting that the primary translation product of the ftsI gene may be processed to yield mature PBP-3...
  40. pmc New mutations fts-36, lts-33, and ftsW clustered in the mra region of the Escherichia coli chromosome induce thermosensitive cell growth and division
    F Ishino
    Institute of Applied Microbiology, University of Tokyo, Japan
    J Bacteriol 171:5523-30. 1989
    ..By isolation of these three mutants, about 90% of the 17-kilobase region from fts-36-lts-33 to envA could be filled with genes for cell division and growth, and the genes could be aligned...
  41. pmc Inhibition of growth of ftsQ, ftsA, and ftsZ mutant cells of Escherichia coli by amplification of a chromosomal region encompassing closely aligned cell division and cell growth genes
    H K Jung
    Institute of Applied Microbiology, University of Tokyo, Japan
    J Bacteriol 171:6379-82. 1989
    ..coli strains with mutations of the flanking cell division genes ftsQ, ftsA, and ftsZ. A shortened fragment in which the major portion of ftsI was deleted also had lethal effects on ftsQ and ftsZ mutants...
  42. pmc Nucleotide sequence of the regulatory region of the gene pbpB of Escherichia coli
    M J Gomez
    Centro de Biologia Molecular, U A M, Canto Blanco, Madrid, Spain
    Nucleic Acids Res 18:2813. 1990
  43. ncbi Alkaline phosphatase fusions in the study of cell division genes
    J J Barondess
    Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, MA 02115
    Res Microbiol 142:295-9. 1991
    ..coli host. 2) The ftsQ and ftsl gene products are integral proteins of the cytoplasmic membrane with small cytoplasmic domains and large ..
  44. pmc Escherichia coli mraR gene involved in cell growth and division
    M Ueki
    Institute of Applied Microbiology, University of Tokyo, Japan
    J Bacteriol 174:7841-3. 1992
    The mraR gene, which has a coding frame of 363 bp and lies close to and upstream of the ftsI gene of Escherichia coli, is involved in both cell division and cell lysis...

Research Grants1

  1. ASSEMBLY OF THE DIVISION SEPTUM IN ESCHERICHIA COLI
    David Weiss; Fiscal Year: 2003
    ..In this regard, it is worth noting that four of the proteins to be studied here (FtsI and the three transglycosylases) are primary targets of beta-lactam antibiotics. ..