degQ

Summary

Gene Symbol: degQ
Description: serine endoprotease, periplasmic
Alias: ECK3223, JW3203, hhoA
Species: Escherichia coli str. K-12 substr. MG1655

Top Publications

  1. pmc Molecular adaptation of the DegQ protease to exert protein quality control in the bacterial cell envelope
    Justyna Sawa
    Institute of Molecular Pathology, A 1030 Vienna, Austria
    J Biol Chem 286:30680-90. 2011
  2. doi Characterization of the structure and function of Escherichia coli DegQ as a representative of the DegQ-like proteases of bacterial HtrA family proteins
    Xiao Chen Bai
    State Key Laboratory of Biomembrane and Membrane Biotechnology, Tsinghua University, Beijing 100084, China
    Structure 19:1328-37. 2011
  3. pmc Newly folded substrates inside the molecular cage of the HtrA chaperone DegQ
    Helene Malet
    Institute of Structural and Molecular Biology, Crystallography, Birkbeck College, London, UK
    Nat Struct Mol Biol 19:152-7. 2012
  4. pmc Characterization of degQ and degS, Escherichia coli genes encoding homologs of the DegP protease
    P R Waller
    Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
    J Bacteriol 178:1146-53. 1996
  5. pmc Multicopy suppressors of prc mutant Escherichia coli include two HtrA (DegP) protease homologs (HhoAB), DksA, and a truncated R1pA
    S Bass
    Department of Molecular Biology, Genentech Inc, South San Francisco, California 94080 4990, USA
    J Bacteriol 178:1154-61. 1996
  6. pmc The DegP and DegQ periplasmic endoproteases of Escherichia coli: specificity for cleavage sites and substrate conformation
    H Kolmar
    Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
    J Bacteriol 178:5925-9. 1996
  7. pmc Roles of DegP in prevention of protein misfolding in the periplasm upon overexpression of penicillin acylase in Escherichia coli
    Kao Lu Pan
    Department of Chemical Engineering, Feng Chia University, Taichung, Taiwan 407, Republic of China
    J Bacteriol 185:3020-30. 2003
  8. pmc pH-dependent catabolic protein expression during anaerobic growth of Escherichia coli K-12
    Elizabeth Yohannes
    Department of Biology, Kenyon College, Gambier, Ohio 43022, USA
    J Bacteriol 186:192-9. 2004
  9. ncbi [Characterization of the HtrA family of proteins]
    Dorota Zurawa-Janicka
    Katedra Biochemii, Instytut Biologii, Uniwersytet Gdanski, Gdansk
    Postepy Biochem 53:27-36. 2007

Scientific Experts

  • H Kolmar
  • Dorota Zurawa-Janicka
  • Helene Malet
  • Justyna Sawa
  • Tim Clausen
  • Flavia Canellas
  • Michael Ehrmann
  • Xiao Chen Bai
  • Elizabeth Yohannes
  • Kao Lu Pan
  • Konstantinos Thalassinos
  • Jun Yan
  • Helen R Saibil
  • Sen Fang Sui
  • Xi Jiang Pan
  • Xiao Jing Wang
  • Jianlin Lei
  • Dong Leng
  • Lei Fu Chang
  • Yun Ying Ye
  • Tobias Krojer
  • D Michael Barnhart
  • Joan L Slonczewski
  • C Perry Chou
  • Hsu Chou Hsiao
  • Chiao Ling Weng
  • Ming Sheng Wu
  • P R Waller
  • S Bass
  • Q Gu
  • R T Sauer
  • A Christen

Detail Information

Publications9

  1. pmc Molecular adaptation of the DegQ protease to exert protein quality control in the bacterial cell envelope
    Justyna Sawa
    Institute of Molecular Pathology, A 1030 Vienna, Austria
    J Biol Chem 286:30680-90. 2011
    ..of proteins in the cell envelope of Escherichia coli is monitored by the HtrA proteases DegS, DegP, and DegQ. In contrast with DegP and DegS, the structure and function of DegQ has not been addressed in detail...
  2. doi Characterization of the structure and function of Escherichia coli DegQ as a representative of the DegQ-like proteases of bacterial HtrA family proteins
    Xiao Chen Bai
    State Key Laboratory of Biomembrane and Membrane Biotechnology, Tsinghua University, Beijing 100084, China
    Structure 19:1328-37. 2011
    HtrA family proteins play a central role in protein quality control in the bacterial periplasmic space. DegQ-like proteases, a group of bacterial HtrA proteins, are characterized by a short LA loop as compared with DegP-like proteases, ..
  3. pmc Newly folded substrates inside the molecular cage of the HtrA chaperone DegQ
    Helene Malet
    Institute of Structural and Molecular Biology, Crystallography, Birkbeck College, London, UK
    Nat Struct Mol Biol 19:152-7. 2012
    ..Here we describe cryo-EM structures of Escherichia coli DegQ in its 12- and 24-mer states in complex with model substrates, providing a structural model of HtrA chaperone ..
  4. pmc Characterization of degQ and degS, Escherichia coli genes encoding homologs of the DegP protease
    P R Waller
    Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
    J Bacteriol 178:1146-53. 1996
    The degQ and degS genes of Escherichia coli encode proteins of 455 and 355 residues, respectively, which are homologs of the DegP protease...
  5. pmc Multicopy suppressors of prc mutant Escherichia coli include two HtrA (DegP) protease homologs (HhoAB), DksA, and a truncated R1pA
    S Bass
    Department of Molecular Biology, Genentech Inc, South San Francisco, California 94080 4990, USA
    J Bacteriol 178:1154-61. 1996
    ..5 centisomes on the chromosome. We propose the names hhoA and hhoB, for htrA homolog, to denote that these genes encode proteins that are 58 and 35% identical, respectively, ..
  6. pmc The DegP and DegQ periplasmic endoproteases of Escherichia coli: specificity for cleavage sites and substrate conformation
    H Kolmar
    Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
    J Bacteriol 178:5925-9. 1996
    DegP and DegQ are homologous endoproteases found in the periplasmic compartment of Escherichia coli...
  7. pmc Roles of DegP in prevention of protein misfolding in the periplasm upon overexpression of penicillin acylase in Escherichia coli
    Kao Lu Pan
    Department of Chemical Engineering, Feng Chia University, Taichung, Taiwan 407, Republic of China
    J Bacteriol 185:3020-30. 2003
    ..in culture performance upon pac overexpression because coexpression of a DegP-homologous periplasmic protease, DegQ or DegS, could not suppress the physiological toxicity...
  8. pmc pH-dependent catabolic protein expression during anaerobic growth of Escherichia coli K-12
    Elizabeth Yohannes
    Department of Biology, Kenyon College, Gambier, Ohio 43022, USA
    J Bacteriol 186:192-9. 2004
    ..these proteins included metabolic enzymes (DhaKLM, GapA, TnaA, HisC, and HisD), periplasmic proteins (ProX, OppA, DegQ, MalB, and MglB), and stress proteins (DsbA, Tig, and UspA)...
  9. ncbi [Characterization of the HtrA family of proteins]
    Dorota Zurawa-Janicka
    Katedra Biochemii, Instytut Biologii, Uniwersytet Gdanski, Gdansk
    Postepy Biochem 53:27-36. 2007
    ..This article summarizes recent studies regarding the HtrA family of proteins, their structure, regulation and function. It also presents practical applications of this knowledge and perspective of its use in the future...