HBA

Summary

Gene Symbol: HBA
Description: hemoglobin, alpha 1
Alias: HBA1, hemoglobin subunit alpha, alpha-globin, globin, alpha 1, hemoglobin alpha chain
Species: equine

Top Publications

  1. ncbi The structure of horse methaemoglobin at 2-0 A resolution
    R C Ladner
    J Mol Biol 114:385-414. 1977
  2. ncbi A correction to the sequence of the alpha chains of horse haemoglobin
    R Ladner
    J Mol Biol 103:675-7. 1976
  3. ncbi Gene conversions in the horse alpha-globin gene complex
    J B Clegg
    MRC Molecular Haematology Unit, Nuffield Department of Clinical Medicine, University of Oxford, United Kingdom
    Mol Biol Evol 4:492-503. 1987
  4. ncbi Structure and evolution of the horse zeta globin locus
    J Flint
    MRC Molecular Haematology Unit, Nuffield Department of Clinical Medicine, University of Oxford, John Radcliffe Hospital, Headington, U K
    J Mol Biol 199:427-37. 1988
  5. ncbi Three-dimensional Fourier synthesis of horse oxyhaemoglobin at 2.8 A resolution: (1) x-ray analysis
    M F Perutz
    Nature 219:29-32. 1968
  6. ncbi Three-dimensional Fourier synthesis of horse oxyhaemoglobin at 2.8 A resolution: the atomic model
    M F Perutz
    Nature 219:131-9. 1968
  7. pmc Genetic organization of the polymorphic equine alpha globin locus and sequence of the BII alpha 1 gene
    J B Clegg
    Nucleic Acids Res 12:7847-58. 1984
  8. ncbi [Hemoglobins, XXXIII. Note on the Sequence of the hemoglobins of the horse (author's transl)]
    G Matsuda
    Hoppe Seylers Z Physiol Chem 361:1107-16. 1980
  9. ncbi Phylogenetic relationships within the genus Equus and the evolution of alpha and theta globin genes
    E A Oakenfull
    Institute of Molecular Medicine, University of Oxford, Oxford, UK
    J Mol Evol 47:772-83. 1998
  10. pmc Preliminary neutron and X-ray crystallographic studies of equine cyanomethemoglobin
    A Y Kovalevsky
    Bioscience Division, MS M888, Los Alamos National Laboratory, Los Alamos, NM 87545, USA
    Acta Crystallogr Sect F Struct Biol Cryst Commun 66:474-7. 2010

Scientific Experts

  • E A Oakenfull
  • A Y Kovalevsky
  • Sean Seaver
  • S Zoe Fisher
  • B Leif Hanson
  • Paul Langan
  • Timothy C Mueser
  • Marat Mustyakimov
  • Narayanasami Sukumar
  • J B Clegg
  • M F Perutz
  • J M Cox
  • R C Ladner
  • J Flint
  • R Ladner
  • L C Goaman
  • G Matsuda
  • T Maita
  • G M Air
  • L E Webb
  • F S Mathews
  • E J Heidner
  • B Schrank
  • J H Fogg
  • E L McGandy
  • S E Goodbourn
  • G Braunitzer
  • A M Taylor
  • H Miurhead
  • H Muirhead
  • M Braend

Detail Information

Publications10

  1. ncbi The structure of horse methaemoglobin at 2-0 A resolution
    R C Ladner
    J Mol Biol 114:385-414. 1977
  2. ncbi A correction to the sequence of the alpha chains of horse haemoglobin
    R Ladner
    J Mol Biol 103:675-7. 1976
  3. ncbi Gene conversions in the horse alpha-globin gene complex
    J B Clegg
    MRC Molecular Haematology Unit, Nuffield Department of Clinical Medicine, University of Oxford, United Kingdom
    Mol Biol Evol 4:492-503. 1987
    ..5 Myr and that the alpha 1 genes may have undergone a recent interchromosomal gene conversion...
  4. ncbi Structure and evolution of the horse zeta globin locus
    J Flint
    MRC Molecular Haematology Unit, Nuffield Department of Clinical Medicine, University of Oxford, John Radcliffe Hospital, Headington, U K
    J Mol Biol 199:427-37. 1988
    ..Comparisons of sequences flanking the zeta and psi zeta genes reveal areas of considerable interspecies homology, which can be explained by a zeta gene duplication that pre-dated the mammalian radiation...
  5. ncbi Three-dimensional Fourier synthesis of horse oxyhaemoglobin at 2.8 A resolution: (1) x-ray analysis
    M F Perutz
    Nature 219:29-32. 1968
  6. ncbi Three-dimensional Fourier synthesis of horse oxyhaemoglobin at 2.8 A resolution: the atomic model
    M F Perutz
    Nature 219:131-9. 1968
  7. pmc Genetic organization of the polymorphic equine alpha globin locus and sequence of the BII alpha 1 gene
    J B Clegg
    Nucleic Acids Res 12:7847-58. 1984
    The equine alpha globin gene complex comprises two functional alpha genes and an alpha-like pseudogene arranged in the order 5'-alpha 2-(5kb)-alpha 1-(3kb)-psi alpha-3'...
  8. ncbi [Hemoglobins, XXXIII. Note on the Sequence of the hemoglobins of the horse (author's transl)]
    G Matsuda
    Hoppe Seylers Z Physiol Chem 361:1107-16. 1980
    ..According to these data and biological contributions of other authors, the biological aspects of the primary structure and the polymorphism of the hemoglobins of the horse are discussed...
  9. ncbi Phylogenetic relationships within the genus Equus and the evolution of alpha and theta globin genes
    E A Oakenfull
    Institute of Molecular Medicine, University of Oxford, Oxford, UK
    J Mol Evol 47:772-83. 1998
    ..9 million years ago. These results from the alpha genes are corroborated by theta gene data and are in contrast to mitochondrial DNA studies of the phylogeny of this genus, which suggest a more gradual set of speciation events...
  10. pmc Preliminary neutron and X-ray crystallographic studies of equine cyanomethemoglobin
    A Y Kovalevsky
    Bioscience Division, MS M888, Los Alamos National Laboratory, Los Alamos, NM 87545, USA
    Acta Crystallogr Sect F Struct Biol Cryst Commun 66:474-7. 2010
    ..Interestingly, a water molecule that is in the vicinity of the heme group and coordinated to the distal histidine appears to be expelled from this site in the low-temperature structure...