RAC1

Summary

Gene Symbol: RAC1
Description: ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
Alias: RAC2, ras-related C3 botulinum toxin substrate 1, Rac 1b, p21-Rac1, rac2 GTP-binding protein
Species: dog

Top Publications

  1. pmc Immediate-early signaling induced by E-cadherin engagement and adhesion
    Tomas D Perez
    Department of Molecular and Cellular Physiology, Stanford University, Stanford, California 94305 5430, USA
    J Biol Chem 283:5014-22. 2008
  2. pmc Localized zones of Rho and Rac activities drive initiation and expansion of epithelial cell-cell adhesion
    Soichiro Yamada
    Department of Molecular and Cellular Physiology, Stanford University, Stanford, CA 94305, USA
    J Cell Biol 178:517-27. 2007
  3. pmc ARF6-dependent activation of ERK and Rac1 modulates epithelial tubule development
    Jogender Singh Tushir
    Department of Biological Sciences, University of Notre Dame, Notre Dame, IN 46656, USA
    EMBO J 26:1806-19. 2007
  4. ncbi Rho family GTPases bind to phosphoinositide kinases
    K F Tolias
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, USA
    J Biol Chem 270:17656-9. 1995
  5. ncbi Early herpes simplex virus type 1 infection is dependent on regulated Rac1/Cdc42 signalling in epithelial MDCKII cells
    Sven Hoppe
    Max Planck Institute for Neurological Research, University of Cologne, Cologne, Germany
    J Gen Virol 87:3483-94. 2006
  6. ncbi Identification of IQGAP as a putative target for the small GTPases, Cdc42 and Rac1
    S Kuroda
    Division of Signal Transduction, Nara Institute of Science and Technology, 8916 5 Takayama, Ikoma 630 01, Japan
    J Biol Chem 271:23363-7. 1996
  7. ncbi Identification of a putative effector for Cdc42Hs with high sequence similarity to the RasGAP-related protein IQGAP1 and a Cdc42Hs binding partner with similarity to IQGAP2
    S J McCallum
    Department of Biochemistry, Veterinary Medical Center, Cornell University, Ithaca, New York 14853, USA
    J Biol Chem 271:21732-7. 1996
  8. pmc IQGAP1, a calmodulin-binding protein with a rasGAP-related domain, is a potential effector for cdc42Hs
    M J Hart
    Onyx Pharmaceuticals, Richmond, CA 94806, USA
    EMBO J 15:2997-3005. 1996
  9. ncbi A brain serine/threonine protein kinase activated by Cdc42 and Rac1
    E Manser
    Institute of Molecular and Cell Biology, National University of Singapore, Kent Ridge
    Nature 367:40-6. 1994
  10. ncbi Interaction of Rac with p67phox and regulation of phagocytic NADPH oxidase activity
    D Diekmann
    Medical Research Council Laboratory for Molecular Cell Biology, University College London, UK
    Science 265:531-3. 1994

Detail Information

Publications22

  1. pmc Immediate-early signaling induced by E-cadherin engagement and adhesion
    Tomas D Perez
    Department of Molecular and Cellular Physiology, Stanford University, Stanford, California 94305 5430, USA
    J Biol Chem 283:5014-22. 2008
    ..Phosphoinositides and Rac1 co-accumulated with E-cadherin, reached peak levels with E-cadherin, but then rapidly dispersed...
  2. pmc Localized zones of Rho and Rac activities drive initiation and expansion of epithelial cell-cell adhesion
    Soichiro Yamada
    Department of Molecular and Cellular Physiology, Stanford University, Stanford, CA 94305, USA
    J Cell Biol 178:517-27. 2007
    ..Using high-resolution live-cell imaging, biosensors, and small molecule inhibitors, we investigate how Rac1 and RhoA regulate actin dynamics during de novo contact formation between pairs of epithelial cells...
  3. pmc ARF6-dependent activation of ERK and Rac1 modulates epithelial tubule development
    Jogender Singh Tushir
    Department of Biological Sciences, University of Notre Dame, Notre Dame, IN 46656, USA
    EMBO J 26:1806-19. 2007
    ..First, ARF6 regulates the subcellular distribution of the GTPase, Rac1, to tubule extensions...
  4. ncbi Rho family GTPases bind to phosphoinositide kinases
    K F Tolias
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, USA
    J Biol Chem 270:17656-9. 1995
    ..We found that both GTP- and GDP-bound Rac1 associate with phosphatidylinositol-4-phosphate 5-kinase in vitro and in vivo...
  5. ncbi Early herpes simplex virus type 1 infection is dependent on regulated Rac1/Cdc42 signalling in epithelial MDCKII cells
    Sven Hoppe
    Max Planck Institute for Neurological Research, University of Cologne, Cologne, Germany
    J Gen Virol 87:3483-94. 2006
    ..Thus, the impact of the small Rho-like GTPases Rac1, Cdc42 and RhoA acting as key regulators of actin dynamics was addressed...
  6. ncbi Identification of IQGAP as a putative target for the small GTPases, Cdc42 and Rac1
    S Kuroda
    Division of Signal Transduction, Nara Institute of Science and Technology, 8916 5 Takayama, Ikoma 630 01, Japan
    J Biol Chem 271:23363-7. 1996
    Cdc42 and Rac1 have been implicated in the regulation of various cell functions such as cell morphology, polarity, and cell proliferation...
  7. ncbi Identification of a putative effector for Cdc42Hs with high sequence similarity to the RasGAP-related protein IQGAP1 and a Cdc42Hs binding partner with similarity to IQGAP2
    S J McCallum
    Department of Biochemistry, Veterinary Medical Center, Cornell University, Ithaca, New York 14853, USA
    J Biol Chem 271:21732-7. 1996
    ..Both p180 and p175 were capable of binding to Rac1 but not to RhoA or Ha-Ras...
  8. pmc IQGAP1, a calmodulin-binding protein with a rasGAP-related domain, is a potential effector for cdc42Hs
    M J Hart
    Onyx Pharmaceuticals, Richmond, CA 94806, USA
    EMBO J 15:2997-3005. 1996
    ..These results suggest that IQGAP1 is an effector target for cdc42Hs and may mediate the effects of this GTPase on cell morphology...
  9. ncbi A brain serine/threonine protein kinase activated by Cdc42 and Rac1
    E Manser
    Institute of Molecular and Cell Biology, National University of Singapore, Kent Ridge
    Nature 367:40-6. 1994
    A new brain serine/threonine protein kinase may be a target for the p21ras-related proteins Cdc42 and Rac1. The kinase sequence is related to that of the yeast protein STE20, implicated in pheromone-response pathways...
  10. ncbi Interaction of Rac with p67phox and regulation of phagocytic NADPH oxidase activity
    D Diekmann
    Medical Research Council Laboratory for Molecular Cell Biology, University College London, UK
    Science 265:531-3. 1994
    ..b>Rac1 interacted directly with p67phox in a GTP-dependent manner...
  11. ncbi Activation of phosphoinositide 3-kinase activity by Cdc42Hs binding to p85
    Y Zheng
    Department of Pharmacology, Cornell University, Ithaca, New York 14853
    J Biol Chem 269:18727-30. 1994
    ..Similar interactions were observed between p85 and GST-Rac1-GTP gamma S but not between p85 and GST-RhoA-GTP gamma S...
  12. pmc A novel serine kinase activated by rac1/CDC42Hs-dependent autophosphorylation is related to PAK65 and STE20
    G A Martin
    Onyx Pharmaceuticals, Richmond, CA 94806, USA
    EMBO J 14:1970-8. 1995
    ..proteins in neutrophil cytosol of molecular size 65, 62 and 68 kDa which interact in a GTP-dependent manner with rac1 and CDC42Hs, but not with rho...
  13. ncbi A 68-kDa kinase and NADPH oxidase component p67phox are targets for Cdc42Hs and Rac1 in neutrophils
    E Prigmore
    Department of Neurochemistry, Institute of Neurology, London, United Kingdom
    J Biol Chem 270:10717-22. 1995
    Cdc42Hs and Rac1 are members of the Ras superfamily of small molecular weight (p21) GTP binding proteins. Cdc42Hs induces filopodia formation in Swiss 3T3 fibroblasts while Rac1 induces membrane ruffling...
  14. pmc Establishing epithelial glandular polarity: interlinked roles for ARF6, Rac1, and the matrix microenvironment
    Christine L Monteleon
    Department of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556, USA
    Mol Biol Cell 23:4495-505. 2012
    ..This inversion of glandular orientation is accompanied by Rac1 inactivation during early cystogenesis, and temporal activation of Rac1 is sufficient to recover the normal cyst ..
  15. ncbi Activation of Rac by cadherin through the c-Src-Rap1-phosphatidylinositol 3-kinase-Vav2 pathway
    T Fukuyama
    Department of Molecular Biology and Biochemistry, Osaka University Graduate School of Medicine Faculty of Medicine, Suita, Osaka, Japan
    Oncogene 25:8-19. 2006
    ..This effect of Rap1 on Vav2 was mediated by phosphatidylinositol 3-kinase. We describe here the signaling pathway from trans-interacting cadherin to the activation of Rac...
  16. ncbi Rac-WAVE-mediated actin reorganization is required for organization and maintenance of cell-cell adhesion
    Daisuke Yamazaki
    Department of Biochemistry, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    J Cell Sci 120:86-100. 2007
    ..Thus, Rac-WAVE-dependent actin reorganization is not only involved in formation of cell-cell adhesions but is also required for their maintenance...
  17. ncbi Rac1 is required for reorientation of polarity and lumen formation through a PI 3-kinase-dependent pathway
    Kathleen D Liu
    Division of Nephrology, University of California, San Francisco, Box 2140, San Francisco, CA 94143 2140, USA
    Am J Physiol Renal Physiol 293:F1633-40. 2007
    ..Specifically, expression of a dominant-negative form of Rac1 (DN-Rac1) blocks the reorientation of polarity...
  18. pmc Molecular cloning of YPT1/SEC4-related cDNAs from an epithelial cell line
    P Chavrier
    European Molecular Biology Laboratory, Heidelberg, Federal Republic of Germany
    Mol Cell Biol 10:6578-85. 1990
    ..This diversity supports their proposed function in controlling different steps in membrane traffic...
  19. pmc Paracingulin regulates the activity of Rac1 and RhoA GTPases by recruiting Tiam1 and GEF-H1 to epithelial junctions
    Laurent Guillemot
    Department of Molecular Biology, University of Geneva, CH 1211 Geneva, Switzerland
    Mol Biol Cell 19:4442-53. 2008
    ..we characterize the junctional protein paracingulin as a novel regulator of the activity of two small GTPases, Rac1 and RhoA, through the functional interaction with their respective activators, Tiam1 and GEF-H1...
  20. pmc Role of Src signal transduction pathways in scatter factor-mediated cellular protection
    Saijun Fan
    Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC 20057, USA
    J Biol Chem 284:7561-77. 2009
    ..to stimulate Akt and IkappaB kinase activity; and Src-mediated stimulation of NF-kappaB was due, in part, to a Rac1/MKK3/6/p38 pathway and was Akt-dependent. SF caused the activation of Src and the Rac1 effector Pak1...
  21. doi Numb is a negative regulator of HGF dependent cell scattering and Rac1 activation
    Kimberly M Lau
    Department of Medical Biophysics, University of Toronto, Canada
    Exp Cell Res 317:539-51. 2011
    ..Examination of Rac1-GTP levels in Numb knockdown cells revealed hyperactivation of Rac1 following extracellular calcium depletion and ..
  22. pmc Rapid suppression of activated Rac1 by cadherins and nectins during de novo cell-cell adhesion
    Khameeka N Kitt
    Department of Biology, The James H Clark Center, The Bio X Program, Stanford University, Stanford, California, United States of America
    PLoS ONE 6:e17841. 2011
    ..and nectins, and the reorganization of the actin cytoskeleton and membrane dynamics by Rho GTPases, particularly Rac1. However, it remains unclear whether E-cadherin and nectins up-regulate, maintain or suppress Rac1 activity during ..