TGFBR1

Summary

Gene Symbol: TGFBR1
Description: transforming growth factor beta receptor 1
Alias: TGF-beta receptor type-1, TGF-beta receptor type I, TGF-beta type I receptor, TGFR-1, tbetaR-I, transforming growth factor, beta receptor I (activin A receptor type II-like kinase, 53kDa), transforming growth factor-beta receptor type I
Species: cow

Top Publications

  1. pmc ALK5 and ALK1 play antagonistic roles in transforming growth factor β-induced podosome formation in aortic endothelial cells
    Filipa Curado
    IECB and INSERM U1045, University of Bordeaux, Bordeaux, France
    Mol Cell Biol 34:4389-403. 2014
  2. doi Localization of TGF-β and TGF-β receptor in bovine term placentome and expression differences between spontaneous and induced parturition
    Hiroki Hirayama
    Animal Biotechnology Group, Animal Research Center, Hokkaido Research Organization, Shintoku, Hokkaido 081 0038, Japan Electronic address
    Placenta 36:1239-45. 2015
  3. doi Increase in ALK1/ALK5 ratio as a cause for elevated MMP-13 expression in osteoarthritis in humans and mice
    Esmeralda N Blaney Davidson
    Rheumatology Research and Advanced Therapeutics, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    J Immunol 182:7937-45. 2009
  4. pmc Expression of vascular endothelial growth factor is coordinately regulated by the activin-like kinase receptors 1 and 5 in endothelial cells
    Esther S Shao
    Division of Cardiology, David Geffen School of Medicine, University of California Los Angeles, CA 90095 1679, USA
    Blood 114:2197-206. 2009
  5. doi Transforming growth factor-beta1 downregulates caveolin-1 expression and enhances sphingosine 1-phosphate signaling in cultured vascular endothelial cells
    Junsuke Igarashi
    Department of Cardiovascular, Faculty of Medicine, Kagawa University, Kagawa, Japan
    Am J Physiol Cell Physiol 297:C1263-74. 2009
  6. pmc Regulation of endothelial barrier function by TGF-β type I receptor ALK5: potential role of contractile mechanisms and heat shock protein 90
    Alexander S Antonov
    Vascular Biology Center, Medical College of Georgia, Augusta, Georgia 30912, USA
    J Cell Physiol 227:759-71. 2012
  7. ncbi Molecular cloning, genetic mapping, and developmental expression of a bovine transforming growth factor beta (TGF-beta) type I receptor
    B A Roelen
    Hubrecht Laboratory, Netherlands Institute for Developmental Biology, Utrecht, The Netherlands
    Mol Reprod Dev 49:1-9. 1998
  8. ncbi GM-CSF increases airway smooth muscle cell connective tissue expression by inducing TGF-beta receptors
    Gang Chen
    Department of Medicine, Vancouver Hospital and Health Sciences Centre, University of British Columbia, Vancouver, British Columbia V6Z 3Z6, Canada
    Am J Physiol Lung Cell Mol Physiol 284:L548-56. 2003
  9. ncbi ALK5 and Smad4 are involved in TGF-beta1-induced pulmonary endothelial permeability
    Anna A Birukova
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    FEBS Lett 579:4031-7. 2005
  10. ncbi Cholesterol modulates cellular TGF-beta responsiveness by altering TGF-beta binding to TGF-beta receptors
    Chun Lin Chen
    Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, St Louis, Missouri 63104, USA
    J Cell Physiol 215:223-33. 2008

Scientific Experts

  • Esmeralda N Blaney Davidson
  • Qing Lu
  • J Igarashi
  • Hiroki Hirayama
  • Filipa Curado
  • Alexander S Antonov
  • Esther S Shao
  • Alexander D Verin
  • Chun Lin Chen
  • Anna A Birukova
  • Gang Chen
  • Takashi Fujii
  • Akira Naito
  • Ken Sawai
  • Keisuke Koyama
  • Soichi Kageyama
  • Shigeo Fukuda
  • Thomas Daubon
  • Anne Leclercq
  • Isabel Egaña
  • Paul Duhamel
  • Véronique Veillat
  • Pirjo Spuul
  • Etienne Gontier
  • Patricia Rottiers
  • Elisabeth Genot
  • Galina N Antonova
  • John D Catravas
  • Vaishali Handa
  • Peter Ten Dijke
  • Makiko Fujii
  • Yucheng Yao
  • KRISTINA I BOSTROM
  • Laura Lin
  • Jung San Huang
  • Shuan Shian Huang
  • B A Roelen
  • Konstantin G Birukov
  • Boris Gorshkov
  • Djanibek Adyshev
  • Nasreen Khalil
  • Gary Grotendorst
  • Thomas Eichholtz
  • M M Bevers
  • C L Mummery
  • H A Lewin
  • J H Larson
  • M A Van Rooijen
  • M J van Eijk

Detail Information

Publications11

  1. pmc ALK5 and ALK1 play antagonistic roles in transforming growth factor β-induced podosome formation in aortic endothelial cells
    Filipa Curado
    IECB and INSERM U1045, University of Bordeaux, Bordeaux, France
    Mol Cell Biol 34:4389-403. 2014
    ..Thus, ALK1 possesses passive and active modalities. Altogether, our results reveal specific features of ALK1 and ALK5 signaling with potential clinical implications. ..
  2. doi Localization of TGF-β and TGF-β receptor in bovine term placentome and expression differences between spontaneous and induced parturition
    Hiroki Hirayama
    Animal Biotechnology Group, Animal Research Center, Hokkaido Research Organization, Shintoku, Hokkaido 081 0038, Japan Electronic address
    Placenta 36:1239-45. 2015
    ....
  3. doi Increase in ALK1/ALK5 ratio as a cause for elevated MMP-13 expression in osteoarthritis in humans and mice
    Esmeralda N Blaney Davidson
    Rheumatology Research and Advanced Therapeutics, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    J Immunol 182:7937-45. 2009
    ..Our data suggest that dominant ALK1 signaling results in deviant chondrocyte behavior, thereby contributing to age-related cartilage destruction and OA...
  4. pmc Expression of vascular endothelial growth factor is coordinately regulated by the activin-like kinase receptors 1 and 5 in endothelial cells
    Esther S Shao
    Division of Cardiology, David Geffen School of Medicine, University of California Los Angeles, CA 90095 1679, USA
    Blood 114:2197-206. 2009
    ..Our results suggest that ALK1 and ALK5 are both essential for correct regulation of VEGF, and that disruption of either pathway leads to disease...
  5. doi Transforming growth factor-beta1 downregulates caveolin-1 expression and enhances sphingosine 1-phosphate signaling in cultured vascular endothelial cells
    Junsuke Igarashi
    Department of Cardiovascular, Faculty of Medicine, Kagawa University, Kagawa, Japan
    Am J Physiol Cell Physiol 297:C1263-74. 2009
    ....
  6. pmc Regulation of endothelial barrier function by TGF-β type I receptor ALK5: potential role of contractile mechanisms and heat shock protein 90
    Alexander S Antonov
    Vascular Biology Center, Medical College of Georgia, Augusta, Georgia 30912, USA
    J Cell Physiol 227:759-71. 2012
    ..We hypothesize that specific translocation of ubiquitinated ALK5 receptor into the cytoskeleton compartment due to its lack of degradation is the mechanism that causes the divergence of caALK1 and caALK5 signaling...
  7. ncbi Molecular cloning, genetic mapping, and developmental expression of a bovine transforming growth factor beta (TGF-beta) type I receptor
    B A Roelen
    Hubrecht Laboratory, Netherlands Institute for Developmental Biology, Utrecht, The Netherlands
    Mol Reprod Dev 49:1-9. 1998
    ..Genetic mapping assigned the TGFBR1 gene to bovine chromosome 8 at a male genetic distance of 2 centimorgan from D8S28...
  8. ncbi GM-CSF increases airway smooth muscle cell connective tissue expression by inducing TGF-beta receptors
    Gang Chen
    Department of Medicine, Vancouver Hospital and Health Sciences Centre, University of British Columbia, Vancouver, British Columbia V6Z 3Z6, Canada
    Am J Physiol Lung Cell Mol Physiol 284:L548-56. 2003
    ..In conclusion, GM-CSF increases the responsiveness of ASMC to TGF-beta1-mediated connective tissue expression by induction of TbetaRs, which is inhibited by corticosteroids...
  9. ncbi ALK5 and Smad4 are involved in TGF-beta1-induced pulmonary endothelial permeability
    Anna A Birukova
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    FEBS Lett 579:4031-7. 2005
    ..Thus, our data demonstrate for the first time direct link between TGF-beta1-mediated activation of ALK5/Smad and EC barrier dysfunction...
  10. ncbi Cholesterol modulates cellular TGF-beta responsiveness by altering TGF-beta binding to TGF-beta receptors
    Chun Lin Chen
    Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, St Louis, Missouri 63104, USA
    J Cell Physiol 215:223-33. 2008
    ..These results indicate that high plasma cholesterol levels may contribute to the pathogenesis of certain diseases (e.g., atherosclerosis) by suppressing TGF-beta responsiveness...
  11. pmc Transforming growth factor-beta1 protects against pulmonary artery endothelial cell apoptosis via ALK5
    Qing Lu
    Vascular Research Laboratory, Providence Veterans Affairs Medical Center, Providence, Rhode Island 02908, USA
    Am J Physiol Lung Cell Mol Physiol 295:L123-33. 2008
    ..Understanding the mechanism by which TGF-beta1 promotes endothelial cell survival may provide a better treatment for apoptosis-dependent vascular diseases, such as emphysema...