IFNG

Summary

Gene Symbol: IFNG
Description: interferon gamma
Alias: interferon gamma, IFN-gamma, boIFNG, interferon gamma type 2
Species: cow

Top Publications

  1. ncbi Augmentation of secreted and intracellular gamma interferon following johnin purified protein derivative sensitization of cows naturally infected with Mycobacterium avium subsp. paratuberculosis
    Judith R Stabel
    USDA ARS, National Animal Disease Center, 2300 Dayton Rd, Ames, IA 50010, USA
    J Vet Diagn Invest 19:43-51. 2007
  2. doi Toll-like receptors, IFN-γ and IL-12 expression in bovine leukemia virus-infected animals with low or high proviral load
    María Victoria Nieto Farias
    Laboratorio de Virologia, Centro de Investigación Veterinaria de Tandil CIVETAN, Conicet Cicpba, Facultad de Cs Veterinarias, UNCPBA, Paraje Arroyo Seco S N, 7000 Tandil, Argentina
    Res Vet Sci 107:190-5. 2016
  3. doi A novel regulatory B-cell population in sheep Peyer's patches spontaneously secretes IL-10 and downregulates TLR9-induced IFNalpha responses
    J S BOOTH
    Vaccine and Infectious Disease Organization International Vaccine Center, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
    Mucosal Immunol 2:265-75. 2009
  4. ncbi Changes occurring in immune responsiveness of single- and twin-bearing Comisana ewes during the transition period
    M Caroprese
    Dipartimento PRIME, Universita di Foggia, Via Napoli 25, 71100 Foggia, Italy
    J Dairy Sci 89:562-8. 2006
  5. doi Interferon-gamma and B-cell Activating Factor (BAFF) promote bovine B cell activation independent of TLR9 and T-cell signaling
    Rachelle Buchanan
    Vaccine and Infectious Disease Organization International Vaccine Centre VIDO InterVac, University of Saskatchewan, 120 Veterinary Road, Saskatoon, Saskatchewan, Canada S7N
    Vet Immunol Immunopathol 145:453-63. 2012
  6. pmc Effects of parturition and dexamethasone on DNA methylation patterns of IFN-γ and IL-4 promoters in CD4+ T-lymphocytes of Holstein dairy cows
    Marlene Paibomesai
    Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada
    Can J Vet Res 77:54-62. 2013
  7. doi Gamma interferon production and plasma concentrations of pregnancy-associated glycoproteins 1 and 2 in gestating dairy cows naturally infected with Neospora caninum
    B Serrano-Pérez
    Department of Animal Production, Agrotecnio Center, University of Lleida, Lleida, Spain
    Reprod Domest Anim 49:275-80. 2014
  8. pmc Expression of matrix metalloproteinases in bovine luteal cells induced by prostaglandin F2α, interferon γ and tumor necrosis factor α
    Hironori Abe
    Laboratory of Reproductive Physiology, Graduate School of Environmental and Life Science, Okayama University, Okayama 700 8530, Japan
    J Reprod Dev 61:277-86. 2015
  9. ncbi Development of detection methods for ruminant interleukin (IL)-12
    J C Hope
    Institute for Animal Health, Compton, Near Newbury, UK
    J Immunol Methods 266:117-26. 2002
  10. doi Genetic variants in interferon gamma (IFN-γ) gene are associated with resistance against ticks in Bos taurus and Bos indicus
    J Maryam
    Institute of Biochemistry and Biotechnology, University of Veterinary and Animal Sciences, Lahore, Pakistan
    Mol Biol Rep 39:4565-70. 2012

Scientific Experts

  • M A Gonzalez-Gay
  • J R Stabel
  • Wai Po Chong
  • Jayne C Hope
  • D N Wedlock
  • Peter Schmidt
  • María Victoria Nieto Farias
  • Hironori Abe
  • B Serrano-Pérez
  • Marlene Paibomesai
  • Kiyoshi Okuda
  • Rachelle Buchanan
  • J Maryam
  • Felix N Toka
  • B Mohana Subramanian
  • Chris P Verschoor
  • Takuo Hojo
  • Rocío Pérez-Rodríguez
  • Pablo J Pinedo
  • J S BOOTH
  • Chuan Li
  • Eun J Sohn
  • M Caroprese
  • I R Moldovan
  • Anne Marie Belliard
  • Maria Carolina Ceriani
  • Maia Marin
  • Pamela Anahi Lendez
  • Silvina Quintana
  • Guillermina Laura Dolcini
  • Lucía Martínez-Cuesta
  • Ryosuke Sakumoto
  • J F Beckers
  • I García-Ispierto
  • N M de Sousa
  • F Lopez-Gatius
  • S Almeria
  • Bonnie A Mallard
  • Maria Nino-Soto
  • Brendan Hussey
  • Yurij Popowych
  • A Nadeem
  • Heather L Wilson
  • T Hussain
  • Andrew A Potter
  • Natasa Arsic
  • M E Babar
  • Crystal Dagenais
  • Philip J Griebel
  • George K Mutwiri
  • Lorne A Babiuk
  • Flavio S Schenkel
  • K G Tirumurugaan
  • Bhawani S Sharma
  • G Dhinakar Raj
  • D Thiagarajan
  • Graham A Biggar
  • Sameer D Pant
  • Niel A Karrow
  • Mary A Kenney
  • S Senthuran
  • William T Golde
  • M Randal
  • Seung Hyung Lee
  • Akihiro ODA
  • Tomas J Acosta
  • María Pilar González
  • Rongling Wu
  • María Jesús Oset-Gasque
  • D Owen Rae
  • L A Babiuk
  • Taimour Y Langaee
  • Cesáreo Roncero
  • P J Griebel
  • G Art Donovan
  • Claus D Buergelt
  • G K Mutwiri
  • Laurence Morel
  • Ana María Oliván
  • Pedro Melendez
  • W M Grosse
  • Douglas D Bannerman
  • Ying Yut Chen
  • Raymond H Fetterer
  • Ya Di Tan
  • Ai Zhen Guo
  • Zhang Gui Rong Yan
  • Qiao Yun Hu
  • Bo Qin
  • Yan Jie Chao

Detail Information

Publications30

  1. ncbi Augmentation of secreted and intracellular gamma interferon following johnin purified protein derivative sensitization of cows naturally infected with Mycobacterium avium subsp. paratuberculosis
    Judith R Stabel
    USDA ARS, National Animal Disease Center, 2300 Dayton Rd, Ames, IA 50010, USA
    J Vet Diagn Invest 19:43-51. 2007
    ..In addition, CD8+ lymphocytes appear to play an important role as a mediator of M. paratuberculosis infection in naturally exposed cattle...
  2. doi Toll-like receptors, IFN-γ and IL-12 expression in bovine leukemia virus-infected animals with low or high proviral load
    María Victoria Nieto Farias
    Laboratorio de Virologia, Centro de Investigación Veterinaria de Tandil CIVETAN, Conicet Cicpba, Facultad de Cs Veterinarias, UNCPBA, Paraje Arroyo Seco S N, 7000 Tandil, Argentina
    Res Vet Sci 107:190-5. 2016
    ..Further studies on different subpopulations of immune cells may help clarify their role in response to BLV and its consequences on viral dissemination. ..
  3. doi A novel regulatory B-cell population in sheep Peyer's patches spontaneously secretes IL-10 and downregulates TLR9-induced IFNalpha responses
    J S BOOTH
    Vaccine and Infectious Disease Organization International Vaccine Center, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
    Mucosal Immunol 2:265-75. 2009
    ..These IL-10-secreting PP B cells may represent a novel subset of the recently proposed regulatory B cells (B(regs)) in the intestine...
  4. ncbi Changes occurring in immune responsiveness of single- and twin-bearing Comisana ewes during the transition period
    M Caroprese
    Dipartimento PRIME, Universita di Foggia, Via Napoli 25, 71100 Foggia, Italy
    J Dairy Sci 89:562-8. 2006
    ..In contrast, a relationship was found for the IgG secretions in milk and blood, which suggests that the assessment of humoral immune status may be combined with milking routine in dairy animals...
  5. doi Interferon-gamma and B-cell Activating Factor (BAFF) promote bovine B cell activation independent of TLR9 and T-cell signaling
    Rachelle Buchanan
    Vaccine and Infectious Disease Organization International Vaccine Centre VIDO InterVac, University of Saskatchewan, 120 Veterinary Road, Saskatoon, Saskatchewan, Canada S7N
    Vet Immunol Immunopathol 145:453-63. 2012
    ....
  6. pmc Effects of parturition and dexamethasone on DNA methylation patterns of IFN-γ and IL-4 promoters in CD4+ T-lymphocytes of Holstein dairy cows
    Marlene Paibomesai
    Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada
    Can J Vet Res 77:54-62. 2013
    ..with ConA alone or ConA plus dexamethasone (Dex) had significant effects on production of the cytokines interferon gamma (IFN-γ, type 1) and interleukin 4 (IL-4, type 2) that were consistent with DNA methylation profiles of the ..
  7. doi Gamma interferon production and plasma concentrations of pregnancy-associated glycoproteins 1 and 2 in gestating dairy cows naturally infected with Neospora caninum
    B Serrano-Pérez
    Department of Animal Production, Agrotecnio Center, University of Lleida, Lleida, Spain
    Reprod Domest Anim 49:275-80. 2014
    ..Accordingly, IFN-γ production could be linked to the transplacental migration of tachyzoites, which may cause a reduction in PAG levels. ..
  8. pmc Expression of matrix metalloproteinases in bovine luteal cells induced by prostaglandin F2α, interferon γ and tumor necrosis factor α
    Hironori Abe
    Laboratory of Reproductive Physiology, Graduate School of Environmental and Life Science, Okayama University, Okayama 700 8530, Japan
    J Reprod Dev 61:277-86. 2015
    ..cells is regulated by luteolytic factors, we investigated the effects of prostaglandin F2α (PGF), interferon γ (IFNG) and tumor necrosis factor α (TNF) on the mRNA expression of MMPs and TIMPs in cultured luteal cells...
  9. ncbi Development of detection methods for ruminant interleukin (IL)-12
    J C Hope
    Institute for Animal Health, Compton, Near Newbury, UK
    J Immunol Methods 266:117-26. 2002
    ..The ability to detect ruminant IL-12 by three methods: ELISA, bioassay with neutralising mAb and cytoplasmic staining, will permit studies of the role of this important cytokine in the immunology and pathogenesis of animal diseases...
  10. doi Genetic variants in interferon gamma (IFN-γ) gene are associated with resistance against ticks in Bos taurus and Bos indicus
    J Maryam
    Institute of Biochemistry and Biotechnology, University of Veterinary and Animal Sciences, Lahore, Pakistan
    Mol Biol Rep 39:4565-70. 2012
    ..Genetic markers identified in this study can be useful in future breeding selection programs against tick resistance...
  11. doi Rapid and transient activation of γδ T cells to IFN-γ production, NK cell-like killing, and antigen processing during acute virus infection
    Felix N Toka
    Plum Island Animal Disease Center, Agricultural Research Service, United States Department of Agriculture, Greenport, NY 11944, USA
    J Immunol 186:4853-61. 2011
    ..However, these results are unique in that all these functions are detected in the same samples of WC1(+) γδ T cells, suggesting a pivotal role of these cells in controlling virus infection...
  12. doi Identification of SNPs in interferon gamma, interleukin-22, and their receptors and associations with health and production-related traits in Canadian Holstein bulls
    Chris P Verschoor
    Centre for Genetic Improvement of Livestock, Department of Animal and Poultry Science, University of Guelph, Guelph, Ontario, Canada
    Anim Biotechnol 22:7-15. 2011
    ..Therefore, in the following study, the genes coding interferon gamma (IFNG), IFNG receptor 1 and 2 domains, interleukin-22 (IL22), and IL22 receptor alpha 1, were investigated ..
  13. ncbi Effects of tumor necrosis factor α and Interferon γ on the viability and mRNA expression of TNF receptor type I in endothelial cells from the bovine corpus luteum
    Takuo Hojo
    Laboratory of Reproductive Endocrinology, Graduate School of Natural Science and Technology, Okayama University, Japan
    J Reprod Dev 56:515-9. 2010
    ..We previously reported that a treatment combining tumor necrosis factor α (TNF) and interferon γ (IFNG) induced cell death in LSCs and that LECs express TNF receptor type I (TNFRI)...
  14. doi Difference in the level of interferon gamma mRNA transcripts on stimulation of cattle and buffalo mononuclear cells with foot and mouth disease virus-antigen: a possible role of sequence variation in promoter region
    B Mohana Subramanian
    Department of Animal Biotechnology, Madras Veterinary College, Tamil Nadu Veterinary and Animal Sciences University, Chennai 600007, India
    Res Vet Sci 90:55-8. 2011
    ..to compare the mitogen (conA) or antigen (foot and mouth disease virus) induced expression levels of interferon gamma (IFN-γ mRNA in peripheral blood mononuclear cells (PBMCs) by real-time quantitative PCR...
  15. doi Candidate gene polymorphisms (BoIFNG, TLR4, SLC11A1) as risk factors for paratuberculosis infection in cattle
    Pablo J Pinedo
    Department of Large Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL 32610 0136, USA
    Prev Vet Med 91:189-96. 2009
    ..b>Interferon gamma is an inducible cytokine with a crucial role in the innate host response to intracellular bacteria...
  16. doi Signaling mechanisms of interferon gamma induced apoptosis in chromaffin cells: involvement of nNOS, iNOS, and NFkappaB
    Rocío Pérez-Rodríguez
    Department of Biochemistry and Molecular Biology, Complutense University of Madrid, Spain
    J Neurochem 108:1083-96. 2009
    ..inducible NOS (iNOS) and neuronal NOS (nNOS), and their particular participation in cell death induced by interferon gamma (IFNgamma). Lipopolysaccharide (LPS) and IFNgamma increase iNOS expression, with no effect on nNOS expression...
  17. ncbi Cloning, sequence, and expression of bovine interferon-gamma
    D P Cerretti
    J Immunol 136:4561-4. 1986
    ..w. of 16,858. It has an amino acid homology of 63% with human IFN-gamma, and 47% with murine IFN-gamma. Biologically active bovine IFN-gamma was synthesized in an Escherichia coli expression system...
  18. ncbi Bacterial lipopolysaccharide stimulates bovine neutrophil production of TNF-alpha, IL-1beta, IL-12 and IFN-gamma
    Eun J Sohn
    Department of Animal and Avian Sciences, University of Maryland, College Park, MD 20742, USA
    Vet Res 38:809-18. 2007
    ....
  19. ncbi Vaccination of cattle with Danish and Pasteur strains of Mycobacterium bovis BCG induce different levels of IFNgamma post-vaccination, but induce similar levels of protection against bovine tuberculosis
    D Neil Wedlock
    AgResearch, Wallaceville Animal Research Centre, Upper Hutt, New Zealand
    Vet Immunol Immunopathol 118:50-8. 2007
    ..The results also show that post-vaccination antigen-specific IFN-gamma levels in whole blood is not always a reliable indicator of protection against a subsequent virulent challenge...
  20. ncbi [Preparation antibodies against recombinant bovine IFN-gamma and development of sandwich ELISA for bovine IFN-gamma detection]
    Chuan Li
    The State Key Laboratory of Agricultural Microbiology, Wuhan 430070, China
    Sheng Wu Gong Cheng Xue Bao 23:40-5. 2007
    ..The results indicated that the sensitivity was 2ng/mL. This sandwich ELISA to detect BovIFN-gamma paved the way to develop a sensitive method for specific infection detection such as bovine tuberculosis diagnosis...
  21. pmc The interferon gamma gene polymorphism +874 A/T is associated with severe acute respiratory syndrome
    Wai Po Chong
    Department of Paediatrics and Adolescent Medicine, The Hong Kong Jockey Club Research Centre, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
    BMC Infect Dis 6:82. 2006
    ..Cytokines play important roles in antiviral action. We examined whether polymorphisms of IFN-gamma,TNF-alpha and IL-10 affect the susceptibility to and outcome of severe acute respiratory syndrome (SARS)...
  22. ncbi Longitudinal single-cell cytokine responses reveal recurrent autoimmune myelin reactivity in relapsing--remitting multiple sclerosis patients
    I R Moldovan
    Department of Neurosciences, Cleveland Clinic Foundation, Cleveland, OH 44195 0001, USA
    Mult Scler 11:251-60. 2005
    ..The majority of patients with gad-enhancing lesions showed PLP/IFN gamma and MBP/IFN gamma recurrent burst responses...
  23. ncbi Interferon-gamma gene microsatellite polymorphisms in patients with biopsy-proven giant cell arteritis and isolated polymyalgia rheumatica
    M A Gonzalez-Gay
    Division of Rheumatology, Hospital Xeral Calde, Lugo, Spain
    Clin Exp Rheumatol 22:S18-20. 2004
    ..In this study we have examined the potential association of a CA repeat polymorphism in the first intron of the interferon gamma (IFN-gamma) gene with disease susceptibility and clinical expression of these conditions.
  24. ncbi Structure of recombinant bovine interferon-gamma at 3.0 A resolution
    C T Samudzi
    National Cancer Institute Frederick Cancer Research Development Center, ABL Basic Research Program, Frederick, Maryland 21702, USA
    Acta Crystallogr D Biol Crystallogr 49:513-21. 1993
    ..These structural similarities strongly indicate the presence of a unique topological feature (fold) among gamma-interferons from different species, and also among the different classes of interferons...
  25. ncbi Effect of tumor necrosis factor-alpha and interferon-gamma on intestinal P-glycoprotein expression, activity, and localization in Caco-2 cells
    Anne Marie Belliard
    Laboratoire de Physiologie Pharmacie Clinique, UPRES 2706, Faculte de Pharmacie, 5 rue J B Clement, 92296 Chatenay Malabry Cedex, France
    J Pharm Sci 93:1524-36. 2004
    ..The aim of this study was to investigate the effects of TNF alpha and IFN gamma on intestinal Pgp expression, activity, and localization in Caco-2 cells grown on filters...
  26. ncbi A comprehensive survey for polymorphisms in the bovine IFN-gamma gene reveals a highly polymorphic intronic DNA sequence allowing improved genotyping of Bovinae
    Peter Schmidt
    Research Unit of Molecular Biology of the Research Institute for the Biology of Farm Animals, 18196 Dummerstorf, Germany
    J Interferon Cytokine Res 22:923-34. 2002
    ..Therefore, the entire bovine IFN-gamma gene (BoIFNG) and 2605 bp of its promoter DNA were sequenced...
  27. ncbi The 2.0 A structure of bovine interferon-gamma; assessment of the structural differences between species
    M Randal
    Graduate Group in Biophysics, University of California, San Francisco, California 94000, USA
    Acta Crystallogr D Biol Crystallogr 56:14-24. 2000
    ..1992), Faraday Discuss. 93, 25-34]. The resulting statistical scoring indicated that BOV was consistent with expected criteria for a 2.0 A structure, whereas both 1rfb and 2rig fell below acceptable criteria...
  28. ncbi Single nucleotide polymorphism (SNP) discovery and linkage mapping of bovine cytokine genes
    W M Grosse
    United States Department of Agriculture, Agricultural Research Service, Roman L Hruska U S Meat Animal Research Center MARC, P O Box 166, State Spur 18D, Clay Center, Nebraska 68933, USA
    Mamm Genome 10:1062-9. 1999
    ..The polymorphic nature of these SNP haplotype markers suggests that they will be useful for mapping complex traits in cattle, such as resistance to infectious disease...