FABP4

Summary

Gene Symbol: FABP4
Description: fatty acid binding protein 4, adipocyte
Alias: fatty acid-binding protein, adipocyte, A-FABP, AFABP, ALBP, adipocyte lipid-binding protein, adipocyte-type fatty acid-binding protein
Species: cow

Top Publications

  1. ncbi The bovine fatty acid binding protein 4 gene is significantly associated with marbling and subcutaneous fat depth in Wagyu x Limousin F2 crosses
    J J Michal
    Department of Animal Sciences, Washington State University, Pullman, WA 99164 6351, USA
    Anim Genet 37:400-2. 2006
  2. ncbi Identification of genetic polymorphisms in FABP3 and FABP4 and putative association with back fat thickness in Korean native cattle
    Seoae Cho
    Laboratory of Bioinformatics and Biostatistics, Interdisciplinary Program in Bioinformatics, Department of Statistics, Seoul National University, Seoul, Korea
    BMB Rep 41:29-34. 2008
  3. doi Adenovirus-mediated interference of FABP4 regulates mRNA expression of ADIPOQ, LEP and LEPR in bovine adipocytes
    S Wei
    College of Animal Science and Technology, Northwest A and F University, Yangling, Shaanxi, P R China
    Genet Mol Res 12:494-505. 2013
  4. doi Overexpression of the A-FABP gene facilitates intermuscular fat deposition in transgenic mice
    Z W Liu
    College of Animal Science and Animal Medicine, Tianjin Agricultural University, Tianjin, China
    Genet Mol Res 14:2742-9. 2015
  5. pmc Variation in the bovine FABP4 gene affects milk yield and milk protein content in dairy cows
    H Zhou
    Department of Agricultural Science, Faculty of Agricultural and Life Sciences, Lincoln University, Lincoln 7647, New Zealand
    Sci Rep 5:10023. 2015
  6. doi Subcellular Localization and Polymorphism of Bovine FABP4 in Bovine Intramuscular Adipocytes
    Shinichi Yonekura
    a Department of Interdisciplinary Genome Sciences and Cell Metabolism, Institute for Biomedical Sciences, Interdisciplinary Cluster for Cutting Edge Research ICCER, Shinshu University, Nagano, Japan
    Anim Biotechnol 27:96-103. 2016
  7. ncbi Mammary derived growth inhibitor is not a distinct protein but a mix of heart-type and adipocyte-type fatty acid-binding protein
    B Specht
    Department of Biochemistry, University of Munster, D 48149 Munster, Germany
    J Biol Chem 271:19943-9. 1996
  8. pmc Association between fatty acid compositions and genotypes of FABP4 and LXR-alpha in Japanese black cattle
    Shogo Hoashi
    Laboratory of Animal Breeding and Genetics, Graduate School of Agricultural Science, Kobe University, Nada, Kobe, Japan
    BMC Genet 9:84. 2008
  9. doi A splice site single nucleotide polymorphism of the fatty acid binding protein 4 gene appears to be associated with intramuscular fat deposition in longissimus muscle in Australian cattle
    W Barendse
    Cooperative Research Centre for Beef Genetic Technologies, CSIRO Livestock Industries, Queensland Bioscience Precinct, St Lucia 4067, Australia
    Anim Genet 40:770-3. 2009
  10. doi Genetic polymorphisms of the bovine fatty acid binding protein 4 gene are significantly associated with marbling and carcass weight in Hanwoo (Korean Cattle)
    S H Lee
    Animal Genome and Bioinformatics Division, National Institute of Animal Science, RDA, Suwon 441 701, Korea
    Anim Genet 41:442-4. 2010

Scientific Experts

  • Shogo Hoashi
  • William Barendse
  • Shinichi Yonekura
  • Z W Liu
  • H Zhou
  • S Wei
  • Takahiro Narukami
  • S H Lee
  • L Pannier
  • Z Jiang
  • Seoae Cho
  • J J Michal
  • Honami Miyazaki
  • Shohei Hirota
  • Yukako Tokutake
  • G R Edwards
  • S Hodge
  • X B Ding
  • H Guo
  • J G H Hickford
  • L Cheng
  • G N Sui
  • W Azimu
  • H L Fan
  • X F Liu
  • T Wang
  • G P Li
  • G J Hausman
  • L S Zan
  • M V Dodson
  • H B Wang
  • M Du
  • G Cheng
  • D C McFarland
  • Shinji Sasazaki
  • Takuya Nogi
  • Masaaki Taniguchi
  • Kenji Oyama
  • Hideyuki Mannen
  • J P Gibson
  • J M Thompson
  • R M Hamill
  • P C Stapleton
  • E W Park
  • J H J Van der Werf
  • A M Mullen
  • S J Oh
  • T Sweeney
  • Il Cheong Cheong
  • Du Hak Yoon
  • Byung Lae Park
  • Hyun Sub Cheong
  • Heebal Kim
  • Sohg Namgoong
  • Hyoung Doo Shin
  • Eun Mi Kim
  • Tae Sung Park
  • Hye Won Lee
  • Chang Soo Han
  • C T Gaskins
  • Z W Zhang
  • B Specht
  • H Kuhl
  • C Hohoff
  • T Borchers
  • F Spener
  • N Bartetzko
  • R Franke

Detail Information

Publications14

  1. ncbi The bovine fatty acid binding protein 4 gene is significantly associated with marbling and subcutaneous fat depth in Wagyu x Limousin F2 crosses
    J J Michal
    Department of Animal Sciences, Washington State University, Pullman, WA 99164 6351, USA
    Anim Genet 37:400-2. 2006
    Fatty acid binding protein 4 (FABP4), which is expressed in adipose tissue, interacts with peroxisome proliferator-activated receptors and binds to hormone-sensitive lipase and therefore, plays an important role in lipid metabolism and ..
  2. ncbi Identification of genetic polymorphisms in FABP3 and FABP4 and putative association with back fat thickness in Korean native cattle
    Seoae Cho
    Laboratory of Bioinformatics and Biostatistics, Interdisciplinary Program in Bioinformatics, Department of Statistics, Seoul National University, Seoul, Korea
    BMB Rep 41:29-34. 2008
    ..single nucleotide polymorphisms (SNP) in the beef cattle adipocyte fatty-acid binding protein 3 and 4 (FABP3 and FABP4) genes are associated with carcass weight (CW) and back fat thickness (BF) of beef cattle...
  3. doi Adenovirus-mediated interference of FABP4 regulates mRNA expression of ADIPOQ, LEP and LEPR in bovine adipocytes
    S Wei
    College of Animal Science and Technology, Northwest A and F University, Yangling, Shaanxi, P R China
    Genet Mol Res 12:494-505. 2013
    Fatty acid binding protein 4 (FABP4) is an important adipocyte gene, with roles in fatty acid transport and fat deposition in animals as well as human metabolic syndrome...
  4. doi Overexpression of the A-FABP gene facilitates intermuscular fat deposition in transgenic mice
    Z W Liu
    College of Animal Science and Animal Medicine, Tianjin Agricultural University, Tianjin, China
    Genet Mol Res 14:2742-9. 2015
    ..In addition, triglycerides were remarkably higher in the skeletal muscle but lower in the myocardium of transgenic mice. Thus, overexpression of cattle A-FABP gene promoted fat deposition in the skeletal muscle of transgenic mice. ..
  5. pmc Variation in the bovine FABP4 gene affects milk yield and milk protein content in dairy cows
    H Zhou
    Department of Agricultural Science, Faculty of Agricultural and Life Sciences, Lincoln University, Lincoln 7647, New Zealand
    Sci Rep 5:10023. 2015
    ..Of the known bovine FABP genes, FABP4 has been mapped to a region on chromosome 14 that contains quantitative trait loci for milk traits...
  6. doi Subcellular Localization and Polymorphism of Bovine FABP4 in Bovine Intramuscular Adipocytes
    Shinichi Yonekura
    a Department of Interdisciplinary Genome Sciences and Cell Metabolism, Institute for Biomedical Sciences, Interdisciplinary Cluster for Cutting Edge Research ICCER, Shinshu University, Nagano, Japan
    Anim Biotechnol 27:96-103. 2016
    Fatty acid binding protein 4 (FABP4) I74 V, a gene polymorphism associated with unsaturated fatty acid contents, was discovered in Japanese Black cattle...
  7. ncbi Mammary derived growth inhibitor is not a distinct protein but a mix of heart-type and adipocyte-type fatty acid-binding protein
    B Specht
    Department of Biochemistry, University of Munster, D 48149 Munster, Germany
    J Biol Chem 271:19943-9. 1996
    ..Taking into account that deviations of the MDGI sequence from the bovine H-FABP sequence correspond with A-FABP we attribute the structure originally reported as MDGI to a mix of these proteins...
  8. pmc Association between fatty acid compositions and genotypes of FABP4 and LXR-alpha in Japanese black cattle
    Shogo Hoashi
    Laboratory of Animal Breeding and Genetics, Graduate School of Agricultural Science, Kobe University, Nada, Kobe, Japan
    BMC Genet 9:84. 2008
    ..study, we examined the association between polymorphisms of six genes, adipocytes-type fatty acid binding protein (FABP4), liver X receptor alpha (LXRalpha), cytochrome b5 (Cyt b5), long-chain acyl-CoA synthetase (ACSL) 1, ACSL4 and ..
  9. doi A splice site single nucleotide polymorphism of the fatty acid binding protein 4 gene appears to be associated with intramuscular fat deposition in longissimus muscle in Australian cattle
    W Barendse
    Cooperative Research Centre for Beef Genetic Technologies, CSIRO Livestock Industries, Queensland Bioscience Precinct, St Lucia 4067, Australia
    Anim Genet 40:770-3. 2009
    Fatty acid binding protein 4 (FABP4) is a candidate gene affecting fatness traits of mammals. However, its association with fatness traits in cattle and other livestock species is not consistent from one study to another...
  10. doi Genetic polymorphisms of the bovine fatty acid binding protein 4 gene are significantly associated with marbling and carcass weight in Hanwoo (Korean Cattle)
    S H Lee
    Animal Genome and Bioinformatics Division, National Institute of Animal Science, RDA, Suwon 441 701, Korea
    Anim Genet 41:442-4. 2010
    The objective of this study was to investigate an association between polymorphisms in the FABP4 gene and phenotypic variation for marbling and carcass weight (CWT) in a population of Hanwoo steers. We re-sequenced 4...
  11. doi Association analysis of single nucleotide polymorphisms in DGAT1, TG and FABP4 genes and intramuscular fat in crossbred Bos taurus cattle
    L Pannier
    Teagasc, Ashtown Food Research Centre, Ashtown, Dublin 15, Ireland
    Meat Sci 85:515-8. 2010
    ..in the diacylglycerol-O-acyltransferase1 (DGAT1), thyroglobulin (TG) and adipose fatty acid binding protein (FABP4) genes are associated with intramuscular fat (IMF) levels or marbling scores in beef...
  12. doi Effect of DNA polymorphisms related to fatty acid composition in adipose tissue of Holstein cattle
    Takahiro Narukami
    Graduate School of Agricultural Science, Kobe University, Nada, Japan
    Anim Sci J 82:406-11. 2011
    ..alpha (LXR), stearoyl-CoA desaturase (SCD), Fatty acid synthase (FASN), and Fatty acid binding protein 4 (FABP4) on fatty acid composition in intramuscular fat tissue of Holstein steers. The major allele frequencies were 0...