COL2A1

Summary

Gene Symbol: COL2A1
Description: collagen type II alpha 1 chain
Alias: CB11, collagen alpha-1(II) chain, alpha-1 type II collagen, collagen, type II, alpha 1, pro-alpha 1(II)
Species: cow

Top Publications

  1. pmc Lethal chondrodysplasia in a family of Holstein cattle is associated with a de novo splice site variant of COL2A1
    Jørgen S Agerholm
    Department of Large Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Dyrlægevej 68, Frederiksberg C, DK 1870, Denmark
    BMC Vet Res 12:100. 2016
  2. pmc Definition of the native and denatured type II collagen binding site for fibronectin using a recombinant collagen system
    Bo An
    From the Department of Biomedical Engineering, Tufts University, Medford, Massachusetts 02155 and
    J Biol Chem 289:4941-51. 2014
  3. ncbi Domains and maturation processes that regulate the activity of ADAMTS-2, a metalloproteinase cleaving the aminopropeptide of fibrillar procollagens types I-III and V
    Alain Colige
    Laboratory of Connective Tissues Biology, Center of Biomedical Integrative Genoproteomics, University of Liege, B 4000 SartTilman, Belgium
    J Biol Chem 280:34397-408. 2005
  4. doi Disc strain and resulting positive mRNA expression from application of a noninvasive treatment
    Geoffrey T Desmoulin
    Optima Health Solutions International Corp, KKT International, Vancouver, BC, Canada
    Spine (Phila Pa 1976) 36:E921-8. 2011
  5. doi Free axial vibrations at 0 to 200 Hz positively affect extracellular matrix messenger ribonucleic acid expression in bovine nucleus pulposi
    Geoffrey T Desmoulin
    Optima Health Solutions International Corporation KKT International, Vancouver, British Columbia, Canada
    Spine (Phila Pa 1976) 35:1437-44. 2010
  6. pmc Type II and VI collagen in nasal and articular cartilage and the effect of IL-1alpha on the distribution of these collagens
    I D C Jansen
    Department of Periodontology, Academic Center for Dentistry Amsterdam ACTA, University of Amsterdam and VU University, Research Institute MOVE, Amsterdam, The Netherlands
    J Mol Histol 41:9-17. 2010
  7. doi Cartilage formation measured by a novel PIINP assay suggests that IGF-I does not stimulate but maintains cartilage formation ex vivo
    S H Madsen
    Nordic Bioscience, Herlev, Denmark
    Scand J Rheumatol 38:222-6. 2009
  8. doi Sphingomyelinase decreases type II collagen expression in bovine articular cartilage chondrocytes via the ERK signaling pathway
    S J Gilbert
    Cardiff University, Cardiff, Wales, UK
    Arthritis Rheum 58:209-20. 2008
  9. ncbi Regulation of cartilaginous ECM gene transcription by chondrocytes and MSCs in 3D culture in response to dynamic loading
    R L Mauck
    Department of Health and Human Services Cartilage Biology and Orthopaedics Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, 50 South Drive, MSC 8022, Building 50, Bethesda, MD 20892 8022, USA
    Biomech Model Mechanobiol 6:113-25. 2007
  10. ncbi The covalent structure of cartilage collagen. Amino acid sequence of the NH2-terminal helical portion of the alpha 1 (II) chain
    W T Butler
    Biochemistry 15:3000-6. 1976

Scientific Experts

  • Jørgen S Agerholm
  • S H Madsen
  • I D C Jansen
  • Geoffrey T Desmoulin
  • Sophie J Gilbert
  • Bo An
  • R L Mauck
  • Alain Colige
  • Yuekang Xu
  • Barbara Brodsky
  • David L Kaplan
  • Alessandra Balduini
  • Vittorio Abbonante
  • Sezin Yigit
  • B Tang
  • X Yuan
  • D D Brand
  • B A Byers
  • R S Tuan
  • Alain Beschin
  • Betty Nusgens
  • Florence Ruggiero
  • Lea Brys
  • Frederic Kesteloot
  • Isabel Vandenberghe
  • Jozef Van Beeumen
  • Johanne Dubail
  • Charles M Lapiere
  • Marita Scealy
  • Paul A Ramsland
  • A H Kang
  • Janet M Davies
  • Merrill J Rowley
  • Rikard Holmdahl
  • Kutty Selva Nandakumar
  • J M Stuart
  • L K Myers
  • J J Wu
  • M L Gumanovskaya
  • T M Chiang
  • W T Butler
  • D R Eyre
  • E J Miller
  • E F Rosloniec
  • K B Whittington
  • K Terato
  • J E Finch
  • F O Sangiorgi
  • J M Seyer
  • F Ramirez
  • L G Lunde
  • T Inagami
  • V Benson-Chanda
  • W J de Wet
  • K A Hasty
  • M E Sobel

Detail Information

Publications21

  1. pmc Lethal chondrodysplasia in a family of Holstein cattle is associated with a de novo splice site variant of COL2A1
    Jørgen S Agerholm
    Department of Large Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Dyrlægevej 68, Frederiksberg C, DK 1870, Denmark
    BMC Vet Res 12:100. 2016
    ..The normal phenotype of the sire suggested a dominant inheritance with incomplete penetrance or a mosaic mutation...
  2. pmc Definition of the native and denatured type II collagen binding site for fibronectin using a recombinant collagen system
    Bo An
    From the Department of Biomedical Engineering, Tufts University, Medford, Massachusetts 02155 and
    J Biol Chem 289:4941-51. 2014
    ..Megakaryocytes cultured on chimeric collagen with fibronectin affinity showed improved adhesion and differentiation, suggesting a strategy for generating bioactive materials in biomedical applications. ..
  3. ncbi Domains and maturation processes that regulate the activity of ADAMTS-2, a metalloproteinase cleaving the aminopropeptide of fibrillar procollagens types I-III and V
    Alain Colige
    Laboratory of Connective Tissues Biology, Center of Biomedical Integrative Genoproteomics, University of Liege, B 4000 SartTilman, Belgium
    J Biol Chem 280:34397-408. 2005
    ..This finding and the existence of multiple processed forms of ADAMTS-2 strongly suggest that ADAMTS-2 may be involved in function(s) other than processing of fibrillar procollagen types I-III...
  4. doi Disc strain and resulting positive mRNA expression from application of a noninvasive treatment
    Geoffrey T Desmoulin
    Optima Health Solutions International Corp, KKT International, Vancouver, BC, Canada
    Spine (Phila Pa 1976) 36:E921-8. 2011
    ..5 to 5 g and frequencies of 0, 16, 50 to 80, and a combined 16+50 to 80 Hz treatment. Expression of mRNA for aggrecan, collagen type I, collagen type II, biglycan, decorin, and versican were assayed...
  5. doi Free axial vibrations at 0 to 200 Hz positively affect extracellular matrix messenger ribonucleic acid expression in bovine nucleus pulposi
    Geoffrey T Desmoulin
    Optima Health Solutions International Corporation KKT International, Vancouver, British Columbia, Canada
    Spine (Phila Pa 1976) 35:1437-44. 2010
    ..5 g and 0 to 200 Hz. Expression of messenger ribonucleic acid for aggrecan, collagen type I, collagen type II, biglycan, decorin, and versican were assayed, as was apoptosis...
  6. pmc Type II and VI collagen in nasal and articular cartilage and the effect of IL-1alpha on the distribution of these collagens
    I D C Jansen
    Department of Periodontology, Academic Center for Dentistry Amsterdam ACTA, University of Amsterdam and VU University, Research Institute MOVE, Amsterdam, The Netherlands
    J Mol Histol 41:9-17. 2010
    ..Since type VI collagen is known to be relatively resistant to proteolysis we speculate that the higher level of type VI collagen in articular cartilage is important in protecting cartilage from digestion...
  7. doi Cartilage formation measured by a novel PIINP assay suggests that IGF-I does not stimulate but maintains cartilage formation ex vivo
    S H Madsen
    Nordic Bioscience, Herlev, Denmark
    Scand J Rheumatol 38:222-6. 2009
    ..This was performed in a cartilage model...
  8. doi Sphingomyelinase decreases type II collagen expression in bovine articular cartilage chondrocytes via the ERK signaling pathway
    S J Gilbert
    Cardiff University, Cardiff, Wales, UK
    Arthritis Rheum 58:209-20. 2008
    ..The accumulation of ceramide is associated with arthritis in Farber's disease. The aim of this study was to investigate the mechanism of ceramide-induced down-regulation of type II collagen...
  9. ncbi Regulation of cartilaginous ECM gene transcription by chondrocytes and MSCs in 3D culture in response to dynamic loading
    R L Mauck
    Department of Health and Human Services Cartilage Biology and Orthopaedics Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, 50 South Drive, MSC 8022, Building 50, Bethesda, MD 20892 8022, USA
    Biomech Model Mechanobiol 6:113-25. 2007
    ..These results demonstrate the utility of a new reporter promoter system for optimizing loading protocols to improve the outcome of engineered chondrocyte- and MSC-laden cartilaginous constructs...
  10. ncbi The covalent structure of cartilage collagen. Amino acid sequence of the NH2-terminal helical portion of the alpha 1 (II) chain
    W T Butler
    Biochemistry 15:3000-6. 1976
    ..The sequences of alpha 1 (II)-CB6, alpha 1 (II),-CB12, and 39 residues of alpha 1 (II)-CB11 were determined largely by automated Edman degradation...
  11. ncbi Two monoclonal antibodies to precisely the same epitope of type II collagen select non-crossreactive phage clones by phage display: implications for autoimmunity and molecular mimicry
    Yuekang Xu
    Department of Biochemistry and Molecular Biology, Box 13D, Monash University, Clayton 3800, Australia
    Mol Immunol 41:411-9. 2004
    ....
  12. ncbi Molecular definition and characterization of recombinant bovine CB8 and CB10: immunogenicity and arthritogenicity
    B Tang
    Departments of Pediatrics, Biochemistry and Medicine, University of Tennessee, Memphis, Tennessee, 38163, USA
    Clin Immunol 92:256-64. 1999
    ..Thus, these recombinant CII peptides expressed in E. coli can induce an effective immunologic response and suggest that functionally useful CII peptides can be generated by the prokaryotic expression system...
  13. ncbi Structural analysis of cross-linking domains in cartilage type XI collagen. Insights on polymeric assembly
    J J Wu
    Department of Orthopaedics, University of Washington, Seattle 98195, USA
    J Biol Chem 270:18865-70. 1995
    ..N-propeptides in cartilage matrix and that the alpha 3 (XI) chain was the IIB splicing variant product of the COL2A1 gene...
  14. ncbi Characterization of the T cell determinants in the induction of autoimmune arthritis by bovine alpha 1(II)-CB11 in H-2q mice
    D D Brand
    Department of Medicine, University of Tennessee, Memphis
    J Immunol 152:3088-97. 1994
    ....
  15. ncbi Homologous regions of collagen alpha1(I) and alpha1(II) chains: apparent clustering of variable and invariant amino acid residues
    W T Butler
    Biochem Biophys Res Commun 57:190-5. 1974
  16. ncbi Isolation and characterization of the cyanogen bromide peptides from the alpha 1(II) chain of bovine and human cartilage collagen
    E J Miller
    Biochemistry 12:3153-9. 1973
  17. ncbi Covalent structure of collagen. Amino acid sequence of an arthritogenic cyanogen bromide peptide from type II collagen of bovine cartilage
    J M Seyer
    Connective Tissue Research Laboratory, Veterans Administration Medical Center, Memphis, TN 38104
    Eur J Biochem 181:159-73. 1989
    ..The peptide alpha 1(II)-CB11 was isolated by carboxymethylcellulose chromatography and Sephadex G-75S gel filtration...
  18. pmc Analysis of cDNA and genomic clones coding for the pro alpha 1 chain of calf type II collagen
    F O Sangiorgi
    Nucleic Acids Res 13:2815-26. 1985
    ..These clones span 23 kb of DNA and contain approximately 17 kb of the pro alpha 1(II) calf gene. Sequencing of exon 1 has determined the length of the 3' untranslated region and the exact location of the polyadenylation attachment site...
  19. ncbi The covalent structure of cartilage collagen. Evidence for sequence heterogeneity of bovine alpha1(II) chains
    W T Butler
    J Biol Chem 252:639-43. 1977
    ..During studies on the amino acid sequence of bovine nasal cartilage collagen, the cyanogen bromide peptide alpha1(II)-CB11 was degraded to smaller peptides with trypsin...