ovotransferrin

Summary

Gene Symbol: ovotransferrin
Description: transferrin (ovotransferrin)
Alias: LTF, TFEW, conalbumin, ovotransferrin, allergen Gal d III, lactotransferrin, ovotransferrin BB type, ovotransferrin BC type, ovotransferrin CC type, serum transferrin
Species: chicken

Top Publications

  1. pmc Ovalbumin: a secreted protein without a transient hydrophobic leader sequence
    R D Palmiter
    Proc Natl Acad Sci U S A 75:94-8. 1978
  2. doi Qualitative and quantitative peptidomic and proteomic approaches to phenotyping chicken semen
    Valerie Labas
    INRA, UMR85 Physiologie de la Reproduction et des Comportements, F 37380 Nouzilly, France CNRS, UMR7247, F 37380 Nouzilly, France Université François Rabelais de Tours, F 37000 Tours, France IFCE, Institut Français du Cheval et de l Equitation, F 37380 Nouzilly, France INRA, Plate forme d Analyse Intégrative des Biomolécules, Laboratoire de Spectrometrie de masse, F 37380 Nouzilly, France
    J Proteomics 112:313-35. 2015
  3. doi Expression of transferrin binding protein in the capillaries of the brain in the developing chick embryo
    Dong Woon Kim
    Department of Anatomy, Research Institute for Medical Sciences, Chungnam National University College of Medicine, Daejeon, 301 131, South Korea
    Neurochem Res 33:2288-93. 2008
  4. ncbi Precursor of egg white ovomucoid. Amino acid sequence of an NH2-terminal extension
    S N Thibodeau
    J Biol Chem 253:9018-23. 1978
  5. doi pH-dependent conformational transitions in conalbumin (ovotransferrin), a metalloproteinase from hen egg white
    Gulam Rabbani
    Interdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh 202 002, India
    Cell Biochem Biophys 61:551-60. 2011
  6. ncbi Structural evidence for a pH-sensitive dilysine trigger in the hen ovotransferrin N-lobe: implications for transferrin iron release
    J C Dewan
    Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York 10461
    Biochemistry 32:11963-8. 1993
  7. doi Unexpected differences in the behavior of ovotransferrin at the air-water interface at pH 6.5 and 8.0
    Cécile Le Floch-Fouéré
    INRA, UMR1253 Science et Technologie du Lait et de l Œuf, F 35042 Rennes, France
    J Colloid Interface Sci 356:614-23. 2011
  8. doi Identification of novel antioxidative peptides derived from a thermolytic hydrolysate of ovotransferrin by LC-MS/MS
    Shengwen Shen
    4 10 Agriculture Forestry Centre, Department of Agricultural and Food Nutritional Science, University of Alberta, Edmonton, Alberta, Canada T6G 2P5
    J Agric Food Chem 58:7664-72. 2010
  9. ncbi Organization and sequence studies of the 17-piece chicken conalbumin gene
    M Cochet
    Nature 282:567-74. 1979
  10. ncbi Identification of eggshell membrane proteins and purification of ovotransferrin and beta-NAGase from hen egg white
    G J Ahlborn
    Department of Food Science, North Carolina State University, Raleigh, NC, 27695, USA
    Protein J 25:71-81. 2006

Scientific Experts

  • Hisham R Ibrahim
  • Valerie Labas
  • Gulam Rabbani
  • Cécile Le Floch-Fouéré
  • Shengwen Shen
  • Dong Woon Kim
  • G J Ahlborn
  • Ikuko Okamoto
  • H Kurokawa
  • Nadine Gerard
  • Sabine Alves
  • Isabelle Grasseau
  • Audrey Gargaros
  • Grégoire Harichaux
  • Elisabeth Blesbois
  • Marie Bourin
  • Ana Paula Teixeira-Gomes
  • Karine Cahier
  • Anne Renault
  • Michel Pézolet
  • Stéphane Pezennec
  • Ejaz Ahmad
  • Sylvie Beaufils
  • Rizwan Hasan Khan
  • Nida Zaidi
  • Jean François Rioux-Dubé
  • Kaustav Majumder
  • Y Nys
  • J Gautron
  • Sun Jong You
  • J M Dominguez-Vera
  • Baljot Chahal
  • Jianping Wu
  • M Panheleux
  • S Cermelli
  • Sa Sun Cho
  • Gye Sun Jeon
  • Young Ho Lee
  • Ji Eun Song
  • Kyung Jin Jung
  • Chun Kee Chung
  • Kisang Kwon
  • Woo Mi Yang
  • Ha Na Lee
  • M Hirose
  • B Mikami
  • R W Kelly
  • D A Clare
  • B W Sheldon
  • J C Dewan
  • Kimihiko Mizutani
  • J Williams
  • Masaaki Hirose
  • J C Sacchettini
  • C Farquharson
  • R Cancedda
  • M T Hincke
  • T Boldicke
  • F D Cancedda
  • M Carlevaro
  • C Gentili
  • B Thorp
  • B Zerega
  • J M Garcia-Ruiz
  • P M Jacquinot
  • J Montreuil
  • G Spik
  • D Leger
  • S N Thibodeau
  • J M Wieruszeski
  • B Coddeville
  • J M Jeltsch
  • R D Palmiter
  • P Chambon
  • T C Elleman
  • I B Kingston
  • K A Walsh
  • R Hen
  • L Maroteaux
  • M Cochet
  • R R Crichton
  • L Dorland
  • D C Lee
  • J Haverkamp
  • F Perrin
  • F Gannon
  • J M Garnier
  • A G Wilkins
  • K A Kuhn
  • J F Vliegenthart

Detail Information

Publications29

  1. pmc Ovalbumin: a secreted protein without a transient hydrophobic leader sequence
    R D Palmiter
    Proc Natl Acad Sci U S A 75:94-8. 1978
    ....
  2. doi Qualitative and quantitative peptidomic and proteomic approaches to phenotyping chicken semen
    Valerie Labas
    INRA, UMR85 Physiologie de la Reproduction et des Comportements, F 37380 Nouzilly, France CNRS, UMR7247, F 37380 Nouzilly, France Université François Rabelais de Tours, F 37000 Tours, France IFCE, Institut Français du Cheval et de l Equitation, F 37380 Nouzilly, France INRA, Plate forme d Analyse Intégrative des Biomolécules, Laboratoire de Spectrometrie de masse, F 37380 Nouzilly, France
    J Proteomics 112:313-35. 2015
    ..Thus proteomic is a "phenomic molecular tool" that may help to discriminate avian males on their reproductive capacity. The data have been deposited with ProteomeXchange (identifiers PXD000287 and PXD001254)...
  3. doi Expression of transferrin binding protein in the capillaries of the brain in the developing chick embryo
    Dong Woon Kim
    Department of Anatomy, Research Institute for Medical Sciences, Chungnam National University College of Medicine, Daejeon, 301 131, South Korea
    Neurochem Res 33:2288-93. 2008
    ..The up-regulated expression of TfBP, together with the Tf-receptor of the brain capillaries, suggests that pericytes may be associated with the high iron uptake required for the metabolic demands of the developing brain...
  4. ncbi Precursor of egg white ovomucoid. Amino acid sequence of an NH2-terminal extension
    S N Thibodeau
    J Biol Chem 253:9018-23. 1978
    ..The precursor sequence differs from those of two other proteins (pre-lysozyme and pre-conalbumin) secreted by the same cell, but resembles these and other secretory protein "signal peptides" in both ..
  5. doi pH-dependent conformational transitions in conalbumin (ovotransferrin), a metalloproteinase from hen egg white
    Gulam Rabbani
    Interdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh 202 002, India
    Cell Biochem Biophys 61:551-60. 2011
    Acid unfolding pathway of conalbumin (CA), a monomeric glycoprotein from hen egg white, has been investigated using far- and near-UV CD spectroscopy, intrinsic fluorescence emission, extrinsic fluorescence probe 1-anilino-8-napthalene ..
  6. ncbi Structural evidence for a pH-sensitive dilysine trigger in the hen ovotransferrin N-lobe: implications for transferrin iron release
    J C Dewan
    Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York 10461
    Biochemistry 32:11963-8. 1993
    ..The structure of the monoferric N-terminal half-molecule of hen ovotransferrin, reported here at 2...
  7. doi Unexpected differences in the behavior of ovotransferrin at the air-water interface at pH 6.5 and 8.0
    Cécile Le Floch-Fouéré
    INRA, UMR1253 Science et Technologie du Lait et de l Œuf, F 35042 Rennes, France
    J Colloid Interface Sci 356:614-23. 2011
    Adsorption of purified apo-ovotransferrin at the air-water interface was studied by ellipsometry, surface tension, polarization-modulation infrared reflection-absorption spectroscopy (PM-IRRAS), and shear elastic constant measurements...
  8. doi Identification of novel antioxidative peptides derived from a thermolytic hydrolysate of ovotransferrin by LC-MS/MS
    Shengwen Shen
    4 10 Agriculture Forestry Centre, Department of Agricultural and Food Nutritional Science, University of Alberta, Edmonton, Alberta, Canada T6G 2P5
    J Agric Food Chem 58:7664-72. 2010
    b>Ovotransferrin is a glycoprotein well-known for its iron-binding property. Ovotransferrin was reported to have antioxidative properties, but the presence of antioxidant peptides within the protein has not been reported...
  9. ncbi Organization and sequence studies of the 17-piece chicken conalbumin gene
    M Cochet
    Nature 282:567-74. 1979
    The conalbumin gene has been cloned and shown to consist of at least 17 exons approximately 60-200 base pairs long...
  10. ncbi Identification of eggshell membrane proteins and purification of ovotransferrin and beta-NAGase from hen egg white
    G J Ahlborn
    Department of Food Science, North Carolina State University, Raleigh, NC, 27695, USA
    Protein J 25:71-81. 2006
    ..associated with the ESM activity have been identified including beta-N-acetylglucosaminidase, lysozyme and ovotransferrin, with each displaying varying degrees of antibacterial activity...
  11. ncbi Ovotransferrin is a redox-dependent autoprocessing protein incorporating four consensus self-cleaving motifs flanking the two kringles
    Hisham Radwan Ibrahim
    Department of Biochemistry and Biotechnology, Faculty of Agriculture, Kagoshima University, Kagoshima 890 0065, Japan
    Biochim Biophys Acta 1760:347-55. 2006
    ..In this study, we found that ovotransferrin (OTf), the second major protein in egg albumin, undergoes autocleavage at distinct sites upon reduction with ..
  12. ncbi Iron-binding process in the amino- and carboxyl-terminal lobes of ovotransferrin: quantitative studies utilizing single Fe3+-binding mutants
    Ikuko Okamoto
    Division of Applied Life Sciences, The Graduate School of Agriculture, Kyoto University, Uji, Kyoto 611 0011, Japan
    Biochemistry 43:11118-25. 2004
    Iron-liganding-residue mutants of ovotransferrin, Y191F and Y524F, were investigated for their Fe(3+)-binding properties...
  13. ncbi The effect of avian uterine fluid on the growth behavior of calcite crystals
    J M Dominguez-Vera
    Department de Quimica Inorganica, University of Granada, Spain
    Poult Sci 79:901-7. 2000
    ..The predominant constituents were ovalbumin and ovotransferrin at the initial phase and lysozyme, ovocleidin-17, ovocalyxin-32, 36- and 21-kDa bands, and ovocleidin-116 at ..
  14. ncbi Extraction and quantification by ELISA of eggshell organic matrix proteins (ovocleidin-17, ovalbumin, ovotransferrin) in shell from young and old hens
    M Panheleux
    Station de Recherches Avicoles, Institut National de la Recherche Agronomique, Nouzilly, France
    Poult Sci 79:580-8. 2000
    ..of these proteins as biomarkers of eggshell quality by developing a competitive indirect ELISA for quantifying ovotransferrin, ovalbumin, and ovocleidin-17 in eggshell extract...
  15. ncbi Extracellular fatty acid binding protein (Ex-FABP) modulation by inflammatory agents: "physiological" acute phase response in endochondral bone formation
    S Cermelli
    Istituto Nazionale per la Ricerca sul Cancro, Centro di Biotecnologie Avanzate, Genova Italy
    Eur J Cell Biol 79:155-64. 2000
    ..We also suggest that during endochondral bone formation other responses characteristic of a local inflammatory status, such as gelatinase production and angiogenic factor secretion, are "physiologically" activated...
  16. ncbi Crystal structure of hen apo-ovotransferrin. Both lobes adopt an open conformation upon loss of iron
    H Kurokawa
    Research Institute for Food Science, Kyoto University, Uji, Kyoto 611, Japan
    J Biol Chem 274:28445-52. 1999
    The three-dimensional crystal structure of hen apo-ovotransferrin has been solved by molecular replacement and refined by simulated annealing and restrained least squares to a 3.0-A resolution...
  17. ncbi Identical precursors for serum transferrin and egg white conalbumin
    S N Thibodeau
    J Biol Chem 253:3771-4. 1978
    The NH2-terminal sequences of egg white conalbumin and chicken serum transferrin were examined and found to be identical...
  18. ncbi Change in glycosylation of chicken transferrin glycans biosynthesized during embryogenesis and primary culture of embryo hepatocytes
    P M Jacquinot
    Laboratoire de Chimie Biologique, Centre National de la Recherche Scientifique n 111, Universite des Sciences et Technologies de Lille, Villeneuve d Ascq, France
    Glycobiology 4:617-24. 1994
    ..In particular, the embryo serum transferrin glycan differed from that of chicken serum transferrin by the presence of a bisecting N-acetylglucosamine, ..
  19. ncbi Crystal structure of diferric hen ovotransferrin at 2.4 A resolution
    H Kurokawa
    Research Institute for Food Science, Kyoto University, Japan
    J Mol Biol 254:196-207. 1995
    ..The overall structure of ovotransferrin is similar to those of human lactoferrin and rabbit serum transferrin, being folded into two homologous lobes, each containing two dissimilar domains with one Fe3+ and one CO3(2)-..
  20. ncbi The complete nucleotide sequence of the chicken ovotransferrin mRNA
    J M Jeltsch
    Eur J Biochem 122:291-5. 1982
    ..S., Lee, D. C., Mayo, K. E., and Palmiter, R. D. (1979) Nucleic Acids Res. 6, 2435-2452] of chicken ovotransferrin (conalbumin) mRNA has been determined. Taking into account the previously reported 5'-end sequence [Cochet, M...
  21. ncbi The primary structure of hen ovotransferrin
    J Williams
    Eur J Biochem 122:297-303. 1982
    Peptide sequences obtained from hen ovotransferrin are compared with the complete amino acid sequence of the protein deduced from a cDNA sequence (Jeltsch and Chambon, preceding paper)...
  22. pmc The amino acid sequences of cysteic acid-containing peptides from performic acid-oxidized ovotransferrin
    T C Elleman
    Biochem J 116:515-32. 1970
    1. The half-cystine content of ovotransferrin, measured as cysteic acid, was 31mol/80000g of protein. 2. The amino acid sequences of cysteic acid-containing peptides from performic acid-oxidized ovotransferrin were studied. 3...
  23. pmc Sequence of the chicken ovotransferrin gene
    J M Jeltsch
    INSERM U184, Faculte de Medecine, Strasbourg, France
    Nucleic Acids Res 15:7643-5. 1987
  24. ncbi Iron transport and storage
    R R Crichton
    Eur J Biochem 164:485-506. 1987
  25. pmc The amino acid sequence of a carbohydrate-containing fragment of hen ovotransferrin
    I B Kingston
    Biochem J 147:463-72. 1975
    1. Hen ovotransferrin was treated with CNBr and fractionated by gel filtration. 2. After further treatment by reduction and carboxymethylation a carbohydrate-containing fragment of molecular weight 11990 was obtained (fragment BCd). 3...
  26. ncbi Investigation by 360-MHz 1H-nuclear-magnetic-resonance spectroscopy and methylation analysis of the single glycan chain of chicken ovotransferrin
    L Dorland
    Eur J Biochem 100:569-74. 1979
    The primary structure of two glycopeptides obtained by pronase digestion of chicken ovotransferrin has been investigated by 360-MHz proton nuclear magnetic resonance (NMR) spectroscopy and methylation analysis...