interferon gamma

Summary

Gene Symbol: interferon gamma
Description: interferon gamma
Alias: interferon gamma, IFN-gamma, Interferon-gamma level, interferon-gama
Species: chicken

Top Publications

  1. ncbi IL-18 stimulates the proliferation and IFN-gamma release of CD4+ T cells in the chicken: conservation of a Th1-like system in a nonmammalian species
    Thomas W Göbel
    Institute for Animal Physiology, University of Munich, Munich, Germany
    J Immunol 171:1809-15. 2003
  2. doi Molecular cloning, expression, and characterization of chicken IFN -lambda
    Adam J Karpala
    CSIRO, Livestock Industries, Australian Animal Health Laboratory, Geelong, Victoria, Australia
    J Interferon Cytokine Res 28:341-50. 2008
  3. doi Both host and parasite MIF molecules bind to chicken macrophages via CD74 surface receptor
    Sungwon Kim
    Avian Immunobiology Laboratory, Department of Animal and Poultry Sciences, Virginia Tech, Blacksburg, VA 24061, USA
    Dev Comp Immunol 47:319-26. 2014
  4. pmc Effects of interferon-γ knockdown on vaccine-induced immunity against Marek's disease in chickens
    Kamran Haq
    Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, Ontario N1G 2W1 Haq, Wootton, Barjesteh, Sharif Department of Animal and Food Sciences, University of Delaware, Newark, Delaware, 19716 USA Golovan Department of Molecular and Cellular Biology, College of Biological Sciences, University of Guelph, Guelph, Ontario N1G 2W1 Bendall
    Can J Vet Res 79:1-7. 2015
  5. doi Genetic effects analysis of myeloid leukemia factor 2 and T cell receptor-beta on resistance to coccidiosis in chickens
    E S Kim
    Bovine Functional Genomics Laboratory, Animal and Natural Resources Institute, USDA, Beltsville, MD 20705, USA
    Poult Sci 89:20-7. 2010
  6. pmc IFN-γ, IL-21, and IL-10 co-expression in evolving autoimmune vitiligo lesions of Smyth line chickens
    Fengying Shi
    Department of Poultry Science, University of Arkansas Division of Agriculture, Fayetteville, Arkansas 72701, USA
    J Invest Dermatol 132:642-9. 2012
  7. doi Changes of IgA+ cells and cytokines in the cecal tonsil of broilers fed on diets supplemented with vanadium
    Yuanxin Deng
    Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Ya an, China
    Biol Trace Elem Res 147:149-55. 2012
  8. pmc Effects of zearalenone on IL-2, IL-6, and IFN-γ mRNA levels in the splenic lymphocytes of chickens
    Y C Wang
    College of Veterinary Medicine, Sichuan Agricultural University, Yaan, Sichuan 625014, China
    ScientificWorldJournal 2012:567327. 2012
  9. ncbi Cloning and expression of the chicken interferon-gamma gene
    M R Digby
    CSIRO Division of Animal Health, Animal Health Research Laboratory, Parkville, Victoria, Australia
    J Interferon Cytokine Res 15:939-45. 1995
  10. ncbi Biological properties of recombinant chicken interferon-gamma
    K C Weining
    Abteilung Virologie, University of Freiburg, Germany
    Eur J Immunol 26:2440-7. 1996

Scientific Experts

  • Adam J Karpala
  • P Kaiser
  • Kamran Haq
  • Sungwon Kim
  • Fengying Shi
  • Y C Wang
  • Yuanxin Deng
  • E S Kim
  • Mark P Ariaans
  • Tim Downing
  • Janet Bhagat
  • Fabienne Rauw
  • Thomas W Göbel
  • Shayan Sharif
  • Serguei Golovan
  • Andrew Bendall
  • Sarah K Wootton
  • Neda Barjesteh
  • Ray H Fetterer
  • Rami A Dalloul
  • Mark C Jenkins
  • Katarzyna B Miska
  • Chasity M Cox
  • Z C Zuo
  • Gisela F Erf
  • Z H Ren
  • J L Deng
  • Jing Fang
  • Kangping Wang
  • Xi Peng
  • Y Wang
  • Hengmin Cui
  • Zhicai Zuo
  • Bangyuan Wu
  • S W Xu
  • Wei Cui
  • H M Cui
  • X Peng
  • Y H Hong
  • H S Lillehoj
  • Arifa N Naqvi
  • Baitsi Podisi
  • Lonneke Vervelde
  • Olivier Hanotte
  • Daniel G Bradley
  • A K Fazlul Haque Bhuiyan
  • David J Lynn
  • Racine Samba Sow
  • Evert J Hensen
  • Peter M van de Haar
  • Cliona O'Farrelly
  • Andrew T Lloyd
  • Pradeepa Silva
  • Rahamame Sanfo
  • Sarah Connell
  • V K Saxena
  • Praveen Tyagi
  • K A Ahmed
  • M Saxena
  • Benedicte Lambrecht
  • Thierry van den Berg
  • Peter Staeheli
  • Beatrice Schaerer
  • Florian Puehler
  • Iris Mejri
  • Steffen Weigend
  • Kirsten Schneider
  • Bernd Kaspers
  • K C Weining
  • M R Digby
  • P Staeheli
  • U Münster
  • U Schultz
  • B Kaspers
  • J W Lowenthal

Detail Information

Publications16

  1. ncbi IL-18 stimulates the proliferation and IFN-gamma release of CD4+ T cells in the chicken: conservation of a Th1-like system in a nonmammalian species
    Thomas W Göbel
    Institute for Animal Physiology, University of Munich, Munich, Germany
    J Immunol 171:1809-15. 2003
    ....
  2. doi Molecular cloning, expression, and characterization of chicken IFN -lambda
    Adam J Karpala
    CSIRO, Livestock Industries, Australian Animal Health Laboratory, Geelong, Victoria, Australia
    J Interferon Cytokine Res 28:341-50. 2008
    ..Our results demonstrate that in the chicken, as in human, the antiviral activity demonstrated by ChIFN-lambda supports its inclusion in therapeutic strategies directed against viral infections...
  3. doi Both host and parasite MIF molecules bind to chicken macrophages via CD74 surface receptor
    Sungwon Kim
    Avian Immunobiology Laboratory, Department of Animal and Poultry Sciences, Virginia Tech, Blacksburg, VA 24061, USA
    Dev Comp Immunol 47:319-26. 2014
    ..during infection, bound to chicken macrophages via ChCD74p41 as a surface receptor. Together, this study provides conclusive evidence that both host and parasite MIF molecules bind to chicken macrophages via the surface receptor ChCD74...
  4. pmc Effects of interferon-γ knockdown on vaccine-induced immunity against Marek's disease in chickens
    Kamran Haq
    Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, Ontario N1G 2W1 Haq, Wootton, Barjesteh, Sharif Department of Animal and Food Sciences, University of Delaware, Newark, Delaware, 19716 USA Golovan Department of Molecular and Cellular Biology, College of Biological Sciences, University of Guelph, Guelph, Ontario N1G 2W1 Bendall
    Can J Vet Res 79:1-7. 2015
    ..However, administration of the rAAAV expressing shRNA targeting chicken IFN-γ did not seem to fully abrogate vaccine-induced protection...
  5. doi Genetic effects analysis of myeloid leukemia factor 2 and T cell receptor-beta on resistance to coccidiosis in chickens
    E S Kim
    Bovine Functional Genomics Laboratory, Animal and Natural Resources Institute, USDA, Beltsville, MD 20705, USA
    Poult Sci 89:20-7. 2010
    ..These results suggest that the SNP in the MLF2 gene can be one of the markers to select coccidiosis resistance in chickens...
  6. pmc IFN-γ, IL-21, and IL-10 co-expression in evolving autoimmune vitiligo lesions of Smyth line chickens
    Fengying Shi
    Department of Poultry Science, University of Arkansas Division of Agriculture, Fayetteville, Arkansas 72701, USA
    J Invest Dermatol 132:642-9. 2012
    ..Taken together, SLV appears to be a Th1-polarized autoimmune disease, whereby IFN-γ expression is strongly associated with parallel increases in IL-10 and IL-21, particularly during early and active stages of SLV...
  7. doi Changes of IgA+ cells and cytokines in the cecal tonsil of broilers fed on diets supplemented with vanadium
    Yuanxin Deng
    Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Ya an, China
    Biol Trace Elem Res 147:149-55. 2012
    ..Simultaneously, the changes in interleukin-6 (IL-6), interleukin-10 (IL-10), interferon gamma (IFN-γ) and tumor necrosis factor-alpha (TNF-α) contents in the cecal tonsil were also quantified by enzyme-..
  8. pmc Effects of zearalenone on IL-2, IL-6, and IFN-γ mRNA levels in the splenic lymphocytes of chickens
    Y C Wang
    College of Veterinary Medicine, Sichuan Agricultural University, Yaan, Sichuan 625014, China
    ScientificWorldJournal 2012:567327. 2012
    ..05). These data suggest that ZEN has potent effects on the expression of chicken splenic lymphocytes cytokines at the mRNA level...
  9. ncbi Cloning and expression of the chicken interferon-gamma gene
    M R Digby
    CSIRO Division of Animal Health, Animal Health Research Laboratory, Parkville, Victoria, Australia
    J Interferon Cytokine Res 15:939-45. 1995
    ..These findings show that the emergence of the two principal types of IFN predates the divergence of avians and mammals that occurred some 350 million years ago...
  10. ncbi Biological properties of recombinant chicken interferon-gamma
    K C Weining
    Abteilung Virologie, University of Freiburg, Germany
    Eur J Immunol 26:2440-7. 1996
    ....
  11. ncbi Structure of the chicken interferon-gamma gene, and comparison to mammalian homologues
    P Kaiser
    Institute for Animal Health, Compton, Berkshire, UK
    Gene 207:25-32. 1998
    ..However, promoter sequence polymorphisms between different inbred lines of chickens have been identified, with possible links to disease resistance...
  12. ncbi Effects of supplemental chromium on interferon-gamma (IFN-gamma) mRNA expression in response to Newcastle disease vaccine in broiler chicken
    Janet Bhagat
    Division of Nutrition and Feed Technology, Central Avian Research Institute, Izatnagar 243122, Bareilly, India
    Res Vet Sci 85:46-51. 2008
    ..Thus, the supplementation of chromium at appropriate dose might be helpful to enhance the IFN-gamma mRNA expression in response to NDV...
  13. ncbi Pivotal role of ChIFNgamma in the pathogenesis and immunosuppression of infectious bursal disease
    Fabienne Rauw
    Avian Virology and Immunology Unit, Veterinary and Agrochemical Research Centre, Ukkel Brussels, Belgium
    Avian Pathol 36:367-74. 2007
    ..In conclusion, a ChIFNgamma dysregulation occurs in chickens infected with IBDV and the overproduction of ChIFNgamma by T lymphocytes plays a key role in the pathogenesis and immunosuppression induced by this virus...
  14. doi Infectious Bronchitis Virus induces acute interferon-gamma production through polyclonal stimulation of chicken leukocytes
    Mark P Ariaans
    Department of Infectious Diseases and Immunology, Utrecht University, The Netherlands
    Virology 385:68-73. 2009
    ..These results indicate that IBV acts as a polyclonal stimulus, inducing a rapid production of IFN-gamma even without previous exposure to the virus...
  15. doi Contrasting evolution of diversity at two disease-associated chicken genes
    Tim Downing
    Smurfit Institute of Genetics, Trinity College, University of Dublin, Dublin, Ireland
    Immunogenetics 61:303-14. 2009
    ....