CDH6

Summary

Gene Symbol: CDH6
Description: cadherin 6
Alias: c-cad6B, cadherin-6, cadherin-6B, cadherin-6, cadherin 6, type 2, K-cadherin (fetal kidney), cadherin 6B
Species: chicken

Top Publications

  1. ncbi Neural crest cell-cell adhesion controlled by sequential and subpopulation-specific expression of novel cadherins
    S Nakagawa
    Department of Biophysics, Faculty of Science, Kyoto University, Japan
    Development 121:1321-32. 1995
  2. ncbi Neural crest emigration from the neural tube depends on regulated cadherin expression
    S Nakagawa
    Department of Biophysics, Faculty of Science, Kyoto University, Kitashirakawa, Sakyo ku, Kyoto 606 8502, Japan
    Development 125:2963-71. 1998
  3. pmc Snail2 directly represses cadherin6B during epithelial-to-mesenchymal transitions of the neural crest
    Lisa A Taneyhill
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Development 134:1481-90. 2007
  4. pmc Cadherin 6B induces BMP signaling and de-epithelialization during the epithelial mesenchymal transition of the neural crest
    Ki Sook Park
    Department of Cell Biology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    Development 137:2691-701. 2010
  5. pmc Cadherin-6B stimulates an epithelial mesenchymal transition and the delamination of cells from the neural ectoderm via LIMK/cofilin mediated non-canonical BMP receptor signaling
    Ki Sook Park
    Department of Cell Biology, University of Virginia School of Medicine, PO Box 800732, Charlottesville, VA 22908, USA
    Dev Biol 366:232-43. 2012
  6. pmc Cadherin-6B is proteolytically processed during epithelial-to-mesenchymal transitions of the cranial neural crest
    Andrew T Schiffmacher
    Department of Animal and Avian Sciences, University of Maryland, College Park, MD 20742
    Mol Biol Cell 25:41-54. 2014
  7. pmc Cadherin-6B is required for the generation of Islet-1-expressing dorsal interneurons
    Ki Sook Park
    East West Medical Research Institute, Kyung Hee University, Seoul 130 701, Republic of Korea College of Medicine, Kyung Hee University, Seoul 130 701, Republic of Korea Electronic address
    Biochem Biophys Res Commun 459:504-8. 2015
  8. pmc Cadherin-6B undergoes macropinocytosis and clathrin-mediated endocytosis during cranial neural crest cell EMT
    Rangarajan Padmanabhan
    National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Cell Sci 128:1773-86. 2015
  9. pmc Cadherin-6B proteolysis promotes the neural crest cell epithelial-to-mesenchymal transition through transcriptional regulation
    Andrew T Schiffmacher
    Department of Animal and Avian Sciences, University of Maryland, College Park, MD 20742
    J Cell Biol 215:735-747. 2016
  10. pmc Tetraspanin18 is a FoxD3-responsive antagonist of cranial neural crest epithelial-to-mesenchymal transition that maintains cadherin-6B protein
    Corinne L Fairchild
    Department of Genetics, Cell Biology, and Development, 6 160 Jackson Hall, 321 Church Street SE, University of Minnesota, Minneapolis, MN 55455, USA
    J Cell Sci 126:1464-76. 2013

Scientific Experts

  • Ki Sook Park
  • Eiji Matsunaga
  • Lisa A Taneyhill
  • Andrew T Schiffmacher
  • Rangarajan Padmanabhan
  • Corinne L Fairchild
  • Sarah H Barnes
  • D Heyers
  • Vivien Xie
  • S Nakagawa
  • Sharon Jhingory
  • Laura S Gammill
  • Corinna Wentzel
  • Sarah C Guthrie
  • Stephen R Price
  • Edward G Coles
  • Marianne Bronner-Fraser
  • C Redies
  • H Luksch
  • M Takeichi

Detail Information

Publications13

  1. ncbi Neural crest cell-cell adhesion controlled by sequential and subpopulation-specific expression of novel cadherins
    S Nakagawa
    Department of Biophysics, Faculty of Science, Kyoto University, Japan
    Development 121:1321-32. 1995
    ..The cadherin-mediated specific interaction between crest cells likely plays a role in intercellular signaling between homotypic cells as well as in sorting of heterotypic cells...
  2. ncbi Neural crest emigration from the neural tube depends on regulated cadherin expression
    S Nakagawa
    Department of Biophysics, Faculty of Science, Kyoto University, Kitashirakawa, Sakyo ku, Kyoto 606 8502, Japan
    Development 125:2963-71. 1998
    ..These findings suggest that the regulation of cadherin expression or its activity at the neural crest-forming area plays a critical role in neural crest emigration from the neural tube...
  3. pmc Snail2 directly represses cadherin6B during epithelial-to-mesenchymal transitions of the neural crest
    Lisa A Taneyhill
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Development 134:1481-90. 2007
    ..These results are the first to describe a direct target of Snail2 repression in vivo and in the context of the EMT that characterizes neural crest development...
  4. pmc Cadherin 6B induces BMP signaling and de-epithelialization during the epithelial mesenchymal transition of the neural crest
    Ki Sook Park
    Department of Cell Biology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    Development 137:2691-701. 2010
    ..of neural crest cells involves an epithelial-mesenchymal transition (EMT) associated with the restriction of cadherin 6B expression to the pre-migratory neural crest cells (PMNCCs), as well as a loss of N-cadherin expression...
  5. pmc Cadherin-6B stimulates an epithelial mesenchymal transition and the delamination of cells from the neural ectoderm via LIMK/cofilin mediated non-canonical BMP receptor signaling
    Ki Sook Park
    Department of Cell Biology, University of Virginia School of Medicine, PO Box 800732, Charlottesville, VA 22908, USA
    Dev Biol 366:232-43. 2012
    ..These findings suggest that the de-epithelialization step of the neural crest EMT by cadherin-6B/BMPRII involves regulation of actin dynamics via LIMK/cofilin...
  6. pmc Cadherin-6B is proteolytically processed during epithelial-to-mesenchymal transitions of the cranial neural crest
    Andrew T Schiffmacher
    Department of Animal and Avian Sciences, University of Maryland, College Park, MD 20742
    Mol Biol Cell 25:41-54. 2014
    ..Collectively these results suggest a dual mechanism for Cad6B proteolysis involving two ADAMs, along with γ-secretase, during cranial neural crest cell EMT. ..
  7. pmc Cadherin-6B is required for the generation of Islet-1-expressing dorsal interneurons
    Ki Sook Park
    East West Medical Research Institute, Kyung Hee University, Seoul 130 701, Republic of Korea College of Medicine, Kyung Hee University, Seoul 130 701, Republic of Korea Electronic address
    Biochem Biophys Res Commun 459:504-8. 2015
    ..Our results thus indicate that Cadherin-6B is necessary for the generation of Islet-1-positive dorsal interneurons, as well as the initiation of pre-migratory neural crest cell emigration. ..
  8. pmc Cadherin-6B undergoes macropinocytosis and clathrin-mediated endocytosis during cranial neural crest cell EMT
    Rangarajan Padmanabhan
    National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Cell Sci 128:1773-86. 2015
    ..Collectively, our findings reveal the significance of post-translational events in controlling cadherins during neural crest cell EMT and migration. ..
  9. pmc Cadherin-6B proteolysis promotes the neural crest cell epithelial-to-mesenchymal transition through transcriptional regulation
    Andrew T Schiffmacher
    Department of Animal and Avian Sciences, University of Maryland, College Park, MD 20742
    J Cell Biol 215:735-747. 2016
    ..Collectively, our data reveal how Cad6B proteolysis orchestrates multiple pro-EMT regulatory inputs, including CTF2-mediated up-regulation of the Cad6B repressor Snail2, to ensure proper cranial neural crest EMT...
  10. pmc Tetraspanin18 is a FoxD3-responsive antagonist of cranial neural crest epithelial-to-mesenchymal transition that maintains cadherin-6B protein
    Corinne L Fairchild
    Department of Genetics, Cell Biology, and Development, 6 160 Jackson Hall, 321 Church Street SE, University of Minnesota, Minneapolis, MN 55455, USA
    J Cell Sci 126:1464-76. 2013
    ..These results offer new insight into the molecular mechanisms of cranial neural crest EMT and expand our understanding of tetraspanin function relevant to metastasis...
  11. ncbi Selective synaptic cadherin expression by traced neurons of the chicken visual system
    D Heyers
    Institute of Anatomy, University of Duisburg Essen School of Medicine, D 45122 Essen, Germany
    Neuroscience 127:901-12. 2004
    ..Our findings support the idea that a cadherin-based adhesive mechanism can mediate synaptic specificity...
  12. doi Expression analysis of cadherins in the songbird brain: relationship to vocal system development
    Eiji Matsunaga
    Laboratory for Biolinguistics, RIKEN Brain Science Institute, Wako, Japan
    J Comp Neurol 508:329-42. 2008
    ..These patterns of song nuclei related expression suggest the possibility that cadherins are involved in the formation and maintenance of the song nuclei or neural pathways of the song system...
  13. pmc Cadherin-7 and cadherin-6B differentially regulate the growth, branching and guidance of cranial motor axons
    Sarah H Barnes
    MRC Centre for Developmental Neurobiology, 4th floor New Hunt s House, Kings College, Guy s Campus, London SE1 1UL, UK
    Development 137:805-14. 2010
    ..We also demonstrate that Cad6B functions via the phosphatidylinositol 3-kinase pathway. Together, these data show that Cad7 and Cad6B differentially regulate cranial motoneuron growth, branching and axon guidance...