unc-103

Summary

Gene Symbol: unc-103
Description: Protein UNC-103
Species: Caenorhabditis elegans

Top Publications

  1. ncbi Caenorhabditis elegans UNC-103 ERG-like potassium channel regulates contractile behaviors of sex muscles in males before and during mating
    L Rene Garcia
    Department of Biology, Texas A and M University, College Station, Texas 77843 3258, USA
    J Neurosci 23:2696-705. 2003
  2. pmc In vivo identification of genes that modify ether-a-go-go-related gene activity in Caenorhabditis elegans may also affect human cardiac arrhythmia
    Christina I Petersen
    Department of Anesthesiology and Division of Clinical Pharmacology, Vanderbilt University, Nashville, TN 37232, USA
    Proc Natl Acad Sci U S A 101:11773-8. 2004
  3. pmc Genetic screening in C. elegans identifies rho-GTPase activating protein 6 as novel HERG regulator
    Franck Potet
    Department of Anesthesiology, Vanderbilt University, Nashville, TN 37232, USA
    J Mol Cell Cardiol 46:257-67. 2009
  4. pmc Mutations with dominant effects on the behavior and morphology of the nematode Caenorhabditis elegans
    E C Park
    Genetics 113:821-52. 1986

Research Grants

Scientific Experts

  • LUIS R GARCIA
  • Christina I Petersen
  • Franck Potet
  • Jeffrey R Balser
  • Svetlana Z Stepanovic
  • Olivier Boutaud
  • Wen Shuai
  • Sabina Kupershmidt
  • David J Reiner
  • James H Thomas
  • Ping Yang
  • Dan M Roden
  • Kenshi Hayashi
  • Alfred L George
  • Toni R McFarland
  • E C Park
  • H R Horvitz

Detail Information

Publications4

  1. ncbi Caenorhabditis elegans UNC-103 ERG-like potassium channel regulates contractile behaviors of sex muscles in males before and during mating
    L Rene Garcia
    Department of Biology, Texas A and M University, College Station, Texas 77843 3258, USA
    J Neurosci 23:2696-705. 2003
    ..The premature prolonged contractions cause the spicules to extend from the male tail before the spicule tips penetrate the vulva. These observations demonstrate that unc-103 controls various aspects of spicule function...
  2. pmc In vivo identification of genes that modify ether-a-go-go-related gene activity in Caenorhabditis elegans may also affect human cardiac arrhythmia
    Christina I Petersen
    Department of Anesthesiology and Division of Clinical Pharmacology, Vanderbilt University, Nashville, TN 37232, USA
    Proc Natl Acad Sci U S A 101:11773-8. 2004
    ..Our studies demonstrate the feasibility of using C. elegans to assay and potentially identify aLQTS candidate genes...
  3. pmc Genetic screening in C. elegans identifies rho-GTPase activating protein 6 as novel HERG regulator
    Franck Potet
    Department of Anesthesiology, Vanderbilt University, Nashville, TN 37232, USA
    J Mol Cell Cardiol 46:257-67. 2009
    ..These data link a rhoGAP-activated PLC pathway to HERG membrane expression and implicate this family of proteins as candidate genes in disorders involving HERG...
  4. pmc Mutations with dominant effects on the behavior and morphology of the nematode Caenorhabditis elegans
    E C Park
    Genetics 113:821-52. 1986
    ..elegans would result in a nonmutant phenotype. Second, the dominant effects of mutations in nine of these ten genes are caused by novel gene functions, and in all nine cases the novel function is antagonized by the wild-type function...

Research Grants1

  1. Genetic Regulation of Mating Behavior in C. elegan Males
    Luis Garcia; Fiscal Year: 2009
    ..Additionally, this project will identify components of activating pathways that must be attenuated by unc-103 during periods between mating. ..