sas-4

Summary

Gene Symbol: sas-4
Description: Spindle assembly abnormal protein 4
Species: Caenorhabditis elegans

Top Publications

  1. ncbi SAS-4 is a C. elegans centriolar protein that controls centrosome size
    Matthew Kirkham
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany
    Cell 112:575-87. 2003
  2. ncbi SAS-4 is essential for centrosome duplication in C elegans and is recruited to daughter centrioles once per cell cycle
    Sebastian Leidel
    Swiss Institute for Experimental, Cancer Research ISREC, CH 1066 Epalinges, Lausanne, Switzerland
    Dev Cell 4:431-9. 2003
  3. ncbi Centriole assembly requires both centriolar and pericentriolar material proteins
    Alexander Dammermann
    Ludwig Institute for Cancer Research, Department of Cellular and Molecular Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Dev Cell 7:815-29. 2004
  4. ncbi SAS-6 defines a protein family required for centrosome duplication in C. elegans and in human cells
    Sebastian Leidel
    Swiss Institute for Experimental Cancer Research ISREC, CH 1066 Epalinges Lausanne, Switzerland
    Nat Cell Biol 7:115-25. 2005
  5. pmc The hydrolethalus syndrome protein HYLS-1 links core centriole structure to cilia formation
    Alexander Dammermann
    Ludwig Institute for Cancer Research, Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, California 92093, USA
    Genes Dev 23:2046-59. 2009
  6. pmc Protein phosphatase 2A-SUR-6/B55 regulates centriole duplication in C. elegans by controlling the levels of centriole assembly factors
    Mi Hye Song
    Laboratory of Biochemistry and Genetics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Dev Cell 20:563-71. 2011
  7. pmc Chromatin and RNAi factors protect the C. elegans germline against repetitive sequences
    Valérie J P Robert
    Hubrecht Laboratory, 3584 CT Utrecht, The Netherlands
    Genes Dev 19:782-7. 2005
  8. pmc SAS-4 is recruited to a dynamic structure in newly forming centrioles that is stabilized by the gamma-tubulin-mediated addition of centriolar microtubules
    Alexander Dammermann
    Department of Cellular and Molecular Medicine, Ludwig Institute for Cancer Research, University of California, San Diego, La Jolla, CA 92093, USA
    J Cell Biol 180:771-85. 2008

Scientific Experts

  • Alexander Dammermann
  • Mi Hye Song
  • Sebastian Leidel
  • Valérie J P Robert
  • PIERRE GONCZY
  • Matthew Kirkham
  • Lorenzo Cerutti
  • Ronald H A Plasterk
  • Marie Delattre
  • Titia Sijen
  • Josien van Wolfswinkel
  • Karine Baumer
  • Anthony A Hyman
  • Karen Oegema
  • Stephan Grill
  • Thomas Müller-Reichert

Detail Information

Publications8

  1. ncbi SAS-4 is a C. elegans centriolar protein that controls centrosome size
    Matthew Kirkham
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany
    Cell 112:575-87. 2003
    ..Thus, SAS-4 is a centriole-associated component whose amount dictates centrosome size. These results provide novel insight into the poorly understood role of centrioles as centrosomal organizers...
  2. ncbi SAS-4 is essential for centrosome duplication in C elegans and is recruited to daughter centrioles once per cell cycle
    Sebastian Leidel
    Swiss Institute for Experimental, Cancer Research ISREC, CH 1066 Epalinges, Lausanne, Switzerland
    Dev Cell 4:431-9. 2003
    ..Additional evidence indicates that SAS-4 is recruited to the daughter centriole or a closely associated structure. These findings identify SAS-4 recruitment as a key step in the centrosome duplication cycle...
  3. ncbi Centriole assembly requires both centriolar and pericentriolar material proteins
    Alexander Dammermann
    Ludwig Institute for Cancer Research, Department of Cellular and Molecular Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Dev Cell 7:815-29. 2004
    ..Thus, both centriolar and pericentriolar material proteins contribute to centriole assembly...
  4. ncbi SAS-6 defines a protein family required for centrosome duplication in C. elegans and in human cells
    Sebastian Leidel
    Swiss Institute for Experimental Cancer Research ISREC, CH 1066 Epalinges Lausanne, Switzerland
    Nat Cell Biol 7:115-25. 2005
    ..Therefore, HsSAS-6 is also required for centrosome duplication, indicating that the function of SAS-6-related proteins has been widely conserved during evolution...
  5. pmc The hydrolethalus syndrome protein HYLS-1 links core centriole structure to cilia formation
    Alexander Dammermann
    Ludwig Institute for Cancer Research, Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, California 92093, USA
    Genes Dev 23:2046-59. 2009
    ....
  6. pmc Protein phosphatase 2A-SUR-6/B55 regulates centriole duplication in C. elegans by controlling the levels of centriole assembly factors
    Mi Hye Song
    Laboratory of Biochemistry and Genetics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Dev Cell 20:563-71. 2011
    ..Together, our findings indicate that PP2A-SUR-6 promotes centriole assembly by protecting ZYG-1 and SAS-5 from degradation...
  7. pmc Chromatin and RNAi factors protect the C. elegans germline against repetitive sequences
    Valérie J P Robert
    Hubrecht Laboratory, 3584 CT Utrecht, The Netherlands
    Genes Dev 19:782-7. 2005
    ..Together with molecular data also presented in this study, these results suggest that in C. elegans repetitive sequences trigger transcriptional gene silencing using RNAi and chromatin factors...
  8. pmc SAS-4 is recruited to a dynamic structure in newly forming centrioles that is stabilized by the gamma-tubulin-mediated addition of centriolar microtubules
    Alexander Dammermann
    Department of Cellular and Molecular Medicine, Ludwig Institute for Cancer Research, University of California, San Diego, La Jolla, CA 92093, USA
    J Cell Biol 180:771-85. 2008
    ..Such a mechanism may help restrict new centriole assembly to the vicinity of preexisting parent centrioles that recruit PCM...