Genomes and Genes
Gene Symbol: sas-4
Description: Spindle assembly abnormal protein 4
Species: Caenorhabditis elegans
- SAS-4 is a C. elegans centriolar protein that controls centrosome sizeMatthew Kirkham
Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany
Cell 112:575-87. 2003..Thus, SAS-4 is a centriole-associated component whose amount dictates centrosome size. These results provide novel insight into the poorly understood role of centrioles as centrosomal organizers...
- SAS-4 is essential for centrosome duplication in C elegans and is recruited to daughter centrioles once per cell cycleSebastian Leidel
Swiss Institute for Experimental, Cancer Research ISREC, CH 1066 Epalinges, Lausanne, Switzerland
Dev Cell 4:431-9. 2003..Additional evidence indicates that SAS-4 is recruited to the daughter centriole or a closely associated structure. These findings identify SAS-4 recruitment as a key step in the centrosome duplication cycle...
- Centriole assembly requires both centriolar and pericentriolar material proteinsAlexander Dammermann
Ludwig Institute for Cancer Research, Department of Cellular and Molecular Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
Dev Cell 7:815-29. 2004..Thus, both centriolar and pericentriolar material proteins contribute to centriole assembly...
- SAS-6 defines a protein family required for centrosome duplication in C. elegans and in human cellsSebastian Leidel
Swiss Institute for Experimental Cancer Research ISREC, CH 1066 Epalinges Lausanne, Switzerland
Nat Cell Biol 7:115-25. 2005..Therefore, HsSAS-6 is also required for centrosome duplication, indicating that the function of SAS-6-related proteins has been widely conserved during evolution...
- The hydrolethalus syndrome protein HYLS-1 links core centriole structure to cilia formationAlexander Dammermann
Ludwig Institute for Cancer Research, Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, California 92093, USA
Genes Dev 23:2046-59. 2009....
- Protein phosphatase 2A-SUR-6/B55 regulates centriole duplication in C. elegans by controlling the levels of centriole assembly factorsMi Hye Song
Laboratory of Biochemistry and Genetics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Dev Cell 20:563-71. 2011..Together, our findings indicate that PP2A-SUR-6 promotes centriole assembly by protecting ZYG-1 and SAS-5 from degradation...
- Chromatin and RNAi factors protect the C. elegans germline against repetitive sequencesValérie J P Robert
Hubrecht Laboratory, 3584 CT Utrecht, The Netherlands
Genes Dev 19:782-7. 2005..Together with molecular data also presented in this study, these results suggest that in C. elegans repetitive sequences trigger transcriptional gene silencing using RNAi and chromatin factors...
- SAS-4 is recruited to a dynamic structure in newly forming centrioles that is stabilized by the gamma-tubulin-mediated addition of centriolar microtubulesAlexander Dammermann
Department of Cellular and Molecular Medicine, Ludwig Institute for Cancer Research, University of California, San Diego, La Jolla, CA 92093, USA
J Cell Biol 180:771-85. 2008..Such a mechanism may help restrict new centriole assembly to the vicinity of preexisting parent centrioles that recruit PCM...