Gene Symbol: rhgf-1
Description: RHo Guanine nucleotide exchange Factor
Species: Caenorhabditis elegans
- RHGF-1/PDZ-RhoGEF and retrograde DLK-1 signaling drive neuronal remodeling on microtubule disassemblyChun Hao Chen
Institute of Molecular Medicine, College of Medicine, and
Proc Natl Acad Sci U S A 111:16568-73. 2014..Our data represent a neuronal remodeling paradigm during development that reshapes the neural circuit by the coordinated removal of the dysfunctional synaptic branch compartment and compensatory extension of the primary neurite. ..
- The Rac GTP exchange factor TIAM-1 acts with CDC-42 and the guidance receptor UNC-40/DCC in neuronal protrusion and axon guidanceRafael S Demarco
Programs in Genetics and Molecular, Cellular, and Developmental Biology, Department of Molecular Biosciences, University of Kansas, Lawrence, Kansas, United States of America
PLoS Genet 8:e1002665. 2012..Our results also suggest that Rac GTPase activity is controlled by different GEFs in distinct axon guidance contexts, explaining how Rac GTPases can specifically control multiple cellular functions...
- Identification and molecular characterization of the G alpha12-Rho guanine nucleotide exchange factor pathway in Caenorhabditis elegansDouglas M Yau
Department of Pharmacology, University of Illinois, Chicago, IL 60612, USA
Proc Natl Acad Sci U S A 100:14748-53. 2003..Thus, the G alpha 12/13-RhoGEF pathway is likely to be involved in embryonic development and neuronal function in C. elegans...
- The Galpha12-RGS RhoGEF-RhoA signalling pathway regulates neurotransmitter release in C. elegansEmma Hiley
MRC Cell Biology Unit, MRC Laboratory for Molecular Cell Biology, University College London, Gower Sttreet, London, UK
EMBO J 25:5884-95. 2006..elegans neurons...