rhgf-1

Summary

Gene Symbol: rhgf-1
Description: RHo Guanine nucleotide exchange Factor
Species: Caenorhabditis elegans

Top Publications

  1. pmc RHGF-1/PDZ-RhoGEF and retrograde DLK-1 signaling drive neuronal remodeling on microtubule disassembly
    Chun Hao Chen
    Institute of Molecular Medicine, College of Medicine, and
    Proc Natl Acad Sci U S A 111:16568-73. 2014
  2. pmc The Rac GTP exchange factor TIAM-1 acts with CDC-42 and the guidance receptor UNC-40/DCC in neuronal protrusion and axon guidance
    Rafael S Demarco
    Programs in Genetics and Molecular, Cellular, and Developmental Biology, Department of Molecular Biosciences, University of Kansas, Lawrence, Kansas, United States of America
    PLoS Genet 8:e1002665. 2012
  3. pmc Identification and molecular characterization of the G alpha12-Rho guanine nucleotide exchange factor pathway in Caenorhabditis elegans
    Douglas M Yau
    Department of Pharmacology, University of Illinois, Chicago, IL 60612, USA
    Proc Natl Acad Sci U S A 100:14748-53. 2003
  4. pmc The Galpha12-RGS RhoGEF-RhoA signalling pathway regulates neurotransmitter release in C. elegans
    Emma Hiley
    MRC Cell Biology Unit, MRC Laboratory for Molecular Cell Biology, University College London, Gower Sttreet, London, UK
    EMBO J 25:5884-95. 2006

Detail Information

Publications4

  1. pmc RHGF-1/PDZ-RhoGEF and retrograde DLK-1 signaling drive neuronal remodeling on microtubule disassembly
    Chun Hao Chen
    Institute of Molecular Medicine, College of Medicine, and
    Proc Natl Acad Sci U S A 111:16568-73. 2014
    ..Our data represent a neuronal remodeling paradigm during development that reshapes the neural circuit by the coordinated removal of the dysfunctional synaptic branch compartment and compensatory extension of the primary neurite. ..
  2. pmc The Rac GTP exchange factor TIAM-1 acts with CDC-42 and the guidance receptor UNC-40/DCC in neuronal protrusion and axon guidance
    Rafael S Demarco
    Programs in Genetics and Molecular, Cellular, and Developmental Biology, Department of Molecular Biosciences, University of Kansas, Lawrence, Kansas, United States of America
    PLoS Genet 8:e1002665. 2012
    ..Our results also suggest that Rac GTPase activity is controlled by different GEFs in distinct axon guidance contexts, explaining how Rac GTPases can specifically control multiple cellular functions...
  3. pmc Identification and molecular characterization of the G alpha12-Rho guanine nucleotide exchange factor pathway in Caenorhabditis elegans
    Douglas M Yau
    Department of Pharmacology, University of Illinois, Chicago, IL 60612, USA
    Proc Natl Acad Sci U S A 100:14748-53. 2003
    ..Thus, the G alpha 12/13-RhoGEF pathway is likely to be involved in embryonic development and neuronal function in C. elegans...
  4. pmc The Galpha12-RGS RhoGEF-RhoA signalling pathway regulates neurotransmitter release in C. elegans
    Emma Hiley
    MRC Cell Biology Unit, MRC Laboratory for Molecular Cell Biology, University College London, Gower Sttreet, London, UK
    EMBO J 25:5884-95. 2006
    ..elegans neurons...