Gene Symbol: gmhA
Description: phosphoheptose isomerase
Species: Burkholderia pseudomallei K96243
- Novel pathways for biosynthesis of nucleotide-activated glycero-manno-heptose precursors of bacterial glycoproteins and cell surface polysaccharidesMiguel A Valvano
Department of Microbiology and Immunology and Medicine, University of Western Ontario, London, Ontario, N6A 5C1, Canada
Microbiology 148:1979-89. 2002
- Detection of bacterial virulence genes by subtractive hybridization: identification of capsular polysaccharide of Burkholderia pseudomallei as a major virulence determinantS L Reckseidler
Department of Microbiology and Infectious Diseases, University of Calgary Health Sciences Center, Calgary, Alberta, Canada T2N 4N1
Infect Immun 69:34-44. 2001..Thus, the combination of PCR-based subtractive hybridization, insertional inactivation, and animal virulence studies has facilitated the identification of an important virulence determinant in B. pseudomallei...
- A preliminary X-ray study of sedoheptulose-7-phosphate isomerase from Burkholderia pseudomalleiMi Sun Kim
Ewha Womans University, Seoul, Republic of Korea
Acta Crystallogr Sect F Struct Biol Cryst Commun 65:1110-2. 2009Sedoheptulose-7-phosphate isomerase (GmhA) converts d-sedoheptulose 7-phosphate to d,d-heptose 7-phosphate. This is the first step in the biosynthesis pathway of NDP-heptose, which is responsible for the pleiotropic phenotype...
- The structure of sedoheptulose-7-phosphate isomerase from Burkholderia pseudomallei reveals a zinc binding site at the heart of the active siteNicholas J Harmer
School of Biosciences, University of Exeter, Geoffrey Pope Building, Stocker Road, Exeter EX4 4QD, UK
J Mol Biol 400:379-92. 2010..The best characterized biosynthetic enzyme is GmhA, which catalyzes the conversion of sedoheptulose-7-phosphate into D-glycero-D-manno-heptopyranose-7-phosphate, the ..