cspA

Summary

Gene Symbol: cspA
Description: complement regulator-acquiring surface protein 1
Species: Borrelia burgdorferi B31

Top Publications

  1. pmc Further structural insights into the binding of complement factor H by complement regulator-acquiring surface protein 1 (CspA) of Borrelia burgdorferi
    Joseph J E Caesar
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, England
    Acta Crystallogr Sect F Struct Biol Cryst Commun 69:629-33. 2013
  2. pmc CspA from Borrelia burgdorferi inhibits the terminal complement pathway
    Teresia Hallström
    Department of Infection Biology, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knöll Institute, Jena, Germany
    MBio 4:. 2013
  3. ncbi Complement resistance of Borrelia burgdorferi correlates with the expression of BbCRASP-1, a novel linear plasmid-encoded surface protein that interacts with human factor H and FHL-1 and is unrelated to Erp proteins
    Peter Kraiczy
    Institute of Medical Microbiology, University Hospital of Frankfurt, Paul Ehrlich Strasse 40, D 60596 Frankfurt, Germany
    J Biol Chem 279:2421-9. 2004
  4. ncbi A novel fold for the factor H-binding protein BbCRASP-1 of Borrelia burgdorferi
    Frank S Cordes
    Laboratory of Molecular Biophysics, Department of Biochemistry, South Parks Road, Oxford, UK
    Nat Struct Mol Biol 12:276-7. 2005
  5. ncbi Artificial-infection protocols allow immunodetection of novel Borrelia burgdorferi antigens suitable as vaccine candidates against Lyme disease
    Reinhard Wallich
    Institut fur Immunologie, Universitatsklinikum Heidelberg, Heidelberg, Germany
    Eur J Immunol 33:708-19. 2003
  6. ncbi Crystallization and preliminary crystallographic analysis of BbCRASP-1, a complement regulator-acquiring surface protein of Borrelia burgdorferi
    Frank S Cordes
    Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, England
    Acta Crystallogr D Biol Crystallogr 60:929-32. 2004
  7. pmc Putative coiled-coil structural elements of the BBA68 protein of Lyme disease spirochetes are required for formation of its factor H binding site
    John V McDowell
    Department of Microbiology and Immunology, Medical College of Virginia Commonwealth University, Richmond, VA 23298, USA
    J Bacteriol 187:1317-23. 2005

Scientific Experts

  • P Kraiczy
  • Reinhard Wallich
  • Peter F Zipfel
  • Frank S Cordes
  • Susan M Lea
  • Christine Skerka
  • Teresia Hallström
  • Joseph J E Caesar
  • Markus M Simon
  • John V McDowell
  • Pietro Roversi
  • Volker Brade
  • Oliver Jahraus
  • Corinna Siegel
  • Matthias Morgelin
  • Russell Wallis
  • Richard T Marconi
  • Elizabeth A Rogers
  • Matthew E Harlin
  • Peter Zipfel
  • Edward D Lowe
  • Michael Kirschfink
  • Thomas Stehle
  • Lise Gern
  • Christiane Brenner
  • Thi Thanh Thao Tran
  • Heidelore Hofmann

Detail Information

Publications7

  1. pmc Further structural insights into the binding of complement factor H by complement regulator-acquiring surface protein 1 (CspA) of Borrelia burgdorferi
    Joseph J E Caesar
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, England
    Acta Crystallogr Sect F Struct Biol Cryst Commun 69:629-33. 2013
    ..mediated by a family of complement regulator-acquiring surface proteins (CRASPs), of which the atomic structure of CspA (BbCRASP-1) is known and shows the formation of a homodimeric species which is required for binding...
  2. pmc CspA from Borrelia burgdorferi inhibits the terminal complement pathway
    Teresia Hallström
    Department of Infection Biology, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knöll Institute, Jena, Germany
    MBio 4:. 2013
    ..These Gram-negative spirochetes use CspA (CRASP-1) and four additional immune evasion proteins to bind combinations of human plasma regulators, including ..
  3. ncbi Complement resistance of Borrelia burgdorferi correlates with the expression of BbCRASP-1, a novel linear plasmid-encoded surface protein that interacts with human factor H and FHL-1 and is unrelated to Erp proteins
    Peter Kraiczy
    Institute of Medical Microbiology, University Hospital of Frankfurt, Paul Ehrlich Strasse 40, D 60596 Frankfurt, Germany
    J Biol Chem 279:2421-9. 2004
    ..is the key molecule of the complement resistance of spirochetes, and (iii). is distinct from the Erp protein family. Thus, BbCRASP-1 most likely contributes to persistence of B. burgdorferi and to pathogenesis of Lyme disease...
  4. ncbi A novel fold for the factor H-binding protein BbCRASP-1 of Borrelia burgdorferi
    Frank S Cordes
    Laboratory of Molecular Biophysics, Department of Biochemistry, South Parks Road, Oxford, UK
    Nat Struct Mol Biol 12:276-7. 2005
    ..Here we report the atomic structure for the key FHL-1- and FH-binding protein BbCRASP-1 and reveal a homodimer that presents a novel target for drug design...
  5. ncbi Artificial-infection protocols allow immunodetection of novel Borrelia burgdorferi antigens suitable as vaccine candidates against Lyme disease
    Reinhard Wallich
    Institut fur Immunologie, Universitatsklinikum Heidelberg, Heidelberg, Germany
    Eur J Immunol 33:708-19. 2003
    ..These findings suggest that all three recombinant antigens represent potential candidates for a "second generation" vaccine to prevent and/or cure Lyme disease...
  6. ncbi Crystallization and preliminary crystallographic analysis of BbCRASP-1, a complement regulator-acquiring surface protein of Borrelia burgdorferi
    Frank S Cordes
    Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, England
    Acta Crystallogr D Biol Crystallogr 60:929-32. 2004
    ..2 A resolution have been collected. The selenium substructure has been solved and initial phases have been refined to 3.0 A by density-modification methods. Model building and refinement are under way...
  7. pmc Putative coiled-coil structural elements of the BBA68 protein of Lyme disease spirochetes are required for formation of its factor H binding site
    John V McDowell
    Department of Microbiology and Immunology, Medical College of Virginia Commonwealth University, Richmond, VA 23298, USA
    J Bacteriol 187:1317-23. 2005
    ..These analyses revealed that the factor H binding site is discontinuous and provide strong evidence that coiled-coil structural elements are involved in the formation of the binding site...