AFUA_5G09360

Summary

Gene Symbol: AFUA_5G09360
Description: calcineurin catalytic subunit CnaA
Alias: Afu5g09360
Species: Aspergillus fumigatus Af293

Top Publications

  1. pmc Calcineurin controls growth, morphology, and pathogenicity in Aspergillus fumigatus
    William J Steinbach
    Department of Pediatrics, Division of Pediatric Infectious Diseases, Box 3499, Duke University Medical Center, Durham, North Carolina 27710, USA
    Eukaryot Cell 5:1091-103. 2006
  2. pmc Calcineurin localizes to the hyphal septum in Aspergillus fumigatus: implications for septum formation and conidiophore development
    Praveen Rao Juvvadi
    Department of Pediatrics, Duke University Medical Center, Durham, NC 27710, USA
    Eukaryot Cell 7:1606-10. 2008
  3. pmc Localization and activity of the calcineurin catalytic and regulatory subunit complex at the septum is essential for hyphal elongation and proper septation in Aspergillus fumigatus
    Praveen Rao Juvvadi
    Department of Pediatrics, Division of Pediatric Infectious Diseases, Duke University Medical Center, Durham, NC, USA
    Mol Microbiol 82:1235-59. 2011
  4. pmc Phosphorylation of Calcineurin at a novel serine-proline rich region orchestrates hyphal growth and virulence in Aspergillus fumigatus
    Praveen R Juvvadi
    Department of Pediatrics, Division of Pediatric Infectious Diseases, Duke University Medical Center, Durham, North Carolina, United States of America
    PLoS Pathog 9:e1003564. 2013
  5. pmc Novel motif in calcineurin catalytic subunit is required for septal localization of calcineurin in Aspergillus fumigatus
    Praveen R Juvvadi
    Division of Pediatric Infectious Diseases, Department of Pediatrics, Duke University Medical Center, Durham, NC, USA
    FEBS Lett 590:501-8. 2016
  6. doi Aspergillus fumigatus calcineurin interacts with a nucleoside diphosphate kinase
    Taísa Magnani Dinamarco
    Faculdade de Filosofia, Ciencias e Letras de Ribeirao Preto, Universidade de Sao Paulo, Sao Paulo, Brazil
    Microbes Infect 14:922-9. 2012
  7. pmc Calcineurin target CrzA regulates conidial germination, hyphal growth, and pathogenesis of Aspergillus fumigatus
    Robert A Cramer
    Duke University Medical Center, Box 3499, Pediatric Infectious Diseases, Durham, NC 27710, USA
    Eukaryot Cell 7:1085-97. 2008
  8. doi Calcineurin-dependent galactomannan release in Aspergillus fumigatus
    M A S H Mennink-Kersten
    Department of Medical Microbiology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Eur J Clin Microbiol Infect Dis 30:551-3. 2011

Research Grants

  1. Calcineurin and Aspergillus fumigatus Pathogenesis
    WILLIAM STEINBACH; Fiscal Year: 2008

Scientific Experts

  • W J Steinbach
  • Praveen R Juvvadi
  • Praveen Rao Juvvadi
  • Jarrod R Fortwendel
  • Taísa Magnani Dinamarco
  • M A S H Mennink-Kersten
  • Yohannes G Asfaw
  • Robert A Cramer
  • Joseph Heitman
  • Nadthanan Pinchai
  • B Zachary Perfect
  • Charles W Pemble
  • Yan Ma
  • M Arthur Moseley
  • Michael A Hast
  • Erik J Soderblom
  • Erik C Cook
  • Frederic Lamoth
  • Trevor P Creamer
  • Christopher Gehrke
  • Ricardo Sergio Couto de Almeida
  • Neil Andrew Brown
  • Marcela Savoldi
  • Patrícia Alves de Castro
  • Maria Helena de Souza Goldman
  • Gustavo Henrique Goldman
  • Kimberlie A Burns
  • D Ruegebrink
  • Scott H Randell
  • Luise E Rogg
  • P E Verweij
  • David S Perlin
  • Steven Park
  • John R Perfect

Detail Information

Publications8

  1. pmc Calcineurin controls growth, morphology, and pathogenicity in Aspergillus fumigatus
    William J Steinbach
    Department of Pediatrics, Division of Pediatric Infectious Diseases, Box 3499, Duke University Medical Center, Durham, North Carolina 27710, USA
    Eukaryot Cell 5:1091-103. 2006
    ..Our findings reveal that calcineurin appears to play a globally conserved role in the virulence of several pathogenic fungi and yet plays specialized roles in each and can be an excellent target for therapeutic intervention...
  2. pmc Calcineurin localizes to the hyphal septum in Aspergillus fumigatus: implications for septum formation and conidiophore development
    Praveen Rao Juvvadi
    Department of Pediatrics, Duke University Medical Center, Durham, NC 27710, USA
    Eukaryot Cell 7:1606-10. 2008
    ..This is the first study to implicate calcineurin in septum formation and conidiophore development of a filamentous fungus...
  3. pmc Localization and activity of the calcineurin catalytic and regulatory subunit complex at the septum is essential for hyphal elongation and proper septation in Aspergillus fumigatus
    Praveen Rao Juvvadi
    Department of Pediatrics, Division of Pediatric Infectious Diseases, Duke University Medical Center, Durham, NC, USA
    Mol Microbiol 82:1235-59. 2011
    ..These findings confirm a cooperative role for the calcineurin complex in regulating hyphal growth and septation...
  4. pmc Phosphorylation of Calcineurin at a novel serine-proline rich region orchestrates hyphal growth and virulence in Aspergillus fumigatus
    Praveen R Juvvadi
    Department of Pediatrics, Division of Pediatric Infectious Diseases, Duke University Medical Center, Durham, North Carolina, United States of America
    PLoS Pathog 9:e1003564. 2013
    ..These findings suggest the possibility of harnessing this unique SPRR for innovative antifungal drug design to combat invasive aspergillosis. ..
  5. pmc Novel motif in calcineurin catalytic subunit is required for septal localization of calcineurin in Aspergillus fumigatus
    Praveen R Juvvadi
    Division of Pediatric Infectious Diseases, Department of Pediatrics, Duke University Medical Center, Durham, NC, USA
    FEBS Lett 590:501-8. 2016
    ....
  6. doi Aspergillus fumigatus calcineurin interacts with a nucleoside diphosphate kinase
    Taísa Magnani Dinamarco
    Faculdade de Filosofia, Ciencias e Letras de Ribeirao Preto, Universidade de Sao Paulo, Sao Paulo, Brazil
    Microbes Infect 14:922-9. 2012
    ..The SwoH(V83F) mutation did not cause a loss in virulence in the Galleria mellonella infection model. Taken together these results imply that CalA interacts with SwoH...
  7. pmc Calcineurin target CrzA regulates conidial germination, hyphal growth, and pathogenesis of Aspergillus fumigatus
    Robert A Cramer
    Duke University Medical Center, Box 3499, Pediatric Infectious Diseases, Durham, NC 27710, USA
    Eukaryot Cell 7:1085-97. 2008
    ..In addition, the importance of CrzA to the production of disease is critical, and thus CrzA is an attractive fungus-specific antifungal target for the treatment of invasive aspergillosis...
  8. doi Calcineurin-dependent galactomannan release in Aspergillus fumigatus
    M A S H Mennink-Kersten
    Department of Medical Microbiology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Eur J Clin Microbiol Infect Dis 30:551-3. 2011
    ....

Research Grants1

  1. Calcineurin and Aspergillus fumigatus Pathogenesis
    WILLIAM STEINBACH; Fiscal Year: 2008
    ..I will also test the non-immunosuppressive calcineurin inhibitor analogs to decrease the total level of immunosuppression and therefore increase the overall antifungal efficacy of exploiting the calcineurin pathway. ..