Ling Zheng

Summary

Publications

  1. doi request reprint Ursolic acid inhibits the development of nonalcoholic fatty liver disease by attenuating endoplasmic reticulum stress
    Jian Shuang Li
    College of Life Sciences, Wuhan University, Wuhan, Hubei 430072, P R China
    Food Funct 6:1643-51. 2015
  2. pmc Apelin inhibits the development of diabetic nephropathy by regulating histone acetylation in Akita mouse
    Hong Chen
    College of Life Sciences, Wuhan University, Wuhan 430072, China Kun Huang Tongji School of Pharmacy, Huazhong University of Science and Technology, Wuhan 430030, China Email
    J Physiol 592:505-21. 2014
  3. pmc Pharmacologic intervention targeting glycolytic-related pathways protects against retinal injury due to ischemia and reperfusion
    Ling Zheng
    College of Life Sciences, Wuhan University, Wuhan, PR China
    Proteomics 9:1869-82. 2009
  4. doi request reprint Salvianolic acid B inhibits the amyloid formation of human islet amyloid polypeptide and protects pancreatic beta-cells against cytotoxicity
    Biao Cheng
    Department of Bio pharmaceutics, Tongji School of Pharmacy, Huazhong University of Science and Technology, Wuhan, Hubei, People s Republic of China
    Proteins 81:613-21. 2013
  5. doi request reprint The effect of exposing a critical hydrophobic patch on amyloidogenicity and fibril structure of insulin
    Yang Li
    Tongji School of Pharmacy, Huazhong University of Science and Technology, Wuhan, Hubei 430030, PR China
    Biochem Biophys Res Commun 440:56-61. 2013
  6. pmc Bisphenol A accelerates toxic amyloid formation of human islet amyloid polypeptide: a possible link between bisphenol A exposure and type 2 diabetes
    Hao Gong
    Tongji School of Pharmacy, Huazhong University of Science and Technology, Wuhan, Hubei, People s Republic of China
    PLoS ONE 8:e54198. 2013
  7. doi request reprint Proanthocyanidins are the major anti-diabetic components of cinnamon water extract
    Lihua Jiao
    Tongji School of Pharmacy, Huazhong University of Science and Technology, Wuhan 430030, PR China
    Food Chem Toxicol 56:398-405. 2013
  8. doi request reprint How the imidazole ring modulates amyloid formation of islet amyloid polypeptide: A chemical modification study
    Xin Zhang
    Tongji School of Pharmacy, Huazhong University of Science and Technology, Wuhan 430030, China
    Biochim Biophys Acta 1860:719-26. 2016
  9. doi request reprint Endoplasmic reticulum stress in retinal vascular degeneration: protective role of resveratrol
    Chuanzhou Li
    College of Life Sciences, Wuhan University, Wuhan, China
    Invest Ophthalmol Vis Sci 53:3241-9. 2012
  10. doi request reprint Restoration of Opa1-long isoform inhibits retinal injury-induced neurodegeneration
    Yue Sun
    College of Life Sciences, Wuhan University, Wuhan, Hubei, 430072, People s Republic of China
    J Mol Med (Berl) 94:335-46. 2016

Collaborators

Detail Information

Publications32

  1. doi request reprint Ursolic acid inhibits the development of nonalcoholic fatty liver disease by attenuating endoplasmic reticulum stress
    Jian Shuang Li
    College of Life Sciences, Wuhan University, Wuhan, Hubei 430072, P R China
    Food Funct 6:1643-51. 2015
    ..Together, UA may be further considered as a natural compound for NAFLD treatment. ..
  2. pmc Apelin inhibits the development of diabetic nephropathy by regulating histone acetylation in Akita mouse
    Hong Chen
    College of Life Sciences, Wuhan University, Wuhan 430072, China Kun Huang Tongji School of Pharmacy, Huazhong University of Science and Technology, Wuhan 430030, China Email
    J Physiol 592:505-21. 2014
    ..Thus, apelin-13 may be a novel therapeutic candidate for treatment of diabetic nephropathy via regulation of histone acetylation. ..
  3. pmc Pharmacologic intervention targeting glycolytic-related pathways protects against retinal injury due to ischemia and reperfusion
    Ling Zheng
    College of Life Sciences, Wuhan University, Wuhan, PR China
    Proteomics 9:1869-82. 2009
    ..Select glycolytic enzymes may provide novel therapeutic targets for inhibiting the neuronal and vascular degeneration after retinal I/R injury...
  4. doi request reprint Salvianolic acid B inhibits the amyloid formation of human islet amyloid polypeptide and protects pancreatic beta-cells against cytotoxicity
    Biao Cheng
    Department of Bio pharmaceutics, Tongji School of Pharmacy, Huazhong University of Science and Technology, Wuhan, Hubei, People s Republic of China
    Proteins 81:613-21. 2013
    ..These results provide evidence that SalB may further be studied on the possible pharmacological treatment for T2DM...
  5. doi request reprint The effect of exposing a critical hydrophobic patch on amyloidogenicity and fibril structure of insulin
    Yang Li
    Tongji School of Pharmacy, Huazhong University of Science and Technology, Wuhan, Hubei 430030, PR China
    Biochem Biophys Res Commun 440:56-61. 2013
    ..In conclusion, exposing the hydrophobic core of insulin can induce the increase of amyloidogenicity and formation of higher-order polymerized fibrils, which is less toxic to membranes...
  6. pmc Bisphenol A accelerates toxic amyloid formation of human islet amyloid polypeptide: a possible link between bisphenol A exposure and type 2 diabetes
    Hao Gong
    Tongji School of Pharmacy, Huazhong University of Science and Technology, Wuhan, Hubei, People s Republic of China
    PLoS ONE 8:e54198. 2013
    ..Taken together, our results suggest that BPA exposure increased T2DM risk may involve the exacerbated toxic aggregation of hIAPP...
  7. doi request reprint Proanthocyanidins are the major anti-diabetic components of cinnamon water extract
    Lihua Jiao
    Tongji School of Pharmacy, Huazhong University of Science and Technology, Wuhan 430030, PR China
    Food Chem Toxicol 56:398-405. 2013
    ..Together, these results suggest a possible way by which cinnamon shows beneficial effects on T2DM, and indicate a potential pharmacological usage of proanthocyanidins as an anti-diabetic drug candidate...
  8. doi request reprint How the imidazole ring modulates amyloid formation of islet amyloid polypeptide: A chemical modification study
    Xin Zhang
    Tongji School of Pharmacy, Huazhong University of Science and Technology, Wuhan 430030, China
    Biochim Biophys Acta 1860:719-26. 2016
    ..A number of studies have been focused on His(18), the only histidine of hIAPP, whose imidazole ring and the protonation state might impact hIAPP amyloid formation, but the exact mechanism remains unclear...
  9. doi request reprint Endoplasmic reticulum stress in retinal vascular degeneration: protective role of resveratrol
    Chuanzhou Li
    College of Life Sciences, Wuhan University, Wuhan, China
    Invest Ophthalmol Vis Sci 53:3241-9. 2012
    ..We investigated the possible role of ER stress in retinal vascular degeneration in vivo, and the effects of resveratrol on tunicamycin and ischemia and reperfusion (I/R)-induced retinal vascular degeneration...
  10. doi request reprint Restoration of Opa1-long isoform inhibits retinal injury-induced neurodegeneration
    Yue Sun
    College of Life Sciences, Wuhan University, Wuhan, Hubei, 430072, People s Republic of China
    J Mol Med (Berl) 94:335-46. 2016
    ..Opa1-ΔS1 overexpression inhibits H/R-induced mitochondria morphology change. Opa1-ΔS1 and genipin inhibit retinal I/R injury-induced necroptosis. Opa1-ΔS1 and genipin inhibit retinal I/R injury-induced neurodegeneration...
  11. doi request reprint Dissecting the role of disulfide bonds on the amyloid formation of insulin
    Yang Li
    Tongji School of Pharmacy, Huazhong University of Science and Technology, Wuhan 430030, PR China
    Biochem Biophys Res Commun 423:373-8. 2012
    ....
  12. doi request reprint Coffee components inhibit amyloid formation of human islet amyloid polypeptide in vitro: possible link between coffee consumption and diabetes mellitus
    Biao Cheng
    Tongji School of Pharmacy, Huazhong University of Science and Technology, Wuhan, Hubei 430030, People s Republic of China
    J Agric Food Chem 59:13147-55. 2011
    ..These findings suggest that the beneficial effects of coffee consumption on T2DM may be partly due to the ability of the major coffee components and metabolites to inhibit the toxic aggregation of hIAPP...
  13. doi request reprint Curcumin, a potential therapeutic candidate for retinal diseases
    Lei Lei Wang
    College of Life Sciences, Wuhan University, Wuhan, PR China
    Mol Nutr Food Res 57:1557-68. 2013
    ....
  14. doi request reprint Apelin alleviates diabetes-associated endoplasmic reticulum stress in the pancreas of Akita mice
    Hong Chen
    Tongji School of Pharmacy, Huazhong University of Science and Technology, Wuhan 430030, China
    Peptides 32:1634-9. 2011
    ..Taken together, these results suggest a novel physiological role of apelin in alleviating ER stress in the pancreas of type 1 diabetes...
  15. doi request reprint Silibinin inhibits the toxic aggregation of human islet amyloid polypeptide
    Biao Cheng
    Tongji School of Pharmacy, Huazhong University of Science and Technology, Wuhan, Hubei, PR China
    Biochem Biophys Res Commun 419:495-9. 2012
    ....
  16. pmc Effects of several quinones on insulin aggregation
    Hao Gong
    Tongji School of Pharmacy, Huazhong University of Science and Technology, Wuhan, Hubei, P R China430030
    Sci Rep 4:5648. 2014
    ..The results suggest a potential action of native anthraquinone derivatives in preventing protein misfolding diseases, the quinone skeleton may thus be further explored for designing effective anti-amyloidosis compounds. ..
  17. doi request reprint Inhibiting toxic aggregation of amyloidogenic proteins: a therapeutic strategy for protein misfolding diseases
    Biao Cheng
    Tongji School of Pharmacy, Huazhong University of Science and Technology, Wuhan, People s Republic of China
    Biochim Biophys Acta 1830:4860-71. 2013
    ..Novel drug candidates targeting self-assembled amyloidogenic proteins represent a potential therapeutic approach for protein misfolding diseases...
  18. doi request reprint Accumulation of endoplasmic reticulum stress and lipogenesis in the liver through generational effects of high fat diets
    Jiong Li
    College of Life Sciences, Wuhan University, Wuhan, Hubei, PR China
    J Hepatol 56:900-7. 2012
    ..In the present study, the aforementioned feed-forward circle was investigated in mice by employing continuous HFD feeding for three generations...
  19. doi request reprint MPHOSPH1: a potential therapeutic target for hepatocellular carcinoma
    Xinran Liu
    Tongji School of Pharmacy, Huazhong University of Science and Technology, Wuhan, China Centre for Biomedicine Research, Wuhan Institute of Biotechnology, Wuhan, China
    Cancer Res 74:6623-34. 2014
    ..Furthermore, Ad-shMPP1 tail vein injection suppressed formation of orthotopic liver nodules and prevented hepatic dysfunction. Taken together, our results identify MPHOSPH1 as an oncogenic driver and candidate therapeutic target in HCC...
  20. doi request reprint Effect of Liraglutide on endoplasmic reticulum stress in diabetes
    Linlin Zhao
    Tongji School of Pharmacy, Huazhong University of Science and Technology, Wuhan 430030, PR China
    Biochem Biophys Res Commun 441:133-8. 2013
    ..Taken together, our findings suggest that Liraglutide may protect pancreatic cells from ER stress and its related cell death. ..
  21. doi request reprint Inhibition of poly(ADP-ribose) polymerase inhibits ischemia/reperfusion induced neurodegeneration in retina via suppression of endoplasmic reticulum stress
    Chuanzhou Li
    College of Life Sciences, Wuhan University, Wuhan 430072, China
    Biochem Biophys Res Commun 423:276-81. 2012
    ..These results provide evidence that GPI 15427 inhibits retinal I/R injury at least in part via inhibition of endoplasmic reticulum stress...
  22. doi request reprint Apelin protects against acute renal injury by inhibiting TGF-β1
    Hong Chen
    Tongji School of Pharmacy, Huazhong University of Science and Technology, Wuhan, China, 430030 Centre for Biomedicine Research, Wuhan Institute of Biotechnology, Wuhan, China, 430074
    Biochim Biophys Acta 1852:1278-87. 2015
    ..The present study therefore suggests apelin-13 may be a therapeutic candidate for treating acute kidney injury...
  23. doi request reprint Elevated histone acetylations in Müller cells contribute to inflammation: a novel inhibitory effect of minocycline
    Lei Lei Wang
    College of Life Sciences, Wuhan University, Wuhan 430072, People s Republic of China
    Glia 60:1896-905. 2012
    ..Inhibition of histone acetylation by minocycline is a novel function that may contribute to its beneficial effects on DR...
  24. doi request reprint Inhibitory effect of leonurine on the formation of advanced glycation end products
    Lianqi Huang
    Tongji School of Pharmacy, Huazhong University of Science and Technology, Wuhan, China430030
    Food Funct 6:584-9. 2015
    ..Our results thus indicate that LN is a promising anti-glycation agent for the prevention of diabetes and its complications via inhibiting AGE formation. ..
  25. pmc Curcumin inhibits neuronal and vascular degeneration in retina after ischemia and reperfusion injury
    Leilei Wang
    College of Life Sciences, Wuhan University, Wuhan, China
    PLoS ONE 6:e23194. 2011
    ..The present study was conducted to explore the ability of curcumin to inhibit retinal I/R injury, and to investigate underlying mechanisms of the drug effects...
  26. doi request reprint Porcine islet amyloid polypeptide fragments are refractory to amyloid formation
    Xin Zhang
    Tongji School of Pharmacy, Huazhong University of Science and Technology, Wuhan, Hubei, PR China
    FEBS Lett 585:71-7. 2011
    ..Among all human to porcine substitutions, S20R caused the most prolonged lag time and significantly attenuated cytotoxicity. The different oligomerization and amyloidogenic properties of hIAPP and pIAPP fragments are discussed...
  27. pmc Inhibitory effects of magnolol and honokiol on human calcitonin aggregation
    Caiao Guo
    Tongji School of Pharmacy, Huazhong University of Science and Technology, Wuhan, Hubei, P R China, 430030
    Sci Rep 5:13556. 2015
    ..Furthermore, isothermal titration calorimetry indicated Mag and Hon both interact with hCT. Together, our study suggested a potential anti-amyloidogenic property of these two compounds and their structure related derivatives. ..
  28. doi request reprint Overexpression of glyceraldehyde 3-phosphate dehydrogenase prevents neurovascular degeneration after retinal injury
    Ruiqi Cai
    College of Life Sciences, Wuhan University, Wuhan, Hubei, People s Republic of China Departments of Pathology, Neuroscience, and Neurology, Case Western Reserve University, Cleveland, Ohio, USA and Tongji School of Pharmacy, Huazhong University of Science and Technology, Wuhan, Hubei, People s Republic of China
    FASEB J 29:2749-58. 2015
    ....
  29. pmc Identification of protein network alterations upon retinal ischemia-reperfusion injury by quantitative proteomics using a Rattus norvegicus model
    Han Tian
    College of Life Sciences, Wuhan University, Wuhan, China
    PLoS ONE 9:e116453. 2014
    ..Our results provide new systems-biology clues for the study of retinal ischemia. ..
  30. ncbi request reprint Ursolic acid inhibits early lesions of diabetic nephropathy
    Yi Zhou
    College of Life Sciences, Wuhan University, Wuhan, P R China
    Int J Mol Med 26:565-70. 2010
    ..Furthermore, diabetes-induced overexpression of iNOS in the renal cortex was also significantly suppressed by the treatment. UA may thus be considered as a potential therapeutic agent in treating DN...
  31. ncbi request reprint Role of nitric oxide, superoxide, peroxynitrite and PARP in diabetic retinopathy
    Ling Zheng
    College of Life Sciences, Wuhan University, Wuhan, China
    Front Biosci (Landmark Ed) 14:3974-87. 2009
    ..The possible roles of these components in the development of diabetic retinopathy are reviewed here, and their values as therapeutic targets for inhibiting or delaying the development of diabetic retinopathy are highlighted...
  32. doi request reprint Comparative proteomic analysis of histone post-translational modifications upon ischemia/reperfusion-induced retinal injury
    Xiaolu Zhao
    College of Life Sciences, Wuhan University, Wuhan 430072, P R China
    J Proteome Res 13:2175-86. 2014
    ..Specifically, DNA damage associated histone PTMs may contribute to neurovascular degeneration during the process of ischemia/reperfusion injury. ..