Qiang Zhao

Summary

Publications

  1. doi request reprint Structure of hepatitis C virus IRES subdomain IIa
    Qiang Zhao
    Department of Structural Chemistry, Anadys Pharmaceuticals Inc, 3115 Merryfield Row, San Diego, CA 92121, USA
    Acta Crystallogr D Biol Crystallogr 64:436-43. 2008
  2. doi request reprint Hexahydro-pyrrolo- and hexahydro-1H-pyrido[1,2-b]pyridazin-2-ones as potent inhibitors of HCV NS5B polymerase
    Frank Ruebsam
    Anadys Pharmaceuticals, Inc, 3115 Merryfield Row, San Diego, CA 92121, USA
    Bioorg Med Chem Lett 18:5002-5. 2008
  3. ncbi request reprint 5,5'- and 6,6'-dialkyl-5,6-dihydro-1H-pyridin-2-ones as potent inhibitors of HCV NS5B polymerase
    David A Ellis
    Anadys Pharmaceuticals, Inc, 3115 Merryfield Row, San Diego, CA 92121, USA
    Bioorg Med Chem Lett 19:6047-52. 2009
  4. doi request reprint Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'lambda(6)-benzo[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 3: Further optimization of the 2-, 6-, and 7'-substituents and initial pharmacokinetic assessme
    Lian Sheng Li
    Anadys Pharmaceuticals, Inc, 3115 Merryfield Row, San Diego, CA 92121, USA
    Bioorg Med Chem Lett 18:3446-55. 2008
  5. doi request reprint Structure-based design, synthesis, and biological evaluation of 1,1-dioxoisothiazole and benzo[b]thiophene-1,1-dioxide derivatives as novel inhibitors of hepatitis C virus NS5B polymerase
    Sun Hee Kim
    Anadys Pharmaceuticals, Inc, 3115 Merryfield Row, San Diego, CA 92121, USA
    Bioorg Med Chem Lett 18:4181-5. 2008
  6. ncbi request reprint Aminoglycoside-hybrid ligands targeting the ribosomal decoding site
    Dionisios Vourloumis
    Department of Medicinal Chemistry, Anadys Pharmaceuticals, Inc 3115 Merryfield Row, San Diego, CA 92121, USA
    Chembiochem 6:58-65. 2005
  7. ncbi request reprint Molecular recognition by glycoside pseudo base pairs and triples in an apramycin-RNA complex
    Qing Han
    Department of Structural Chemistry, Anadys Pharmaceuticals, Inc, San Diego, CA 92121, USA
    Angew Chem Int Ed Engl 44:2694-700. 2005
  8. ncbi request reprint Molecular recognition of RNA by neomycin and a restricted neomycin derivative
    Fang Zhao
    Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, 92093, USA
    Angew Chem Int Ed Engl 44:5329-34. 2005
  9. ncbi request reprint Monitoring molecular recognition of the ribosomal decoding site
    Sarah Shandrick
    Department of Structural Chemistry, Anadys Pharmaceuticals, Inc 9050 Camino Santa Fe, San Diego, CA 92121, USA
    Angew Chem Int Ed Engl 43:3177-82. 2004
  10. doi request reprint Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'lambda6-benzo[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 1: exploration of 7'-substitution of benzothiadiazine
    Yuefen Zhou
    Anadys Pharmaceuticals, Inc, 3115 Merryfield Row, San Diego, CA 92121, USA
    Bioorg Med Chem Lett 18:1413-8. 2008

Collaborators

  • Thomas Hermann
  • Yuefen Zhou
  • Frank Ruebsam
  • Dionisios Vourloumis
  • Klaus B Simonsen
  • Masayuki Takahashi
  • Peter S Dragovich
  • Bin Li
  • Peggy A Thompson
  • Kenneth F Blount
  • Christine Schubert Wright
  • Qing Han
  • Douglas E Murphy
  • Mei Tsan
  • Lian Sheng Li
  • Laurie A LeBrun
  • Darian M Bartkowski
  • Stephen E Webber
  • Amit M Shah
  • Daniel A Norris
  • Chinh V Tran
  • Thomas G Nolan
  • Maria V Sergeeva
  • Charles R Kissinger
  • Leo Kirkovsky
  • Richard E Showalter
  • Zihe Rao
  • Sarah Shandrick
  • David A Ellis
  • Alberto Gobbi
  • Alan X Xiang
  • Ruhi Kamran
  • Jingjing Zhao
  • Rupal Patel
  • Benjamin Ayida
  • Sun Hee Kim
  • Beili Wu
  • Donghai Chen
  • Fuguo Jiang
  • Fang Zhao
  • Geoffrey C Winters
  • Benjamin K Ayida
  • Sofia Barluenga
  • Xuemei Li
  • Rupal A Patel
  • Matthew Lardy
  • Julie K Blazel
  • Helen M McGuire
  • Thomas Bertolini
  • Julie Blazel
  • David Ellis
  • Helen McGuire
  • Jennifer Brooks
  • Zhongxiang Sun
  • Martin T Tran
  • Nebojsa Stankovic
  • Shuang Liao
  • Weifeng Chen
  • Jun Zhang
  • Mark Bartlam
  • Yuanfeng Liu
  • Ah Kau Ng
  • Michael Pearl
  • Naoko Hirashima
  • Yoshiyuki Mori
  • Giulio Ghersi
  • Wen Tien Chen
  • Jaw Yuan Wang
  • Lipeng Qin
  • Xuetao Pei
  • Tetsu Yamane
  • Alanna Kennedy
  • Zhenhe Suo
  • Wei Zeng
  • Jahn M Nesland
  • Hai Pang
  • Yuhuan Qiao
  • Mengzhen Zhang
  • Masako Mitsumata
  • Sarah Fish
  • Jamie M Froelich
  • Yitzhak Tor
  • Daniel Wall
  • Xin Duan
  • Ethel S Littlefield
  • Xueqi Liu
  • Yiwei Liu

Detail Information

Publications19

  1. doi request reprint Structure of hepatitis C virus IRES subdomain IIa
    Qiang Zhao
    Department of Structural Chemistry, Anadys Pharmaceuticals Inc, 3115 Merryfield Row, San Diego, CA 92121, USA
    Acta Crystallogr D Biol Crystallogr 64:436-43. 2008
    ..The information obtained from the crystal structure provides a basis for structure-guided design of HCV translation inhibitors targeting disruption of ribosomal assembly...
  2. doi request reprint Hexahydro-pyrrolo- and hexahydro-1H-pyrido[1,2-b]pyridazin-2-ones as potent inhibitors of HCV NS5B polymerase
    Frank Ruebsam
    Anadys Pharmaceuticals, Inc, 3115 Merryfield Row, San Diego, CA 92121, USA
    Bioorg Med Chem Lett 18:5002-5. 2008
    ..Among these, compound 4c displayed potent inhibitory activities in biochemical and replicon assays (IC(50) (1b) <10 nM; EC(50) (1b)=34 nM) as well as good stability towards human liver microsomes (HLM t(1/2) =59 min)...
  3. ncbi request reprint 5,5'- and 6,6'-dialkyl-5,6-dihydro-1H-pyridin-2-ones as potent inhibitors of HCV NS5B polymerase
    David A Ellis
    Anadys Pharmaceuticals, Inc, 3115 Merryfield Row, San Diego, CA 92121, USA
    Bioorg Med Chem Lett 19:6047-52. 2009
    ..10 microM). In vitro DMPK data for selected compounds as well as crystal structures of representative inhibitors complexed with the NS5B protein are also disclosed...
  4. doi request reprint Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'lambda(6)-benzo[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 3: Further optimization of the 2-, 6-, and 7'-substituents and initial pharmacokinetic assessme
    Lian Sheng Li
    Anadys Pharmaceuticals, Inc, 3115 Merryfield Row, San Diego, CA 92121, USA
    Bioorg Med Chem Lett 18:3446-55. 2008
    ....
  5. doi request reprint Structure-based design, synthesis, and biological evaluation of 1,1-dioxoisothiazole and benzo[b]thiophene-1,1-dioxide derivatives as novel inhibitors of hepatitis C virus NS5B polymerase
    Sun Hee Kim
    Anadys Pharmaceuticals, Inc, 3115 Merryfield Row, San Diego, CA 92121, USA
    Bioorg Med Chem Lett 18:4181-5. 2008
    ..The most potent compound exhibited IC(50) less than 10nM against the genotype 1b HCV polymerase and EC(50) of 70 nM against a genotype 1b replicon in cell culture. The DMPK properties of selected compounds were also evaluated...
  6. ncbi request reprint Aminoglycoside-hybrid ligands targeting the ribosomal decoding site
    Dionisios Vourloumis
    Department of Medicinal Chemistry, Anadys Pharmaceuticals, Inc 3115 Merryfield Row, San Diego, CA 92121, USA
    Chembiochem 6:58-65. 2005
  7. ncbi request reprint Molecular recognition by glycoside pseudo base pairs and triples in an apramycin-RNA complex
    Qing Han
    Department of Structural Chemistry, Anadys Pharmaceuticals, Inc, San Diego, CA 92121, USA
    Angew Chem Int Ed Engl 44:2694-700. 2005
  8. ncbi request reprint Molecular recognition of RNA by neomycin and a restricted neomycin derivative
    Fang Zhao
    Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, 92093, USA
    Angew Chem Int Ed Engl 44:5329-34. 2005
  9. ncbi request reprint Monitoring molecular recognition of the ribosomal decoding site
    Sarah Shandrick
    Department of Structural Chemistry, Anadys Pharmaceuticals, Inc 9050 Camino Santa Fe, San Diego, CA 92121, USA
    Angew Chem Int Ed Engl 43:3177-82. 2004
  10. doi request reprint Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'lambda6-benzo[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 1: exploration of 7'-substitution of benzothiadiazine
    Yuefen Zhou
    Anadys Pharmaceuticals, Inc, 3115 Merryfield Row, San Diego, CA 92121, USA
    Bioorg Med Chem Lett 18:1413-8. 2008
    ..The synthesis, structure-activity relationships (SAR), metabolic stability, and structure-based design approach for this new class of compounds are discussed...
  11. ncbi request reprint Rational design of azepane-glycoside antibiotics targeting the bacterial ribosome
    Sofia Barluenga
    Department of Medicinal Chemistry, Anadys Pharmaceuticals, Inc, 9050 Camino Santa Fe, San Diego, CA 92121, USA
    Bioorg Med Chem Lett 14:713-8. 2004
    ..Azepane-glycosides showed target binding and translation inhibition in the low micromolar range and inhibited growth of Staphylococcus aureus, including aminoglycoside-resistant strains...
  12. doi request reprint Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'lambda(6)-benzo[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 2: Variation of the 2- and 6-pyridazinone substituents
    Yuefen Zhou
    Anadys Pharmaceuticals, Inc, 3115 Merryfield Row, San Diego, CA 92121, USA
    Bioorg Med Chem Lett 18:1419-24. 2008
    ..The structure-activity relationship (SAR) associated with variation of the pyridazinone 2- and 6-substituents is discussed. The synthesis and metabolic stability of this new class of compounds are also described...
  13. ncbi request reprint Crystal structure of RS21-C6, involved in nucleoside triphosphate pyrophosphohydrolysis
    Beili Wu
    Tsinghua IBP Nankai Joint Research Group for Structural Biology, Tsinghua University, Beijing 100084, China
    J Mol Biol 367:1405-12. 2007
    ..Tetramer formation is shown to be required for substrate binding...
  14. ncbi request reprint Structure of human spindlin1. Tandem tudor-like domains for cell cycle regulation
    Qiang Zhao
    Tsinghua Institute of Biophysics Joint Research Group for Structural Biology, Tsinghua University, Beijing 100084, China
    J Biol Chem 282:647-56. 2007
    ..We further identified associations of spindlin1 with nucleic acid to provide a biochemical basis for its cell cycle regulation and other functions...
  15. pmc Activation of EDTA-resistant gelatinases in malignant human tumors
    Donghai Chen
    Department of Medicine, Stony Brook University, Stony Brook, New York 11794, USA
    Cancer Res 66:9977-85. 2006
    ..Together, these data show that, in malignant tumors, seprase is proteolytically activated to confer its substrate specificity in collagen proteolysis and tumor invasion...
  16. ncbi request reprint Expression, purification, crystallization and preliminary X-ray analysis of human spindlin1, an ovarian cancer-related protein
    Fuguo Jiang
    Laboratory of Structural Biology, Tsinghua University, Beijing, 100084, China
    Protein Pept Lett 13:203-5. 2006
    ..The crystals belong to the space group P2(1)2(1)2(1), with unit-cell parameters a =40.7 A, b =84.4 A, c =136.4 A, alpha=beta=gamma=90 degrees . Assuming two molecules per asymmetric unit, the solvent content is calculated to be 42.4%...
  17. ncbi request reprint Crystallization and preliminary crystallographic studies of human coactosin-like protein (CLP)
    Xuemei Li
    National Laboratory of Biomacromolecules, Institute of Biophysics of Chinese Academy of Sciences, Beijing 100101, People s Republic of China
    Acta Crystallogr D Biol Crystallogr 60:2387-8. 2004
    ..5. Diffraction data to 1.9 A resolution were collected from a crystal belonging to space group P2(1), with unit-cell parameters a = 25.6, b = 55.2, c = 37.4 A, beta = 96.0 degrees. There is one molecule per asymmetric unit...
  18. ncbi request reprint Identification of a conserved sequence motif that promotes Cdc37 and cyclin D1 binding to Cdk4
    Qiang Zhao
    Department of Oncology, Wyeth Research, 401 North Middletown Road, Pearl River, NY 10965, USA
    J Biol Chem 279:12560-4. 2004
    ..Under the same conditions, p16 binding to wild type Cdk4 was suppressed. Our findings show that the interaction of Cdc37 with its client protein kinases requires amino acid residues within a motif that is present in many protein kinases...
  19. ncbi request reprint Structural analysis of lipid complexes of GM2-activator protein
    Christine Schubert Wright
    Department of Pharmacology, X ray Laboratory and University of Virginia Health System, PO Box 800735, Charlottesville, VA 22908 0735, USA
    J Mol Biol 331:951-64. 2003
    ....