Leiliang Zhang

Summary

Publications

  1. pmc IL28B inhibits hepatitis C virus replication through the JAK-STAT pathway
    Leiliang Zhang
    Gastrointestinal Unit, Department of Medicine, Warren 1007, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Hepatol 55:289-98. 2011
  2. pmc HIV infection increases HCV-induced hepatocyte apoptosis
    Jae Young Jang
    Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Hepatol 54:612-20. 2011
  3. pmc A functional genomic screen reveals novel host genes that mediate interferon-alpha's effects against hepatitis C virus
    Hong Zhao
    Department of Infectious Diseases, Peking University First Hospital, Beijing 100034, China
    J Hepatol 56:326-33. 2012
  4. pmc HIV and HCV cooperatively promote hepatic fibrogenesis via induction of reactive oxygen species and NFkappaB
    Wenyu Lin
    Gastrointestinal Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Biol Chem 286:2665-74. 2011
  5. pmc The AMPK-related kinase SNARK regulates hepatitis C virus replication and pathogenesis through enhancement of TGF-β signaling
    Kaku Goto
    Gastrointestinal Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA The Advanced Clinical Research Center, The Institute of Medical Science, The University of Tokyo, Tokyo 108 8639, Japan Japan Society for the Promotion of Science, Tokyo 102 8472, Japan
    J Hepatol 59:942-8. 2013
  6. pmc A genetic screen identifies interferon-α effector genes required to suppress hepatitis C virus replication
    Dahlene N Fusco
    Gastrointestinal Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Gastroenterology 144:1438-49, 1449.e1-9. 2013
  7. pmc Hepatitis C virus NS5A disrupts STAT1 phosphorylation and suppresses type I interferon signaling
    Kattareeya Kumthip
    Gastrointestinal Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Virol 86:8581-91. 2012
  8. pmc Hepatitis C virus regulates transforming growth factor beta1 production through the generation of reactive oxygen species in a nuclear factor kappaB-dependent manner
    Wenyu Lin
    Gastrointestinal Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Gastroenterology 138:2509-18, 2518.e1. 2010
  9. pmc Suppressor of cytokine signaling 3 suppresses hepatitis C virus replication in an mTOR-dependent manner
    Run Xuan Shao
    Gastrointestinal Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Virol 84:6060-9. 2010

Collaborators

Detail Information

Publications9

  1. pmc IL28B inhibits hepatitis C virus replication through the JAK-STAT pathway
    Leiliang Zhang
    Gastrointestinal Unit, Department of Medicine, Warren 1007, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Hepatol 55:289-98. 2011
    ..We sought to determine whether IL28B was capable of inhibiting HCV replication and to determine the pathway by which IL28B exhibits anti-HCV activity...
  2. pmc HIV infection increases HCV-induced hepatocyte apoptosis
    Jae Young Jang
    Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Hepatol 54:612-20. 2011
    ..We hypothesized that HCV-HIV coinfection increases HCV related hepatocyte apoptosis and that HCV and HIV influence TRAIL signaling in hepatocytes...
  3. pmc A functional genomic screen reveals novel host genes that mediate interferon-alpha's effects against hepatitis C virus
    Hong Zhao
    Department of Infectious Diseases, Peking University First Hospital, Beijing 100034, China
    J Hepatol 56:326-33. 2012
    ..The precise mechanisms by which IFN exerts its antiviral effect against HCV have not yet been elucidated. We sought to identify host genes that mediate the antiviral effect of IFN-α by conducting a whole-genome siRNA library screen...
  4. pmc HIV and HCV cooperatively promote hepatic fibrogenesis via induction of reactive oxygen species and NFkappaB
    Wenyu Lin
    Gastrointestinal Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Biol Chem 286:2665-74. 2011
    ..Strategies to limit the viral induction of oxidative stress are warranted to inhibit fibrogenesis...
  5. pmc The AMPK-related kinase SNARK regulates hepatitis C virus replication and pathogenesis through enhancement of TGF-β signaling
    Kaku Goto
    Gastrointestinal Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA The Advanced Clinical Research Center, The Institute of Medical Science, The University of Tokyo, Tokyo 108 8639, Japan Japan Society for the Promotion of Science, Tokyo 102 8472, Japan
    J Hepatol 59:942-8. 2013
    ..The biological and therapeutic importance of host cellular cofactors for viral replication has been recently appreciated. Here we examined the roles of SNF1/AMP kinase-related kinase (SNARK) in HCV replication and pathogenesis...
  6. pmc A genetic screen identifies interferon-α effector genes required to suppress hepatitis C virus replication
    Dahlene N Fusco
    Gastrointestinal Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Gastroenterology 144:1438-49, 1449.e1-9. 2013
    ..In contrast to candidate approaches based on analyses of messenger RNA (mRNA) expression, identification of IEGs requires a broad functional approach...
  7. pmc Hepatitis C virus NS5A disrupts STAT1 phosphorylation and suppresses type I interferon signaling
    Kattareeya Kumthip
    Gastrointestinal Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Virol 86:8581-91. 2012
    ..We propose a model in which the binding of the C-terminal region of NS5A to STAT1 leads to decreased levels of P-STAT1, ISRE signaling, and ISG transcription and, ultimately, to preferential GT1 resistance to IFN treatment...
  8. pmc Hepatitis C virus regulates transforming growth factor beta1 production through the generation of reactive oxygen species in a nuclear factor kappaB-dependent manner
    Wenyu Lin
    Gastrointestinal Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Gastroenterology 138:2509-18, 2518.e1. 2010
    ....
  9. pmc Suppressor of cytokine signaling 3 suppresses hepatitis C virus replication in an mTOR-dependent manner
    Run Xuan Shao
    Gastrointestinal Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Virol 84:6060-9. 2010
    ....