Zhenglin Yang

Summary

Publications

  1. doi request reprint [Association of PLEKHA7, COL11A1 and PCMTD1-ST18 gene polymorphisms with primary angle closure glaucoma in ethnic Han Chinese from Sichuan]
    Chang Tan
    Southwestern Medical University, Luzhou, Sichuan 646000, China Sichuan Key Laboratory for Disease Gene Study, Sichuan Academy of Medical Sciences and Sichuan Provincial People s Hospital, Chengdu, Sichuan 610000, China Email
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 33:545-9. 2016
  2. doi request reprint [Progress in molecular genetic studies of retinitis pigmentosa]
    Youping Li
    Luzhou Medical College, Luzhou, Sichuan 646000, P R China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 32:280-3. 2015
  3. pmc An association study of SERPING1 gene and age-related macular degeneration in a Han Chinese population
    Fang Lu
    Center for Human Molecular Biology and Genetics, Sichuan Academy of Medical Sciences and Sichuan Provincial People s Hospital, Sichuan, China
    Mol Vis 16:1-6. 2010
  4. pmc Identification of two novel LRP5 mutations in families with familial exudative vitreoretinopathy
    Ping Fei
    Department of Ophthalmology, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
    Mol Vis 20:395-409. 2014
  5. pmc A novel PRPF31 mutation in a large Chinese family with autosomal dominant retinitis pigmentosa and macular degeneration
    Fang Lu
    Center for Human Molecular Biology and Genetics, the Institute of Laboratory Medicine, Sichuan Academy of Medical Sciences and Sichuan Provincial People s Hospital, Chengdu, Sichuan, China Sichuan Translational Research Hospital, Chinese Academy of Sciences, Chengdu, Sichuan, China
    PLoS ONE 8:e78274. 2013
  6. pmc An association study of the COL1A1 gene and high myopia in a Han Chinese population
    Dingding Zhang
    Sichuan Key Laboratory for Disease Gene Study, Sichuan Academy of Medical Sciences and Sichuan Provincial People s Hospital, Sichuan, China
    Mol Vis 17:3379-83. 2011
  7. pmc The genetic variants at the HLA-DRB1 gene are associated with primary IgA nephropathy in Han Chinese
    Yang Jiyun
    Center for Human Molecular Biology and Genetics, Sichuan Academy of Medical Science and Sichuan Provincial People s Hospital, Chengdu, Sichuan, 617002, China
    BMC Med Genet 13:33. 2012
  8. doi request reprint Association study of complement factor H, C2, CFB, and C3 and age-related macular degeneration in a Han Chinese population
    Xiaoqi Liu
    Center for Human Molecular Biology and Genetics, Sichuan Academy of Medical Sciences and Sichuan Provincial People s Hospital, Sichuan, China
    Retina 30:1177-84. 2010
  9. pmc Association study of polymorphisms in selenoprotein genes and Kashin-Beck disease and serum selenium/iodine concentration in a Tibetan population
    Lulin Huang
    Center for Human Molecular Biology and Genetics, the Institute of Laboratory Medicine, Sichuan Academy of Medical Sciences and Sichuan Provincial People s Hospital, Chengdu, Sichuan, China Sichuan Translational Research Hospital, Chinese Academy of Sciences, Chengdu, Sichuan, China
    PLoS ONE 8:e71411. 2013
  10. ncbi request reprint HTRA1 variant increases risk to neovascular age-related macular degeneration in Chinese population
    Fang Lu
    Human Molecular Biology and Genetics, Sichuan Academy of Medical Sciences and Sichuan Provincial People s Hospital, Sichuan 610072, China
    Vision Res 47:3120-3. 2007

Collaborators

Detail Information

Publications29

  1. doi request reprint [Association of PLEKHA7, COL11A1 and PCMTD1-ST18 gene polymorphisms with primary angle closure glaucoma in ethnic Han Chinese from Sichuan]
    Chang Tan
    Southwestern Medical University, Luzhou, Sichuan 646000, China Sichuan Key Laboratory for Disease Gene Study, Sichuan Academy of Medical Sciences and Sichuan Provincial People s Hospital, Chengdu, Sichuan 610000, China Email
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 33:545-9. 2016
    ..To assess the association of single nucleotide polymorphisms (SNPs) of PLEKHA7, COL11A1 and PCMTD1-ST18 genes and primary angle closure glaucoma (PACG) among ethnic Han Chinese from Sichuan Province...
  2. doi request reprint [Progress in molecular genetic studies of retinitis pigmentosa]
    Youping Li
    Luzhou Medical College, Luzhou, Sichuan 646000, P R China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 32:280-3. 2015
    ..Sixty-three genes have been identified in nonsyndromic RP. This paper reviews recent progress in the research of the genetics of RP. ..
  3. pmc An association study of SERPING1 gene and age-related macular degeneration in a Han Chinese population
    Fang Lu
    Center for Human Molecular Biology and Genetics, Sichuan Academy of Medical Sciences and Sichuan Provincial People s Hospital, Sichuan, China
    Mol Vis 16:1-6. 2010
    ..A replication study of an association between these SNPs and AMD in a Chinese population is reported in this study...
  4. pmc Identification of two novel LRP5 mutations in families with familial exudative vitreoretinopathy
    Ping Fei
    Department of Ophthalmology, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
    Mol Vis 20:395-409. 2014
    ..To investigate the clinical features and disease-causing mutations in two Chinese families with familial exudative vitreoretinopathy (FEVR)...
  5. pmc A novel PRPF31 mutation in a large Chinese family with autosomal dominant retinitis pigmentosa and macular degeneration
    Fang Lu
    Center for Human Molecular Biology and Genetics, the Institute of Laboratory Medicine, Sichuan Academy of Medical Sciences and Sichuan Provincial People s Hospital, Chengdu, Sichuan, China Sichuan Translational Research Hospital, Chinese Academy of Sciences, Chengdu, Sichuan, China
    PLoS ONE 8:e78274. 2013
    ..This study was intended to identify the disease causing genes in a large Chinese family with autosomal dominant retinitis pigmentosa and macular degeneration...
  6. pmc An association study of the COL1A1 gene and high myopia in a Han Chinese population
    Dingding Zhang
    Sichuan Key Laboratory for Disease Gene Study, Sichuan Academy of Medical Sciences and Sichuan Provincial People s Hospital, Sichuan, China
    Mol Vis 17:3379-83. 2011
    ..This present study was conducted to investigate whether COL1A1 is associated with high myopia in a Han Chinese population...
  7. pmc The genetic variants at the HLA-DRB1 gene are associated with primary IgA nephropathy in Han Chinese
    Yang Jiyun
    Center for Human Molecular Biology and Genetics, Sichuan Academy of Medical Science and Sichuan Provincial People s Hospital, Chengdu, Sichuan, 617002, China
    BMC Med Genet 13:33. 2012
    ..Familial clustering of patients with IgAN suggests a genetic predisposition...
  8. doi request reprint Association study of complement factor H, C2, CFB, and C3 and age-related macular degeneration in a Han Chinese population
    Xiaoqi Liu
    Center for Human Molecular Biology and Genetics, Sichuan Academy of Medical Sciences and Sichuan Provincial People s Hospital, Sichuan, China
    Retina 30:1177-84. 2010
    ..Genetic variants, single-nucleotide polymorphisms (SNPs), in these genes were geno-typed for a case-control association study in a mainland Han Chinese population...
  9. pmc Association study of polymorphisms in selenoprotein genes and Kashin-Beck disease and serum selenium/iodine concentration in a Tibetan population
    Lulin Huang
    Center for Human Molecular Biology and Genetics, the Institute of Laboratory Medicine, Sichuan Academy of Medical Sciences and Sichuan Provincial People s Hospital, Chengdu, Sichuan, China Sichuan Translational Research Hospital, Chinese Academy of Sciences, Chengdu, Sichuan, China
    PLoS ONE 8:e71411. 2013
    ..Kashin-Beck disease is a kind of degenerative osteoarthropathy. Genetic factors may play an important role in the pathogenesis of KBD...
  10. ncbi request reprint HTRA1 variant increases risk to neovascular age-related macular degeneration in Chinese population
    Fang Lu
    Human Molecular Biology and Genetics, Sichuan Academy of Medical Sciences and Sichuan Provincial People s Hospital, Sichuan 610072, China
    Vision Res 47:3120-3. 2007
    ..00x10(-12)). Unlike in the Caucasian population, the risk allele of rs11200638 was not associated with drusen in our Chinese population. These findings confirm the association of HTRA1 with wet AMD...
  11. doi request reprint A genome-wide meta-analysis identifies two novel loci associated with high myopia in the Han Chinese population
    Yi Shi
    The Sichuan Provincial Key Laboratory for Human Disease Gene Study, the Institute of Laboratory Medicine, Sichuan Academy of Medical Sciences and Sichuan Provincial People s Hospital, Chengdu, Sichuan 610072, China
    Hum Mol Genet 22:2325-33. 2013
    ..Our results suggest that variants of the VIPR2 and SNTB1 genes increase susceptibility to high myopia in Han Chinese...
  12. pmc Evaluation of MMP2 as a candidate gene for high myopia
    Bo Gong
    Sichuan Key Laboratory for Disease Gene Study, Sichuan Academy of Medical Sciences and Sichuan Provincial People s Hospital, Chengdu, Sichuan, China
    Mol Vis 19:121-7. 2013
    ..The purpose of this study was to examine the relationship between high myopia and MMP2 in a mainland Han Chinese population...
  13. doi request reprint Genetic variants in the HLA-DRB1 gene are associated with Kashin-Beck disease in the Tibetan population
    Yi Shi
    Sichuan Academy of Medical Sciences and Sichuan Provincial People s Hospital, Sichuan, China
    Arthritis Rheum 63:3408-16. 2011
    ..To investigate the association between variants in the HLA-DRB1 gene and Kashin-Beck disease (KBD), as well as associations of selenium and iodine deficiencies with KBD in a Tibetan population...
  14. pmc Genetic and functional dissection of HTRA1 and LOC387715 in age-related macular degeneration
    Zhenglin Yang
    Center for Human Molecular Biology and Genetics, Sichuan Academy of Medical Sciences and Sichuan Provincial People s Hospital, Chengdu, Sichuan, China
    PLoS Genet 6:e1000836. 2010
    ..These data implicate increased HTRA1 expression in the pathogenesis of AMD and highlight the importance of exploring multiple functional consequences of alleles in haplotypes that confer susceptibility to complex traits...
  15. doi request reprint Mutation in connexin 32 causes Charcot-Marie-Tooth disease in a large Chinese family
    Fuqiang Guo
    Department of Neurology, Sichuan Academy of Medical Sciences and Sichuan Provincial People s Hospital, Sichuan, China
    Muscle Nerve 42:715-21. 2010
    ..758. The H100 of Cx32 is highly conserved among the 10 vertebrates. A large Chinese family had CMTX1 linked to Xq13.1 caused by an H100Y mutation in the Cx32 gene...
  16. pmc Exome sequencing identifies ZNF644 mutations in high myopia
    Yi Shi
    The Sichuan Provincial Key Laboratory for Human Disease Gene Study, Sichuan Academy of Medical Sciences and Sichuan Provincial People s Hospital, Chengdu, Sichuan, China
    PLoS Genet 7:e1002084. 2011
    ..Our results suggest that ZNF644 might be a causal gene for high myopia in a monogenic form...
  17. pmc A genome-wide scan maps a novel autosomal dominant juvenile-onset open-angle glaucoma locus to 2p15-16
    Ying Lin
    Human Molecular Biology and Genetics, Sichuan Academy of Medical Sciences and Sichuan Provincial People s Hospital, Sichuan, China
    Mol Vis 14:739-44. 2008
    ..To study the clinical features and to perform genetic linkage study in two large Chinese families with autosomal dominant juvenile-onset primary open-angle glaucoma (POAG)...
  18. pmc Single nucleotide polymorphisms at the TRAF1/C5 locus are associated with rheumatoid arthritis in a Han Chinese population
    Jing Zhu
    Department of Rheumatology and Immunology, Sichuan Academy of Medical Sciences and Sichuan Provincial People s Hospital, Chengdu, Sichuan, China
    BMC Med Genet 12:53. 2011
    ..The concentrations of anti-cyclic citrullinated peptide antibodies (CCP) and rheumatoid factor (RF) were determined for all affected patients. The difference between the cases and the controls was compared using χ2 analysis...
  19. pmc Toll-like receptor 3 and geographic atrophy in age-related macular degeneration
    Zhenglin Yang
    Sichuan Academy of Medical Sciences and Sichuan Provincial People s Hospital, Chengdu, China
    N Engl J Med 359:1456-63. 2008
    ..Advanced age-related macular degeneration consists of geographic atrophy and choroidal neovascularization. The specific genetic variants that predispose patients to geographic atrophy are largely unknown...
  20. doi request reprint A novel mutation in LMX1B gene causes nail-patella syndrome in a large Chinese family
    Ying Lin
    Center for Human Molecular Biology and Genetics, Sichuan Academy of Medical Sciences and Sichuan Provincial People s Hospital, Sichuan, China
    Bone 43:591-5. 2008
    ..This is the first report that a mutation in the LMX1B gene causes NPS in a Chinese population, which will expand the spectrum of mutations in the LMX1B gene and provide insight into the underlining pathology of NPS...
  21. pmc Genetic variants at 13q12.12 are associated with high myopia in the Han Chinese population
    Yi Shi
    The Sichuan Provincial Key Laboratory for Human Disease Gene Study and The Institute of Laboratory Medicine, Sichuan Academy of Medical Sciences and Sichuan Provincial People s Hospital, Chengdu, Sichuan 610072, China
    Am J Hum Genet 88:805-13. 2011
    ..Our results suggest that the variants at 13q12.12 are associated with high myopia...
  22. pmc Association study of genetic variants in eight genes/loci with type 2 diabetes in a Han Chinese population
    Ying Lin
    Center for Human Molecular Biology and Genetics, Sichuan Academy of Medical Sciences and Sichuan Provincial People s Hospital, Chengdu, Sichuan, China
    BMC Med Genet 11:97. 2010
    ..The meta-analysis of the association between rs7903146 in TCF7L2 gene and T2D in the Han Chinese was performed...
  23. doi request reprint A genetic variant in the SKIV2L gene is significantly associated with age-related macular degeneration in a Han Chinese population
    Fang Lu
    The Sichuan Key Laboratory for Human Disease Gene Study, Institute of Laboratory Medicine, Sichuan Academy of Medical Sciences and Sichuan Provincial People s Hospital, Chengdu, Sichuan, China
    Invest Ophthalmol Vis Sci 54:2911-7. 2013
    ..We conducted this study to investigate whether genetic variants in the SKIV2L gene are associated with AMD in a Han Chinese population...
  24. ncbi request reprint Array-based multiplexed screening and quantitation of human cytokines and chemokines
    Cheng C Wang
    PerkinElmer Life Sciences, 800 Research Parkway, Meriden, Connecticut 06450, USA
    J Proteome Res 1:337-43. 2002
    ..Using this chip, we have examined cytokine expression in breast cancer cells and identified the chemokines associated with human cervical cancers...
  25. pmc Complement factor H genotypes impact risk of age-related macular degeneration by interaction with oxidized phospholipids
    Peter X Shaw
    Molecular Medicine Research Center and Department of Ophthalmology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China
    Proc Natl Acad Sci U S A 109:13757-62. 2012
    ..Together, these findings suggest that CFH influences AMD risk by modulating oxidative stress, inflammation, and abnormal angiogenesis...
  26. pmc Genetic variants in PVRL2-TOMM40-APOE region are associated with human longevity in a Han Chinese population
    Fang Lu
    Sichuan Key Laboratory for Disease Gene Study, Sichuan Academy of Medical Sciences and Sichuan Provincial People s Hospital, Sichuan, China Sichuan Translational Medicine Research Hospital, Chinese Academy of Sciences, Chengdu, Sichuan, China School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, China
    PLoS ONE 9:e99580. 2014
    ..In this study, we aimed to elucidate the association of human longevity with genetic variations in several major candidate genes in a Han Chinese population...
  27. pmc Exome sequencing analysis identifies compound heterozygous mutation in ABCA4 in a Chinese family with Stargardt disease
    Yu Zhou
    Sichuan Provincial Key Laboratory for Human Disease Gene Study and Institute of Laboratory Medicine, Sichuan Academy of Medical Sciences and Sichuan Provincial People s Hospital, Chengdu, Sichuan, China School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, China Chengdu Institute of Biology, Chinese Academy of Sciences and Chinese Academy of Sciences Sichuan Translational Medicine Research Hospital, Chengdu, Sichuan, China
    PLoS ONE 9:e91962. 2014
    ..Our findings provide one novel ABCA4 mutation in Chinese patients with Stargardt disease. ..
  28. pmc Evaluation of four genetic variants in han chinese subjects with high myopia
    Zimeng Ye
    College of Life Science and Engineering, Southwest Jiaotong University, 111, First Section, Northern Second Ring Road, Chengdu, Sichuan 610031, China Sichuan Provincial Key Laboratory for Human Disease Gene Study, Hospital of the University of Electronic Science and Technology of China and Sichuan Provincial People s Hospital, 32 the First Ring Road West 2, Chengdu, Sichuan 610072, China
    J Ophthalmol 2015:729463. 2015
    ..In addition, LOC100506035, a lincRNA gene, might play a crucial role in the susceptibility to high myopia. ..
  29. pmc Whole exome sequencing identified novel CRB1 mutations in Chinese and Indian populations with autosomal recessive retinitis pigmentosa
    Yin Yang
    Sichuan Provincial Key Laboratory for Human Disease Gene Study, School of Medicine, Sichuan Academy of Medical Sciences and Sichuan Provincial People s Hospital, University of Electronic Science and Technology of China, Chengdu, China
    Sci Rep 6:33681. 2016
    ..In conclusion, we identified four novel mutations in CRB1 in a cohort of RP patients from the Chinese and Indian populations. Our data enlarges the CRB1 mutation spectrums and may provide new target loci for RP diagnose and treatment...