Shaohua Yang

Summary

Publications

  1. pmc Methylene blue induces macroautophagy through 5' adenosine monophosphate-activated protein kinase pathway to protect neurons from serum deprivation
    Luokun Xie
    Department of Pharmacology and Neuroscience, Institute for Alzheimer s Disease and Aging Research, University of North Texas Health Science Center at FortWorth FortWorth, TX, USA
    Front Cell Neurosci 7:56. 2013
  2. pmc Neuroprotective actions of methylene blue and its derivatives
    Ethan Poteet
    Department of Pharmacology and Neuroscience, Institute for Alzheimer s Disease and Aging Research, University of North Texas Health Science Center at Fort Worth, Fort Worth, Texas, United States of America
    PLoS ONE 7:e48279. 2012
  3. pmc Pyruvate protects the brain against ischemia-reperfusion injury by activating the erythropoietin signaling pathway
    Myoung Gwi Ryou
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107 2699, USA
    Stroke 43:1101-7. 2012
  4. pmc Modulation of polymorphonuclear neutrophil functions by astrocytes
    Luokun Xie
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, Fort Worth, TX 76107, USA
    J Neuroinflammation 7:53. 2010
  5. ncbi request reprint Estrogen attenuates nuclear factor-kappa B activation induced by transient cerebral ischemia
    Yi Wen
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, 3500 Camp Bowie Blvd, Fort Worth, TX 76107 2699, USA
    Brain Res 1008:147-54. 2004
  6. ncbi request reprint Cell-cycle regulators are involved in transient cerebral ischemia induced neuronal apoptosis in female rats
    Yi Wen
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, 3500 Camp Bowie Blvd, Fort Worth, TX 76107 2699, USA
    FEBS Lett 579:4591-9. 2005
  7. pmc The assessment of non-feminizing estrogens for use in neuroprotection
    Kun Don Yi
    Institute for Aging and Alzheimer s Disease Research, Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
    Brain Res 1379:61-70. 2011
  8. ncbi request reprint Transient cerebral ischemia induces site-specific hyperphosphorylation of tau protein
    Yi Wen
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107 2699, USA
    Brain Res 1022:30-8. 2004
  9. ncbi request reprint Role of nonfeminizing estrogens in brain protection from cerebral ischemia: an animal model of Alzheimer's disease neuropathology
    James W Simpkins
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, 3500 Camp Bowie Blvd, Fort Worth, TX 76107, USA
    Ann N Y Acad Sci 1052:233-42. 2005
  10. ncbi request reprint Neuroprotective effects of 17beta-estradiol and nonfeminizing estrogens against H2O2 toxicity in human neuroblastoma SK-N-SH cells
    Xiaofei Wang
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, 3500 Camp Bowie Blvd, Fort Worth, TX 76107, USA
    Mol Pharmacol 70:395-404. 2006

Collaborators

Detail Information

Publications14

  1. pmc Methylene blue induces macroautophagy through 5' adenosine monophosphate-activated protein kinase pathway to protect neurons from serum deprivation
    Luokun Xie
    Department of Pharmacology and Neuroscience, Institute for Alzheimer s Disease and Aging Research, University of North Texas Health Science Center at FortWorth FortWorth, TX, USA
    Front Cell Neurosci 7:56. 2013
    ..Our findings suggest that methylene blue-induced neuroprotection is mediated, at least in part, by macroautophagy though activation of AMPK signaling...
  2. pmc Neuroprotective actions of methylene blue and its derivatives
    Ethan Poteet
    Department of Pharmacology and Neuroscience, Institute for Alzheimer s Disease and Aging Research, University of North Texas Health Science Center at Fort Worth, Fort Worth, Texas, United States of America
    PLoS ONE 7:e48279. 2012
    ..Our study indicated that MB could attenuate superoxide production by functioning as an alternative mitochondrial electron transfer carrier and as a regenerable anti-oxidant in mitochondria...
  3. pmc Pyruvate protects the brain against ischemia-reperfusion injury by activating the erythropoietin signaling pathway
    Myoung Gwi Ryou
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107 2699, USA
    Stroke 43:1101-7. 2012
    ..We tested the hypothesis that pyruvate protects the brain against ischemia-reperfusion injury by inducing endogenous erythropoietin (EPO) expression...
  4. pmc Modulation of polymorphonuclear neutrophil functions by astrocytes
    Luokun Xie
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, Fort Worth, TX 76107, USA
    J Neuroinflammation 7:53. 2010
    ..In the CNS, astrocytes are the most abundant glial cell population and participate in the local innate immune response triggered by a variety of insults. In the present study, we investigated the impacts of astrocytes on PMN function...
  5. ncbi request reprint Estrogen attenuates nuclear factor-kappa B activation induced by transient cerebral ischemia
    Yi Wen
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, 3500 Camp Bowie Blvd, Fort Worth, TX 76107 2699, USA
    Brain Res 1008:147-54. 2004
    ..These studies also provide evidence that suppression of post-ischemic inflammation may play a critical role in estrogen-mediated neuroprotection...
  6. ncbi request reprint Cell-cycle regulators are involved in transient cerebral ischemia induced neuronal apoptosis in female rats
    Yi Wen
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, 3500 Camp Bowie Blvd, Fort Worth, TX 76107 2699, USA
    FEBS Lett 579:4591-9. 2005
    ..These results suggest that ischemia/reperfusion cerebral damage induces signalings at the G1/S cell-cycle transition, and may constitute a critical step in the neuronal apoptotic pathway in ischemia/reperfusion induced neuronal damage...
  7. pmc The assessment of non-feminizing estrogens for use in neuroprotection
    Kun Don Yi
    Institute for Aging and Alzheimer s Disease Research, Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
    Brain Res 1379:61-70. 2011
    ..The success of this program of research suggests that strategies to optimize non-feminizing estrogens for use in postmenopausal women can be successful...
  8. ncbi request reprint Transient cerebral ischemia induces site-specific hyperphosphorylation of tau protein
    Yi Wen
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107 2699, USA
    Brain Res 1022:30-8. 2004
    ..Finally, our results also suggest that neuronal apoptosis may be a therapeutic target in preventing tauopathy-related neurodegenerative diseases...
  9. ncbi request reprint Role of nonfeminizing estrogens in brain protection from cerebral ischemia: an animal model of Alzheimer's disease neuropathology
    James W Simpkins
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, 3500 Camp Bowie Blvd, Fort Worth, TX 76107, USA
    Ann N Y Acad Sci 1052:233-42. 2005
    ....
  10. ncbi request reprint Neuroprotective effects of 17beta-estradiol and nonfeminizing estrogens against H2O2 toxicity in human neuroblastoma SK-N-SH cells
    Xiaofei Wang
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, 3500 Camp Bowie Blvd, Fort Worth, TX 76107, USA
    Mol Pharmacol 70:395-404. 2006
    ..In conclusion, estrogens exert protective effects against oxidative stress by inhibiting lipid peroxidation and subsequently preserving Ca2+ homeostasis, mitochondrial membrane potential, and ATP levels...
  11. ncbi request reprint Increased beta-secretase activity and expression in rats following transient cerebral ischemia
    Yi Wen
    Department of Pharmacology and Neuroscience, University of North Texas, Health Science Center Fort Worth, 3500 Camp Bowie Blvd, Fort Worth, TX 76107, USA
    Brain Res 1009:1-8. 2004
    ....
  12. pmc The potential for estrogens in preventing Alzheimer's disease and vascular dementia
    James W Simpkins
    Department of Pharmacology and Neuroscience, Institute for Aging and Alzheimer s Disease Research, Center FOR HER Focused On Resources for her Health, Education and Research, University of North Texas Health Science Center, Fort Worth, TX, USA
    Ther Adv Neurol Disord 2:31-49. 2009
    ..Several approaches to enhance brain specificity of estrogen action are now underway in an attempt to reduce the side effects of chronic estrogen therapy in AD...
  13. ncbi request reprint Transient cerebral ischemia induces aberrant neuronal cell cycle re-entry and Alzheimer's disease-like tauopathy in female rats
    Yi Wen
    Department of Pharmacology, University of North Texas Health Science Center, Fort Worth, Texas 76107, USA
    J Biol Chem 279:22684-92. 2004
    ....
  14. pmc Glutathione-conjugate transport by RLIP76 is required for clathrin-dependent endocytosis and chemical carcinogenesis
    Sharad S Singhal
    Corresponding Authors Sanjay Awasthi or Sharad S Singhal, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
    Mol Cancer Ther 10:16-28. 2011
    ..In RLIP76(-/-) mice, p53, p38, and JNK activation did not occur in response to either carcinogen. Our findings show a fundamental role of RLIP76 in chemical carcinogenesis...

Research Grants7

  1. Interaction of Estrogen and Tissue Plasminogen Activator
    Shaohua Yang; Fiscal Year: 2010
    ..The application's objectives are to explore the feasibility for further clinical trials of combination therapy of estrogen and rtPA for ischemic stroke. ..
  2. Vascular Cognitive Impairment Induced by Ischemic Stroke: mechanism and therapy
    Shaohua Yang; Fiscal Year: 2010
    ..The studies proposed will provide new insight on the mechanism of vascular dementia and identify potential therapeutic target for the prevention of cognitive decline following cerebral ischemia. ..
  3. Interaction of Estrogen and Tissue Plasminogen Activator
    Shaohua Yang; Fiscal Year: 2009
    ..The application's objectives are to explore the feasibility for further clinical trials of combination therapy of estrogen and rtPA for ischemic stroke. ..
  4. Vascular Cognitive Impairment Induced by Ischemic Stroke: mechanism and therapy
    Shaohua Yang; Fiscal Year: 2009
    ..The studies proposed will provide new insight on the mechanism of vascular dementia and identify potential therapeutic target for the prevention of cognitive decline following cerebral ischemia. ..