Ivana V Yang

Summary

Publications

  1. pmc Identification of novel genes that mediate innate immunity using inbred mice
    Ivana V Yang
    Department of Medicine, National Jewish Health, Denver, Colorado 80206, USA
    Genetics 183:1535-44. 2009
  2. pmc Identification of novel innate immune genes by transcriptional profiling of macrophages stimulated with TLR ligands
    Ivana V Yang
    Center for Genes, Environment, and Health, National Jewish Health, Denver, CO 80206, United States
    Mol Immunol 48:1886-95. 2011
  3. pmc Novel regulators of the systemic response to lipopolysaccharide
    Ivana V Yang
    Center for Genes, Environment and Health, National Jewish Health, Denver, CO 80206, USA
    Am J Respir Cell Mol Biol 45:393-402. 2011
  4. pmc Epigenetic control of gene expression in the lung
    Ivana V Yang
    Center for Genes, Environment, and Health, National Jewish Health, Denver, CO 80206, USA
    Am J Respir Crit Care Med 183:1295-301. 2011
  5. pmc A locus on chromosome 9 is associated with differential response of 129S1/SvImJ and FVB/NJ strains of mice to systemic LPS
    Ivana V Yang
    Center for Genes, Environment and Health and Department of Medicine, National Jewish Health, 1400 Jackson Street, A650, Denver, CO 80206, USA
    Mamm Genome 22:518-29. 2011
  6. doi request reprint Expression of cilium-associated genes defines novel molecular subtypes of idiopathic pulmonary fibrosis
    Ivana V Yang
    Department of Medicine, University of Colorado School of Medicine, Aurora, Colorado, USA
    Thorax 68:1114-21. 2013
  7. pmc Role of macrophage receptor with collagenous structure in innate immune tolerance
    Jian Jing
    Department of Medicine, University of Colorado School of Medicine, Aurora, CO 80045, USA
    J Immunol 190:6360-7. 2013
  8. pmc Genome-wide imputation study identifies novel HLA locus for pulmonary fibrosis and potential role for auto-immunity in fibrotic idiopathic interstitial pneumonia
    Tasha E Fingerlin
    Center for Genes, Environment and Health, National Jewish Health, Denver, CO, USA
    BMC Genet 17:74. 2016
  9. pmc Spatiotemporal inhibition of innate immunity signaling by the Tbc1d23 RAB-GAP
    Lesly De Arras
    Integrated Department of Immunology, National Jewish Health and University of Colorado, Denver, CO 80206, USA
    J Immunol 188:2905-13. 2012
  10. pmc The peripheral blood transcriptome identifies the presence and extent of disease in idiopathic pulmonary fibrosis
    Ivana V Yang
    Center for Genes, Environment and Health, National Jewish Health, Denver, Colorado, United States of America
    PLoS ONE 7:e37708. 2012

Collaborators

Detail Information

Publications29

  1. pmc Identification of novel genes that mediate innate immunity using inbred mice
    Ivana V Yang
    Department of Medicine, National Jewish Health, Denver, Colorado 80206, USA
    Genetics 183:1535-44. 2009
    ..These genes could represent potential sepsis biomarkers or therapeutic targets that should be further investigated in human populations...
  2. pmc Identification of novel innate immune genes by transcriptional profiling of macrophages stimulated with TLR ligands
    Ivana V Yang
    Center for Genes, Environment, and Health, National Jewish Health, Denver, CO 80206, United States
    Mol Immunol 48:1886-95. 2011
    ..1 and RAW264.7 macrophages stimulated with LPS. Together, these findings delineate macrophage gene response patterns induced by different PAMPs and identify new genes that have not previously been implicated in innate immunity...
  3. pmc Novel regulators of the systemic response to lipopolysaccharide
    Ivana V Yang
    Center for Genes, Environment and Health, National Jewish Health, Denver, CO 80206, USA
    Am J Respir Cell Mol Biol 45:393-402. 2011
    ..Our results provide potential sepsis biomarkers and therapeutic targets that should be further investigated in human populations...
  4. pmc Epigenetic control of gene expression in the lung
    Ivana V Yang
    Center for Genes, Environment, and Health, National Jewish Health, Denver, CO 80206, USA
    Am J Respir Crit Care Med 183:1295-301. 2011
    ....
  5. pmc A locus on chromosome 9 is associated with differential response of 129S1/SvImJ and FVB/NJ strains of mice to systemic LPS
    Ivana V Yang
    Center for Genes, Environment and Health and Department of Medicine, National Jewish Health, 1400 Jackson Street, A650, Denver, CO 80206, USA
    Mamm Genome 22:518-29. 2011
    ..Differences in the induction of Casp4 expression by LPS in the two strains suggest that Casp4 is the most likely candidate gene in this region...
  6. doi request reprint Expression of cilium-associated genes defines novel molecular subtypes of idiopathic pulmonary fibrosis
    Ivana V Yang
    Department of Medicine, University of Colorado School of Medicine, Aurora, Colorado, USA
    Thorax 68:1114-21. 2013
    ..We hypothesised that gene expression profiles of lung tissue may identify molecular subtypes of disease that could classify subtypes of IPF/UIP that have clinical implications...
  7. pmc Role of macrophage receptor with collagenous structure in innate immune tolerance
    Jian Jing
    Department of Medicine, University of Colorado School of Medicine, Aurora, CO 80045, USA
    J Immunol 190:6360-7. 2013
    ..In aggregate, we found that histone methylation was critical to MARCO expression and phagocytosis in tolerized macrophages, but did not affect the inflammatory component of innate immune tolerance...
  8. pmc Genome-wide imputation study identifies novel HLA locus for pulmonary fibrosis and potential role for auto-immunity in fibrotic idiopathic interstitial pneumonia
    Tasha E Fingerlin
    Center for Genes, Environment and Health, National Jewish Health, Denver, CO, USA
    BMC Genet 17:74. 2016
    ..Here we extend that work to imputed genome-wide genotypes and conduct new RNA sequencing studies of lung tissue to identify and characterize new fIIP risk loci...
  9. pmc Spatiotemporal inhibition of innate immunity signaling by the Tbc1d23 RAB-GAP
    Lesly De Arras
    Integrated Department of Immunology, National Jewish Health and University of Colorado, Denver, CO 80206, USA
    J Immunol 188:2905-13. 2012
    ..The identification of a novel spatiotemporal regulator of innate immunity signaling validates the comparative genomics approach for innate immunity gene discovery...
  10. pmc The peripheral blood transcriptome identifies the presence and extent of disease in idiopathic pulmonary fibrosis
    Ivana V Yang
    Center for Genes, Environment and Health, National Jewish Health, Denver, Colorado, United States of America
    PLoS ONE 7:e37708. 2012
    ..We hypothesize that peripheral blood biomarkers will identify disease in its early stages, and facilitate monitoring for disease progression...
  11. pmc Neutrophil transmigration triggers repair of the lung epithelium via beta-catenin signaling
    Rachel L Zemans
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, National Jewish Health, Denver, CO 80206, USA
    Proc Natl Acad Sci U S A 108:15990-5. 2011
    ..This pathway represents a potential therapeutic target to accelerate physiological recovery in inflammatory lung diseases...
  12. pmc Idiopathic Pulmonary Fibrosis: A Genetic Disease That Involves Mucociliary Dysfunction of the Peripheral Airways
    Christopher M Evans
    Department of Medicine, University of Colorado Denver, School of Medicine, Aurora, Colorado National Jewish Health, Denver, Colorado and Department of Immunology, University of Colorado Denver, School of Medicine, Aurora, Colorado
    Physiol Rev 96:1567-91. 2016
    ....
  13. pmc Relationship between gene expression and lung function in Idiopathic Interstitial Pneumonias
    Mark P Steele
    Department of Medicine, Vanderbilt University, Nashville, TN, USA
    BMC Genomics 16:869. 2015
    ..Since lung function is a key determinant of survival, we reasoned that the transcriptional profile in IIP lung tissue would be associated with measures of lung function, and could enhance prognostic approaches to IIPs...
  14. pmc CruzDB: software for annotation of genomic intervals with UCSC genome-browser database
    Brent S Pedersen
    Department of Medicine, University of Colorado Denver, School of Medicine, Denver, CO, USA and Molecular Oncology Program, University of Colorado Cancer Center, Aurora, CO, USA
    Bioinformatics 29:3003-6. 2013
    ..The biological significance of genomic features is often context dependent. Annotating a particular dataset with existing external data can provide insight into function...
  15. pmc Ozone enhances pulmonary innate immune response to a Toll-like receptor-2 agonist
    Judy L Oakes
    Department of Medicine, University of Colorado School of Medicine, Aurora, CO 80045, USA
    Am J Respir Cell Mol Biol 48:27-34. 2013
    ..Gene expression profiling of lung tissue identified transcriptional networks and genes that contribute to the priming of innate immunity at the molecular level...
  16. pmc The clinical and environmental determinants of airway transcriptional profiles in allergic asthma
    Ivana V Yang
    Department of Medicine, University of Colorado Denver, Aurora, CO 80045, USA
    Am J Respir Crit Care Med 185:620-7. 2012
    ..Gene expression profiling of airway epithelial and inflammatory cells can be used to identify genes involved in environmental asthma...
  17. pmc Novel Innate Immune Genes Regulating the Macrophage Response to Gram Positive Bacteria
    Scott Alper
    Department of Biomedical Research, National Jewish Health, Denver, Colorado 80206 Center for Genes, Environment, and Health, National Jewish Health, Denver, Colorado 80206 Department of Immunology and Microbiology, University of Colorado Anschutz Medical Campus, Aurora, Colorado 80045
    Genetics 204:327-36. 2016
    ..aureus, validating the genetic and RNAi approach to identify novel regulators of the response to LTA. We have identified four innate immune response genes that may contribute to Gram positive bacterial susceptibility. ..
  18. pmc The Toll-like receptor 4 polymorphism Asp299Gly but not Thr399Ile influences TLR4 signaling and function
    Huaicong Long
    Center for Genes, Environment and Health, National Jewish Health, Denver, Colorado, United States of America Department of Geriatrics, Sichuan Academy of Medical Sciences and Sichuan Provincial People s Hospital, Chengdu, Sichuan, P R of China
    PLoS ONE 9:e93550. 2014
    ..Taken together, we observed that the TLR4 Asp299Gly variant, but not the Thr399Ile variant, is responsible for impaired responsiveness of TLR4 to LPS and corresponding activation of NF-κB. ..
  19. pmc The next generation of complex lung genetic studies
    Ivana V Yang
    Department of Medicine, University of Colorado Denver, 12700 East 19th Avenue, 8611, Aurora, CO 80045, USA
    Am J Respir Crit Care Med 186:1087-94. 2012
    ....
  20. pmc Epigenomics of idiopathic pulmonary fibrosis
    Ivana V Yang
    Center for Genes, Environment and Health and the Department of Medicine, National Jewish Health, Denver, CO, USA
    Epigenomics 4:195-203. 2012
    ..The majority of the discussion will focus on epigenetic studies conducted so far in IPF, the limitations, challenges nd future directions in this field...
  21. pmc Fine ambient particles induce oxidative stress and metal binding genes in human alveolar macrophages
    Yuh Chin T Huang
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27705, USA
    Am J Respir Cell Mol Biol 41:544-52. 2009
    ..5) induced a gene expression profile prevalent with genes related to metal binding and oxidative stress in human AMs, independent of oxidative stress. Metals associated with PM may play an important role in particle-induced gene changes...
  22. pmc Unique DNA Methylation Patterns in Offspring of Hypertensive Pregnancy
    Colleen G Julian
    Department of Medicine, University of Colorado School of Medicine, Aurora, Colorado, USA
    Clin Transl Sci 8:740-5. 2015
    ..On the basis of these findings we speculate that epigenomic mechanisms may be involved in mediating the effect of HTNPREG to raise the risk of vascular disease later in life. ..
  23. pmc Epigenetic mechanisms and the development of asthma
    Ivana V Yang
    Department of Medicine, University of Colorado School of Medicine, Aurora, CO 80045, USA
    J Allergy Clin Immunol 130:1243-55. 2012
    ..Epigenetic mechanisms represent a promising line of inquiry that might, in part, explain the inheritance and immunobiology of asthma...
  24. pmc Incorporating genetics into the identification and treatment of Idiopathic Pulmonary Fibrosis
    Susan K Mathai
    Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado Denver, Anschutz Medical Campus, 12631 East 17th Avenue, Aurora, CO, 80045, USA
    BMC Med 13:191. 2015
    ..More recently, studies have confirmed that specific genetic variants are associated with both familial and sporadic forms of pulmonary fibrosis...
  25. pmc DNA methylation and childhood asthma in the inner city
    Ivana V Yang
    Department of Medicine, University of Colorado, School of Medicine, Aurora, Colo Departments of Pediatrics and Medicine, National Jewish Health, Denver, Colo
    J Allergy Clin Immunol 136:69-80. 2015
    ..Thus it is important to define epigenetic alterations in asthmatic populations...
  26. pmc AKT network of genes and impaired myocardial contractility during murine acute Chagasic myocarditis
    Andres F Henao-Martinez
    Division of Infectious Diseases and Departments of Medicine and Immunology, University of Colorado, Denver, Colorado Department of Epidemiology, Colorado School of Public Health, Denver, Colorado Department of Pathology, Denver Health, Denver, Colorado
    Am J Trop Med Hyg 92:523-9. 2015
    ..These specific phenotypic features of cardiac response during acute Chagasic myocarditis may, in part, be related to host AKT network regulation. ..
  27. pmc Stanniocalcin-1 is induced by hypoxia inducible factor in rat alveolar epithelial cells
    Yoko Ito
    Department of Medicine, National Jewish Health, Denver, CO, USA Electronic address
    Biochem Biophys Res Commun 452:1091-7. 2014
    ....
  28. pmc Comb-p: software for combining, analyzing, grouping and correcting spatially correlated P-values
    Brent S Pedersen
    Department of Medicine, University of Colorado, Denver, Anschutz Medical Campus, Aurora, CO 80045, USA
    Bioinformatics 28:2986-8. 2012
    ..Because the library accepts input in a simple, standardized format and is unaffected by the origin of the P-values, it can be used for a wide variety of applications...
  29. pmc A common MUC5B promoter polymorphism and pulmonary fibrosis
    Max A Seibold
    National Jewish Health, Denver, USA
    N Engl J Med 364:1503-12. 2011
    ..The mutations that have been implicated in pulmonary fibrosis account for only a small proportion of the population risk...