Hao Yang

Summary

Publications

  1. pmc Direct transdifferentiation of spermatogonial stem cells to morphological, phenotypic and functional hepatocyte-like cells via the ERK1/2 and Smad2/3 signaling pathways and the inactivation of cyclin A, cyclin B and cyclin E
    Zhenzhen Zhang
    Renji Hospital, Stem Cell Research Center, Shanghai Jiao Tong University School of Medicine, 1630 Dongfang Road, Shanghai 200127, China
    Cell Commun Signal 11:67. 2013
  2. doi request reprint Sonic hedgehog released from scratch-injured astrocytes is a key signal necessary but not sufficient for the astrocyte de-differentiation
    Hao Yang
    Institute of Neurosciences, The Fourth Military Medical University, Xi an, China
    Stem Cell Res 9:156-66. 2012
  3. doi request reprint In vitro beneficial activation of microglial cells by mechanically-injured astrocytes enhances the synthesis and secretion of BDNF through p38MAPK
    Hao Yang
    Institute of Neurosciences, The Fourth Military Medical University, Xi an 710032, China
    Neurochem Int 61:175-86. 2012
  4. doi request reprint Thymosin-beta4 attenuates ethanol-induced neurotoxicity in cultured cerebral cortical astrocytes by inhibiting apoptosis
    Hao Yang
    Institute of Neurosciences, The Fourth Military Medical University, 710032, Xi an, China
    Cell Mol Neurobiol 30:149-60. 2010
  5. doi request reprint Evidence for heterogeneity of astrocyte de-differentiation in vitro: astrocytes transform into intermediate precursor cells following induction of ACM from scratch-insulted astrocytes
    Hao Yang
    Institute of Neurosciences, The Fourth Military Medical University, 17 West Chang le Road, 710032, Xi an, China
    Cell Mol Neurobiol 30:483-91. 2010
  6. doi request reprint Long-term primary culture of highly-pure rat embryonic hippocampal neurons of low-density
    Hao Yang
    Institute of Neurosciences, The Fourth Military Medical University, Xi an, China
    Neurochem Res 35:1333-42. 2010
  7. doi request reprint ErbB2 activation contributes to de-differentiation of astrocytes into radial glial cells following induction of scratch-insulted astrocyte conditioned medium
    Hao Yang
    Institute of Neurosciences, The Fourth Military Medical University, Xi an 710032, China
    Neurochem Int 59:1010-8. 2011
  8. doi request reprint De-differentiation response of cultured astrocytes to injury induced by scratch or conditioned culture medium of scratch-insulted astrocytes
    Hao Yang
    Institute of Neurosciences, The Fourth Military Medical University, Xi an, Shaanxi, PR China
    Cell Mol Neurobiol 29:455-73. 2009
  9. doi request reprint Retinoic acid and human olfactory ensheathing cells cooperate to promote neural induction from human bone marrow stromal stem cells
    Song tao Xie
    Department of Burns and Cutaneous Surgery, Xijing Hospital, The Fourth Military Medical University, Xi an, 710032, China
    Neuromolecular Med 15:252-64. 2013
  10. doi request reprint The promotive effects of thymosin beta4 on neuronal survival and neurite outgrowth by upregulating L1 expression
    Hao Yang
    The Institute of Neuroscience, The Fourth Military Medical University, Xi an, Shaanxi, 710032, People s Republic of China
    Neurochem Res 33:2269-80. 2008

Collaborators

Detail Information

Publications21

  1. pmc Direct transdifferentiation of spermatogonial stem cells to morphological, phenotypic and functional hepatocyte-like cells via the ERK1/2 and Smad2/3 signaling pathways and the inactivation of cyclin A, cyclin B and cyclin E
    Zhenzhen Zhang
    Renji Hospital, Stem Cell Research Center, Shanghai Jiao Tong University School of Medicine, 1630 Dongfang Road, Shanghai 200127, China
    Cell Commun Signal 11:67. 2013
    ..Here we hypothesized that spermatogonial stem cells (SSCs) can directly transdifferentiate to hepatic stem-like cells capable of differentiating into mature hepatocyte-like cells in vitro without an intervening pluripotent state...
  2. doi request reprint Sonic hedgehog released from scratch-injured astrocytes is a key signal necessary but not sufficient for the astrocyte de-differentiation
    Hao Yang
    Institute of Neurosciences, The Fourth Military Medical University, Xi an, China
    Stem Cell Res 9:156-66. 2012
    ..These data above suggest that Shh is a key instructive molecule while other molecules secreted from insulted astrocytes may synergistically promote the de-differentiation event...
  3. doi request reprint In vitro beneficial activation of microglial cells by mechanically-injured astrocytes enhances the synthesis and secretion of BDNF through p38MAPK
    Hao Yang
    Institute of Neurosciences, The Fourth Military Medical University, Xi an 710032, China
    Neurochem Int 61:175-86. 2012
    ..Therefore, these findings may lay a foundation to further investigations on the microglial beneficial activation role in the repair of traumatic CNS injury and neurodegenerative diseases...
  4. doi request reprint Thymosin-beta4 attenuates ethanol-induced neurotoxicity in cultured cerebral cortical astrocytes by inhibiting apoptosis
    Hao Yang
    Institute of Neurosciences, The Fourth Military Medical University, 710032, Xi an, China
    Cell Mol Neurobiol 30:149-60. 2010
    ....
  5. doi request reprint Evidence for heterogeneity of astrocyte de-differentiation in vitro: astrocytes transform into intermediate precursor cells following induction of ACM from scratch-insulted astrocytes
    Hao Yang
    Institute of Neurosciences, The Fourth Military Medical University, 17 West Chang le Road, 710032, Xi an, China
    Cell Mol Neurobiol 30:483-91. 2010
    ....
  6. doi request reprint Long-term primary culture of highly-pure rat embryonic hippocampal neurons of low-density
    Hao Yang
    Institute of Neurosciences, The Fourth Military Medical University, Xi an, China
    Neurochem Res 35:1333-42. 2010
    ..Thus, our modified method proved to be a simple, feasible as well as time- and resource-saving approach for a long-term survival of pure rat embryonic hippocampal neurons of low-density...
  7. doi request reprint ErbB2 activation contributes to de-differentiation of astrocytes into radial glial cells following induction of scratch-insulted astrocyte conditioned medium
    Hao Yang
    Institute of Neurosciences, The Fourth Military Medical University, Xi an 710032, China
    Neurochem Int 59:1010-8. 2011
    ..Thereby these results provide a potential mechanism by which ACM could induce mature astrocytes to regain the profile of radial glial progenitors due to activating the ErbB2 signaling pathways...
  8. doi request reprint De-differentiation response of cultured astrocytes to injury induced by scratch or conditioned culture medium of scratch-insulted astrocytes
    Hao Yang
    Institute of Neurosciences, The Fourth Military Medical University, Xi an, Shaanxi, PR China
    Cell Mol Neurobiol 29:455-73. 2009
    ..These results reveal that the in vitro injured ASTs can de-differentiate into nestin-positive stem/precursor cells, the process of de-differentiation may arise from direct injury or some diffusible factors released from injured ASTs...
  9. doi request reprint Retinoic acid and human olfactory ensheathing cells cooperate to promote neural induction from human bone marrow stromal stem cells
    Song tao Xie
    Department of Burns and Cutaneous Surgery, Xijing Hospital, The Fourth Military Medical University, Xi an, 710032, China
    Neuromolecular Med 15:252-64. 2013
    ..Therefore, these findings may provide an alternative strategy for the repair of traumatic nerve injury and neurological diseases with application of the optimal combination of RA and OECs for neuronal differentiation of hBMSCs...
  10. doi request reprint The promotive effects of thymosin beta4 on neuronal survival and neurite outgrowth by upregulating L1 expression
    Hao Yang
    The Institute of Neuroscience, The Fourth Military Medical University, Xi an, Shaanxi, 710032, People s Republic of China
    Neurochem Res 33:2269-80. 2008
    ..These above results indicate that the promotive effect of Tbeta4 on the survival and neurite outgrowth of cultured spinal cord neurons might be mediated, at least in part via a stimulation of the production of L1 in the neurons...
  11. doi request reprint Neutralization of BDNF attenuates the in vitro protective effects of olfactory ensheathing cell-conditioned medium on scratch-insulted retinal ganglion cells
    Tao Wang
    Institute of Neurosciences, The Fourth Military Medical University, Xi an, China
    Cell Mol Neurobiol 31:357-64. 2011
    ..It is thus concluded that neurotrophic factors including BDNF secreted by OECs can protect injured OECs in vitro and BDNF plays a major role in such a protection of OECs...
  12. ncbi request reprint Differentiation-inducing and protective effects of adult rat olfactory ensheathing cell conditioned medium on PC12 cells
    Ya Zhou Wang
    Institute of Neurosciences, The Fourth Military Medical University, 17 Chang Le Xi Road, Xi an, 710032, PR China
    Neurosci Lett 346:9-12. 2003
    ..The results show that the factors secreted by the adult olfactory ensheathing cells can promote PC12 cell differentiation and protect it from Zn(2+) insult...
  13. doi request reprint Over-expression of Mash1 improves the GABAergic differentiation of bone marrow mesenchymal stem cells in vitro
    Kai Wang
    Department of Neurosurgery, Xijing Institute of Clinical Neuroscience, Fourth Military Medical University, No 17 Chang le West Road, Xi an 710032, China Department of Neurosurgery, Qingdao 401 Hospital of PLA, No 22 Minjiang Road, Qingdao 266071, China
    Brain Res Bull 99:84-94. 2013
    ..In conclusion, our study demonstrated that over-expression of Mash1 can improve GABAergic differentiation of BMSCs in vitro. ..
  14. ncbi request reprint Intraneuronal localization of Nogo-A in the rat
    Wei Lin Jin
    Institute of Neurosciences, The Fourth Military Medical University, Xi an 710032, China
    J Comp Neurol 458:1-10. 2003
    ..This study provides the first immunocytochemical evidence for intraneuronal distribution of Nogo-A. Apparently, the significance of Nogo-A in the central nervous system is far more complex than what has been envisioned...
  15. doi request reprint Death of axotomized retinal ganglion cells delayed after intraoptic nerve transplantation of olfactory ensheathing cells in adult rats
    Ming Mei Wu
    Institute of Neurosciences, The Fourth Military Medical University, Xi an, China
    Cell Transplant 19:159-66. 2010
    ..Our findings suggest that OEC transplantation induces the expression of BDNF in the ocular ON stump and retina and delays the death of axotomized RGCs at a certain survival period...
  16. doi request reprint Decreased neural stem/progenitor cell proliferation in mice with chronic/nonremitting experimental autoimmune encephalomyelitis
    Jun Guo
    Department of Neurology, Tangdu Hospital, Xi an, China
    Neurosignals 18:1-8. 2010
    ..The hippocampus is well known to be an important region involved in learning and memory; thus, our finding may offer a possible explanation for the cognitive impairment in human chronic MS...
  17. ncbi request reprint [Expression and biological activity of human neurotrophin-3 in olfactory ensheathing cells mediated by retroviral vector]
    Hao Yang
    Institute of Neurosciences, Fourth Military Medical University, Xi an 710032
    Shi Yan Sheng Wu Xue Bao 36:5-12. 2003
    ..Our results indicate that Tet-On-regulated NT-3 expression in OECs was efficient, offering novel material of in vivo transplantation for the repair of CNS injury...
  18. doi request reprint The protective effects of inosine against chemical hypoxia on cultured rat oligodendrocytes
    Quan Rui Ma
    Institute of Neurosciences, The Fourth Military Medical University, Xi an 710032, China
    Cell Mol Neurobiol 31:1171-86. 2011
    ..As OLs form myelin in the central nervous system, inosine could be used as a promising drug to treat demyelination-involved disorders...
  19. doi request reprint Involvement of α7 nAChR signaling cascade in epigallocatechin gallate suppression of β-amyloid-induced apoptotic cortical neuronal insults
    Xijing Zhang
    Department of Anesthesiology, Xijing Hospital, The Fourth Military Medical University, Xi an, 710032, China
    Mol Neurobiol 49:66-77. 2014
    ....
  20. doi request reprint The effect of the coumarin-like derivative osthole on the osteogenic properties of human periodontal ligament and jaw bone marrow mesenchymal stem cell sheets
    Li Na Gao
    Department of Periodontology and Oral Medicine, School of Stomatology, Fourth Military Medical University, Xi an, PR China Research and Development Center for Tissue Engineering, Fourth Military Medical University, Xi an, PR China Translational Research Team, School of Stomatology, Fourth Military Medical University, Xi an, PR China
    Biomaterials 34:9937-51. 2013
    ..001). Our data suggest that a suitable concentration and mode of osthole stimulation may enhance ECM production and positively affect cell behavior in cell sheet engineering...
  21. pmc Brain Tumor Stem-Like Cells Identified by Neural Stem Cell Marker CD15
    Xing gang Mao
    Department of Neurosurgery, Xijing Hospital, The Fourth Military Medical University, Xi an, Shaanxi Province, China
    Transl Oncol 2:247-57. 2009
    ..Therefore, CD15 can be used as a marker of stem-like cells derived from brain tumors that might contain CD133(-) BTSCs...