Christopher K Willie

Summary

Publications

  1. pmc Integrative regulation of human brain blood flow
    Christopher K Willie
    Centre for Heart, Lung and Vascular Health, School of Health and Exercise Sciences, University of British Columbia Okanagan, Kelowna, British Columbia, Canada V1V 1V7
    J Physiol 592:841-59. 2014
  2. doi Maintained cerebrovascular function during post-exercise hypotension
    Christopher K Willie
    Centre for Heart, Lung and Vascular Health, School of Health and Exercise Sciences, University of British Columbia, 3333 University Way, Okanagan, Kelowna, BC, Canada
    Eur J Appl Physiol 113:1597-604. 2013
  3. pmc Regional brain blood flow in man during acute changes in arterial blood gases
    C K Willie
    School of Health and Exercise Sciences, Faculty of Health and Social Development, University of British Columbia, Okanagan Campus, Canada, 3333 University Way, Kelowna, BC Canada V1V 1V7
    J Physiol 590:3261-75. 2012
  4. doi Utility of transcranial Doppler ultrasound for the integrative assessment of cerebrovascular function
    C K Willie
    Department of Human Kinetics, Faculty of Health and Social Development, University of British Columbia Okanagan, 3333 University Way, Kelowna, BC, Canada V1V 1V7
    J Neurosci Methods 196:221-37. 2011
  5. doi Neuromechanical features of the cardiac baroreflex after exercise
    Christopher K Willie
    Department of Human Kinetics, Faculty of Health and Social Development, University of British Columbia Okanagan, Kelowna, 3333 University Way, Kelowna, British Columbia, Canada V1V 1V7
    Hypertension 57:927-33. 2011
  6. doi Neurovascular coupling and distribution of cerebral blood flow during exercise
    C K Willie
    Department of Human Kinetics, Faculty of Health and Social Development, University of British Columbia Okanagan, 3333 University Way, Kelowna, BC V1V1V7, Canada
    J Neurosci Methods 198:270-3. 2011
  7. doi Stability of cerebral metabolism and substrate availability in humans during hypoxia and hyperoxia
    Philip N Ainslie
    School of Health and Exercise Sciences, University of British Columbia, British Columbia, Canada
    Clin Sci (Lond) 126:661-70. 2014
  8. pmc The contribution of arterial blood gases in cerebral blood flow regulation and fuel utilization in man at high altitude
    Christopher K Willie
    Centre for Heart, Lung and Vascular Health, School of Health and Exercise Sciences, University of British Columbia Okanagan, Kelowna, British Columbia, Canada
    J Cereb Blood Flow Metab 35:873-81. 2015
  9. doi Regional changes in brain blood flow during severe passive hyperthermia: effects of PaCO2 and extracranial blood flow
    Anthony R Bain
    Center for Heart, Lung, and Vascular Health, University of British Columbia, Okanagan, British Columbia, Canada
    J Appl Physiol (1985) 115:653-9. 2013
  10. pmc Impact of hypocapnia and cerebral perfusion on orthostatic tolerance
    Nia C S Lewis
    Centre for Heart, Lung and Vascular Health, University of British Columbia, Okanagan, Canada
    J Physiol 592:5203-19. 2014

Collaborators

Detail Information

Publications11

  1. pmc Integrative regulation of human brain blood flow
    Christopher K Willie
    Centre for Heart, Lung and Vascular Health, School of Health and Exercise Sciences, University of British Columbia Okanagan, Kelowna, British Columbia, Canada V1V 1V7
    J Physiol 592:841-59. 2014
    ..Finally, we summarize the state of our knowledge with respect to these areas, outline important gaps in the literature and suggest avenues for future research. ..
  2. doi Maintained cerebrovascular function during post-exercise hypotension
    Christopher K Willie
    Centre for Heart, Lung and Vascular Health, School of Health and Exercise Sciences, University of British Columbia, 3333 University Way, Okanagan, Kelowna, BC, Canada
    Eur J Appl Physiol 113:1597-604. 2013
    ..05). These data indicate that cerebrovascular regulation remains intact following a moderate bout of aerobic exercise...
  3. pmc Regional brain blood flow in man during acute changes in arterial blood gases
    C K Willie
    School of Health and Exercise Sciences, Faculty of Health and Social Development, University of British Columbia, Okanagan Campus, Canada, 3333 University Way, Kelowna, BC Canada V1V 1V7
    J Physiol 590:3261-75. 2012
    ....
  4. doi Utility of transcranial Doppler ultrasound for the integrative assessment of cerebrovascular function
    C K Willie
    Department of Human Kinetics, Faculty of Health and Social Development, University of British Columbia Okanagan, 3333 University Way, Kelowna, BC, Canada V1V 1V7
    J Neurosci Methods 196:221-37. 2011
    ..The integration of these regulatory mechanisms from an integrated systems perspective is discussed, and future research directions are explored...
  5. doi Neuromechanical features of the cardiac baroreflex after exercise
    Christopher K Willie
    Department of Human Kinetics, Faculty of Health and Social Development, University of British Columbia Okanagan, Kelowna, 3333 University Way, Kelowna, British Columbia, Canada V1V 1V7
    Hypertension 57:927-33. 2011
    ..We suggest that impaired neural transduction of the cardiac baroreflex, and its influence on hysteresis, plays an important role in transient autonomic dysfunction after exercise...
  6. doi Neurovascular coupling and distribution of cerebral blood flow during exercise
    C K Willie
    Department of Human Kinetics, Faculty of Health and Social Development, University of British Columbia Okanagan, 3333 University Way, Kelowna, BC V1V1V7, Canada
    J Neurosci Methods 198:270-3. 2011
    ..2±13.6% and 26.1±22.5% increase from rest in the MCAv and PCAv, respectively, neurovascular coupling was unaltered. Thus, despite regionally heterogeneous elevations in CBV during exercise, neurometabolic coupling is maintained...
  7. doi Stability of cerebral metabolism and substrate availability in humans during hypoxia and hyperoxia
    Philip N Ainslie
    School of Health and Exercise Sciences, University of British Columbia, British Columbia, Canada
    Clin Sci (Lond) 126:661-70. 2014
    ..As such, cerebral metabolism is still supported almost exclusively by carbohydrate oxidation during severe levels of hypoxaemia. ..
  8. pmc The contribution of arterial blood gases in cerebral blood flow regulation and fuel utilization in man at high altitude
    Christopher K Willie
    Centre for Heart, Lung and Vascular Health, School of Health and Exercise Sciences, University of British Columbia Okanagan, Kelowna, British Columbia, Canada
    J Cereb Blood Flow Metab 35:873-81. 2015
    ..4) At SL hypoxia increased CBF, and restoration of oxygen at HA reduced CBF, but neither had any effect on cerebral metabolism. Acclimatization resets the cerebrovasculature to chronic hypocapnia...
  9. doi Regional changes in brain blood flow during severe passive hyperthermia: effects of PaCO2 and extracranial blood flow
    Anthony R Bain
    Center for Heart, Lung, and Vascular Health, University of British Columbia, Okanagan, British Columbia, Canada
    J Appl Physiol (1985) 115:653-9. 2013
    ....
  10. pmc Impact of hypocapnia and cerebral perfusion on orthostatic tolerance
    Nia C S Lewis
    Centre for Heart, Lung and Vascular Health, University of British Columbia, Okanagan, Canada
    J Physiol 592:5203-19. 2014
    ..In summary, cerebral hypoperfusion either at rest or induced by hypocapnia at pre-syncope does not impact OT, probably due to a compensatory increase in oxygen extraction. ..
  11. pmc Regulation of brain blood flow and oxygen delivery in elite breath-hold divers
    Christopher K Willie
    Centre for Heart, Lung, and Vascular Health, School of Health and Exercise, Sciences, University of British Columbia Okanagan, Kelowna, British Columbia, Canada
    J Cereb Blood Flow Metab 35:66-73. 2015
    ..Termination of apnea was not determined by reduced cerebral oxygen delivery; despite 40% to 50% reductions in arterial oxygen content, oxygen delivery was maintained by commensurately increased CBF...