Robert W Williams

Summary

Publications

  1. ncbi request reprint Resources for Systems Genetics
    Robert W Williams
    Department of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, 77 S Manassas Street, Memphis, TN, 38163, USA
    Methods Mol Biol 1488:3-29. 2017
  2. pmc A novel genetic locus linked to pro-inflammatory cytokines after virulent H5N1 virus infection in mice
    Adrianus C M Boon
    Departments of Internal Medicine, Division of Infectious Diseases, Molecular Microbiology and Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    BMC Genomics 15:1017. 2014
  3. pmc Joint genetic analysis of hippocampal size in mouse and human identifies a novel gene linked to neurodegenerative disease
    David G Ashbrook
    Computational and Evolutionary Biology, Faculty of Life Sciences, University of Manchester, Michael Smith Building, Oxford Road, Manchester M13 9PT, UK
    BMC Genomics 15:850. 2014
  4. pmc Abundance of female-biased and paucity of male-biased somatically expressed genes on the mouse X-chromosome
    Björn Reinius
    Department of Organismal Biology, Evolutionary Biology Centre, Uppsala University, Uppsala, Sweden
    BMC Genomics 13:607. 2012
  5. pmc Distinct gene loci control the host response to influenza H1N1 virus infection in a time-dependent manner
    Tatiana Nedelko
    Department of Infection Genetics, Helmholtz Centre for Infection Research and University of Veterinary Medicine Hannover, 38124, Braunschweig, Germany
    BMC Genomics 13:411. 2012
  6. pmc Genetic and molecular network analysis of behavior
    Robert W Williams
    Department of Anatomy and Neurobiology, Center for Integrative and Translational Genomics, University of Tennessee Health Science Center, Memphis, Tennessee, USA
    Int Rev Neurobiol 104:135-57. 2012
  7. pmc Genome Reshuffling for Advanced Intercross Permutation (GRAIP): simulation and permutation for advanced intercross population analysis
    Jeremy L Peirce
    Center for Neuroscience, Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America
    PLoS ONE 3:e1977. 2008
  8. ncbi request reprint Inferring gene transcriptional modulatory relations: a genetical genomics approach
    Hongqiang Li
    Department of Molecular Sciences, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Hum Mol Genet 14:1119-25. 2005
  9. pmc Genetic modulation of the iris transillumination defect: a systems genetics analysis using the expanded family of BXD glaucoma strains
    Shankar Swaminathan
    Department of Ophthalmology, Hamilton Eye Institute, University of Tennessee Health Science Center, Memphis, TN, USA
    Pigment Cell Melanoma Res 26:487-98. 2013
  10. pmc Dissection of a QTL hotspot on mouse distal chromosome 1 that modulates neurobehavioral phenotypes and gene expression
    Khyobeni Mozhui
    Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, Memphis, TN, USA
    PLoS Genet 4:e1000260. 2008

Collaborators

Detail Information

Publications72

  1. ncbi request reprint Resources for Systems Genetics
    Robert W Williams
    Department of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, 77 S Manassas Street, Memphis, TN, 38163, USA
    Methods Mol Biol 1488:3-29. 2017
    ..We consider factors such as costs, availability, and ease of breeding for common scenarios. In general, we recommend using complementary resources and minimizing depth of resampling of any given genome or strain...
  2. pmc A novel genetic locus linked to pro-inflammatory cytokines after virulent H5N1 virus infection in mice
    Adrianus C M Boon
    Departments of Internal Medicine, Division of Infectious Diseases, Molecular Microbiology and Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    BMC Genomics 15:1017. 2014
    ....
  3. pmc Joint genetic analysis of hippocampal size in mouse and human identifies a novel gene linked to neurodegenerative disease
    David G Ashbrook
    Computational and Evolutionary Biology, Faculty of Life Sciences, University of Manchester, Michael Smith Building, Oxford Road, Manchester M13 9PT, UK
    BMC Genomics 15:850. 2014
    ..A key challenge is to understand how genetically based differences in brain structure lead to the propensity to develop specific neurological disorders...
  4. pmc Abundance of female-biased and paucity of male-biased somatically expressed genes on the mouse X-chromosome
    Björn Reinius
    Department of Organismal Biology, Evolutionary Biology Centre, Uppsala University, Uppsala, Sweden
    BMC Genomics 13:607. 2012
    ..We performed a large-scale sex-bias expression analysis of genes on the X-chromosome in six different somatic tissues from mouse...
  5. pmc Distinct gene loci control the host response to influenza H1N1 virus infection in a time-dependent manner
    Tatiana Nedelko
    Department of Infection Genetics, Helmholtz Centre for Infection Research and University of Veterinary Medicine Hannover, 38124, Braunschweig, Germany
    BMC Genomics 13:411. 2012
    ..In particular, C57BL/6J, the most widely used mouse strain in biomedical research, is comparatively resistant. In contrast, DBA/2J is highly susceptible...
  6. pmc Genetic and molecular network analysis of behavior
    Robert W Williams
    Department of Anatomy and Neurobiology, Center for Integrative and Translational Genomics, University of Tennessee Health Science Center, Memphis, Tennessee, USA
    Int Rev Neurobiol 104:135-57. 2012
    ..on behavior? (2) Can we map causal relations between gene variants and behavioral differences? (3) Can we simultaneously use these highly coherent data sets to understand more about the underlying molecular and cellular basis of behavior?..
  7. pmc Genome Reshuffling for Advanced Intercross Permutation (GRAIP): simulation and permutation for advanced intercross population analysis
    Jeremy L Peirce
    Center for Neuroscience, Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America
    PLoS ONE 3:e1977. 2008
    ..The critical problem with naïve mapping approaches in AIL populations is that the individual is not an exchangeable unit...
  8. ncbi request reprint Inferring gene transcriptional modulatory relations: a genetical genomics approach
    Hongqiang Li
    Department of Molecular Sciences, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Hum Mol Genet 14:1119-25. 2005
    ..SNPs that distinguish between the two progenitor strains were used to further winnow the list of candidate modulators. Bayesian network was then used to identify the genetic modulatory relations that best explain the microarray data...
  9. pmc Genetic modulation of the iris transillumination defect: a systems genetics analysis using the expanded family of BXD glaucoma strains
    Shankar Swaminathan
    Department of Ophthalmology, Hamilton Eye Institute, University of Tennessee Health Science Center, Memphis, TN, USA
    Pigment Cell Melanoma Res 26:487-98. 2013
    ..Our model accounted for 71-88% of the explained variance of the TID phenotype across the age bins. These results demonstrate that along with Tyrp1 and Gpnmb, Oca2, Myo5a, Prkcz, and Zbtb20 modulate the TID in an age-dependent manner. ..
  10. pmc Dissection of a QTL hotspot on mouse distal chromosome 1 that modulates neurobehavioral phenotypes and gene expression
    Khyobeni Mozhui
    Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, Memphis, TN, USA
    PLoS Genet 4:e1000260. 2008
    ..Our analysis revealed a highly complex gene expression regulatory interval in Qrr1, composed of multiple loci modulating the expression of functionally cognate sets of genes...
  11. pmc Genetic analysis of tongue size and taste papillae number and size in recombinant inbred strains of mice
    David J Reiner
    Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, College of Medicine, 855 Monroe Avenue, Memphis, TN 38163, USA
    Chem Senses 33:693-707. 2008
    ..This study is an important first step in identifying genetic factors underlying tongue size, papillae size, and papillae number using QTL analysis...
  12. ncbi request reprint An integrative genomics strategy for systematic characterization of genetic loci modulating phenotypes
    Lei Bao
    Department of Molecular Sciences, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Hum Mol Genet 16:1381-90. 2007
    ..This strategy integrates gene-phenotype relations from decades of experimental mutagenesis studies and new genomic resources to provide an approach to rapidly expand knowledge on genetic loci modulating phenotypes...
  13. ncbi request reprint Integrative genetic analysis of transcription modules: towards filling the gap between genetic loci and inherited traits
    Hongqiang Li
    Department of Molecular Sciences, University of Tennessee Health Science Center, 858 Madison Avenue Memphis, TN 38163, USA
    Hum Mol Genet 15:481-92. 2006
    ....
  14. ncbi request reprint Combining gene expression QTL mapping and phenotypic spectrum analysis to uncover gene regulatory relationships
    Lei Bao
    Department of Molecular Sciences, University of Tennessee Health Science Center, 858 Madison Avenue, Memphis, TN 38163, USA
    Mamm Genome 17:575-83. 2006
    ..Our results show that the combination of gene eQTL mapping and phenotypic spectrum analysis may provide a valuable approach to uncovering gene regulatory relations underlying mammalian phenotypes...
  15. pmc Host genetics and Chlamydia disease: prediction and validation of disease severity mechanisms
    Isao Miyairi
    Department of Microbiology, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America
    PLoS ONE 7:e33781. 2012
    ..Our results show that genetic mapping and network modeling can be combined to identify causal pathways underlying chlamydial disease susceptibility...
  16. pmc Detection, validation, and downstream analysis of allelic variation in gene expression
    Daniel C Ciobanu
    Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    Genetics 184:119-28. 2010
    ..Using a systems genetics approach we show that two validated cis-modulated genes, Stk25 and Rasd2, are likely to control expression of downstream targets and affect disease susceptibility...
  17. pmc Genetic networks controlling retinal injury
    Felix R Vazquez-Chona
    Department of Ophthalmology, The Hamilton Eye Institute, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Mol Vis 11:958-70. 2005
    ..The present study defines genomic loci underlying coordinate changes in gene expression following retinal injury...
  18. ncbi request reprint The Tennessee Mouse Genome Consortium: identification of ocular mutants
    Monica M Jablonski
    Department of Ophthalmology, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Vis Neurosci 22:595-604. 2005
    ..Mice from each of these pedigrees of mutant mice are available for distribution to researchers for independent study...
  19. ncbi request reprint How replicable are mRNA expression QTL?
    Jeremy L Peirce
    Center for Neuroscience, Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Mamm Genome 17:643-56. 2006
    ..Finally, we note that while trans-acting QTL do not replicate well between data sets in general, at least one cluster of trans-acting QTL on distal Chr 1 is notably preserved between data sets...
  20. pmc Host genetic variation affects resistance to infection with a highly pathogenic H5N1 influenza A virus in mice
    Adrianus C M Boon
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Virol 83:10417-26. 2009
    ..One of the validated genes, the hemolytic complement gene, affected virus titer 7 days after infection. We conclude that H5N1 influenza virus-induced pathology is affected by a complex and multigenic host component...
  21. pmc Complex interactions of Tyrp1 in the eye
    Hong Lu
    Department of Ophthalmology, Hamilton Eye Institute, University of Tennessee Health Science Center, Memphis, TN, USA
    Mol Vis 17:2455-68. 2011
    ....
  22. pmc Differential response of C57BL/6J mouse and DBA/2J mouse to optic nerve crush
    Justin P Templeton
    Department of Ophthalmology, University of Tennessee Health Science Center, Memphis TN, 38163, USA
    BMC Neurosci 10:90. 2009
    ..Indeed, this process appears to be influenced by a wide variety of genetic and environmental factors. In this study we explored the genetic basis for differences in ganglion cell death in two inbred strains of mice...
  23. pmc PolymiRTS Database: linking polymorphisms in microRNA target sites with complex traits
    Lei Bao
    Department of Molecular Sciences, Memphis, TN 38163, USA
    Nucleic Acids Res 35:D51-4. 2007
    ..It is a resource for studying PolymiRTSs and their implications in phenotypic variations. PolymiRTS database can be accessed at http://compbio.utmem.edu/miRSNP/...
  24. pmc Strain differences in stress responsivity are associated with divergent amygdala gene expression and glutamate-mediated neuronal excitability
    Khyobeni Mozhui
    Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    J Neurosci 30:5357-67. 2010
    ..Collectively, our data support a model in which genetic variation in glutamatergic neuroplasticity in corticolimbic circuitry underlies phenotypic variation in responsivity to stress...
  25. pmc Genetic networks in the mouse retina: growth associated protein 43 and phosphatase tensin homolog network
    Natalie E Freeman
    Department of Ophthalmology and Center for Vision Research, Memphis, TN, USA
    Mol Vis 17:1355-72. 2011
    ..For example, we define the genetic network regulating growth associated protein 43 (Gap43) and phosphatase tensin homolog (Pten)...
  26. pmc A simple method for combining genetic mapping data from multiple crosses and experimental designs
    Jeremy L Peirce
    Center for Neuroscience, Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America
    PLoS ONE 2:e1036. 2007
    ..Many phenotypes are now associated with enough mapping data that meta-analysis could help refine locations of known QTLs and detect many novel QTLs...
  27. pmc Iris transillumination defect and its gene modulators do not correlate with intraocular pressure in the BXD family of mice
    Hong Lu
    Department of Ophthalmology, Hamilton Eye Institute, University of Tennessee Health Science Center, Memphis, TN Department of Ophthalmology, Nantong Eye Institute, Affiliated Hospital of Nantong University, Nantong, China
    Mol Vis 22:224-33. 2016
    ..The role of these genes in the iris transillumination defect (TID) has been well documented; however, their possible roles in modulating IOP during glaucoma onset and progression are yet not well understood...
  28. pmc Gene expression in the mouse eye: an online resource for genetics using 103 strains of mice
    Eldon E Geisert
    Department of Ophthalmology and Center for Vision Research, Memphis, TN 38163, USA
    Mol Vis 15:1730-63. 2009
    ..We examined the causes of expression differences, and in their linkage to sequence variants, functional differences, and ocular pathophysiology...
  29. ncbi request reprint Complex trait analysis of gene expression uncovers polygenic and pleiotropic networks that modulate nervous system function
    Elissa J Chesler
    University of Tennessee Health Science Center, 855 Monroe Avenue, Memphis, Tennessee 38163, USA
    Nat Genet 37:233-42. 2005
    ..We built these tools into an open web resource called WebQTL that can be used to test a broad array of hypotheses...
  30. pmc Innate immune network in the retina activated by optic nerve crush
    Justin P Templeton
    Department of Ophthalmology, University of Tennessee Health Science Center, Memphis, TN, USA
    Invest Ophthalmol Vis Sci 54:2599-606. 2013
    ..We have used transcriptome profiling in the mouse to identify a network of genes involved in innate immunity that is present in the normal retina and that is activated by optic nerve crush (ONC)...
  31. pmc Genetic pathways regulating glutamate levels in retinal Müller cells
    Monica M Jablonski
    Department of Ophthalmology, Hamilton Eye Institute, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Neurochem Res 36:594-603. 2011
    ....
  32. pmc A transposon in Comt generates mRNA variants and causes widespread expression and behavioral differences among mice
    Zhengsheng Li
    Department of Anatomy and Neurobiology, Center for Integrative and Translational Genomics, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America
    PLoS ONE 5:e12181. 2010
    ..This study identifies the key sequence variant that leads to differences in Comt mRNA and protein levels among mice, and that modulates synaptic function and pharmacological and behavioral traits...
  33. pmc Treatment- and population-dependent activity patterns of behavioral and expression QTLs
    Jesse D Ziebarth
    Center for Integrative and Translational Genomics, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America
    PLoS ONE 7:e31805. 2012
    ....
  34. ncbi request reprint WebQTL: rapid exploratory analysis of gene expression and genetic networks for brain and behavior
    Elissa J Chesler
    Department of Anatomy and Neurobiology, Center for Genomics and Bioinformatics, University of Tennessee Health Science Center, 855 Monroe Avenue, Memphis, Tennessee 38163, USA
    Nat Neurosci 7:485-6. 2004
  35. pmc Complex control of GABA(A) receptor subunit mRNA expression: variation, covariation, and genetic regulation
    Megan K Mulligan
    Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America
    PLoS ONE 7:e34586. 2012
    ..Our findings identify novel sources of variation that modulate subunit expression and highlight the extraordinary capacity of biological networks to buffer 4-100 fold differences in mRNA levels...
  36. ncbi request reprint The ldis1 lens mutation in RIIIS/J mice maps to chromosome 8 near cadherin 1
    Monica M Jablonski
    Department of Ophthalmology, University of Tennessee Health Science Center, Memphis, TN, USA
    Mol Vis 10:577-87. 2004
    ..We also have fine-mapped the mutation, ldis1 (lens disrupter 1), and have evaluated positional candidate genes...
  37. pmc Weighting by heritability for detection of quantitative trait loci with microarray estimates of gene expression
    Kenneth F Manly
    Department of Pathology, University of Tennessee Health Science Center, 855 Monroe Avenue, Memphis, TN 38163, USA
    Genome Biol 6:R27. 2005
    ..This heritability varies greatly. We have tested heritability-weighted averages to define expression of a transcript and found that these allow detection of more QTLs than previously described methods...
  38. ncbi request reprint An ENU-induced mutation in Rs1h causes disruption of retinal structure and function
    Monica M Jablonski
    Department of Ophthalmology, University of Tennessee Health Science Center and Tennessee Mouse Genome Consortium, Memphis, TN, USA
    Mol Vis 11:569-81. 2005
    ..Herein we present its retinal phenotype and genetic basis...
  39. pmc Genetic analysis of posterior medial barrel subfield (PMBSF) size in somatosensory cortex (SI) in recombinant inbred strains of mice
    Taha A Jan
    Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    BMC Neurosci 9:3. 2008
    ..Cytochrome oxidase labeling was used to visualize barrels within the PMBSF...
  40. ncbi request reprint Genetic and structural analysis of the basolateral amygdala complex in BXD recombinant inbred mice
    Khyobeni Mozhui
    Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, 855 Monroe Avenue, Memphis, TN 38163, USA
    Behav Genet 37:223-43. 2007
    ..Other candidates include Large, and Thra. Responses to drugs of abuse and locomotor activity were the most notable behavioral correlates of the BLAc traits...
  41. pmc Genetic control of a central pattern generator: rhythmic oromotor movement in mice is controlled by a major locus near Atp1a2
    John D Boughter
    Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America
    PLoS ONE 7:e38169. 2012
    ....
  42. ncbi request reprint Genetic analysis of barrel field size in the first somatosensory area (SI) in inbred and recombinant inbred strains of mice
    Cheng X Li
    Department of Anatomy and Neurobiology, College of Medicine, University of Tennessee Health Sciences Center, Memphis, TN 38163, USA
    Somatosens Mot Res 22:141-50. 2005
    ....
  43. doi request reprint Genetic divergence in the transcriptional engram of chronic alcohol abuse: A laser-capture RNA-seq study of the mouse mesocorticolimbic system
    Megan K Mulligan
    Department of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, United States Electronic address
    Alcohol 58:61-72. 2017
    ..Substantial strain differences exist in the temporal pattern of transcriptional neuroadaptation to CIE, and these may drive individual differences in risk of addiction following excessive alcohol consumption...
  44. pmc An unbiased systems genetics approach to mapping genetic loci modulating susceptibility to severe streptococcal sepsis
    Nourtan F Abdeltawab
    Mid South Center for Biodefense and Security, The University of Tennessee Health Science Center, Memphis, Tennessee, United States of America
    PLoS Pathog 4:e1000042. 2008
    ..The association of GAS sepsis with multiple pathways underscores the complexity of traits modulating GAS sepsis and provides a powerful approach for analyzing interactive traits affecting outcomes of other infectious diseases...
  45. pmc Joint mouse-human phenome-wide association to test gene function and disease risk
    Xusheng Wang
    Department of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    Nat Commun 7:10464. 2016
    ....
  46. ncbi request reprint GenomeMixer: a complex genetic cross simulator
    Alexander G Williams
    Center of Genomics and Bioinformatics, Department of Anatomy and Neurobiology, University of Tennessee, 875 Monroe Avenue, Memphis, TN 38163, USA
    Bioinformatics 20:2491-2. 2004
    ....
  47. ncbi request reprint Brain gene expression: genomics and genetics
    Elissa J Chesler
    Department of Anatomy and Neurobiology, Center for Genomics and Bioinformatics, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    Int Rev Neurobiol 60:59-95. 2004
  48. ncbi request reprint Complex genetics of interactions of alcohol and CNS function and behavior
    Douglas B Matthews
    Department of Psychology, University of Memphis, Memphis, Tennessee 38152, USA
    Alcohol Clin Exp Res 29:1706-19. 2005
    ..J. Hitzemann, and (5) The use of gene arrays in conjunction with transgenic and selected animals to understand anxiety in alcoholism, by. B. Tabakoff...
  49. pmc Genetic dissection of strain dependent paraquat-induced neurodegeneration in the substantia nigra pars compacta
    Yun Jiao
    Department of Developmental Neurobiology, Saint Jude Children s Research Hospital, Memphis, Tennessee, United States of America
    PLoS ONE 7:e29447. 2012
    ....
  50. ncbi request reprint The p47 GTPases Iigp2 and Irgb10 regulate innate immunity and inflammation to murine Chlamydia psittaci infection
    Isao Miyairi
    Department of Pediatrics, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    J Immunol 179:1814-24. 2007
    ..Data indicate that these p47 GTPases have cell-autonomous effects that result in vastly different inflammatory stimulations, leading to either recovery or death...
  51. pmc A new set of BXD recombinant inbred lines from advanced intercross populations in mice
    Jeremy L Peirce
    Center for Neuroscience, Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, 855 Monroe Avenue, Memphis, Tennessee 38163, USA
    BMC Genet 5:7. 2004
    ..elegans, and Drosophila, mouse RI panels typically consist of fewer than 30 lines. This is a severe constraint on the power and precision of mapping efforts and greatly hampers analysis of epistatic interactions...
  52. pmc Genetic and immunohistochemical analysis of HSPA5 in mouse and human retinas
    Sumana R Chintalapudi
    Department of Ophthalmology, Hamilton Eye Institute, The University of Tennessee Health Science Center, Memphis, TN Department of Anatomy and Neurobiology, The University of Tennessee Health Science Center, Memphis, TN
    Mol Vis 22:1318-1331. 2016
    ..In this study, we used systems genetic methods, statistical modeling, and immunostaining to identify and analyze candidate genes that modulate Hspa5 expression in the retina...
  53. pmc Identification of candidate genes that underlie the QTL on chromosome 1 that mediates genetic differences in stress-ethanol interactions
    Melloni N Cook
    Department of Psychology, University of Memphis, Memphis, Tennessee
    Physiol Genomics 47:308-17. 2015
    ..Our findings support the hypothesis that variants in one or both of these genes modulate heritable differences in the effects of ethanol on anxiety-related behaviors. ..
  54. pmc Functionally enigmatic genes: a case study of the brain ignorome
    Ashutosh K Pandey
    UT Center for Integrative and Translational Genomics and Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America
    PLoS ONE 9:e88889. 2014
    ..In several cases--ELMOD1, TMEM88B, and DZANK1--we have exploited sequence polymorphisms, large phenome data sets, and reverse genetic methods to evaluate the function of ignorome genes...
  55. doi request reprint Somatic and reproductive outcomes in mice treated with cyclophosphamide in pre-pubertal age
    Laura Detti
    University of Tennessee Health Science Center, Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, University of Tennessee, Memphis, Tennessee 38163, USA
    Syst Biol Reprod Med 59:140-5. 2013
    ..However, uterine development seems to be dependent on the hormonal status created by CTX more than on its direct effect...
  56. pmc Trps1 differentially modulates the bone mineral density between male and female mice and its polymorphism associates with BMD differently between women and men
    Lishi Wang
    Department of Orthopedic Surgery and Biomedical Engineering, Campbell Clinic, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America Department of Basic Medicine, Inner Mongolia Medical University, Huhhot, Inner Mongolia, P R China
    PLoS ONE 9:e84485. 2014
    ..SNP analysis identified a nonsynonymous SNP (rs32398060) in Trps1 that co-segregated with bone mineral density. Analysis of association between this SNP within TRPS1 and BMD in a human population confirmed its significance. ..
  57. ncbi request reprint Expression genetics and the phenotype revolution
    Robert W Williams
    Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, 855 Monroe Avenue, Memphis, TN 38163, USA
    Mamm Genome 17:496-502. 2006
    ..These models will also be essential to test new treatments in a robust systems context that accounts for genetic variation...
  58. pmc Genome-wide gene expression profiles in antioxidant pathways and their potential sex differences and connections to vitamin C in mice
    Yan Jiao
    Department of Orthopedic Surgery and BME Campbell Clinic, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Int J Mol Sci 14:10042-62. 2013
    ..Our study indicates the importance of investigating sex differences in Gulo and its oxidative function by using available mouse models...
  59. ncbi request reprint GeneNetwork: A Toolbox for Systems Genetics
    Megan K Mulligan
    Department of Genetics, Genomics, and Informatics, University of Tennessee Health Science Center, 855 Monroe Ave, Suite 515, Memphis, TN, 38163, USA
    Methods Mol Biol 1488:75-120. 2017
    ..Finally, we provide two detailed case studies that take advantage of human and mouse cohorts to evaluate linkage between gene variants, addiction, and aging...
  60. pmc Genome-Wide Gene Expression Profiling of Nucleus Accumbens Neurons Projecting to Ventral Pallidum Using both Microarray and Transcriptome Sequencing
    Hao Chen
    Department of Pharmacology, University of Tennessee Health Science Center Memphis, TN, USA
    Front Neurosci 5:98. 2011
    ....
  61. pmc Genetic control of weight loss during pneumonic Burkholderia pseudomallei infection
    Felicia D Emery
    Department of Microbiology, Immunology and Biochemistry, The University of Tennessee Health Science Center, Memphis, TN, USA
    Pathog Dis 71:249-64. 2014
    ..We then analyzed and ranked positional candidate genes in this interval, several of which have intriguing connections with innate immunity, calcium homeostasis, lipid transport, host cell growth and development, and autophagy. ..
  62. doi request reprint Metabolic stress modulates Alzheimer's β-secretase gene transcription via SIRT1-PPARγ-PGC-1 in neurons
    Ruishan Wang
    Department of Pharmacology, University of Tennessee Health Science Center, College of Medicine, 874 Union Avenue, Memphis, TN 38163, USA
    Cell Metab 17:685-94. 2013
    ..The interference on the BACE1 gene identified here represents a unique noncanonical mechanism of PPARγ-PGC-1 in transcriptional repression in neurons in response to metabolic signals that may involve recruitment of corepressor NCoR...
  63. pmc Genetic variation of the cutaneous HPA axis: an analysis of UVB-induced differential responses
    Cezary Skobowiat
    Department of Pathology and Laboratory Medicine, Center for Cancer Research, University of Tennessee Health Science Center, Memphis, TN 38163, USA Electronic address
    Gene 530:1-7. 2013
    ....
  64. pmc Sex-specific modulation of gene expression networks in murine hypothalamus
    Khyobeni Mozhui
    Department of Anatomy and Neurobiology, University of Tennessee Health Science Center Memphis, TN, USA
    Front Neurosci 6:63. 2012
    ....
  65. ncbi request reprint Genetic correlates of gene expression in recombinant inbred strains: a relational model system to explore neurobehavioral phenotypes
    Elissa J Chesler
    Department of Anatomy and Neurobiology, Center for Genomics and Bioinformatics, University of Tennessee Health Science Center, Memphis, TN, USA
    Neuroinformatics 1:343-57. 2003
    ..By repeatedly studying the same panel of mice, early data can be re-examined in light of technological advances unforeseen at the time of their initial collection...
  66. doi request reprint Counting cells in sectioned material: a suite of techniques, tools, and tips
    Robert W Williams
    University of Tennessee Health Science Center, Memphis, Tennessee, USA
    Curr Protoc Neurosci . 2003
    ....
  67. pmc A Murine Hypertrophic Cardiomyopathy Model: The DBA/2J Strain
    Wenyuan Zhao
    Division of Cardiovascular Diseases, Department of Medicine, University of Tennessee HealthScience Center, Memphis, Tennessee, United States of America
    PLoS ONE 10:e0133132. 2015
    ..Because D2 and B6 strains have been used to generate a large family of recombinant inbred strains, the BXD cohort, the D2 model can be effectively exploited for in-depth genetic analysis of HCM susceptibility and modifier screens. ..
  68. doi request reprint Multipronged approach to identify and validate a novel upstream regulator of Sncg in mouse retinal ganglion cells
    Sumana R Chintalapudi
    Department of Ophthalmology, The Hamilton Eye Institute, The University of Tennessee Health Science Center, Memphis, TN, USA
    FEBS J 283:678-93. 2016
    ..Gene Ontology analysis indicated shared mitochondrial function associated with Sncg and Pfdn2. These data solidify the relationship between Sncg and Pfdn2 in RGCs, and provide a novel mechanism for maintaining RGC health. ..
  69. pmc Systems genetics identifies Hp1bp3 as a novel modulator of cognitive aging
    Sarah M Neuner
    Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Neurobiol Aging 46:58-67. 2016
    ..Overall, our results suggest Hp1bp3 may serve as a potential target against cognitive aging and demonstrate the utility of genetically diverse animal models for the study of complex human disease. ..
  70. pmc Genetics of gene expression in CNS
    Ashutosh K Pandey
    Department of Genetics, Genomics and Informatics, Center for Integrative and Translational Genomics, University of Tennessee Health Science Center, Memphis, Tennessee, USA
    Int Rev Neurobiol 116:195-231. 2014
    ....
  71. pmc Integrative genetic analysis of alcohol dependence using the GeneNetwork Web resources
    Robert W Williams
    Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, Memphis, Tennessee
    Alcohol Res Health 31:275-7. 2008
    ....
  72. ncbi request reprint P2P-R expression is genetically coregulated with components of the translation machinery and with PUM2, a translational repressor that associates with the P2P-R mRNA
    Robert E Scott
    Department of Pathology, University of Tennessee Health Science Center, Memphis Tennessee, USA
    J Cell Physiol 204:99-105. 2005
    ..This study represents the first description of a RNA target for mammalian Puf proteins and the first molecular confirmation of information obtained using the WebQTL database...