Leanne M Williams

Summary

Publications

  1. pmc Sensitivity, specificity, and predictive power of the "Brief Risk-resilience Index for SCreening," a brief pan-diagnostic web screen for emotional health
    Leanne M Williams
    BRAINnet Foundation 71 Stephenson Street, Suite 400, San Francisco, California, 94105 University of Sydney Medical School and Westmead Millennium Institute Sydney, New South Wales, 2145, Australia
    Brain Behav 2:576-89. 2012
  2. doi request reprint COMT Val(108/158)Met polymorphism effects on emotional brain function and negativity bias
    Leanne M Williams
    The Brain Dynamics Center, Sydney Medical School and Westmead Millennium Institute, Acacia House, University of Sydney at Westmead Hospital, Sydney, NSW, Westmead 2145, Australia
    Neuroimage 53:918-25. 2010
  3. doi request reprint An 'integrative neuroscience' perspective on ADHD: linking cognition, emotion, brain and genetic measures with implications for clinical support
    Leanne M Williams
    BRAINnet, Brain Research and Integrative Neuroscience Network, CA, USA
    Expert Rev Neurother 10:1607-21. 2010
  4. ncbi request reprint The mellow years?: neural basis of improving emotional stability over age
    Leanne M Williams
    Brain Dynamics Centre, Westmead Millenium Institute and Western Clinical School, University of Sydney, Westmead Hospital, Westmead, Sydney, New South Wales, 2145, Australia
    J Neurosci 26:6422-30. 2006
  5. doi request reprint Association between BDNF Val66Met polymorphism and trait depression is mediated via resting EEG alpha band activity
    Justine M Gatt
    The Brain Dynamics Centre, Westmead Millennium Institute, Westmead Hospital and Western Clinical School, University of Sydney, Sydney, Australia
    Biol Psychol 79:275-84. 2008
  6. doi request reprint Misinterpreting emotional expressions in attention-deficit/hyperactivity disorder: evidence for a neural marker and stimulant effects
    Leanne M Williams
    Brain Dynamics Centre and Clinics, Westmead Millennium Institute and Western Clinical School, University of Sydney, Westmead Hospital, New South Wales, Australia
    Biol Psychiatry 63:917-26. 2008
  7. doi request reprint Heterogeneity of non-conscious fear perception in posttraumatic stress disorder as a function of physiological arousal: an fMRI study
    Andrew H Kemp
    School of Psychology, University of Sydney, Sydney, NSW, Australia
    Psychiatry Res 174:158-61. 2009
  8. ncbi request reprint Fronto-limbic and autonomic disjunctions to negative emotion distinguish schizophrenia subtypes
    Leanne M Williams
    Brain Dynamics Centre, Westmead Hospital, NSW, 2145, Australia
    Psychiatry Res 155:29-44. 2007
  9. ncbi request reprint Mapping frontal-limbic correlates of orienting to change detection
    Leanne M Williams
    The Brain Dynamics Centre, Westmead Millennium Institute and Western Clinical School, University of Sydney, Westmead Hospital, New South Wales, Sydney, Australia
    Neuroreport 18:197-202. 2007
  10. ncbi request reprint Progressive grey matter atrophy over the first 2-3 years of illness in first-episode schizophrenia: a tensor-based morphometry study
    Thomas J Whitford
    The Brain Dynamics Centre, Westmead Millennium Institute and University of Sydney, Acacia House, Westmead Hospital, NSW 2145, Australia
    Neuroimage 32:511-9. 2006

Detail Information

Publications75

  1. pmc Sensitivity, specificity, and predictive power of the "Brief Risk-resilience Index for SCreening," a brief pan-diagnostic web screen for emotional health
    Leanne M Williams
    BRAINnet Foundation 71 Stephenson Street, Suite 400, San Francisco, California, 94105 University of Sydney Medical School and Westmead Millennium Institute Sydney, New South Wales, 2145, Australia
    Brain Behav 2:576-89. 2012
    ..7%). The BRISC and mini-BRISC both offer a brief, clinically useful screen to identify individuals at risk of disorders characterized by poor emotion regulation, from those with good emotional health and coping...
  2. doi request reprint COMT Val(108/158)Met polymorphism effects on emotional brain function and negativity bias
    Leanne M Williams
    The Brain Dynamics Center, Sydney Medical School and Westmead Millennium Institute, Acacia House, University of Sydney at Westmead Hospital, Sydney, NSW, Westmead 2145, Australia
    Neuroimage 53:918-25. 2010
    ..The findings suggest that the COMT Met allele modulates neural substrates of negative versus positive emotion processing. This effect may contribute to negativity biases, which confer susceptibility for emotional disorders...
  3. doi request reprint An 'integrative neuroscience' perspective on ADHD: linking cognition, emotion, brain and genetic measures with implications for clinical support
    Leanne M Williams
    BRAINnet, Brain Research and Integrative Neuroscience Network, CA, USA
    Expert Rev Neurother 10:1607-21. 2010
    ..Understanding these measures and the relationships between them is a first step towards the development of tools that will help to assess the heterogeneity of ADHD, and aid in tailoring treatment choices...
  4. ncbi request reprint The mellow years?: neural basis of improving emotional stability over age
    Leanne M Williams
    Brain Dynamics Centre, Westmead Millenium Institute and Western Clinical School, University of Sydney, Westmead Hospital, Westmead, Sydney, New South Wales, 2145, Australia
    J Neurosci 26:6422-30. 2006
    ....
  5. doi request reprint Association between BDNF Val66Met polymorphism and trait depression is mediated via resting EEG alpha band activity
    Justine M Gatt
    The Brain Dynamics Centre, Westmead Millennium Institute, Westmead Hospital and Western Clinical School, University of Sydney, Sydney, Australia
    Biol Psychol 79:275-84. 2008
    ..They suggest that the BDNF Met/Met homozygote has a direct impact on memory systems, but impacts trait depression via the secondary effects of neural changes...
  6. doi request reprint Misinterpreting emotional expressions in attention-deficit/hyperactivity disorder: evidence for a neural marker and stimulant effects
    Leanne M Williams
    Brain Dynamics Centre and Clinics, Westmead Millennium Institute and Western Clinical School, University of Sydney, Westmead Hospital, New South Wales, Australia
    Biol Psychiatry 63:917-26. 2008
    ..We examined ADHD disturbances in mood and emotion recognition and underlying neural systems before and after treatment with stimulant medication...
  7. doi request reprint Heterogeneity of non-conscious fear perception in posttraumatic stress disorder as a function of physiological arousal: an fMRI study
    Andrew H Kemp
    School of Psychology, University of Sydney, Sydney, NSW, Australia
    Psychiatry Res 174:158-61. 2009
    ....
  8. ncbi request reprint Fronto-limbic and autonomic disjunctions to negative emotion distinguish schizophrenia subtypes
    Leanne M Williams
    Brain Dynamics Centre, Westmead Hospital, NSW, 2145, Australia
    Psychiatry Res 155:29-44. 2007
    ....
  9. ncbi request reprint Mapping frontal-limbic correlates of orienting to change detection
    Leanne M Williams
    The Brain Dynamics Centre, Westmead Millennium Institute and Western Clinical School, University of Sydney, Westmead Hospital, New South Wales, Sydney, Australia
    Neuroreport 18:197-202. 2007
    ....
  10. ncbi request reprint Progressive grey matter atrophy over the first 2-3 years of illness in first-episode schizophrenia: a tensor-based morphometry study
    Thomas J Whitford
    The Brain Dynamics Centre, Westmead Millennium Institute and University of Sydney, Acacia House, Westmead Hospital, NSW 2145, Australia
    Neuroimage 32:511-9. 2006
    ..We argue that the progressive GM atrophy we have found to be associated with the onset of schizophrenia arises from a dysfunction in the dramatic period of healthy brain development typically associated with adolescence...
  11. ncbi request reprint Neural biases to covert and overt signals of fear: dissociation by trait anxiety and depression
    Leanne M Williams
    University of Sydney, Westmead Hospital, Sydney, NSW, Australia
    J Cogn Neurosci 19:1595-608. 2007
    ....
  12. ncbi request reprint Small-world properties of nonlinear brain activity in schizophrenia
    Mikail Rubinov
    Black Dog Institute and School of Psychiatry, University of New South Wales, Sydney, Australia
    Hum Brain Mapp 30:403-16. 2009
    ..This randomization may underlie the cognitive disturbances characteristic of schizophrenia...
  13. pmc Emotion brain alterations in anorexia nervosa: a candidate biological marker and implications for treatment
    Ainslie Hatch
    The Brain Dynamics Center, Westmead Millennium Institute and University of Sydney at Westmead Hospital, Australia
    J Psychiatry Neurosci 35:267-74. 2010
    ..We aimed to determine whether AN is associated with disturbances in the nonconscious neural processing of innate signals of emotion and whether these disturbances persist after weight gain...
  14. doi request reprint Increased absolute magnitude of gamma synchrony in first-episode psychosis
    Gary Flynn
    The Early Psychosis Intervention Program, Liverpool Hospital, and The Brain Dynamics Centre, Westmead Millennium Institute and Western Clinical School, University of Sydney, NSW, 2145, Australia
    Schizophr Res 105:262-71. 2008
    ..We hypothesized that FEP would be associated with abnormalities in absolute GPS, particularly when required to selectively attend to task-relevant stimuli...
  15. ncbi request reprint Amygdala-prefrontal dissociation of subliminal and supraliminal fear
    Leanne M Williams
    Brain Dynamics Centre, Westmead Hospital, Westmead Sydney, NSW, Australia
    Hum Brain Mapp 27:652-61. 2006
    ....
  16. doi request reprint Explicit identification and implicit recognition of facial emotions: II. Core domains and relationships with general cognition
    Danielle Mathersul
    Brain Dynamics Centre, Westmead Millennium Institute and Western Clinical School, University of Sydney, Sydney, New South Wales, Australia
    J Clin Exp Neuropsychol 31:278-91. 2009
    ..These findings contribute to a normative and standardized structure for assessment of emotional and general cognition in clinical groups...
  17. doi request reprint Impact of the HTR3A gene with early life trauma on emotional brain networks and depressed mood
    Justine M Gatt
    The Brain Dynamics Center, Westmead Millennium Institute and Discipline of Psychiatry, University of Sydney at Westmead Hospital, New South Wales, Australia
    Depress Anxiety 27:752-9. 2010
    ..The role of serotonin 3A receptor gene (HTR3A -42C>T polymorphism) and its interaction with early life stress (ELS) was investigated in view of the receptor's localization to brain regions central to emotion processing...
  18. ncbi request reprint Predicting severity of non-clinical depression: preliminary findings using an integrated approach
    Andrew H Kemp
    The Brain Dynamics Center, University of Sydney and Westmead Hospital, NSW 2145, Australia
    J Integr Neurosci 5:89-110. 2006
    ..In this study, we examined the value of combining multiple domains of function in predicting depression severity...
  19. ncbi request reprint Event-related wave activity in the EEG provides new marker of ADHD
    David M Alexander
    The Brain Resource International Database, Brain Resource Company, Sydney, Australia
    Clin Neurophysiol 119:163-79. 2008
    ..This study examines the utility of new measures of event-related spatio-temporal waves in the EEG as a marker of ADHD, previously shown to be closely related to the P3 ERP in an adult sample...
  20. ncbi request reprint An integrative approach to determine the best behavioral and biological markers of methylphenidate
    Daniel F Hermens
    The Brain Dynamics Center, University of Sydney and Westmead Hospital, Westmead, NSW 2145, Australia
    J Integr Neurosci 6:105-40. 2007
    ..To distinguish the most sensitive markers of methylphenidate (MPH) effects on behavior and underlying biology using an integrated cognitive and brain function test battery...
  21. ncbi request reprint Brain structure and function correlates of general and social cognition
    Donald L Rowe
    The Brain Dynamics Center, Westmead Millennium Institute, Westmead Hospital and Western Clinical School, University of Sydney, NSW 2145, Australia
    J Integr Neurosci 6:35-74. 2007
    ..To examine how general (e.g., memory, attention) and social (emotional and interpersonal processes) cognition relate to measures of brain function and structure...
  22. doi request reprint Neural responses to masked fear faces: sex differences and trauma exposure in posttraumatic stress disorder
    Kim Felmingham
    School of Psychology, University of New South Wales, Sydney, Australia
    J Abnorm Psychol 119:241-7. 2010
    ....
  23. pmc A randomized controlled trial investigation of a non-stimulant in attention deficit hyperactivity disorder (ACTION): rationale and design
    Tracey W Tsang
    Brain Dynamics Centre, Sydney Medical School and Westmead Millennium Institute, Sydney, New South Wales, Australia
    Trials 12:77. 2011
    ..This manuscript will describe the methodology and rationale for the ACTION study...
  24. ncbi request reprint Volumetric white matter abnormalities in first-episode schizophrenia: a longitudinal, tensor-based morphometry study
    Thomas J Whitford
    Brain Dynamics Centre, Acacia House, Westmead Hospital, Westmead, NSW, 2145, Australia
    Am J Psychiatry 164:1082-9. 2007
    ....
  25. doi request reprint A polymorphism of the MAOA gene is associated with emotional brain markers and personality traits on an antisocial index
    Leanne M Williams
    The Brain Dynamics Centre, Westmead Millennium Institute, Westmead Hospital and Western Clinical School, University of Sydney, Westmead, NSW, Australia
    Neuropsychopharmacology 34:1797-809. 2009
    ..Monoamines such as noradrenalin and serotonin may modulate these relationships, given that their metabolism varies according to MAOA variants, and that they modulate both emotional brain systems and antisocial aggression...
  26. ncbi request reprint Investigating the neuropsychological and neuroanatomical changes that occur over the first 2-3 years of illness in patients with first-episode schizophrenia
    Lisa Zipparo
    Department of Psychology, Macquarie University, North Ryde, NSW, Australia
    Prog Neuropsychopharmacol Biol Psychiatry 32:531-8. 2008
    ..This study explored the concurrent courses of the neuroanatomical and neuropsychological changes that occurred over the first 2-3 years of illness in patients with first-episode schizophrenia (FES)...
  27. ncbi request reprint The dynamics of cortico-amygdala and autonomic activity over the experimental time course of fear perception
    Leanne M Williams
    The Brain Dynamics Centre, Westmead Hospital, NSW, 2145, Australia
    Brain Res Cogn Brain Res 21:114-23. 2004
    ..These findings suggest that sustained cortico-amygdala and autonomic responses may serve to prime the emotional content of fear signals, and differentiate them from initial stimulus novelty...
  28. ncbi request reprint A genotype-endophenotype-phenotype path model of depressed mood: integrating cognitive and emotional markers
    Justine M Gatt
    The Brain Dynamics Center, Westmead Millennium Institute, Westmead Hospital and Western Clinical School, University of Sydney, NSW 2145, Australia
    J Integr Neurosci 6:75-104. 2007
    ..The brain-derived neurotrophic factor (BDNF) 66Met allele may contribute to both cognitive and emotional aspects of the depression phenotype...
  29. ncbi request reprint Distinct amygdala-autonomic arousal profiles in response to fear signals in healthy males and females
    Leanne M Williams
    The Brain Dynamics Centre, Westmead Millenium Institute, Acacia House, Westmead Hospital, Westmead, NSW 2145, Australia
    Neuroimage 28:618-26. 2005
    ..We suggest that distinct evolutionary pressures might contribute to a lower threshold for vigilance to signals of danger in females, reflected in a profile of sustained amygdala-arousal interaction...
  30. ncbi request reprint Longitudinal changes in neuroanatomy and neural activity in early schizophrenia
    Thomas J Whitford
    The Brain Dynamics Centre, Westmead Millennium Institute and University of Sydney, and Acacia House, Westmead Hospital, New South Wales, Australia
    Neuroreport 18:435-9. 2007
    ..These results suggest that first-episode schizophrenia may be associated with abnormally elevated levels of neural synchrony...
  31. ncbi request reprint Pathways for fear perception: modulation of amygdala activity by thalamo-cortical systems
    Pritha Das
    Neuroscience Institute of Schizophrenia and Allied Disorders NISAD, Darlinghurst, NSW, Australia
    Neuroimage 26:141-8. 2005
    ..Breakdowns in these interactions may give rise to affect-related symptoms seen in a range of neuropsychiatric disorders...
  32. ncbi request reprint Influence of comorbid depression on fear in posttraumatic stress disorder: an fMRI study
    Andrew H Kemp
    Brain Dynamics Centre, Westmead Hospital and Western Clinical, School University of Sydney, Sydney, NSW, Australia
    Psychiatry Res 155:265-9. 2007
    ..Amygdala and medial prefrontal activity was reduced in PTSD-depression compared to PTSD-alone samples, highlighting the need to account for comorbidity...
  33. ncbi request reprint Enhanced amygdala and medial prefrontal activation during nonconscious processing of fear in posttraumatic stress disorder: an fMRI study
    Richard A Bryant
    Brain Dynamics Centre, Westmead Hospital, Sydeny, New South Wales, Australia
    Hum Brain Mapp 29:517-23. 2008
    ..These data extend existing models by suggesting that the impaired MPFC activation in PTSD may be limited to conscious fear processing. Hum Brain Mapp, 2008. (c) 2007 Wiley-Liss, Inc...
  34. doi request reprint Explicit identification and implicit recognition of facial emotions: I. Age effects in males and females across 10 decades
    Leanne M Williams
    Brain Dynamics Centre, Westmead Millennium Institute and Western Clinical School, University of Sydney, Westmead Hospital, Westmead, New South Wales, Australia
    J Clin Exp Neuropsychol 31:257-77. 2009
    ..These findings provide a robust normative platform for assessing clinical groups...
  35. doi request reprint Using brain-based cognitive measures to support clinical decisions in ADHD
    Leanne M Williams
    Brain Dynamics Center, Westmead Millennium Institute and University of Sydney at Westmead Hospital, Westmead, New South Wales, Australia
    Pediatr Neurol 42:118-26. 2010
    ..These markers offer a frame of reference to support diagnostic and treatment decisions, and an objective benchmark for monitoring outcomes of interventions...
  36. ncbi request reprint Sex differences in functional connectivity in first-episode and chronic schizophrenia patients
    Shameran Slewa-Younan
    The Brain Dynamics Centre, Acacia House, Westmead Hospital, University of Sydney, Westmead NSW, 2145, Australia
    Am J Psychiatry 161:1595-602. 2004
    ....
  37. ncbi request reprint Toward an integrated profile of depression: evidence from the brain resource international database
    Andrew H Kemp
    The Brain Dynamics Center, University of Sydney and Westmead Hospital, NSW 2145, Australia
    J Integr Neurosci 4:95-106. 2005
    ..Longitudinal studies are needed to determine the extent to which of these findings will have utility for the prediction of depression onset and treatment response/non-response...
  38. ncbi request reprint General and social cognition in first episode schizophrenia: identification of separable factors and prediction of functional outcome using the IntegNeuro test battery
    Leanne M Williams
    The Brain Dynamics Centre, Westmead Millennium Institute and Western Clinical School, University of Sydney, Westmead Hospital, NSW, 2145, Australia
    Schizophr Res 99:182-91. 2008
    ..We determined the presence of separable factors of general and social cognition, their equivalence to the consensus domains identified by the NIMH MATRICS project, and their effectiveness in predicting real world functional outcomes...
  39. doi request reprint Delusions and dorso-medial frontal cortex volume in first-episode schizophrenia: a voxel-based morphometry study
    Thomas J Whitford
    The Brain Dynamics Centre, Westmead Millennium Institute and University of Sydney, Westmead, NSW, 2145, Australia
    Psychiatry Res 172:175-9. 2009
    ....
  40. doi request reprint In first presentation adolescent anorexia nervosa, do cognitive markers of underweight status change with weight gain following a refeeding intervention?
    Ainslie Hatch
    The Brain Dynamics Centre, Westmead Millennium Institute and University of Sydney, Westmead Hospital, Westmead, Sydney, New South Wales, Australia
    Int J Eat Disord 43:295-306. 2010
    ..To determine the nature and severity of cognitive functioning impairment in adolescent anorexia nervosa (AN) when underweight and following weight gain...
  41. ncbi request reprint Distinguishing symptom profiles in adolescent ADHD using an objective cognitive test battery
    Simon D Clarke
    Brain Dynamics Centre, Westmead Millennium Institute, Westmead Hospital and Western Clinical School, University of Sydney, Westmead, NSW, 2145, Australia
    Int J Adolesc Med Health 19:355-67. 2007
    ..Currently diagnosis and assessment of ADHD relies on clinical interview and subjective ratings. Standardized objective cognitive tests can provide additional information about ADHD and help distinguish symptom profiles...
  42. pmc International Study to Predict Optimized Treatment for Depression (iSPOT-D), a randomized clinical trial: rationale and protocol
    Leanne M Williams
    BRAINnet Foundation, 71 Stephenson Street, Suite 400, San Francisco, CA, 94105, USA
    Trials 12:4. 2011
    ..The aim of iSPOT-D is to identify pretreatment measures that predict or moderate MDD treatment response or remission to escitalopram, sertraline or venlafaxine; and develop a model that incorporates multiple predictors and moderators...
  43. pmc Early exposure to traumatic stressors impairs emotional brain circuitry
    Mayuresh S Korgaonkar
    The Brain Dynamics Centre, University of Sydney Medical School Westmead and Westmead Millennium Institute, Sydney, New South Wales, Australia Discipline of Psychiatry, University of Sydney Medical School Western, Westmead Hospital, Sydney, New South Wales, Australia
    PLoS ONE 8:e75524. 2013
    ..These findings are interesting in the context that the affected regions are central neuroanatomical components in the psychopathology of depression, and adolescence is a peak period for risk and onset of the disorder. ..
  44. ncbi request reprint Neurophysiological markers of contextual processing: the relationship between P3b and Gamma synchrony and their modulation by arousal, performance and individual differences
    Kristan Kang
    The Brain Dynamics Centre, Westmead Hospital, NSW, Australia
    Brain Res Cogn Brain Res 25:472-83. 2005
    ..We concluded that, in simple contextual processing, global and local elements of target stimuli are processed in parallel with little variation being shown between the sexes or resulting from increasing age...
  45. pmc Using standardized fMRI protocols to identify patterns of prefrontal circuit dysregulation that are common and specific to cognitive and emotional tasks in major depressive disorder: first wave results from the iSPOT-D study
    Mayuresh S Korgaonkar
    The Brain Dynamics Center, University of Sydney Medical School and Westmead Millennium Institute, Sydney, NSW, Australia
    Neuropsychopharmacology 38:863-71. 2013
    ..These findings provide the frame of reference for identifying prefrontal biomarker predictors of treatment outcomes in MDD...
  46. ncbi request reprint BOLD, sweat and fears: fMRI and skin conductance distinguish facial fear signals
    Leanne M Williams
    Brain Dynamics Centre, University of Sydney, Westmead Hospital, NSW, 2145, Australia
    Neuroreport 16:49-52. 2005
    ..The findings suggest that fear, anger and disgust perception involves specific interactions in the neural arousal systems for emotion and motivation...
  47. pmc Neural synchrony in patients with a first episode of schizophrenia: tracking relations with grey matter and symptom profile
    Leanne M Williams
    Brain Dynamics Centre, Westmead Millennium Institute and Western Clinical School, University of Sydney, Westmead, Sydney, Australia
    J Psychiatry Neurosci 34:21-9. 2009
    ..We examined relations between 40 Hz Gamma band synchrony and grey matter in patients with schizophrenia at first episode and after 2.5 years...
  48. ncbi request reprint Sex differences in adolescent ADHD: findings from concurrent EEG and EDA
    Daniel F Hermens
    The Brain Dynamics Centre, University of Sydney, Westmead Hospital, NSW, Australia
    Clin Neurophysiol 116:1455-63. 2005
    ..We determined whether psychophysiological differences are associated with the expression of ADHD in males and females, using simultaneously recorded electroencephalography (EEG) and electrodermal activity (EDA)...
  49. ncbi request reprint Neural networks of information processing in posttraumatic stress disorder: a functional magnetic resonance imaging study
    Richard A Bryant
    School of Psychology, University of New South Wales, Sydney, Australia
    Biol Psychiatry 58:111-8. 2005
    ..We investigated whether anterior cingulate-amygdala dysregulation in PTSD would generalize to salient, but nonthreat related signals...
  50. ncbi request reprint ADHD and schizophrenia phenomenology: visual scanpaths to emotional faces as a potential psychophysiological marker?
    Pamela J Marsh
    Western Clinical School, The Brain Dynamics Centre, University of Sydney, Sydney, NSW, Australia
    Neurosci Biobehav Rev 30:651-65. 2006
    ....
  51. ncbi request reprint Mode of functional connectivity in amygdala pathways dissociates level of awareness for signals of fear
    Leanne M Williams
    The Brain Dynamics Centre, Westmead Millenium Institute and University of Sydney, Sydney, New South Wales, 2145, Australia
    J Neurosci 26:9264-71. 2006
    ....
  52. ncbi request reprint Toward an integrated profile of emotional intelligence: introducing a brief measure
    Andrew H Kemp
    The Brain Dynamics Center, University of Sydney and Westmead Hospital, NSW 2145, Australia
    J Integr Neurosci 4:41-61. 2005
    ..In conclusion, examination of the way in which EI measures relate to a complementary range of psychological and biological measures may help to further elucidate this construct...
  53. doi request reprint EEG in adolescent anorexia nervosa: impact of refeeding and weight gain
    Ainslie Hatch
    The Brain Dynamics Centre, Westmead Millennium Institute and University of Sydney, Westmead Hospital, Westmead, Sydney, New South Wales 2145, Australia
    Int J Eat Disord 44:65-75. 2011
    ..To examine resting awake EEG in adolescent AN participants before and after refeeding to determine if EEG abnormalities in Anorexia Nervosa (AN) are reversible...
  54. pmc "Missing links" in borderline personality disorder: loss of neural synchrony relates to lack of emotion regulation and impulse control
    Leanne M Williams
    Brain Dynamics Centre, Westmead Hospital, Westmead, Sydney, New South Wales, Australia
    J Psychiatry Neurosci 31:181-8. 2006
    ..We used a high temporal resolution measure (40-Hz gamma phase synchrony) of brain activity to examine the connectivity of brain function in BPD...
  55. ncbi request reprint Integrating objective gene-brain-behavior markers of psychiatric disorders
    Evian Gordon
    The Brain Resource International Database and the Brain Resource Company, Sydney, NSW 2007, Australia
    J Integr Neurosci 6:1-34. 2007
    ..Establishing these objective markers will be the first step towards determining their sensitivity, specificity and treatment prediction in individual patients...
  56. pmc The neural networks of inhibitory control in posttraumatic stress disorder
    Erin Falconer
    Brain Dynamics Centre, Westmead Millenium Institute, Westmead Hospital, Westmead, NSW, Australia
    J Psychiatry Neurosci 33:413-22. 2008
    ..To date, however, no PTSD neuroimaging study has directly examined PTSD-related changes in executive inhibition. Our objective was to investigate the hypothesis that executive inhibitory control networks are compromised in PTSD...
  57. ncbi request reprint Neural synchrony and gray matter variation in human males and females: integration of 40 Hz gamma synchrony and MRI measures
    Leanne M Williams
    The Brain Dynamics Center, University of Sydney and Westmead Hospital, NSW 2145, Australia
    J Integr Neurosci 4:77-93. 2005
    ..Sex differences in the profile of cortical synchronization may reflect distinct aspects of evolutionary advantage...
  58. ncbi request reprint Brain maturation in adolescence: concurrent changes in neuroanatomy and neurophysiology
    Thomas J Whitford
    Brain Dynamics Centre, Westmead Millennium Institute, University of Sydney, Westmead Hospital, New South Wales, Australia
    Hum Brain Mapp 28:228-37. 2007
    ..We suggest that the reduction in gray matter primarily reflects a reduction of neuropil, and that the corresponding elimination of active synapses is responsible for the observed reduction in EEG power...
  59. doi request reprint Patterns of emotional-cognitive functioning in pediatric conversion patients: implications for the conceptualization of conversion disorders
    Kasia Kozlowska
    Department of Psychological Medicine, The Children s Hospital at Westmead, Westmead, NSW, Australia
    Psychosom Med 73:775-88. 2011
    ..Autobiographical narratives were used to investigate the organization of information about distressing feelings and memories...
  60. doi request reprint Using multiple methods to characterize the phenotype of individuals with a family history of major depressive disorder
    Anna J Watters
    Discipline of Psychiatry, University of Sydney Medical School, NSW, Australia
    J Affect Disord 150:474-80. 2013
    ....
  61. pmc GSK3B and MAPT polymorphisms are associated with grey matter and intracranial volume in healthy individuals
    Carol Dobson-Stone
    Neuroscience Research Australia, Randwick, New South Wales, Australia
    PLoS ONE 8:e71750. 2013
    ..Our genetic and biochemical analyses have identified a role for GSK3B in brain development, which could have important aetiological implications for neurodegenerative and neurodevelopmental disorders. ..
  62. ncbi request reprint An integrative neuroscience model of "significance" processing
    Leanne M Williams
    The Brain Dynamics Center, Westmead Millennium Institute, Westmead Hospital and Western Clinical School, University of Sydney, Westmead Hospital, Westmead, NSW 2145, Australia
    J Integr Neurosci 5:1-47. 2006
    ....
  63. pmc Rostral anterior cingulate volume predicts treatment response to cognitive-behavioural therapy for posttraumatic stress disorder
    Richard A Bryant
    Brain Dynamics Centre, Westmead Hospital, Sydney, Australia
    J Psychiatry Neurosci 33:142-6. 2008
    ..To index the extent to which treatment response in posttraumatic stress disorder (PTSD) is predicted by rostral anterior cingulate cortex (rACC) volume...
  64. ncbi request reprint Dynamic organization of the emotional brain: responsivity, stability, and instability
    Leanne M Williams
    Brain Dynamics Center, Acacia House, Westmead Hospital, Westmead, Sydney, NSW, 2145, Australia
    Neuroscientist 13:349-70. 2007
    ..Variations at distinct points along this continuum, with contributions from constitutional and genetic factors, may contribute to individual differences in emotional stability and instability in neuropsychiatric disorders...
  65. ncbi request reprint Dysregulation of arousal and amygdala-prefrontal systems in paranoid schizophrenia
    Leanne M Williams
    The Brain Dynamics Centre, Westmead Hospital and University of Sydney, NSW, Australia
    Am J Psychiatry 161:480-9. 2004
    ..It was predicted that paranoid patients would be distinguished by a disjunction of hyperarousal but reduced amygdala and medial prefrontal activity relative to both healthy comparison subjects and patients with nonparanoid schizophrenia...
  66. ncbi request reprint Sex differences in adult ADHD: a double dissociation in brain activity and autonomic arousal
    Daniel F Hermens
    The Brain Dynamics Centre, Acacia House, Westmead Hospital, Hawkesbury Road, Westmead, NSW 2145, Australia
    Biol Psychol 66:221-33. 2004
    ..By contrast, adult females (but not males) with ADHD were autonomically hypo-aroused (decreased SCL). These results suggest that distinct mechanisms may underpin adult ADHD in males and females...
  67. ncbi request reprint Grey matter deficits and symptom profile in first episode schizophrenia
    Thomas J Whitford
    The Brain Dynamics Centre, Acacia House, Westmead Hospital and Western Clinical School, University of Sydney, Westmead Hospital, Westmead, NSW 2145, Australia
    Psychiatry Res 139:229-38. 2005
    ..The results also suggest a possible structural underpinning for the abnormal brain activity typically associated with symptoms of Reality Distortion...
  68. doi request reprint Mapping inter-regional connectivity of the entire cortex to characterize major depressive disorder: a whole-brain diffusion tensor imaging tractography study
    Mayuresh S Korgaonkar
    The Brain Dynamics Centre, University of Sydney Medical School, Westmead and Westmead Millennium Institute, Sydney, New South Wales, Australia
    Neuroreport 23:566-71. 2012
    ....
  69. ncbi request reprint Spatiotemporal wavelet resampling for functional neuroimaging data
    Michael Breakspear
    Brain Dynamics Centre, Westmead Hospital and University of Sydney, Sydney, Australia
    Hum Brain Mapp 23:1-25. 2004
    ..The limitations and possible extensions of the proposed technique are discussed...
  70. ncbi request reprint Resting EEG theta activity predicts cognitive performance in attention-deficit hyperactivity disorder
    Daniel F Hermens
    The Brain Dynamics Centre, Westmead Hospital, NSW, Australia School of Psychology, University of Sydney, NSW, Australia
    Pediatr Neurol 32:248-56. 2005
    ..This observation has important implications for the role of trait-like biologic deficits in attention-deficit hyperactivity disorder predicting performance in information processing...
  71. ncbi request reprint Integrative neuroscience approach to predict ADHD stimulant response
    Daniel F Hermens
    The Brain Dynamics Centre, Westmead Millennium Institute and Western Clinical School, University of Sydney, Westmead Hospital, NSW, Australia
    Expert Rev Neurother 6:753-63. 2006
    ....
  72. ncbi request reprint The five symptom dimensions and depression in schizophrenia
    Kwang Hyuk Lee
    Cognitive Neuroscience Unit, The Brain Dynamics Centre, Westmead Hospital, Sydney, NSW, Australia
    Psychopathology 36:226-33. 2003
    ..It is suggested that depression exists as an independent domain, differentiated from negative symptoms, in the structure of schizophrenia symptomatology...
  73. doi request reprint Negative biases and risk for depression; integrating self-report and emotion task markers
    Anna J Watters
    Sydney Medical School, Westmead Millennium Institute, The Brain Dynamics Center, Westmead Hospital, Westmead, Sydney, NSW, Australia
    Depress Anxiety 28:703-18. 2011
    ..The aim of this study was to determine whether self-reported negativity bias is related to objective cognitive measures of emotional reactivity...
  74. ncbi request reprint Integrating "brain" and "body" measures: correlations between EEG and metabolic changes over the human lifespan
    Peter R Boord
    The Brain Dynamics Center, Westmead Millennium Institute, Westmead Hospital and Western Clinical School, University of Sydney, Westmead Hospital, Westmead, NSW 2145, Australia
    J Integr Neurosci 6:205-18. 2007
    ..This study investigated the relationship between electroencephalograph (EEG) power and basal metabolic rate (BMR) over the human lifespan, to better understand the mechanisms involved in the decline of neural activity with age...
  75. ncbi request reprint Emotion perception in schizophrenia: an eye movement study comparing the effectiveness of risperidone vs. haloperidol
    Leanne M Williams
    School of Psychology, University of Sydney, Sydney, NSW 2006, Australia
    Psychiatry Res 120:13-27. 2003
    ....