Thomas L Willett

Summary

Publications

  1. doi γ-Irradiation sterilized bone strengthened and toughened by ribose pre-treatment
    Thomas L Willett
    Musculoskeletal Research Laboratory, Mount Sinai Hospital Lunenfeld Tanenbaum Research Institute, Toronto, ON, Canada Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, ON, Canada Department of Materials Science and Engineering, University of Toronto, Toronto, ON, Canada Division of Orthopaedic Surgery, Mount Sinai Hospital, Toronto, ON, Canada Department of Surgery, University of Toronto, Toronto, ON, Canada Electronic address
    J Mech Behav Biomed Mater 44:147-55. 2015
  2. doi Collagen modifications in postmenopausal osteoporosis: advanced glycation endproducts may affect bone volume, structure and quality
    Thomas L Willett
    Musculoskeletal Research Laboratory, Lunenfeld Tanenbaum Research Institute at Mount Sinai Hospital, 60 Murray Street, Box 42, Toronto, Ontario, Canada, M5T 3L9
    Curr Osteoporos Rep 12:329-37. 2014
  3. doi In vitro non-enzymatic ribation reduces post-yield strain accommodation in cortical bone
    Thomas L Willett
    Division of Orthopaedic Surgery, Department of Surgery, University of Toronto, 100 College Street, Toronto, Ontario, Canada M5G 1L5
    Bone 52:611-22. 2013
  4. doi Enhanced levels of non-enzymatic glycation and pentosidine crosslinking in spontaneous osteoarthritis progression
    T L Willett
    Division of Orthopaedic Surgery, Department of Surgery, University of Toronto, Ontario, Canada
    Osteoarthritis Cartilage 20:736-44. 2012
  5. doi Changes in collagen with aging maintain molecular stability after overload: evidence from an in vitro tendon model
    Thomas L Willett
    Bone Biology Laboratory, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON, M5G 1X5, Canada
    J Biomech Eng 132:031002. 2010
  6. pmc Effect of rosiglitazone on bone quality in a rat model of insulin resistance and osteoporosis
    Laura D Sardone
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
    Diabetes 60:3271-8. 2011
  7. doi Adynamic Bone Decreases Bone Toughness During Aging by Affecting Mineral and Matrix
    Adeline H Ng
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada
    J Bone Miner Res 31:369-79. 2016
  8. doi Biomechanical comparison of the human cadaveric pelvis with a fourth generation composite model
    Brandon L Girardi
    Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada Department of Surgery, University of Toronto, Toronto, ON, Canada Electronic address
    J Biomech 49:537-42. 2016
  9. doi Changes in bone fatigue resistance due to collagen degradation
    Chrystia Wynnyckyj
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Room 840, Toronto, Ontario, Canada M5G 1X5
    J Orthop Res 29:197-203. 2011
  10. pmc Differential effects of PPAR-{gamma} activation versus chemical or genetic reduction of DPP-4 activity on bone quality in mice
    Kimberly A Kyle
    Department of Laboratory Medicine and Pathobiology, Samuel Lunenfeld Research Institute, Mt Sinai Hospital, Toronto, Ontario, Canada
    Endocrinology 152:457-67. 2011

Collaborators

  • David Backstein
  • Jian Wang
  • R Kandel
  • Marc D Grynpas
  • Ian G Aldous
  • Adeline H Ng
  • Brandon L Girardi
  • Oleg Safir
  • Paul R T Kuzyk
  • Benjamin A Alman
  • Tatu J Makinen
  • Brianne Burton
  • Sidney Omelon
  • Kimberly A Kyle
  • Noam Levaot
  • Laura D Sardone
  • Chrystia Wynnyckyj
  • Bedilu Allo
  • Tarik Attia
  • Fabio Variola
  • Herman S Dhotar
  • Matthew J Gunton
  • Mitchell Woodside
  • Simcha G Fichman
  • Jindra Tupy
  • Anne Gaspar
  • David Josey
  • Salima Janmohamed
  • Zhirui Wang
  • Andrew Scotter
  • Ioannis D Dimitriou
  • Robert Rottapel
  • Chiachien J Wang
  • Ivan G Fantus
  • Ernst Reichenberger
  • Jose La Rose
  • Adeline H M Ng
  • Richard Renlund
  • Laurie L Baggio
  • Paul D Simoncic
  • Daniel J Drucker

Detail Information

Publications14

  1. doi γ-Irradiation sterilized bone strengthened and toughened by ribose pre-treatment
    Thomas L Willett
    Musculoskeletal Research Laboratory, Mount Sinai Hospital Lunenfeld Tanenbaum Research Institute, Toronto, ON, Canada Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, ON, Canada Department of Materials Science and Engineering, University of Toronto, Toronto, ON, Canada Division of Orthopaedic Surgery, Mount Sinai Hospital, Toronto, ON, Canada Department of Surgery, University of Toronto, Toronto, ON, Canada Electronic address
    J Mech Behav Biomed Mater 44:147-55. 2015
    ..This study tested the hypothesis that a ribose-based pre-treatment would protect the strength, ductility and toughness of γ-irradiation sterilized cortical bone...
  2. doi Collagen modifications in postmenopausal osteoporosis: advanced glycation endproducts may affect bone volume, structure and quality
    Thomas L Willett
    Musculoskeletal Research Laboratory, Lunenfeld Tanenbaum Research Institute at Mount Sinai Hospital, 60 Murray Street, Box 42, Toronto, Ontario, Canada, M5T 3L9
    Curr Osteoporos Rep 12:329-37. 2014
    ..Anti-oxidant therapies may have the potential to inhibit the oxidative stress based mechanisms of this disease. ..
  3. doi In vitro non-enzymatic ribation reduces post-yield strain accommodation in cortical bone
    Thomas L Willett
    Division of Orthopaedic Surgery, Department of Surgery, University of Toronto, 100 College Street, Toronto, Ontario, Canada M5G 1L5
    Bone 52:611-22. 2013
    ..However, the positive correlations we have found suggest that increased crosslinking may not provide a complete explanation for this embrittlement...
  4. doi Enhanced levels of non-enzymatic glycation and pentosidine crosslinking in spontaneous osteoarthritis progression
    T L Willett
    Division of Orthopaedic Surgery, Department of Surgery, University of Toronto, Ontario, Canada
    Osteoarthritis Cartilage 20:736-44. 2012
    ..To test the hypothesis that heightened advanced glycation endproducts (AGEs) content in cartilage accelerates the progression of spontaneous osteoarthritis (OA) in the Hartley guinea pig (HGP) model...
  5. doi Changes in collagen with aging maintain molecular stability after overload: evidence from an in vitro tendon model
    Thomas L Willett
    Bone Biology Laboratory, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON, M5G 1X5, Canada
    J Biomech Eng 132:031002. 2010
    ..As techniques develop and improve, this new information may lead to important future studies concerning improved detection, prediction, and modeling of mechanical damage at much finer levels of tissue hierarchy than currently possible...
  6. pmc Effect of rosiglitazone on bone quality in a rat model of insulin resistance and osteoporosis
    Laura D Sardone
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
    Diabetes 60:3271-8. 2011
    ..These were not osteoporotic vertebral fractures but, rather, occurred in the limbs. The purpose of this study was to investigate how RSG treatment alters bone quality, which leads to fracture risk, using the Zucker fatty rat as a model...
  7. doi Adynamic Bone Decreases Bone Toughness During Aging by Affecting Mineral and Matrix
    Adeline H Ng
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada
    J Bone Miner Res 31:369-79. 2016
    ..Our mouse model may be useful in the investigation of the mechanisms involved in fractures occurring in elderly patients on antiresorptive therapy who have very low bone turnover. © 2015 American Society for Bone and Mineral Research. ..
  8. doi Biomechanical comparison of the human cadaveric pelvis with a fourth generation composite model
    Brandon L Girardi
    Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada Department of Surgery, University of Toronto, Toronto, ON, Canada Electronic address
    J Biomech 49:537-42. 2016
    ..Altering the cortical wall thickness or tuning the elastic moduli of the composite material may improve future generations of the composite model. ..
  9. doi Changes in bone fatigue resistance due to collagen degradation
    Chrystia Wynnyckyj
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Room 840, Toronto, Ontario, Canada M5G 1X5
    J Orthop Res 29:197-203. 2011
    ..Therefore, collagen degradation caused by KOH treatment may be responsible for the observed altered fatigue behavior at high stresses, since collagen is responsible for the creep behavior in bone...
  10. pmc Differential effects of PPAR-{gamma} activation versus chemical or genetic reduction of DPP-4 activity on bone quality in mice
    Kimberly A Kyle
    Department of Laboratory Medicine and Pathobiology, Samuel Lunenfeld Research Institute, Mt Sinai Hospital, Toronto, Ontario, Canada
    Endocrinology 152:457-67. 2011
    ..sitagliptin vs. genetic Dpp4 inactivation on bone mechanics in mice...
  11. doi Bone embrittlement and collagen modifications due to high-dose gamma-irradiation sterilization
    Brianne Burton
    Institute of Biomaterials and Biomedical Engineering, University of Toronto, 164 Collagen Street, Toronto, ON M5S 3G9, Canada Musculoskeletal Research Laboratory, Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, 25 Orde Street, Room 417, Toronto, ON M5T 3H7, Canada
    Bone 61:71-81. 2014
    ....
  12. doi Periprosthetic supracondylar femoral fractures following knee arthroplasty: a biomechanical comparison of four methods of fixation
    Tatu J Makinen
    Mount Sinai Hospital, Division of Orthopaedic Surgery, University of Toronto, 600 University Avenue, Toronto, Ontario, M5G 1X5, Canada
    Int Orthop 39:1737-42. 2015
    ..The aim of this study was to determine the biomechanical properties of four fixation options for periprosthetic supracondylar femoral fractures...
  13. doi Development, validation and characterization of a novel mouse model of Adynamic Bone Disease (ABD)
    Adeline H Ng
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Bone 68:57-66. 2014
    ..We plan to use our mouse model to investigate the adynamic bone condition in aging and to study changes to bone quality and fracture risk as a consequence of over-suppressed bone turnover. ..
  14. pmc 3BP2-deficient mice are osteoporotic with impaired osteoblast and osteoclast functions
    Noam Levaot
    Campbell Family Cancer Research Institute, Ontario Cancer Institute, Princess Margaret Hospital, University Health Network, Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    J Clin Invest 121:3244-57. 2011
    ..These findings reveal an unanticipated role for the 3BP2 adapter protein in osteoblast function and in coordinating bone homeostatic signals in both osteoclast and osteoblast lineages...