Sara A Wickström

Summary

Publications

  1. doi request reprint Regulation of membrane traffic by integrin signaling
    Sara A Wickström
    Paul Gerson Unna group Skin Homeostasis and Ageing, Max Planck Institute for Biology of Ageing, Gleueler Strasse 50a, 50937 Cologne, Germany
    Trends Cell Biol 21:266-73. 2011
  2. pmc Integrin-linked kinase controls microtubule dynamics required for plasma membrane targeting of caveolae
    Sara A Wickström
    Department of Molecular Medicine, Max Planck Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany
    Dev Cell 19:574-88. 2010
  3. pmc Stabilization of integrin-linked kinase by the Hsp90-CHIP axis impacts cellular force generation, migration and the fibrotic response
    Korana Radovanac
    Department of Molecular Medicine, Max Planck Institute of Biochemistry, Martinsried, Germany
    EMBO J 32:1409-24. 2013
  4. doi request reprint Integrin-linked kinase is an adaptor with essential functions during mouse development
    Anika Lange
    Department of Molecular Medicine, Max Planck Institute of Biochemistry, Martinsried 82152, Germany
    Nature 461:1002-6. 2009
  5. doi request reprint ILK: a pseudokinase with a unique function in the integrin-actin linkage
    Sushmita Ghatak
    Paul Gerson Unna Group Skin Homeostasis and Ageing Max Planck Institute for Biology of Ageing, Joseph Stelzmann Strasse 9b, 50937 Cologne, Germany
    Biochem Soc Trans 41:995-1001. 2013
  6. doi request reprint In vivo SILAC-based proteomics reveals phosphoproteome changes during mouse skin carcinogenesis
    Sara Zanivan
    Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany
    Cell Rep 3:552-66. 2013
  7. pmc CYLD negatively regulates cell-cycle progression by inactivating HDAC6 and increasing the levels of acetylated tubulin
    Sara A Wickström
    Department of Molecular Medicine, Max Planck Institute of Biochemistry, Martinsried, Germany
    EMBO J 29:131-44. 2010
  8. pmc The ILK/PINCH/parvin complex: the kinase is dead, long live the pseudokinase!
    Sara A Wickström
    Department for Molecular Medicine, Max Planck Institute of Biochemistry, Martinsried, Germany
    EMBO J 29:281-91. 2010
  9. pmc Alpha-parvin controls vascular mural cell recruitment to vessel wall by regulating RhoA/ROCK signalling
    Eloi Montanez
    Department of Molecular Medicine, Max Planck Institute of Biochemistry, Martinsried, Germany
    EMBO J 28:3132-44. 2009
  10. doi request reprint Genetic and cell biological analysis of integrin outside-in signaling
    Kyle R Legate
    Department of Molecular Medicine, Max Planck Institute of Biochemistry, Martinsried 82152, Germany
    Genes Dev 23:397-418. 2009

Collaborators

Detail Information

Publications16

  1. doi request reprint Regulation of membrane traffic by integrin signaling
    Sara A Wickström
    Paul Gerson Unna group Skin Homeostasis and Ageing, Max Planck Institute for Biology of Ageing, Gleueler Strasse 50a, 50937 Cologne, Germany
    Trends Cell Biol 21:266-73. 2011
    ..This review discusses these findings and considers their implications for signaling events downstream of integrins and growth factor receptors...
  2. pmc Integrin-linked kinase controls microtubule dynamics required for plasma membrane targeting of caveolae
    Sara A Wickström
    Department of Molecular Medicine, Max Planck Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany
    Dev Cell 19:574-88. 2010
    ..Our results assign an important role to the integrin/ILK complex for caveolar trafficking to the cell surface...
  3. pmc Stabilization of integrin-linked kinase by the Hsp90-CHIP axis impacts cellular force generation, migration and the fibrotic response
    Korana Radovanac
    Department of Molecular Medicine, Max Planck Institute of Biochemistry, Martinsried, Germany
    EMBO J 32:1409-24. 2013
    ..Together, our results uncover how Hsp90 regulates ILK stability and identify a potential therapeutic strategy to alleviate fibrotic diseases...
  4. doi request reprint Integrin-linked kinase is an adaptor with essential functions during mouse development
    Anika Lange
    Department of Molecular Medicine, Max Planck Institute of Biochemistry, Martinsried 82152, Germany
    Nature 461:1002-6. 2009
    ..Thus, we provide genetic evidence that the kinase activity of Ilk is dispensable for mammalian development; however, an interaction between Ilk and alpha-parvin is critical for kidney development...
  5. doi request reprint ILK: a pseudokinase with a unique function in the integrin-actin linkage
    Sushmita Ghatak
    Paul Gerson Unna Group Skin Homeostasis and Ageing Max Planck Institute for Biology of Ageing, Joseph Stelzmann Strasse 9b, 50937 Cologne, Germany
    Biochem Soc Trans 41:995-1001. 2013
    ..The present review discusses the recent advances on the structural and functional characterization of ILK and the long-standing debate regarding its reported kinase activity. ..
  6. doi request reprint In vivo SILAC-based proteomics reveals phosphoproteome changes during mouse skin carcinogenesis
    Sara Zanivan
    Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany
    Cell Rep 3:552-66. 2013
    ..This detailed molecular picture, both at the proteome and phosphoproteome level, will prove useful for the study of mechanisms of tumor progression...
  7. pmc CYLD negatively regulates cell-cycle progression by inactivating HDAC6 and increasing the levels of acetylated tubulin
    Sara A Wickström
    Department of Molecular Medicine, Max Planck Institute of Biochemistry, Martinsried, Germany
    EMBO J 29:131-44. 2010
    ..Altogether these results identify a mechanism by which CYLD regulates cell proliferation at distinct cell-cycle phases...
  8. pmc The ILK/PINCH/parvin complex: the kinase is dead, long live the pseudokinase!
    Sara A Wickström
    Department for Molecular Medicine, Max Planck Institute of Biochemistry, Martinsried, Germany
    EMBO J 29:281-91. 2010
    ..This review focuses on the recent advances made towards understanding the specialized roles this complex and its individual components have acquired during evolution...
  9. pmc Alpha-parvin controls vascular mural cell recruitment to vessel wall by regulating RhoA/ROCK signalling
    Eloi Montanez
    Department of Molecular Medicine, Max Planck Institute of Biochemistry, Martinsried, Germany
    EMBO J 28:3132-44. 2009
    ..Our findings show that alpha-pv represents an essential adhesion checkpoint that controls RhoA/ROCK-mediated contractility in vSMCs...
  10. doi request reprint Genetic and cell biological analysis of integrin outside-in signaling
    Kyle R Legate
    Department of Molecular Medicine, Max Planck Institute of Biochemistry, Martinsried 82152, Germany
    Genes Dev 23:397-418. 2009
    ..This review discusses recent work that has tremendously broadened our understanding of the complexity of integrin-mediated signaling...
  11. pmc Integrin-linked kinase regulates the niche of quiescent epidermal stem cells
    Jessica Morgner
    Paul Gerson Unna group Skin Homeostasis and Ageing, Max Planck Institute for Biology of Ageing, Cologne 50931, Germany
    Nat Commun 6:8198. 2015
    ..Overall, our findings uncover a critical role for the BM niche in regulating stem cell activation and thereby skin homeostasis. ..
  12. pmc Integrin-linked kinase stabilizes myotendinous junctions and protects muscle from stress-induced damage
    Hao Ven Wang
    Department of Molecular Medicine, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany
    J Cell Biol 180:1037-49. 2008
    ..Our data identify the beta1 integrin-ILK complex as an important component of IGF-1R/insulin receptor substrate signaling to PKB/Akt during mechanical stress in skeletal muscle...
  13. ncbi request reprint [Degradation products of endothelial basement membranes: their role as tumor suppressor]
    Sara A Wickström
    Max Planck Institute for Biochemistry, Department of Molecular Medicine, Martinsried, Germany
    Duodecim 121:1829-37. 2005
  14. doi request reprint Integrins anchor the invasive machinery
    Sara A Wickström
    Department of Molecular Medicine, Max Planck Institute of Biochemistry, Martinsried 82152, Germany
    Dev Cell 17:158-60. 2009
    ..In this issue of Developmental Cell, Sherwood and coworkers now identify integrins as integration platforms for a specialized invasive membrane domain in C. elegans...
  15. ncbi request reprint Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry
    Sara Zanivan
    Department of Proteomics and Signal Transduction, Max Planck Institute for Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany
    J Proteome Res 7:5314-26. 2008
    ..Thus, solid tumor can be analyzed by MS-based proteomics with similar efficiency as cell culture models and in amounts compatible with biopsies...