Hongen Wei

Summary

Publications

  1. doi request reprint Inhibition of IL-6 trans-signaling in the brain increases sociability in the BTBR mouse model of autism
    Hongen Wei
    Department of Rehabilitation Medicine, Shanxi Provincial People s Hospital, Affiliate of Shanxi Medical University, Taiyuan, China Electronic address
    Biochim Biophys Acta 1862:1918-25. 2016
  2. ncbi request reprint Reduced Glutamate Release in Adult BTBR Mouse Model of Autism Spectrum Disorder
    Hongen Wei
    Department of Rehabilitation Medicine, Shanxi Provincial People s Hospital, Affiliate of Shanxi Medical University, 29 Shuangta Road, Taiyuan, 030012, China
    Neurochem Res 41:3129-3137. 2016
  3. doi request reprint Reduced plasma levels of microtubule-associated STOP/MAP6 protein in autistic patients
    Hongen Wei
    Department of Rehabilitation Medicine, Shanxi Provincial People s Hospital, Affiliate of Shanxi Medical University, 29 Shuangta Road, 030012 Taiyuan, China Electronic address
    Psychiatry Res 245:116-118. 2016
  4. doi request reprint Proteomic analysis of cortical brain tissue from the BTBR mouse model of autism: Evidence for changes in STOP and myelin-related proteins
    H Wei
    Department of Rehabilitation Medicine, Shanxi Provincial People s Hospital, Affiliate of Shanxi Medical University, Taiyuan, China Electronic address
    Neuroscience 312:26-34. 2016
  5. doi request reprint The apoptotic perspective of autism
    Hongen Wei
    Central Laboratory, Shanxi Provincial People s Hospital, Affiliate of Shanxi Medical University, Taiyuan, China Electronic address
    Int J Dev Neurosci 36:13-8. 2014
  6. doi request reprint Brain IL-6 and autism
    H Wei
    Central Laboratory, Shanxi Provincial People s Hospital, Affiliate of Shanxi Medical University, Taiyuan, China Electronic address
    Neuroscience 252:320-5. 2013
  7. doi request reprint Alteration of brain volume in IL-6 overexpressing mice related to autism
    Hongen Wei
    Central Laboratory, Shanxi Provincial People s Hospital, Taiyuan, China
    Int J Dev Neurosci 30:554-9. 2012
  8. pmc IL-6 is increased in the cerebellum of autistic brain and alters neural cell adhesion, migration and synaptic formation
    Hongen Wei
    Department of Neurochemistry, NY State Institute for Basic Research in Developmental Disabilities, New York, USA
    J Neuroinflammation 8:52. 2011
  9. pmc The therapeutic effect of memantine through the stimulation of synapse formation and dendritic spine maturation in autism and fragile X syndrome
    Hongen Wei
    Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, New York, New York, United States of America
    PLoS ONE 7:e36981. 2012
  10. doi request reprint Up-regulation of Ras/Raf/ERK1/2 signaling impairs cultured neuronal cell migration, neurogenesis, synapse formation, and dendritic spine development
    Kun Yang
    Department of Neurochemistry, NY State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, New York, NY, 10314, USA
    Brain Struct Funct 218:669-82. 2013

Detail Information

Publications13

  1. doi request reprint Inhibition of IL-6 trans-signaling in the brain increases sociability in the BTBR mouse model of autism
    Hongen Wei
    Department of Rehabilitation Medicine, Shanxi Provincial People s Hospital, Affiliate of Shanxi Medical University, Taiyuan, China Electronic address
    Biochim Biophys Acta 1862:1918-25. 2016
    ..Our findings suggest that inhibition of excessive production of IL-6 may have selective therapeutic efficacy in treating abnormal social behaviors in autism. ..
  2. ncbi request reprint Reduced Glutamate Release in Adult BTBR Mouse Model of Autism Spectrum Disorder
    Hongen Wei
    Department of Rehabilitation Medicine, Shanxi Provincial People s Hospital, Affiliate of Shanxi Medical University, 29 Shuangta Road, Taiyuan, 030012, China
    Neurochem Res 41:3129-3137. 2016
    ..Overall, our results suggest that abnormal vesicular glutamate activity may underlie the ASD relevant pathology in the BTBR mice...
  3. doi request reprint Reduced plasma levels of microtubule-associated STOP/MAP6 protein in autistic patients
    Hongen Wei
    Department of Rehabilitation Medicine, Shanxi Provincial People s Hospital, Affiliate of Shanxi Medical University, 29 Shuangta Road, 030012 Taiyuan, China Electronic address
    Psychiatry Res 245:116-118. 2016
    ..Finally, a possible mechanism of STOP/MAP6 protein in the pathogenesis of autism was proposed...
  4. doi request reprint Proteomic analysis of cortical brain tissue from the BTBR mouse model of autism: Evidence for changes in STOP and myelin-related proteins
    H Wei
    Department of Rehabilitation Medicine, Shanxi Provincial People s Hospital, Affiliate of Shanxi Medical University, Taiyuan, China Electronic address
    Neuroscience 312:26-34. 2016
    ..Manipulation of STOP protein could be a promising avenue for therapeutic interventions to autism. ..
  5. doi request reprint The apoptotic perspective of autism
    Hongen Wei
    Central Laboratory, Shanxi Provincial People s Hospital, Affiliate of Shanxi Medical University, Taiyuan, China Electronic address
    Int J Dev Neurosci 36:13-8. 2014
    ..It has been demonstrated a possible association between neural cell death and autism. Here, the abnormal apoptosis found in autism from postmortem and animal studies was reviewed and the possible mechanism was discussed. ..
  6. doi request reprint Brain IL-6 and autism
    H Wei
    Central Laboratory, Shanxi Provincial People s Hospital, Affiliate of Shanxi Medical University, Taiyuan, China Electronic address
    Neuroscience 252:320-5. 2013
    ..Further studies to investigate whether IL-6 could be used for therapeutic interventions in autism would be of great significance. ..
  7. doi request reprint Alteration of brain volume in IL-6 overexpressing mice related to autism
    Hongen Wei
    Central Laboratory, Shanxi Provincial People s Hospital, Taiyuan, China
    Int J Dev Neurosci 30:554-9. 2012
    ..These results indicate that IL-6 elevation in the brain could mediate neuroanatomical abnormalities. Taking together with our previous findings, a mechanism by which IL-6 may be involved in the pathogenesis of autism is proposed...
  8. pmc IL-6 is increased in the cerebellum of autistic brain and alters neural cell adhesion, migration and synaptic formation
    Hongen Wei
    Department of Neurochemistry, NY State Institute for Basic Research in Developmental Disabilities, New York, USA
    J Neuroinflammation 8:52. 2011
    ..Recent evidence shows that IL-6 has a crucial role in the development and plasticity of CNS...
  9. pmc The therapeutic effect of memantine through the stimulation of synapse formation and dendritic spine maturation in autism and fragile X syndrome
    Hongen Wei
    Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, New York, New York, United States of America
    PLoS ONE 7:e36981. 2012
    ..These findings suggest that memantine may exert its therapeutic capacity through a stimulatory effect on dendritic spine maturation and excitatory synapse formation, as well as promoting adhesion of CGCs...
  10. doi request reprint Up-regulation of Ras/Raf/ERK1/2 signaling impairs cultured neuronal cell migration, neurogenesis, synapse formation, and dendritic spine development
    Kun Yang
    Department of Neurochemistry, NY State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, New York, NY, 10314, USA
    Brain Struct Funct 218:669-82. 2013
    ..Together, these results suggest that the up-regulation of the Raf/ERK signaling pathway may contribute to the pathogenesis of autism through both its impairment of cortical neuron development and causing neural circuit imbalances...
  11. doi request reprint Brain IL-6 elevation causes neuronal circuitry imbalances and mediates autism-like behaviors
    Hongen Wei
    Department of Neurochemistry, NY State Institute for Basic Research in Developmental Disabilities, New York, NY 10314, USA
    Biochim Biophys Acta 1822:831-42. 2012
    ..These findings suggest that IL-6 elevation in the brain could mediate autistic-like behaviors, possibly through the imbalances of neural circuitry and impairments of synaptic plasticity...
  12. pmc Abnormal cell properties and down-regulated FAK-Src complex signaling in B lymphoblasts of autistic subjects
    Hongen Wei
    Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, New York, New York 10314, USA
    Am J Pathol 179:66-74. 2011
    ....
  13. pmc Abnormal glutamate release in aged BTBR mouse model of autism
    Hongen Wei
    Central Laboratory, Shanxi Provincial People s Hospital, Affiliate of Shanxi Medical University Taiyuan, China
    Int J Clin Exp Pathol 8:10689-97. 2015
    ..These findings provide new evidences for the hypothesis of excitation/inhibition imbalance in autism. Further work is required to determine the cause of this putative abnormality. ..