Zheng Wang

Summary

Publications

  1. doi request reprint Human embryonic stem cells and liver diseases: from basic research to future clinical application
    Zheng Wang
    Shanghai Institute of Digestive Disease, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
    J Dig Dis 9:14-9. 2008
  2. doi request reprint miR-28-5p-IL-34-macrophage feedback loop modulates hepatocellular carcinoma metastasis
    Shao Lai Zhou
    Liver Surgery Department, Liver Cancer Institute, Zhongshan Hospital, Fudan University Key Laboratory of Carcinogenesis and Cancer Invasion Fudan University, Ministry of Education, Shanghai, China
    Hepatology 63:1560-75. 2016
  3. doi request reprint Tumor-Associated Neutrophils Recruit Macrophages and T-Regulatory Cells to Promote Progression of Hepatocellular Carcinoma and Resistance to Sorafenib
    Shao Lai Zhou
    Liver Surgery Department, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, China Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Fudan University, Shanghai, China Institute of Biomedical Sciences, Fudan University, Shanghai, China
    Gastroenterology 150:1646-1658.e17. 2016
  4. doi request reprint Human miR-1228 as a stable endogenous control for the quantification of circulating microRNAs in cancer patients
    Jie Hu
    Liver Cancer Institute Zhongshan Hospital, Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Fudan University, Shanghai, China
    Int J Cancer 135:1187-94. 2014
  5. doi request reprint High expression of Dickkopf-related protein 1 is related to lymphatic metastasis and indicates poor prognosis in intrahepatic cholangiocarcinoma patients after surgery
    Ruo Yu Shi
    Department of Liver Surgery, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, China
    Cancer 119:993-1003. 2013
  6. doi request reprint Prognostic indicators for tumor recurrence after liver transplantation in hepatocellular carcinoma and related molecular targeted therapy
    Lei Yu
    Liver Cancer Institute, Fudan University, Shanghai, China
    Oncology 81:116-22. 2011
  7. doi request reprint Bench-scale study on zero excess activated sludge production process coupled with ozonation unit in membrane bioreactor
    Zheng Wang
    School of Municipal and Environmental Engineering, Harbin Institute of Technology, Harbin, China
    J Environ Sci Health A Tox Hazard Subst Environ Eng 43:1325-32. 2008
  8. ncbi request reprint ER stress negatively regulates AKT/TSC/mTOR pathway to enhance autophagy
    Liang Qin
    Department of Physiology, Institute of Basic Medical Sciences and School of Basic Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    Autophagy 6:239-47. 2010
  9. doi request reprint Pyridinyl aminohydantoins as small molecule BACE1 inhibitors
    Ping Zhou
    Department of Chemical Sciences, Wyeth Research, CN 8000, Princeton, NJ 08543 8000, United States
    Bioorg Med Chem Lett 20:2326-9. 2010
  10. ncbi request reprint Effect of chitosan molecular weight and deacetylation degree on hemostasis
    Jian Yang
    Tianjin Institute of Medical Equipment, Tianjin 300161, People s Republic of China
    J Biomed Mater Res B Appl Biomater 84:131-7. 2008

Collaborators

Detail Information

Publications38

  1. doi request reprint Human embryonic stem cells and liver diseases: from basic research to future clinical application
    Zheng Wang
    Shanghai Institute of Digestive Disease, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
    J Dig Dis 9:14-9. 2008
    ..Here, we highlight some of the recent efforts in this area, in hope of providing insights toward this complex yet important area of therapeutical modality for treating patients with liver disease...
  2. doi request reprint miR-28-5p-IL-34-macrophage feedback loop modulates hepatocellular carcinoma metastasis
    Shao Lai Zhou
    Liver Surgery Department, Liver Cancer Institute, Zhongshan Hospital, Fudan University Key Laboratory of Carcinogenesis and Cancer Invasion Fudan University, Ministry of Education, Shanghai, China
    Hepatology 63:1560-75. 2016
    ..Patients with low miR-28-5p expression, high IL-34 levels, and high numbers of TAMs had a poor prognosis with shorter overall survival and time to recurrence...
  3. doi request reprint Tumor-Associated Neutrophils Recruit Macrophages and T-Regulatory Cells to Promote Progression of Hepatocellular Carcinoma and Resistance to Sorafenib
    Shao Lai Zhou
    Liver Surgery Department, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, China Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Fudan University, Shanghai, China Institute of Biomedical Sciences, Fudan University, Shanghai, China
    Gastroenterology 150:1646-1658.e17. 2016
    ..We investigated the roles of TANs in progression of hepatocellular carcinoma (HCC) using cell lines and immune cells isolated from patients...
  4. doi request reprint Human miR-1228 as a stable endogenous control for the quantification of circulating microRNAs in cancer patients
    Jie Hu
    Liver Cancer Institute Zhongshan Hospital, Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Fudan University, Shanghai, China
    Int J Cancer 135:1187-94. 2014
    ..The results explained the steady expression of miR-1228 in the blood. In conclusion, miR-1228 is a promising stable endogenous control for quantifying circulating microRNAs in cancer patients. ..
  5. doi request reprint High expression of Dickkopf-related protein 1 is related to lymphatic metastasis and indicates poor prognosis in intrahepatic cholangiocarcinoma patients after surgery
    Ruo Yu Shi
    Department of Liver Surgery, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, China
    Cancer 119:993-1003. 2013
    ..This study sought to investigate the prognostic value of DKK1 in intrahepatic cholangiocarcinoma (ICC) and its role in promoting ICC metastasis...
  6. doi request reprint Prognostic indicators for tumor recurrence after liver transplantation in hepatocellular carcinoma and related molecular targeted therapy
    Lei Yu
    Liver Cancer Institute, Fudan University, Shanghai, China
    Oncology 81:116-22. 2011
    ..Given the efficacy of some molecular targeted drugs in the treatment of HCC or prevention of tumor recurrence after LT, the emerging molecular targeted therapy is also discussed in this review...
  7. doi request reprint Bench-scale study on zero excess activated sludge production process coupled with ozonation unit in membrane bioreactor
    Zheng Wang
    School of Municipal and Environmental Engineering, Harbin Institute of Technology, Harbin, China
    J Environ Sci Health A Tox Hazard Subst Environ Eng 43:1325-32. 2008
    ..041Yuan (USD 0.0053)/m(3) wastewater was obtained. Overall, mass balance showed that the preset value of operation parameters listed in mathematical models matched well with trends of sludge reduction found in this experimental result...
  8. ncbi request reprint ER stress negatively regulates AKT/TSC/mTOR pathway to enhance autophagy
    Liang Qin
    Department of Physiology, Institute of Basic Medical Sciences and School of Basic Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    Autophagy 6:239-47. 2010
    ..Moreover, constitutively-activated mTOR-induced long-term ER stress attenuated the RTK/PI3K/AKT signaling pathway in response to the stimulation by various growth factors, which could also be partly restored by 4-PBA...
  9. doi request reprint Pyridinyl aminohydantoins as small molecule BACE1 inhibitors
    Ping Zhou
    Department of Chemical Sciences, Wyeth Research, CN 8000, Princeton, NJ 08543 8000, United States
    Bioorg Med Chem Lett 20:2326-9. 2010
    ..X-ray crystallography indicated that the interaction between pyridine nitrogen and the tryptophan Trp76 was a key feature in the S2' region of the enzyme that contributed to increased potency...
  10. ncbi request reprint Effect of chitosan molecular weight and deacetylation degree on hemostasis
    Jian Yang
    Tianjin Institute of Medical Equipment, Tianjin 300161, People s Republic of China
    J Biomed Mater Res B Appl Biomater 84:131-7. 2008
    ..The results demonstrated that coagulation factors might not be activated by them...
  11. doi request reprint CXCR2/CXCL5 axis contributes to epithelial-mesenchymal transition of HCC cells through activating PI3K/Akt/GSK-3β/Snail signaling
    Shao Lai Zhou
    Liver Surgery Department, Liver Cancer Institute, Zhongshan Hospital, Key Laboratory of Carcinogenesis and Cancer Invasion Fudan University, Ministry of Education, Fudan University, Shanghai 200032, China Institute of Biomedical Sciences, Fudan University, Shanghai, China
    Cancer Lett 358:124-35. 2015
    ..In conclusion, our data showed that the CXCR2/CXCL5 axis contributes to EMT of HCC cells through activating PI3K/Akt/GSK-3β/Snail signaling, and it may serve as a potential therapeutic target. ..
  12. doi request reprint Expression of hemopexin in acute rejection of rat liver allograft identified by serum proteomic analysis
    Min Xu
    Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, China Departments of General and Visceral Surgery, and Gastroenterology and Endocrinology, University Medical Center Goettingen, Goettingen, Germany and Department of Surgery, Fujian Provincial Tumor Hospital, Teaching Hospital of Fujian Medical University, Fuzhou and Shanghai Key Laboratory of Organ Transplantation, Zhongshan Hospital, Fudan University, Shanghai, China
    Shock 42:65-74. 2014
    ..In view of finding that the HPX serum level is negatively associated with the severity of AR of rat liver allograft, we propose that in vitro treatment with HPX regulates cytokine expression in rat lymphocytes. ..
  13. doi request reprint Sorafenib delays recurrence and metastasis after liver transplantation in a rat model of hepatocellular carcinoma with high expression of phosphorylated extracellular signal-regulated kinase
    Jun Yan
    Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, People s Republic of China
    Liver Transpl 19:507-20. 2013
    ..This study suggests that sorafenib may have potential, particularly as part of a stratified medicine approach to HCC treatment after LT...
  14. pmc RNA interference-mediated silencing of eukaryotic translation initiation factor 3, subunit B (EIF3B) gene expression inhibits proliferation of colon cancer cells
    Zheng Wang
    Department of General Surgery, Renji Hospital, Shanghai Jiaotong University School of Medicine, 145 Shandong Middle Road, Shanghai 200001, China
    World J Surg Oncol 10:119. 2012
    ..Research advances focused on the inhibition of their expression and activity hold the key to the initiation and progression of tumor and tumor prognosis...
  15. doi request reprint Effect of the parvovirus H-1 non-structural protein NS1 on the tumorigenicity of human gastric cancer cells
    Yuan Yuan Wang
    Division of Gastroenterology and Hepatology, Renji Hospital, Shanghai Jiaotong University School of Medicine, China
    J Dig Dis 13:366-73. 2012
    ..To investigate the in vivo oncosuppressive effect of the non-structural protein NS1 of parvovirus H-1 on human gastric cancer cell lines...
  16. doi request reprint Efficient differentiation of newly derived human embryonic stem cells from discarded blastocysts into hepatocyte-like cells
    Hong Lu
    Department of Gastroenterology, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai Institute of Digestive Disease, Shanghai, China
    J Dig Dis 11:376-82. 2010
    ..To establish an optimal method to isolate and culture human embryonic stem (hES) cells from discarded blastocysts and to differentiate these cells into hepatocyte-like cells...
  17. pmc Two-layer regulation of PAQR3 on ATG14-linked class III PtdIns3K activation upon glucose starvation
    Daqian Xu
    a Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China
    Autophagy 12:1047-8. 2016
    ..Thus, this work not only uncovers the regulatory mechanism of PAQR3 on autophagy initiation, but also provides a potential candidate therapeutic target for neurodegenerative diseases. ..
  18. pmc Critical roles of p53 in epithelial-mesenchymal transition and metastasis of hepatocellular carcinoma cells
    Zheng Wang
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China
    PLoS ONE 8:e72846. 2013
    ..In conclusion, this study reveals that p53 plays a pivotal role in EMT and metastasis of HCC cells via its regulation on β-catenin signaling. ..
  19. doi request reprint DDB2 is involved in ubiquitination and degradation of PAQR3 and regulates tumorigenesis of gastric cancer cells
    Shanshan Qiao
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai, China
    Biochem J 469:469-80. 2015
    ..Collectively, our studies not only pinpoint that DDB2 is a post-translational regulator of PAQR3, but also indicate that DDB2 may play an active role in tumorigenesis via regulating PAQR3. ..
  20. pmc Structural insights into Paf1 complex assembly and histone binding
    Xinlei Chu
    State Key Laboratory of Medicinal Chemical Biology, Nankai University, 94 Weijin Road, Tianjin 300071, China, College of Life Sciences, Nankai University, 94 Weijin Road, Tianjin 300071, China and Synergetic Innovation Center of Chemical Science and Engineering, 94 Weijin Road, Tianjin 300071, China
    Nucleic Acids Res 41:10619-29. 2013
    ..Our results shed light on the PAF1C assembly process and substrate recognition during various PAF1C-coordinated histone modifications. ..
  21. doi request reprint A rare case of bilateral massive hemothorax from spontaneous rupture of a primary mediastinal mixed germ cell tumor
    Zheng Ruan
    Department of Thoracic Surgery, the Affiliated First People s Hospital, Shanghai Jiao Tong University, Shanghai, China
    Ann Thorac Surg 93:664-6. 2012
    ..The patient recovered well from the operation and received salvage chemotherapy. Two years after diagnosis, the patient remains in remission with no evidence of disease...
  22. doi request reprint Metadherin promotes hepatocellular carcinoma metastasis through induction of epithelial-mesenchymal transition
    Kai Zhu
    Liver Cancer Institute, Zhong Shan Hospital, Fudan University, Shanghai, China
    Clin Cancer Res 17:7294-302. 2011
    ..To investigate the expression of metadherin (MTDH) for its prognostic value in hepatocellular carcinoma (HCC) and its role in promoting HCC metastasis...
  23. pmc A variant of TNFR2-Fc fusion protein exhibits improved efficacy in treating experimental rheumatoid arthritis
    Tong Yang
    Department of Genetic Engineering Development, Shanghai Fudan Zhangjiang Bio pharmaceutical Co, Ltd, Shanghai, China
    PLoS Comput Biol 6:e1000669. 2010
    ..These data demonstrate that W89Y/E92N is potentially a better candidate with improved efficacy in treating RA and other autoimmune diseases...
  24. ncbi request reprint Indomethacin enhances the cytotoxicity of recombinant human lymphotoxin alpha on tumor cells by suppressing NFkappaB signaling
    Yijun Shen
    Department of Genetic Engineering Development, Shanghai Fudan Zhangjiang Bio pharmaceutical Co, Ltd, Shanghai, China
    Cancer Biol Ther 6:1428-33. 2007
    ....
  25. doi request reprint Modular chiral bidentate phosphonites: design, synthesis, and application in catalytic asymmetric hydroformylation reactions
    Baoguo Zhao
    State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China
    Chemistry 14:7847-57. 2008
    ....
  26. ncbi request reprint Platinums sensitize human epithelial tumor cells to lymphotoxin alpha by inhibiting NFkappaB-dependent transcription
    Yijun Shen
    Department of Genetic Engineering Development, Shanghai Fudan Zhangjiang Bio pharmaceutical Co, Ltd, Shanghai, China
    Cancer Biol Ther 7:1407-14. 2008
    ..Our results suggested that a proper combination of bio-agents such as LTalpha and conventional chemotherapeutic drugs such as platinums may be an efficient treatment strategy for human epithelial cancers...
  27. ncbi request reprint [The feeder layer of human embryonic fibroblasts supports the growth of human spermatogonial stem cells]
    Yu Bin Wang
    Department of Urology, Shanghai Institute of Andrology, Shanghai, China
    Zhonghua Nan Ke Xue 14:1063-8. 2008
    ..To investigate the methods and conditions for the isolation, purification and culture of human spermatogonial stem cells (SSCs) on the feeder layer cells of human embryonic fibroblasts (hEFs)...
  28. pmc Xeno-free culture of human spermatogonial stem cells supported by human embryonic stem cell-derived fibroblast-like cells
    Bin Chen
    Department of Urology, Shanghai Institute of Andrology, Renji Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai 200001, China
    Asian J Androl 11:557-65. 2009
    ..This system provides a new opportunity for the study of the regulatory mechanism of the 'niche' that governs SSC self-renewal, and will be a valuable source of SSCs for potential clinical applications...
  29. ncbi request reprint Removal of nitrogen and phosphorus in a combined A2/O-BAF system with a short aerobic SRT
    Yong wei Ding
    School of Municipal and Environmental Engineering, Harbin Institute of Technology, Harbin 150090, China
    J Environ Sci (China) 18:1082-7. 2006
    ..The adequate BAF effluent return rates should be controlled with 1-4 mg/L nitrate nitrogen in the anoxic zone effluent of A2/O process to achieve the optimal nitrogen and phosphorus removal efficiencies...
  30. ncbi request reprint [Theoretical analysis and experimental research of ozone gas mass transfer efficiency in activated sludge]
    Zheng Wang
    Water Pollution Control Research Centre, Harbin Institute of Technology, Harbin 150090, China
    Huan Jing Ke Xue 28:1703-9. 2007
    ..861 6, was finally obtained, as a reference tool for project design...
  31. ncbi request reprint High-cell-density cultivation for co-production of ergosterol and reduced glutathione by Saccharomyces cerevisiae
    Fei Shang
    College of Life Science and Technology, Beijing University of Chemical Technology, Beijing, People s Republic of China
    Appl Microbiol Biotechnol 77:1233-40. 2008
    ..The dry cell weight, glutathione yield and ergosterol yield reached 110.0 +/- 2.6 g/l, 2,280 +/- 76 mg/l, and 1,510 +/- 28 mg/l in 32 h, respectively...
  32. ncbi request reprint Removal of an anionic dye by adsorption/precipitation processes using alkaline white mud
    Mao Xu Zhu
    Department of Chemistry and Chemical Engineering, Ocean University of China, Qingdao 266100, PR China
    J Hazard Mater 149:735-41. 2007
    ..7 mmolL(-1). The dye removal may be significantly suppressed by the presence of phosphate with increasing concentration, and the reduction in the dye removal is much larger at high dye concentrations than at low ones...
  33. doi request reprint The performance and phase separated characteristics of an anaerobic baffled reactor treating soybean protein processing wastewater
    Ge Fu Zhu
    Institute of Urban Environment, Chinese Academy of Sciences, No 2 Huyuan Road, Xiamen 361003, China
    Bioresour Technol 99:8027-33. 2008
    ..It indicated that the proper anaerobic consortium in each separate compartment was developed along with substrate availability and specific environmental conditions...
  34. ncbi request reprint Redox reactions without direct contact of the reactants. Electron and ion coupled transport through polyaniline membrane
    Nikolai M Kocherginsky
    Department of Chemical and Biomolecular Engineering, Division of Bioengineering, National University of Singapore, 10 Kent Ridge Crescent, Singapore 119260
    J Phys Chem A 109:4010-6. 2005
    ..For thin membranes, the rates of transmembrane redox reactions are determined by interface processes and characteristic times are comparable to those in biomembranes...
  35. ncbi request reprint Subunit exchange of MjHsp16.5 studied by single-molecule imaging and fluorescence resonance energy transfer
    Yinghua Guan
    Beijing National Laboratory for Molecular Sciences, State Key Laboratory for Structural Chemistry of Unstable and Stable Species, and Department of Chemical Biology, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China
    J Am Chem Soc 128:7203-8. 2006
    ....
  36. ncbi request reprint D5 dopamine receptor regulation of reactive oxygen species production, NADPH oxidase, and blood pressure
    Zhiwei Yang
    Department of Pediatrics and Physiology, Georgetown University Medical Center, 3800 Reservoir Rd, NW, Washington, DC 20007, USA
    Am J Physiol Regul Integr Comp Physiol 290:R96-R104. 2006
    ..The ability of D5 receptor stimulation to decrease ROS production may explain, in part, the antihypertensive action of D5 receptor activation...
  37. ncbi request reprint A new submerged membrane photocatalysis reactor (SMPR) for fulvic acid removal using a nano-structured photocatalyst
    Jianfeng Fu
    School of Environmental Science and Engineering, Tianjin University, Weijin Road 92, Nankai District, Tianjin 300072, China
    J Hazard Mater 131:238-42. 2006
    ..Therefore, the submerged membrane photocatalysis reactor can be potentially applied in photocatalytic oxidation process during drinking water treatment...
  38. ncbi request reprint Consequences of a six residual deletion from the N-terminal of rabbit muscle creatine kinase
    Shu Yuan Guo
    Department of Biological Science and Biotechnology, Tsinghua University, Beijing 100084, China
    Biochimie 85:999-1005. 2003
    ..We conclude that a more stable quaternary structure was obtained by deletion of the six residues from the N-terminal of wild-type CK...