Laurian Vlase

Summary

Publications

  1. doi Effect of fluvoxamine on the pharmokinetics of zolpidem: a two-treatment period study in healthy volunteers
    Laurian Vlase
    Department of Pharmaceutical Technology and Biopharmaceutics, Faculty of Pharmacy, University of Medicine and Pharmacy Iuliu Hatieganu, Cluj Napoca, Romania
    Clin Exp Pharmacol Physiol 39:9-12. 2012
  2. ncbi Pharmacokinetics and comparative bioavailability of two vinpocetine tablet formulations in healthy volunteers by using the metabolite apovincaminic acid as pharmacokinetic parameter
    Laurian Vlase
    Department of Pharmaceutical Technology and Biopharmaceutics, Faculty of Pharmacy, University of Medicine and Pharmacy Iuliu Hatieganu Cluj Napoca, Romania
    Arzneimittelforschung 55:664-8. 2005
  3. ncbi Pharmacokinetic interaction between fluoxetine and metoclopramide in healthy volunteers
    Laurian Vlase
    Faculty of Pharmacy, University of Medicine and Pharmacy Iuliu Hatieganu Cluj Napoca, Romania
    Biopharm Drug Dispos 27:285-9. 2006
  4. doi Pharmacokinetic interaction between zolpidem and ciprofloxacin in healthy volunteers
    Laurian Vlase
    Department of Pharmaceutical Technology and Biopharmaceutics, Faculty of Pharmacy, University of Medicine and Pharmacy Iuliu Hatieganu, Emil Isac 13, 400023, Cluj Napoca, Romania
    Eur J Drug Metab Pharmacokinet 35:83-7. 2011
  5. doi Pharmacokinetics and comparative bioavailability of two fenofibrate capsule formulations in healthy volunteers
    Laurian Vlase
    Department of Pharmaceutical Technology and Biopharmaceutics, Faculty of Pharmacy, University of Medicine and Pharmacy Iuliu Hatieganu, Cluj Napoca, Romania
    Arzneimittelforschung 60:560-3. 2010
  6. doi Pharmacokinetic interaction between zolpidem and carbamazepine in healthy volunteers
    Laurian Vlase
    University of Medicine and Pharmacy, Iuliu Hatieganu, Faculty of Pharmacy, Department of Pharmaceutical Technology and Biopharmaceutics, Cluj Napoca, Romania
    J Clin Pharmacol 51:1233-6. 2011
  7. doi Evaluation of a Potential Metabolism-Mediated Drug-Drug Interaction Between Atomoxetine and Bupropion in Healthy Volunteers
    Ioana Todor
    University of Medicine and Pharmacy Iuliu Hatieganu, Faculty of Pharmacy, Department of Pharmaceutical Technology and Biopharmaceutics, Cluj Napoca, Romania
    J Pharm Pharm Sci 19:198-207. 2016
  8. doi Assessment of a Potential Pharmacokinetic Interaction between Nebivolol and Bupropion in Healthy Volunteers
    Ana Maria Gheldiu
    Department of Pharmaceutical Technology and Biopharmaceutics, University of Medicine and Pharmacy, x2018 Iuliu Hatieganu, Cluj Napoca, Romania
    Pharmacology 98:190-8. 2016
  9. doi Influence of Genista tinctoria L. or methylparaben on subchronic toxicity of bisphenol A in rats
    Daniela Saveta Popa
    Department of Toxicology, Faculty of Pharmacy, Iuliu Hatieganu University of Medicine and Pharmacy Cluj Napoca, Cluj Napoca 400012, Romania
    Biomed Environ Sci 27:85-96. 2014
  10. ncbi No effect of short term ranitidine intake on diclofenac pharmacokinetics
    Adrian Leucuta
    3rd Pediatric Clinic, University of Medicine and Pharmacy, Str Campeni 2 4, Cluj Napoca, Romania
    Rom J Gastroenterol 13:306-8. 2004

Collaborators

  • Silvia Imre
  • Ioan Tomuta
  • Neli Kinga Olah
  • Béla Kiss
  • Manuela Banciu
  • Ovidiu Oniga
  • Radu Silaghi-Dumitrescu
  • Simona Clichici
  • Sorin Emilian Leucuta
  • Claudia Burz
  • Oana Rosca-Casian
  • Ana Maria Gheldiu
  • Dana Muntean
  • Daniela Benedec
  • Daniela Hanganu
  • Alina Porfire
  • Marcela Achim
  • Ioana Todor
  • Gianina Crisan
  • Corina Bocsan
  • Corina Briciu
  • Adina Popa
  • Maria Neag
  • Anca Buzoianu
  • Andrei Mocan
  • Oana Raita
  • Daniela Saveta Popa
  • Adrian Leucuta
  • Dana Hales
  • Maria Bianca Abrudan
  • Dana Maria Muntean
  • Cristina Mariana Nastasă
  • Bianca Sylvester
  • Ilioara Oniga
  • Brînduşa Tiperciuc
  • Marius Costel Alupei
  • Emilia Licarete
  • Elisabeta Baiceanu
  • Ramona Păltinean
  • Felicia Loghin
  • Pompei Bolfa
  • Elena Diana Olteanu
  • Dorin Farcau
  • Mircea Nanulescu
  • Maria Adriana Neag
  • Lucian Barbu-Tudoran
  • Andreea Bodoki
  • Sebastian Alin Porav
  • Iulia Popica
  • Constantin Bele
  • Bogdan Sevastre
  • Alina Sesarman
  • Lorena Filip
  • Adrian Pîrnău
  • Mihaela Duma
  • Lavinia Lupuţ
  • Madalina Nanes
  • Ștefan Dezsi
  • Dan Rusu
  • Andrei Baiceanu
  • Radu Oprean
  • Lavinia Luca
  • Cristina Bischin
  • Anca Pop
  • Cornel Catoi
  • Adriana Filip
  • Adriana Muresan
  • Laura Bolojan
  • Ion Dan Postescu
  • Doina Daicoviciu

Detail Information

Publications37

  1. doi Effect of fluvoxamine on the pharmokinetics of zolpidem: a two-treatment period study in healthy volunteers
    Laurian Vlase
    Department of Pharmaceutical Technology and Biopharmaceutics, Faculty of Pharmacy, University of Medicine and Pharmacy Iuliu Hatieganu, Cluj Napoca, Romania
    Clin Exp Pharmacol Physiol 39:9-12. 2012
    ..The experimental data showed the pharmacokinetic interaction between zolpidem and fluvoxamine, and suggest that the observed interaction might be clinically significant, but its relevance has to be confirmed...
  2. ncbi Pharmacokinetics and comparative bioavailability of two vinpocetine tablet formulations in healthy volunteers by using the metabolite apovincaminic acid as pharmacokinetic parameter
    Laurian Vlase
    Department of Pharmaceutical Technology and Biopharmaceutics, Faculty of Pharmacy, University of Medicine and Pharmacy Iuliu Hatieganu Cluj Napoca, Romania
    Arzneimittelforschung 55:664-8. 2005
    ..The test product is therefore bioequivalent to the reference product with respect to the rate and extent of apovincaminic acid pharmacokinetics...
  3. ncbi Pharmacokinetic interaction between fluoxetine and metoclopramide in healthy volunteers
    Laurian Vlase
    Faculty of Pharmacy, University of Medicine and Pharmacy Iuliu Hatieganu Cluj Napoca, Romania
    Biopharm Drug Dispos 27:285-9. 2006
    ..The experimental data demonstrate the pharmacokinetic interaction between fluoxetine and metoclopramide and suggest that the observed interaction may be clinically significant, but its relevance has to be confirmed...
  4. doi Pharmacokinetic interaction between zolpidem and ciprofloxacin in healthy volunteers
    Laurian Vlase
    Department of Pharmaceutical Technology and Biopharmaceutics, Faculty of Pharmacy, University of Medicine and Pharmacy Iuliu Hatieganu, Emil Isac 13, 400023, Cluj Napoca, Romania
    Eur J Drug Metab Pharmacokinet 35:83-7. 2011
    ..Ciprofloxacin interacts with zolpidem in healthy volunteers, raising its bioavailability by about 46%. This magnitude of effect is likely to be clinically significant...
  5. doi Pharmacokinetics and comparative bioavailability of two fenofibrate capsule formulations in healthy volunteers
    Laurian Vlase
    Department of Pharmaceutical Technology and Biopharmaceutics, Faculty of Pharmacy, University of Medicine and Pharmacy Iuliu Hatieganu, Cluj Napoca, Romania
    Arzneimittelforschung 60:560-3. 2010
    ..The test product is therefore bioequivalent to the reference product with respect to the rate and extent of fenofibric acid pharmacokinetics...
  6. doi Pharmacokinetic interaction between zolpidem and carbamazepine in healthy volunteers
    Laurian Vlase
    University of Medicine and Pharmacy, Iuliu Hatieganu, Faculty of Pharmacy, Department of Pharmaceutical Technology and Biopharmaceutics, Cluj Napoca, Romania
    J Clin Pharmacol 51:1233-6. 2011
    ..The experimental data demonstrate the pharmacokinetic interaction between zolpidem and carbamazepine and suggest that the observed interaction may be clinically significant, but its relevance has to be confirmed...
  7. doi Evaluation of a Potential Metabolism-Mediated Drug-Drug Interaction Between Atomoxetine and Bupropion in Healthy Volunteers
    Ioana Todor
    University of Medicine and Pharmacy Iuliu Hatieganu, Faculty of Pharmacy, Department of Pharmaceutical Technology and Biopharmaceutics, Cluj Napoca, Romania
    J Pharm Pharm Sci 19:198-207. 2016
    ..To evaluate the impact of bupropion on the pharmacokinetic profile of atomoxetine and its main active metabolite (glucuronidated form), 4-hydroxyatomoxetine-O-glucuronide, in healthy volunteers...
  8. doi Assessment of a Potential Pharmacokinetic Interaction between Nebivolol and Bupropion in Healthy Volunteers
    Ana Maria Gheldiu
    Department of Pharmaceutical Technology and Biopharmaceutics, University of Medicine and Pharmacy, x2018 Iuliu Hatieganu, Cluj Napoca, Romania
    Pharmacology 98:190-8. 2016
    ....
  9. doi Influence of Genista tinctoria L. or methylparaben on subchronic toxicity of bisphenol A in rats
    Daniela Saveta Popa
    Department of Toxicology, Faculty of Pharmacy, Iuliu Hatieganu University of Medicine and Pharmacy Cluj Napoca, Cluj Napoca 400012, Romania
    Biomed Environ Sci 27:85-96. 2014
    ..To evaluate the influence of an extract of Genista tinctoria L. herba (GT) or methylparaben (MP) on histopathological changes and 2 biomarkers of oxidative stress in rats subchronicly exposed to bisphenol A (BPA)...
  10. ncbi No effect of short term ranitidine intake on diclofenac pharmacokinetics
    Adrian Leucuta
    3rd Pediatric Clinic, University of Medicine and Pharmacy, Str Campeni 2 4, Cluj Napoca, Romania
    Rom J Gastroenterol 13:306-8. 2004
    ..The experimental data did not suggest any consistent effects of ranitidine upon the pharmacokinetics of diclofenac sodium...
  11. doi Pharmacokinetic interaction between ivabradine and phenytoin in healthy subjects
    Laurian Vlase
    Department of Pharmaceutical Technology and Biopharmaceutics, University of Medicine and Pharmacy Iuliu Hatieganu, Cluj Napoca, Romania
    Clin Drug Investig 32:533-8. 2012
    ..Phenytoin is an inductor of the main metabolizing enzyme of ivabradine and it could influence its pharmacokinetics. Changes in ivabradine pharmacokinetics could have clinical significance regarding the safety of the treatment...
  12. ncbi In vitro study of antioxidant activity and phenolic content of Chrysanthemum balsamita varieties
    Daniela Benedec
    Iuliu Hatieganu University of Medicine and Pharmacy, 8, V Babes Street, Cluj Napoca, Romania
    Pak J Pharm Sci 29:1359-64. 2016
    ..tanacetoides extract, in accord with the polyphenolic content. The results show that Chrysanthemum balsamita var. balsamita might be a source of antioxidant flavonoids, especially rutin and isoquercitrin. ..
  13. ncbi Optimization of prednisolone-loaded long-circulating liposomes via application of Quality by Design (QbD) approach
    Bianca Sylvester
    a Department of Pharmaceutical Technology and Biopharmaceutics, Faculty of Pharmacy, University of Medicine and Pharmacy Iuliu Hatieganu, Cluj Napoca, Romania
    J Liposome Res . 2016
    ..LCL-PLP exerted significant anti-angiogenic and anti-inflammatory effects on M2 macrophages, affecting indirectly the C26 colon carcinoma cell proliferation and development...
  14. ncbi Comparative polyphenolic content and antioxidant activities of Genista tinctoria L. and Genistella sagittalis (L.) Gams (Fabaceae)
    Daniela Hanganu
    Department of Pharmacognosy Iuliu Hatieganu University of Medicine and Pharmacy, Creanga Street, Cluj Napoca, Romania
    Pak J Pharm Sci 29:301-7. 2016
    ..Caffeic acid, ferulic acid, hyperoside, rutin, quercitrin and luteolin were found only in G. tinctoria, while quercetin was determined in G. sagittalis. ..
  15. doi Rapid high-performance liquid chromatography-tandem mass spectrometry method for determination of pentoxifylline and its active metabolites M1 and M5 in human plasma and its application in bioavailability study
    Laurian Vlase
    Department of Pharmaceutical Technology and Biopharmaceutics, Faculty of Pharmacy, University of Medicine and Pharmacy Iuliu Hatieganu, No 8 Victor Babeş, RO 400012, Cluj Napoca, Romania
    Talanta 82:945-51. 2010
    ..The validated method has been successfully applied to a bioequivalence study...
  16. ncbi A new, high-throughput high-performance liquid chromatographic/mass spectrometric assay for therapeutic level monitoring of digoxin in human plasma
    Laurian Vlase
    Iuliu Hatieganu University of Medicine and Pharmacy, Department of Pharmaceutical Technology and Biopharmacy, Faculty of Pharmacy, Emil Isac 13, RO 400023, Cluj Napoca, Romania
    J AOAC Int 92:1390-5. 2009
    ..9 min). The developed and validated high-throughput method is very simple, rapid, and efficient, with wide applications in clinical level monitoring, pharmacokinetics, and bioequivalence studies...
  17. doi Effect of fluoxetine on the pharmacokinetics of lansoprazole: a two-treatment period study in healthy male subjects
    Laurian Vlase
    Department of Pharmaceutical Technology and Biopharmaceutics, University of Medicine and Pharmacy Iuliu Hatieganu Cluj Napoca, Cluj, Romania
    Clin Drug Investig 31:727-33. 2011
    ..The changes in lansoprazole pharmacokinetics could have clinical significance concerning the safety of the therapy...
  18. ncbi Determination of loratadine and its active metabolite in human plasma by high-performance liquid chromatography with mass spectrometry detection
    Laurian Vlase
    Faculty of Pharmacy, University of Medicine and Pharmacy Iuliu Hatieganu, Emil Isac 13, RO 400023, Cluj Napoca, Romania
    J Pharm Biomed Anal 44:652-7. 2007
    ..Besides its simplicity, the sample treatment allows obtaining a very good recovery of both analytes, around 100%. The validated LC/MS/MS method has been applied to a pharmacokinetic study of loratadine tablets on healthy volunteers...
  19. doi Evaluation of the Potential Pharmacokinetic Interaction between Atomoxetine and Fluvoxamine in Healthy Volunteers
    Ioana Todor
    Faculty of Pharmacy, Department of Pharmaceutical Technology and Biopharmaceutics, Cluj Napoca, Romania
    Pharmacology 99:84-88. 2017
    ..Therefore, the present study investigated a possible pharmacokinetic interaction between atomoxetine (ATX), a treatment option for ADHD, and an antidepressant, namely, fluvoxamine (FVX)...
  20. doi Optimizing long-circulating liposomes for delivery of simvastatin to C26 colon carcinoma cells
    Alina Porfire
    a Faculty of Pharmacy, Department of Pharmaceutical Technology and Biopharmaceutics, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj Napoca, Romania
    J Liposome Res 25:261-9. 2015
    ..Our preliminary studies suggested that LCL-SIM-OPT exerted cytotoxicity on C26 cells probably via enhancement of oxidative stress in co-culture environment...
  21. ncbi Pharmacokinetic interaction study between ranitidine and metoclopramide
    Adrian Leucuta
    3rd Pediatric Clinic, University of Medicine and Pharmacy, Str Campeni 2 4, Cluj Napoca, Romania
    Rom J Gastroenterol 13:211-4. 2004
    ..The experimental data proved the pharmacokinetic interaction between ranitidine of metoclopramide, and suggest monitoring adverse effects in patients...
  22. ncbi Antifungal activity of Aloe vera leaves
    Oana Rosca-Casian
    Department of Biology, Faculty of Biology and Geology, Babes Bolyai University, 42 Republicii Street, 400015 Cluj Napoca, Romania
    Fitoterapia 78:219-22. 2007
    ..sp. gladioli, Heterosporium pruneti and Penicillium gladioli on Czapek-agar medium. The minimum fungicidal concentration (MFC) varied between 80 and 100 microl/ml, depending on the fungal species...
  23. doi Oxidative Metabolism of Estrone Modified by Genistein and Bisphenol A in Rat Liver Microsomes
    Ana Maria Gheldiu
    Department of Pharmaceutical Technology and Biopharmacy, Faculty of Pharmacy, Iuliu Hatieganu University of Medicine and Pharmacy Cluj Napoca, 8 Victor Babeş, 400012 Cluj Napoca, Romania
    Biomed Environ Sci 28:834-8. 2015
    ..01). Our findings suggest that a synergistic inhibition effect of genistein and BPA on E1 metabolism is associated with an increased risk of breast cancer. ..
  24. ncbi Clinical and pharmacokinetics study of oxaliplatin in colon cancer patients
    Claudia Burz
    Department of Immunology, University of Medicine and Pharmacy Iuliu Hatieganu, Romania
    J Gastrointestin Liver Dis 18:39-43. 2009
    ..to evaluate the therapeutic efficacy of oxaliplatin and to analyze the pharmacokinetics of both ultrafiltrable (free) and protein-bound platinum in patients with metastatic colon cancer...
  25. doi Determination of tramadol and O-desmethyltramadol in human plasma by high-performance liquid chromatography with mass spectrometry detection
    Laurian Vlase
    Faculty of Pharmacy, University of Medicine and Pharmacy Iuliu Hatieganu, Emil Isac 13, RO 400023, Cluj Napoca, Romania
    Talanta 75:1104-9. 2008
    ..The method is very simple and allows obtaining a very good recovery of both analytes. The validated LC/MS method has been applied to a pharmacokinetic study of 50 mg tramadol tablets on healthy volunteers...
  26. doi A quality by design (QbD) study on enoxaparin sodium loaded polymeric microspheres for colon-specific delivery
    Dana Hales
    Department of Pharmaceutical Technology and Biopharmaceutics, Faculty of Pharmacy, University of Medicine and Pharmacy Iuliu Hatieganu, 41 Victor Babes Street, 400012 Cluj Napoca, Romania Electronic address
    Eur J Pharm Sci . 2017
    ..24% in the medium which simulated colonic pH. The in vitro release profile of enoxaparin sodium was close to the ideal one, therefore the system was successfully designed using QbD approach...
  27. ncbi Assessment of rosmarinic acid content in six Lamiaceae species extracts and their antioxidant and antimicrobial potential
    Daniela Benedec
    Iuliu Hatieganu University of Medicine and Pharmacy, Creanga Street, Cluj Napoca, Romania
    Pak J Pharm Sci 28:2297-303. 2015
    ..The antimicrobial testing showed a significant activity against L. monocytogenes, S. aureus and C. albicans for all six extracts. ..
  28. ncbi Comparative studies on antioxidant activity and polyphenolic content of Lycium barbarum L. and Lycium chinense Mill. leaves
    Andrei Mocan
    Iuliu Hatieganu University of Medicine and Pharmacy, Faculty of Pharmacy, 8, V Babes Street, Cluj Napoca, Romania
    Pak J Pharm Sci 28:1511-5. 2015
    ..chinense. In the antioxidant assays, both extracts exhibited important antioxidant activities, as witnessed by the three methods, both correlated with their total polyphenolic content...
  29. doi Simultaneous quantification of simvastatin and excipients in liposomes using near infrared spectroscopy and chemometry
    Alina Porfire
    Department of Pharmaceutical Technology and Biopharmaceutics, University of Medicine and Pharmacy Iuliu Hatieganu, Cluj Napoca, Romania
    J Pharm Biomed Anal 107:40-9. 2015
    ..The encapsulation efficiency of SIM determined by this method was similar with that obtained by the use of reference HPLC method...
  30. ncbi New HPLC-MS method for quantitative determination of apovincaminic acid in human plasma
    Laurian Vlase
    Faculty of Pharmacy, University of Medicine and Pharmacy Iuliu Hatieganu, Cluj Napoca, Romania
    J Sep Sci 29:385-9. 2006
    ..Accuracy and precision were less than 5.2% for within-run assay and 10% for between-run assay. The method was successfully applied in a bioequivalence study of two pharmaceutical products containing 5 mg vinpocetine...
  31. ncbi Pharmacokinetics and metabolic drug interactions
    Sorin E Leucuta
    University of Medicine and Pharmacy Iuliu Hatieganu, Department of Biopharmaceutics and Pharmacokinetics, Cluj Napoca, Romania
    Curr Clin Pharmacol 1:5-20. 2006
    ....
  32. ncbi High-throughput LC/MS/MS analysis of ruscogenin and neoruscogenin in Ruscus aculeatus L
    Laurian Vlase
    University of Medicine and Pharmacy Iuliu Hatieganu, Faculty of Pharmacy, Department of Pharmaceutical Technology and Biopharmacy, No 13 Emil Isac, RO 400023, Cluj Napoca, Romania
    J AOAC Int 92:1055-9. 2009
    ..The method has been successfully applied to quantify the two sapogenins in aerial (phylloclades) and underground parts (rhizomes, roots) of Ruscus aculeatus L...
  33. pmc Development of new 5-(chromene-3-yl)methylene-2,4-thiazolidinediones as antimicrobial agents
    Cristina Mariana Nastasă
    Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj Napoca, Romania
    Clujul Med 89:122-7. 2016
    ..Thiazolidinedione and chromone represent two important scaffolds in medicinal chemistry due to their large pharmacological applicability...
  34. doi The Pharmacokinetic Interaction Study between Carvedilol and Bupropion in Rats
    Maria Bianca Abrudan
    Department of Pharmaceutical Technology and Biopharmaceutics, Faculty of Pharmacy, University of Medicine and Pharmacy Iuliu Hatieganu, Faculty of Medicine, Cluj Napoca, Romania
    Pharmacology 99:139-143. 2017
    ..The effects of multiple-dose bupropion on the pharmacokinetics of single-dose carvedilol were investigated in order to evaluate this possible drug-drug interaction...
  35. doi New Polyphenols Identified in Artemisiae abrotani herba Extract
    Elisabeta Baiceanu
    Pharmaceutical Botany Department, Faculty of Pharmacy, Iuliu Hatieganu University of Medicine and Pharmacy, 23 Marinescu Street, Cluj Napoca 400037, Romania
    Molecules 20:11063-75. 2015
    ..The value of this study consists in its novelty as it adds new data on the chemical composition of A. abrotanum L. and it opens novel perspectives for medical and nutritional applications of this plant. ..
  36. doi Chemical constituents of three Allium species from Romania
    Laurian Vlase
    Department of Pharmaceutical Technology and Biopharmaceutics, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj Napoca, Romania
    Molecules 18:114-27. 2012
    ..obliquum. All three species contain glycosides of kaempferol and quercetol. β-Sitosterol and campesterol were identified in all species. The results obtained showed significant differences in the composition of the three Allium species...
  37. ncbi Photochemoprotective effect of Calluna vulgaris extract on skin exposed to multiple doses of ultraviolet B in SKH-1 hairless mice
    Elena Diana Olteanu
    Department of Physiology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj Napoca, Romania
    J Environ Pathol Toxicol Oncol 31:233-43. 2012
    ..001) and sunburn cells (P < 0.001). The administration of Cv via hydrogel may be a viable method for chemoprevention....