James E Vince

Summary

Publications

  1. doi request reprint Programmed cell death in Legionella infection
    Mary Speir
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, 3800 Victoria, Australia
    Future Microbiol 9:107-18. 2014
  2. pmc Lysosomal degradation of Leishmania hexose and inositol transporters is regulated in a stage-, nutrient- and ubiquitin-dependent manner
    James E Vince
    Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Flemington Rd, Parkville, Victoria 3010, Australia
    Int J Parasitol 41:791-800. 2011
  3. doi request reprint RIPK1 regulates RIPK3-MLKL-driven systemic inflammation and emergency hematopoiesis
    James A Rickard
    The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia Department of Medical Biology, University of Melbourne, Parkville, VIC 3050, Australia
    Cell 157:1175-88. 2014
  4. pmc Leishmania adaptor protein-1 subunits are required for normal lysosome traffic, flagellum biogenesis, lipid homeostasis, and adaptation to temperatures encountered in the mammalian host
    James E Vince
    Department of Biochemistry and Molecular Biology, University of Melbourne, Bio21 Molecular Science and Biotechnology Institute, 30 Flemington Rd, Parkville, Victoria 3010, Australia
    Eukaryot Cell 7:1256-67. 2008
  5. pmc RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL
    Kate E Lawlor
    1 Inflammation Division, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3052, Australia 2 Department of Medical Biology, The University of Melbourne, Parkville, Victoria 3050, Australia
    Nat Commun 6:6282. 2015
  6. doi request reprint cIAPs and XIAP regulate myelopoiesis through cytokine production in an RIPK1- and RIPK3-dependent manner
    W Wei Lynn Wong
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Vic, Australia
    Blood 123:2562-72. 2014
  7. ncbi request reprint Surface determinants of Leishmania parasites and their role in infectivity in the mammalian host
    Thomas Naderer
    Department of Biochemistry and Molecular Biology, University of Melbourne, Royal Parade, Parkville, Victoria 3010, Australia
    Curr Mol Med 4:649-65. 2004
  8. doi request reprint Ambiguities in NLRP3 inflammasome regulation: is there a role for mitochondria?
    Kate E Lawlor
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia Department of Medical Biology, The University of Melbourne, Parkville, Victoria 3050, Australia
    Biochim Biophys Acta 1840:1433-40. 2014
  9. pmc Post-translational control of RIPK3 and MLKL mediated necroptotic cell death
    James M Murphy
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia
    F1000Res 4:. 2015
  10. doi request reprint More to life than death: molecular determinants of necroptotic and non-necroptotic RIP3 kinase signaling
    Nufail Khan
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia Department of Medical Biology, The University of Melbourne, Parkville, Victoria 3050, Australia
    Curr Opin Immunol 26:76-89. 2014

Collaborators

  • Malcolm J McConville
  • Warren S Alexander
  • Ben A Croker
  • Seth L Masters
  • David L Vaux
  • Donald Metcalf
  • Paul G Ekert
  • Paul A Gleeson
  • Suzanne Gokool
  • Scott Landfear
  • Kate E Lawlor
  • James M Murphy
  • Holly Anderton
  • W Wei Lynn Wong
  • Nufail Khan
  • John Silke
  • Thomas Naderer
  • Motti Gerlic
  • Cathrine Hall
  • Mary Speir
  • Najoua Lalaoui
  • Ian P Wicks
  • James A Rickard
  • Andreas Strasser
  • Dedreia Tull
  • Alison Mildenhall
  • Stephen M Condon
  • Akshay A D'Cruz
  • Christopher A Benetatos
  • Sukhdeep Kaur Spall
  • Maryam Rashidi
  • Yasuhiro Mitsuuchi
  • TeWhiti Rogers
  • Joanne A O'Donnell
  • Lorraine O'Reilly
  • Sukhdeep K Spall
  • Matthias Ernst
  • Diep Chau
  • Robert L Ninnis
  • Joseph M Evans
  • Sandra Mifsud
  • Toby J Phesse
  • Helen E Abud
  • Louise H Cengia
  • Aleksandra Bankovacki
  • Ashleigh R Poh
  • Jason Corbin
  • Philipp J Jost
  • Ladina Di Rago
  • Andrew W Roberts
  • Grant Dewson
  • Karen L Parker
  • Scott D Smith
  • Annemarie van Nieuwenhuijze
  • Ian K Campbell
  • Sarah F Drake
  • Tim Spurck
  • Geoffrey I McFadden
  • Graeme Currie
  • Antony Bacic
  • Judy M Callaghan
  • Kris Ferguson

Detail Information

Publications12

  1. doi request reprint Programmed cell death in Legionella infection
    Mary Speir
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, 3800 Victoria, Australia
    Future Microbiol 9:107-18. 2014
    ..Understanding how different forms of programmed cell death contribute to Legionella infectivity and are manipulated by Legionella effector proteins will be important for identifying novel antibacterial therapeutic targets. ..
  2. pmc Lysosomal degradation of Leishmania hexose and inositol transporters is regulated in a stage-, nutrient- and ubiquitin-dependent manner
    James E Vince
    Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Flemington Rd, Parkville, Victoria 3010, Australia
    Int J Parasitol 41:791-800. 2011
    ....
  3. doi request reprint RIPK1 regulates RIPK3-MLKL-driven systemic inflammation and emergency hematopoiesis
    James A Rickard
    The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia Department of Medical Biology, University of Melbourne, Parkville, VIC 3050, Australia
    Cell 157:1175-88. 2014
    ..These results reveal a key function for RIPK1 in inhibiting necroptosis and, thereby, a role in limiting, not only promoting, inflammation. ..
  4. pmc Leishmania adaptor protein-1 subunits are required for normal lysosome traffic, flagellum biogenesis, lipid homeostasis, and adaptation to temperatures encountered in the mammalian host
    James E Vince
    Department of Biochemistry and Molecular Biology, University of Melbourne, Bio21 Molecular Science and Biotechnology Institute, 30 Flemington Rd, Parkville, Victoria 3010, Australia
    Eukaryot Cell 7:1256-67. 2008
    ..The pleiotropic requirements for AP-1 in membrane trafficking and temperature stress responses explain the loss of virulence of these mutants in the mammalian host...
  5. pmc RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL
    Kate E Lawlor
    1 Inflammation Division, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3052, Australia 2 Department of Medical Biology, The University of Melbourne, Parkville, Victoria 3050, Australia
    Nat Commun 6:6282. 2015
    ..Therefore RIPK3 can promote NLRP3 inflammasome and IL-1β inflammatory responses independent of MLKL and necroptotic cell death. ..
  6. doi request reprint cIAPs and XIAP regulate myelopoiesis through cytokine production in an RIPK1- and RIPK3-dependent manner
    W Wei Lynn Wong
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Vic, Australia
    Blood 123:2562-72. 2014
    ..Our results demonstrate that cIAPs and XIAP together restrain RIPK1- and RIPK3-dependent cytokine production in myeloid cells to critically regulate myeloid homeostasis. ..
  7. ncbi request reprint Surface determinants of Leishmania parasites and their role in infectivity in the mammalian host
    Thomas Naderer
    Department of Biochemistry and Molecular Biology, University of Melbourne, Royal Parade, Parkville, Victoria 3010, Australia
    Curr Mol Med 4:649-65. 2004
    ..These mutants will be useful for identifying other surface or intracellular components that are required for virulence in macrophages...
  8. doi request reprint Ambiguities in NLRP3 inflammasome regulation: is there a role for mitochondria?
    Kate E Lawlor
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia Department of Medical Biology, The University of Melbourne, Parkville, Victoria 3050, Australia
    Biochim Biophys Acta 1840:1433-40. 2014
    ..Several recent studies have posited that the mitochondria are a central regulator of NLRP3 function...
  9. pmc Post-translational control of RIPK3 and MLKL mediated necroptotic cell death
    James M Murphy
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia
    F1000Res 4:. 2015
    ..Finally, based on current evidence, we discuss the potential mechanisms by which the essential, and possibly terminal, necroptotic effector, MLKL, triggers the disruption of cellular membranes to cause cell lysis...
  10. doi request reprint More to life than death: molecular determinants of necroptotic and non-necroptotic RIP3 kinase signaling
    Nufail Khan
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia Department of Medical Biology, The University of Melbourne, Parkville, Victoria 3050, Australia
    Curr Opin Immunol 26:76-89. 2014
    ..Therefore it will be important to determine if non-necroptotic RIP3 signaling influences RIP3 dependent pathologies. ..
  11. doi request reprint Bcl-2 overexpression ameliorates immune complex-mediated arthritis by altering FcγRIIb expression and monocyte homeostasis
    Kate E Lawlor
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3052, Australia
    J Leukoc Biol 93:585-97. 2013
    ..These data reveal selective effects of the Bcl-2-regulated apoptotic pathway on monocyte differentiation and the expression of FcRs critical for regulation of antibody/immune complex-mediated disease...
  12. pmc SMP-1, a member of a new family of small myristoylated proteins in kinetoplastid parasites, is targeted to the flagellum membrane in Leishmania
    Dedreia Tull
    Department of Biochemistry and Molecular Biology, University of Melbourne, Royal Parade, Parkville, Victoria 3010, Australia
    Mol Biol Cell 15:4775-86. 2004
    ..These data suggest that flagellar membrane targeting of SMP-1 is not dependent on axonemal structures and that alterations in flagellar membrane lipid composition disrupt axoneme extension...