Jesus Villar

Summary

Publications

  1. ncbi request reprint An early PEEP/FIO2 trial identifies different degrees of lung injury in patients with acute respiratory distress syndrome
    Jesus Villar
    Multidisciplinary Organ Dysfunction Evaluation Research Network, Hospital Universitario Dr Negrin, Las Palmas de Gran Canaria, Canary Islands, Spain
    Am J Respir Crit Care Med 176:795-804. 2007
  2. pmc Neurally adjusted ventilatory assist in patients with acute respiratory failure: study protocol for a randomized controlled trial
    Jesus Villar
    CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Monforte de Lemos 3 5, Pabellon 11, 28029, Madrid, Spain
    Trials 17:500. 2016
  3. pmc Evaluating the efficacy of dexamethasone in the treatment of patients with persistent acute respiratory distress syndrome: study protocol for a randomized controlled trial
    Jesus Villar
    CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain
    Trials 17:342. 2016
  4. pmc The LUNG SAFE: a biased presentation of the prevalence of ARDS!
    Jesus Villar
    CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain
    Crit Care 20:108. 2016
  5. pmc Early activation of pro-fibrotic WNT5A in sepsis-induced acute lung injury
    Jesus Villar
    CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain
    Crit Care 18:568. 2014
  6. pmc Novel approaches to minimize ventilator-induced lung injury
    Eddy Fan
    Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Canada
    BMC Med 11:85. 2013
  7. doi request reprint A universal definition of ARDS: the PaO2/FiO2 ratio under a standard ventilatory setting--a prospective, multicenter validation study
    Jesus Villar
    CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain
    Intensive Care Med 39:583-92. 2013
  8. doi request reprint The American-European Consensus Conference definition of the acute respiratory distress syndrome is dead, long live positive end-expiratory pressure!
    J Villar
    CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain
    Med Intensiva 36:571-5. 2012
  9. pmc A quality assessment of genetic association studies supporting susceptibility and outcome in acute lung injury
    Carlos Flores
    CIBER de Enfermedades Respiratorias Instituto de Salud Carlos III, Carretera Soller km 12, 07110 Mallorca, Spain
    Crit Care 12:R130. 2008
  10. pmc Incidence, organ dysfunction and mortality in severe sepsis: a Spanish multicentre study
    Jesus Blanco
    Critical Care Department, Nuevo Hospital Universitario Río Hortega, Calle Dulzaina s n, 47012 Valladolid, Spain
    Crit Care 12:R158. 2008

Collaborators

Detail Information

Publications72

  1. ncbi request reprint An early PEEP/FIO2 trial identifies different degrees of lung injury in patients with acute respiratory distress syndrome
    Jesus Villar
    Multidisciplinary Organ Dysfunction Evaluation Research Network, Hospital Universitario Dr Negrin, Las Palmas de Gran Canaria, Canary Islands, Spain
    Am J Respir Crit Care Med 176:795-804. 2007
    ....
  2. pmc Neurally adjusted ventilatory assist in patients with acute respiratory failure: study protocol for a randomized controlled trial
    Jesus Villar
    CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Monforte de Lemos 3 5, Pabellon 11, 28029, Madrid, Spain
    Trials 17:500. 2016
    ..It is further hypothesized that NAVA compared to conventional lung-protective MV will result in a decrease in the length of ICU and hospital stay, and mortality...
  3. pmc Evaluating the efficacy of dexamethasone in the treatment of patients with persistent acute respiratory distress syndrome: study protocol for a randomized controlled trial
    Jesus Villar
    CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain
    Trials 17:342. 2016
    ....
  4. pmc The LUNG SAFE: a biased presentation of the prevalence of ARDS!
    Jesus Villar
    CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain
    Crit Care 20:108. 2016
    ..Also, the LUNG SAFE showed a disturbingly large gap between scientific evidence and medical practice. All of these statements demand that we question the interpretations of the study's findings. ..
  5. pmc Early activation of pro-fibrotic WNT5A in sepsis-induced acute lung injury
    Jesus Villar
    CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain
    Crit Care 18:568. 2014
    ..Since the role of WNT/β-catenin signaling appears to be central to lung healing and fibrosis, we hypothesized that this pathway is activated very early in the lungs after sepsis...
  6. pmc Novel approaches to minimize ventilator-induced lung injury
    Eddy Fan
    Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Canada
    BMC Med 11:85. 2013
    ....
  7. doi request reprint A universal definition of ARDS: the PaO2/FiO2 ratio under a standard ventilatory setting--a prospective, multicenter validation study
    Jesus Villar
    CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain
    Intensive Care Med 39:583-92. 2013
    ..We hypothesized that the use of PaO2/FiO2 calculated under a standard ventilatory setting within 24 h of ARDS diagnosis allows a more clinically relevant ARDS classification...
  8. doi request reprint The American-European Consensus Conference definition of the acute respiratory distress syndrome is dead, long live positive end-expiratory pressure!
    J Villar
    CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain
    Med Intensiva 36:571-5. 2012
    ..In this Point of View, we review the history of the definition of ARDS and discussed the methodological concerns regarding adopting this new, revised ARDS definition...
  9. pmc A quality assessment of genetic association studies supporting susceptibility and outcome in acute lung injury
    Carlos Flores
    CIBER de Enfermedades Respiratorias Instituto de Salud Carlos III, Carretera Soller km 12, 07110 Mallorca, Spain
    Crit Care 12:R130. 2008
    ..We aimed to assess the quality of positive genetic association studies with ALI susceptibility and/or outcome in adults in order to highlight their consistency and major limitations...
  10. pmc Incidence, organ dysfunction and mortality in severe sepsis: a Spanish multicentre study
    Jesus Blanco
    Critical Care Department, Nuevo Hospital Universitario Río Hortega, Calle Dulzaina s n, 47012 Valladolid, Spain
    Crit Care 12:R158. 2008
    ..We present the first extensive dataset on the epidemiology of severe sepsis treated in ICUs in Spain...
  11. doi request reprint Acute respiratory distress syndrome definition: do we need a change?
    Jesus Villar
    CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain
    Curr Opin Crit Care 17:13-7. 2011
    ..The purpose of this review is to examine the current definition for ARDS and to discuss why this definition may not be the most appropriate definition for this syndrome...
  12. doi request reprint A risk tertiles model for predicting mortality in patients with acute respiratory distress syndrome: age, plateau pressure, and P(aO(2))/F(IO(2)) at ARDS onset can predict mortality
    Jesus Villar
    Centro de Investigación Biomédica en Red CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain
    Respir Care 56:420-8. 2011
    ..We examined whether stratification by tertiles of respiratory and ventilatory variables at the onset of acute respiratory distress syndrome (ARDS) identifies patients with different risks of death in the intensive care unit...
  13. doi request reprint The ALIEN study: incidence and outcome of acute respiratory distress syndrome in the era of lung protective ventilation
    Jesus Villar
    CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain
    Intensive Care Med 37:1932-41. 2011
    ..The goal of this study was to examine ARDS incidence and outcome under current lung protective ventilatory support practices before and after the diagnosis of ARDS...
  14. ncbi request reprint Ventilator-induced lung injury and sepsis: two sides of the same coin?
    J Villar
    CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Barranco de la Ballena s n, Las Palmas de Gran Canaria, Spain
    Minerva Anestesiol 77:647-53. 2011
    ..In this line of thought, we hypothesize that injurious mechanical ventilation could be responsible for the perpetuation and worsening of sepsis in some patients and for the development of a sepsis-like syndrome in others...
  15. pmc Activation of the Wnt/β-catenin signaling pathway by mechanical ventilation is associated with ventilator-induced pulmonary fibrosis in healthy lungs
    Jesus Villar
    CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain
    PLoS ONE 6:e23914. 2011
    ..Since activation of Wnt/β-catenin signaling has been suggested to be central to mechanisms of lung healing and fibrosis, we hypothesized that the Wnt/β-catenin signaling plays a role during VILI...
  16. doi request reprint What is the acute respiratory distress syndrome?
    Jesus Villar
    Centro de Investigación Biomédica en Red CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain
    Respir Care 56:1539-45. 2011
    ..This paper examines our current understanding of ARDS and discusses why the current definition may not be the most appropriate for research and clinical practice...
  17. doi request reprint Mechanical ventilation modulates Toll-like receptor signaling pathway in a sepsis-induced lung injury model
    Jesus Villar
    CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain
    Intensive Care Med 36:1049-57. 2010
    ..How these two responses interact when present simultaneously remains to be elucidated. We hypothesized that MV modulates innate host response during sepsis by influencing Toll-like receptor (TLR) signaling...
  18. pmc Is acute respiratory distress syndrome an iatrogenic disease?
    Jesus Villar
    Crit Care 14:120. 2010
    ..We examine these interesting results after providing a brief historical perspective and discuss the limitations and implications of the study...
  19. pmc Mechanical ventilation modulates TLR4 and IRAK-3 in a non-infectious, ventilator-induced lung injury model
    Jesus Villar
    CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Spain
    Respir Res 11:27. 2010
    ....
  20. doi request reprint Experimental ventilator-induced lung injury: exacerbation by positive end-expiratory pressure
    Jesus Villar
    CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain
    Anesthesiology 110:1341-7. 2009
    ....
  21. ncbi request reprint Genetic determinants of survival in sepsis and acute lung injury
    J Villar
    Multidisciplinary Organ Dysfunction Evaluation Research Network, Research Unit, Hospital Universitario Dr Negrin, Las Palmas de Gran Canaria, Spain
    Minerva Anestesiol 74:341-5. 2008
  22. pmc Evaluating an educational intervention to improve the accuracy of death certification among trainees from various specialties
    Jesus Villar
    Multidisciplinary Organ Dysfunction Evaluation Research Network MODERN, Research Unit, Hospital Universitario Dr, Negrin, Las Palmas de Gran Canaria, Spain
    BMC Health Serv Res 7:183. 2007
    ....
  23. ncbi request reprint A CXCL2 polymorphism is associated with better outcomes in patients with severe sepsis
    Jesus Villar
    Multidisciplinary Organ Dysfunction Evaluation Research Network, Hospital Universitario Dr Negrin, Las Palmas de Gran Canaria, Canary Islands, Spain
    Crit Care Med 35:2292-7. 2007
    ..We hypothesized that a tandem repeat polymorphism (AC)n in the CXCL2 gene, previously associated with susceptibility to severe sepsis, contributes to morbidity and mortality in severe sepsis...
  24. ncbi request reprint Angiotensin-converting enzyme insertion/deletion polymorphism is not associated with susceptibility and outcome in sepsis and acute respiratory distress syndrome
    Jesus Villar
    Multidisciplinary Organ Dysfunction Evaluation Research Network MODERN, Research Unit, Hospital Universitario Dr Negrin, Barranco de la Ballena, Las Palmas de Gran Canaria, Canary Islands, Spain
    Intensive Care Med 34:488-95. 2008
    ..We hypothesized that the I/D polymorphism also confers susceptibility to sepsis and is a predisposing factor for morbidity and mortality of patients with severe sepsis...
  25. doi request reprint A common haplotype of the LBP gene predisposes to severe sepsis
    Carlos Flores
    CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Spain
    Crit Care Med 37:2759-66. 2009
    ..The lipopolysaccharide-binding protein is an acute-phase protein that plays a dominant role in the genesis of sepsis by initiating signal transduction pathways leading to the activation of the inflammatory host response...
  26. pmc Interleukin-1 receptor-associated kinase 3 gene associates with susceptibility to acute lung injury
    María Pino-Yanes
    Centro de Investigación Biomédica en Red de Enfermedades Respiratorias de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain
    Am J Respir Cell Mol Biol 45:740-5. 2011
    ..017). Despite the need for replication in independent studies, our data suggest that common SNPs in the IRAK3 gene may be determinants of sepsis-induced ALI...
  27. doi request reprint WNT/β-catenin signaling is modulated by mechanical ventilation in an experimental model of acute lung injury
    Jesus Villar
    CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain, Jesús
    Intensive Care Med 37:1201-9. 2011
    ....
  28. ncbi request reprint Positive end-expiratory pressure modulates local and systemic inflammatory responses in a sepsis-induced lung injury model
    Maria Teresa Herrera
    Research Institute, Hospital Universitario N S de Candelaria, Carretera del Rosario s n, 38010, Santa Cruz de Tenerife, Canary Islands, Spain
    Intensive Care Med 29:1345-53. 2003
    ..We examined the effects of positive end-expiratory pressure (PEEP) in the setting of a clinically relevant, in vivo animal model of sepsis-induced acute lung injury ventilated with low or injurious tidal volume...
  29. pmc Serum lipopolysaccharide binding protein levels predict severity of lung injury and mortality in patients with severe sepsis
    Jesus Villar
    CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain
    PLoS ONE 4:e6818. 2009
    ....
  30. pmc Assessing the validity of asthma associations for eight candidate genes and age at diagnosis effects
    María Pino-Yanes
    Centro de Investigación Biomédica en Red de Enfermedades Respiratorias CIBERES, Instituto de Salud Carlos III, Madrid, Spain Research Unit, Hospital Universitario Nuestra Senora de Candelaria, Santa Cruz de Tenerife, Spain
    PLoS ONE 8:e73157. 2013
    ..Here we aimed to assess the reproducibility of these asthma associations and to test if associations were more evident considering the effect of age at diagnosis...
  31. doi request reprint No association between genetic ancestry and susceptibility to asthma or atopy in Canary Islanders
    María Pino-Yanes
    CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain
    Immunogenetics 64:705-11. 2012
    ..Larger studies, examining more genetic variants, would be needed to explore such possibility...
  32. pmc Bench-to-bedside review: understanding genetic predisposition to sepsis
    Jesus Villar
    Division Critical Care Research, Research Institute, Hospital Universitario NS de Candelaria, Tenerife, Canary Islands, Spain
    Crit Care 8:180-9. 2004
    ..We envision a time in the near future when genotyping will be include in the standard evaluation of critically ill patients and will help to prioritize a therapeutic option...
  33. pmc Injurious mechanical ventilation affects neuronal activation in ventilated rats
    María Elisa Quilez
    CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, C Sinesio Delgado 6, Madrid Critical Care Center, Corporacio Sanitaria Parc Tauli, Institut Universitari, Esfera UAB, Parc Taulí sn Sabadell 08208 Universitat Autònoma de Barcelona, Campus de la UAB, Bellaterra 08193, Spain
    Crit Care 15:R124. 2011
    ..We aimed to investigate the effect of the increase of tidal volume (Vt) on brain activation in a rat model...
  34. doi request reprint Open Lung Approach for the Acute Respiratory Distress Syndrome: A Pilot, Randomized Controlled Trial
    Robert M Kacmarek
    1Department of Respiratory Care, Massachusetts General Hospital, Boston, MA 2Department of Anesthesia, Critical Care and Pain Medicine, Harvard Medical School, Boston, MA 3CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain 4Multidisciplinary Organ Dysfunction Evaluation Research Network, Research Unit, Hospital Universitario Dr Negrin, Las Palmas de Gran Canaria, Spain 5Intensive Care Unit, Hospital Universitario NS de Candelaria, Santa Cruz de Tenerife, Spain 6Department of Anesthesiology, Hospital Clinico de Valencia, Valencia, Spain 7Intensive Care Unit, Hospital Universitario Rio Hortega, Valladolid, Spain 8Department of Pulmonary and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea 9Intensive Care Unit, Hospital Universitario Morales Meseguer, Murcia, Spain 10Intensive Care Unit, Hospital Universitario Virgen de la Arrixaca, Murcia, Spain 11Intensive Care Unit, Hospital Universitario de Txagorritxu, Vitoria, Spain 12Respiratory ICU, Hospital das Clinicas, University of Sao Paulo, Sao Paulo, Brazil 13Intensive Care Unit, UK
    Crit Care Med 44:32-42. 2016
    ....
  35. doi request reprint Altered Profile of Circulating Endothelial-Derived Microparticles in Ventilator-Induced Lung Injury
    Nuria E Cabrera-Benítez
    1CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain 2Multidisciplinary Organ Dysfunction Evaluation Research Network, Research Unit, Hospital Universitario Dr Negrin, Las Palmas de Gran Canaria, Spain 3Department of Anatomy, Pathology and Histology, University of La Laguna, Tenerife, Spain 4Department of Immunology, Hospital Universitario Dr Negrin, Las Palmas de Gran Canaria, Spain 5Department of Immunology, Hospital San Espases, Palma de Mallorca, Spain 6Department of Clinical Biochemistry, Hospital Universitario NS de Candelaria, Tenerife, Spain 7Research Unit, Hospital Universitario NS de Candelaria, Tenerife, Spain 8Institute of Medical Science, University of Toronto, Toronto, ON, Canada 9Respiratory and Critical Care Research Group, Toronto General Research Institute, University Health Network, Toronto, ON, Canada 10Keenan Research Center for Biomedical Science, Li Ka Shing Knowledge Institute, St Michael s Hospital, Toronto, ON, Canada 11Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, ON, Canada
    Crit Care Med 43:e551-9. 2015
    ....
  36. ncbi request reprint A high positive end-expiratory pressure, low tidal volume ventilatory strategy improves outcome in persistent acute respiratory distress syndrome: a randomized, controlled trial
    Jesus Villar
    Canarian Institute for Biomedical Research, Tomas Morales 6 1, 35003 Las Palmas de Gran Canaria, Canary Islands, Spain
    Crit Care Med 34:1311-8. 2006
    ....
  37. doi request reprint Inhibition of endotoxin-induced airway epithelial cell injury by a novel family of pyrrol derivates
    Nuria E Cabrera-Benítez
    CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain
    Lab Invest 96:632-40. 2016
    ..Further investigations are needed to examine and validate these mechanisms and effects in a clinically relevant animal model of sepsis and sepsis-induced ARDS. ..
  38. doi request reprint Age, PaO2/FIO2, and Plateau Pressure Score: A Proposal for a Simple Outcome Score in Patients With the Acute Respiratory Distress Syndrome
    Jesus Villar
    1CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain 2Research Unit, Hospital Universitario Dr Negrin, Las Palmas de Gran Canaria, Spain 3Intensive Care Unit, Hospital General de Ciudad Real, Ciudad Real, Spain 4Intensive Care Unit, Hospital Universitario Morales Meseguer, Murcia, Spain 5Intensive Care Unit, Hospital Universitario Virgen de la Arrixaca, Murcia, Spain 6Post Surgical Unit, Department of Anesthesia, Hospital Clinico de Valencia, Valencia, Spain 7Intensive Care Unit, Hospital Virgen de la Luz, Cuenca, Spain 8Intensive Care Unit, Hospital Universitario A Coruña, Coruna, Spain 9Intensive Care Unit, Hospital Universitario Rio Hortega, Valladolid, Spain 10Intensive Care Unit, Hospital Universitario Mutua de Terrassa, Barcelona, Spain 11Intensive Care Unit, Hospital Universitario La Paz, Madrid, Spain 12Intensive Care Unit, Hospital General de León, Leon, Spain 13Intensive Care Unit, Fairfax
    Crit Care Med 44:1361-9. 2016
    ..Our objective was to develop an outcome score that clinicians could easily calculate at the bedside to predict the risk of death of acute respiratory distress syndrome patients 24 hours after diagnosis...
  39. pmc Lung Transcriptomics during Protective Ventilatory Support in Sepsis-Induced Acute Lung Injury
    Marialbert Acosta-Herrera
    CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain Research Unit, Hospital Universitario N S de Candelaria, Santa Cruz de Tenerife, Spain Research Unit, Hospital Universitario Dr Negrin, Las Palmas de Gran Canaria, Spain
    PLoS ONE 10:e0132296. 2015
    ....
  40. pmc Anti-inflammatory activity of a novel family of aryl ureas compounds in an endotoxin-induced airway epithelial cell injury model
    Nuria E Cabrera-Benítez
    CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain
    PLoS ONE 7:e48468. 2012
    ....
  41. pmc Endotoxin-induced lung alveolar cell injury causes brain cell damage
    Raquel Rodríguez-González
    CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, 28029 Madrid, Spain Multidisciplinary Organ Dysfunction Evaluation Research Network, Research Unit, Hospital Universitario Dr Negrin, 35010 Las Palmas de Gran Canaria, Spain Critical Patient Translational Research Group, Department of Anesthesiology, Intensive Care and Pain Management, Hospital Clinico Universitario, Instituto de Investigación Sanitaria IDIS, Universidad de Santiago de Compostela, Santiago de Compostela, 15706, Spain
    Exp Biol Med (Maywood) 240:135-42. 2015
    ..These results support a brain-lung crosstalk during sepsis and sepsis-induced acute respiratory distress syndrome. ..
  42. pmc Common variants of TLR1 associate with organ dysfunction and sustained pro-inflammatory responses during sepsis
    María Pino-Yanes
    CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain
    PLoS ONE 5:e13759. 2010
    ..We examined the association of common variants of TLR1 gene with sepsis-derived complications in an independent study and with serum levels for four inflammatory biomarkers among septic patients...
  43. pmc Moderate Peep After Tracheal Lipopolysaccharide Instillation Prevents Inflammation and Modifies the Pattern of Brain Neuronal Activation
    María Elisa Quilez
    Critical Care Center, Corporacio Sanitaria Parc Tauli, Institut Universitari Parc Tauli, Universitat Autonoma de Barcelona, Campus d Excel lència Internacional, Bellaterra CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid Institut d Investigació i Innovació Parc Taulí I3PT, Fundació Parc Taulí, Corporacio Sanitaria Parc Tauli, Universitat Autonoma de Barcelona, Campus d Excel lència Internacional, Bellaterra Critical Patient Translational Research Group, Department of Anesthesiology, Intensive Care and Pain Management, Hospital Clinico Universitario, Instituto de Investigación Sanitaria IDIS Universidad de Santiago de Compostela, Santiago de Compostela Research Unit, Hospital Universitario Dr Negrin, Las Palmas de Gran Canaria Psychopathology and Neuropsychology Research Unit, Department of Clinical and Health Psychology, Universitat Autonoma de Barcelona, Campus d Excel lència Internacional, Bellaterra Psychopathology and Neuropsychology Research Unit, Department of Clinical and Health Psychology, Universitat Autonoma de Barcelona, Campus d Excel lència Internacional, Bellaterra Department of Respiratory Care, Massachusetts General Hospital Department of Anesthesiology, Harvard University, Boston, Massachusetts
    Shock 44:601-8. 2015
    ..Both inflammation and ventilatory pattern may modify brain activation, possibly worsening the patient's outcome and resulting in cognitive sequelae...
  44. pmc Common variants of NFE2L2 gene predisposes to acute respiratory distress syndrome in patients with severe sepsis
    Marialbert Acosta-Herrera
    CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain
    Crit Care 19:256. 2015
    ..NFE2L2 is involved in the response to oxidative stress, and it has been shown to be associated with the development of ARDS in trauma patients...
  45. pmc Mechanical ventilation-associated lung fibrosis in acute respiratory distress syndrome: a significant contributor to poor outcome
    Nuria E Cabrera-Benítez
    From the Keenan Research Centre in Biomedical Science, St Michael s Hospital, Toronto, Ontario, Canada N E C B, J G L, J V, H Z, A S S CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain N E C B, J V Multidisciplinary Organ Dysfunction Evaluation Research Network, Research Unit, Hospital Universitario Dr Negrin, Las Palmas de Gran Canaria, Spain N E C B, J V Departments of Anesthesia and Physiology, University of Toronto, Toronto, Ontario, Canada J G L, H Z Department of Medicine, Unit of Anesthesiology and Intensive Care, Medical School, University of Padua, Azienda Ospedaliera di Padova, Padua, Italy M P Department of Anesthesiology and Intensive Care Therapy, University Hospital Carl Gustav Carus, Dresden University of Technology, Dresden, Germany P M S and Interdepartmental Division of Critical Care Medicine, Department of Medicine, University of Toronto, Toronto, Ontario, Canada H Z, A S S
    Anesthesiology 121:189-98. 2014
    ..The authors critically appraise possible mechanisms underlying the mechanical stress-induced lung fibrosis and highlight potential therapeutic strategies to mitigate this fibrosis. ..
  46. ncbi request reprint Genetic susceptibility to acute lung injury
    Jesus Villar
    Research Institute, Hospital Universitario N S de Candelaria, Tenerife, Canary Islands, Spain
    Crit Care Med 31:S272-5. 2003
    ..These may affect the responses of critically ill patients to acute lung injury and acute respiratory distress syndrome and may affect outcome...
  47. doi request reprint Searching for novel molecular targets of chronic rejection in an orthotopic experimental lung transplantation model
    Norberto Santana-Rodríguez
    Research Unit, Experimental Surgery, Hospital Dr Negrin, Las Palmas de Gran Canaria, Spain
    J Heart Lung Transplant 31:213-21. 2012
    ..There remains no effective treatment for CR. The aim of this study was to identify new molecular mechanisms involved in CR by using DNA microarray analysis...
  48. pmc North African influences and potential bias in case-control association studies in the Spanish population
    María Pino-Yanes
    CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain
    PLoS ONE 6:e18389. 2011
    ..Using ancestry informative markers (AIMs), we aimed to measure the African influences in Spanish populations and to explore whether these might introduce statistical bias in population-based association studies...
  49. ncbi request reprint A CXCL2 tandem repeat promoter polymorphism is associated with susceptibility to severe sepsis in the Spanish population
    C Flores
    Research Institute Research Center associated to Centro de Investigaciones Biológicas, Consejo Superior de Investigaciones Cientificas, Madrid, Spain, Hospital Universitario NS de Candelaria, Tenerife, Spain
    Genes Immun 7:141-9. 2006
    ..22-4.03; P=0.008) and after a genomic control adjustment (P=0.017). Although replicate studies and functional assays are needed, these results suggest that CXCL2 gene variants may contribute to the development of severe sepsis...
  50. pmc Assessment of PaO₂/FiO₂ for stratification of patients with moderate and severe acute respiratory distress syndrome
    Jesus Villar
    CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain Multidisciplinary Organ Dysfunction Evaluation Research Network, Research Unit, Hospital Universitario Dr Negrin, Las Palmas, Spain
    BMJ Open 5:e006812. 2015
    ..Since the proposal did not mandate PaO₂/FiO₂ calculation under standardised ventilator settings (SVS), we hypothesised that a stratification based on baseline PaO₂/FiOv would not provide accurate assessment of lung injury severity...
  51. doi request reprint A clinical classification of the acute respiratory distress syndrome for predicting outcome and guiding medical therapy*
    Jesus Villar
    1CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain 2Multidisciplinary Organ Dysfunction Evaluation Research Network, Research Unit, Hospital Universitario Dr Negrin, Las Palmas de Gran Canaria, Spain 3Intensive Care Unit, Hospital General de Ciudad Real, Ciudad Real, Spain 4Intensive Care Unit, Hospital Clinico Universitario de Valladolid, Valladolid, Spain 5Intensive Care Unit, Hospital Universitario Rio Hortega, Valladolid, Spain 6Intensive Care Unit, Hospital General de León, Leon, Spain 7Intensive Care Unit, Hospital General Universitario de Albacete, Albacete, Spain 8Critical Care Center, Corporacio Sanitaria Parc Tauli, Sabadell, Spain 9Intensive Care Unit, Hospital Virgen de la Luz, Cuenca, Spain 10Intensive Care Unit, Hospital La Mancha Centro, Alcazar de San Juan, Ciudad Real, Spain 11Intensive Care Unit, Hospital Santa Barbara, Puertollano, Ciudad Real, Spain 12Intensive Care Unit, Hospital General Rio Carrion
    Crit Care Med 43:346-53. 2015
    ..We investigated whether two widely accepted cutoff values of PaO2/FIO2 and positive end-expiratory pressure (PEEP) would identify subsets of patients with ARDS for predicting outcome and guiding therapy...
  52. ncbi request reprint Characterization of the first VanB vancomycin-resistant Enterococcus faecium isolated in a Spanish hospital
    Fabián Lorenzo-Díaz
    Molecular Biology Laboratory, Research Unit, Nuestra Señora de Candelaria University Hospital, Santa Cruz de Tenerife, Spain
    Curr Microbiol 48:199-203. 2004
    ..Sequence analysis of the vanB gene showed that this isolate belonged to subtype vanB2. Moreover, PCR amplification analysis indicated that the vanB gene cluster was linked to a Tn5382-like transposon...
  53. ncbi request reprint Simultaneous PCR detection of ica cluster and methicillin and mupirocin resistance genes in catheter-isolated Staphylococcus
    Juana V Martín-López
    Molecular Biology Laboratory, Research Unit, Nuestra Señora de Candelaria University Hospital, Santa Cruz de Tenerife, 38010 Santa Cruz de Tenerife, Spain
    Int Microbiol 7:63-6. 2004
    ..Furthermore, the method allows differential detection of the ica locus from Staphylococcus aureus and Staphylococcus epidermidis...
  54. ncbi request reprint Why are physicians so skeptical about positive randomized controlled clinical trials in critical care medicine?
    Jesus Villar
    Research Institute, Hospital Universitario N S de Candelaria, Carretera del Rosario s n, Canary Islands, 38010, Santa Cruz de Tenerife, Spain
    Intensive Care Med 31:196-204. 2005
  55. ncbi request reprint Genetics and the pathogenesis of adult respiratory distress syndrome
    Jesus Villar
    Research Institute, Hospital de la Candelaria, Tenerife, Canary Islands, Spain
    Curr Opin Crit Care 8:1-5. 2002
    ..This article reviews some of those susceptibility factors for critical illness and acute lung injury...
  56. doi request reprint Current incidence and outcome of the acute respiratory distress syndrome
    Jesus Villar
    aCIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid bMultidisciplinary Organ Dysfunction Evaluation Research Network MODERN, Research Unit, Hospital Universitario Dr Negrin, Las Palmas de Gran Canaria, Spain cKeenan Research Center for Biomedical Science at the Li Ka Shing Knowledge Institute, St Michael s Hospital, Toronto, Canada dIntensive Care Unit, Hospital Universitario Rio Hortega, Valladolid, Spain eDepartment of Respiratory Care, Massachusetts General Hospital fDepartment of Anesthesia and Critical Care Medicine, Harvard Medical School, Boston, Massachusetts, USA
    Curr Opin Crit Care 22:1-6. 2016
    ..This is a difficult task since there is a marked variability regarding the methodology of the few, large epidemiological, and observational studies on ARDS...
  57. doi request reprint Multiple system organ response induced by hyperoxia in a clinically relevant animal model of sepsis
    Raquel Rodríguez-González
    CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain Multidisciplinary Organ Dysfunction Evaluation Research Network, Research Unit, Hospital Universitario Dr Negrin, Las Palmas de Gran Canaria, Spain Critical Patient Translational Research Group, Department of Anesthesiology, Intensive Care and Pain Management, Hospital Clinico Universitario, Instituto de Investigacion Sanitaria, University of Santiago de Compostela, Santiago de Compostela, Spain Departments of Microbiology, Immunology, and Research Unit, Hospital Universitario Dr Negrin, Las Palmas de Gran Canaria, Spain and Critical Care Center, Corporacio Sanitaria Parc Tauli, Sabadell, Spain and Keenan Research Center for Biomedical Science, Li Ka Shing Knowledge Institute, St Michael s Hospital, Toronto, Canada
    Shock 42:148-53. 2014
    ..If these results are extrapolated to humans, they suggest that oxygen therapy should be carefully managed in septic patients to minimize its deleterious effects. ..
  58. ncbi request reprint Heat shock proteins and ventilator-induced lung injury
    Jesus Villar
    Research Institute, Hospital Universitario N S de Candelaria, and Department of Microbiology, University of La Laguna, Tenerife, Canary Islands, Spain
    Curr Opin Crit Care 9:9-14. 2003
    ..Several studies support the hypothesis that HSPs are cytoprotective In addition, recent investigations have demonstrated that HSP70 is released into the systemic circulation and is involved in the activation of innate immunity...
  59. doi request reprint Pulsed ultrasounds accelerate healing of rib fractures in an experimental animal model: an effective new thoracic therapy?
    Norberto Santana-Rodríguez
    Experimental Surgery Unit, Research Unit, Hospital Universitario Dr Negrin, Las Palmas de Gran Canaria, Spain
    J Thorac Cardiovasc Surg 141:1253-8. 2011
    ..Since it has been reported that pulsed ultrasounds accelerates repair of limb fractures, we hypothesized that the application of pulsed ultrasounds will modify the course of healing in an animal model of rib fracture...
  60. ncbi request reprint Current definitions of acute lung injury and the acute respiratory distress syndrome do not reflect their true severity and outcome
    J Villar
    Research Institute, Hospital de la Candelaria, Tenerife, Canary Islands, Spain
    Intensive Care Med 25:930-5. 1999
    ..However, this definition may not reflect the true prevalence, severity and prognosis of these syndromes...
  61. ncbi request reprint Genetic susceptibility to respiratory diseases
    J Villar
    Research Institute, Hospital N S de Candelaria, Carretera del Rosario, S N, 38010 Santa Cruz de Tenerife, Canary Islands, Spain
    Minerva Anestesiol 67:193-7. 2001
    ..The author reviews some of these complex interactions suggesting that even the inflammatory response during lung injury can be influenced by genetic polymorphisms...
  62. doi request reprint GOLDEN anniversary of the acute respiratory distress syndrome: still much work to do!
    Jesus Villar
    aCIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid bMultidisciplinary Organ Dysfunction Evaluation Research Network MODERN, Research Unit, Hospital Universitario Dr Negrin, Las Palmas de Gran Canaria, Spain cKeenan Research Center for Biomedical Science at the Li Ka Shing Knowledge Institute, St Michael s Hospital dInterdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Canada
    Curr Opin Crit Care 23:4-9. 2017
    ....
  63. doi request reprint The acute respiratory distress syndrome: incidence and mortality, has it changed?
    Jesus Villar
    aCIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid bResearch Unit, Hospital Universitario Dr Negrin, Las Palmas de Gran Canaria, Spain cKeenan Research Center at the Li Ka Shing Knowledge Institute of St Michael s Hospital, Toronto, Ontario, Canada dDepartment of Respiratory Care, Massachusetts General Hospital eDepartment of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Curr Opin Crit Care 20:3-9. 2014
    ..This is a challenging task, as there is no specific clinical sign or diagnostic test that accurately identifies and adequately defines this syndrome...
  64. ncbi request reprint Molecular cloning and expression in yeast of caprine prochymosin
    María C Vega-Hernández
    Molecular Biology Laboratory, Research Unit, Nuestra Señora de Candelaria University Hospital, 38010, Santa Cruz de Tenerife, Spain
    J Biotechnol 114:69-79. 2004
    ..cerevisiae culture supernatants by affinity chromatography. Proteolytic activity assayed toward casein fractions indicated that the recombinant caprine chymosin specifically hydrolysed kappa-casein...
  65. doi request reprint Asynchrony, neural drive, ventilatory variability and COMFORT: NAVA versus pressure support in pediatric patients. A non-randomized cross-over trial
    Pedro de la Oliva
    Pediatric Intensive Care Unit UCIP, Hospital Universitario Materno Infantil La Paz, Paseo de la Castellana, 261, 28046, Madrid, Spain
    Intensive Care Med 38:838-46. 2012
    ..To determine if neurally adjusted ventilatory assist (NAVA) improves asynchrony, ventilatory drive, breath-to-breath variability and COMFORT score when compared to pressure support (PS)...
  66. ncbi request reprint Effects of induced hypothermia in patients with septic adult respiratory distress syndrome
    J Villar
    Intensive Care Unit, Hospital del Pino, Las Palmas, Canary Islands, Spain
    Resuscitation 26:183-92. 1993
    ..30 +/- 6%, P < 0.05). CONCLUSIONS: This study suggests that hypothermia was effective in improving oxygenation and survival in patients with severe ARDS associated with sepsis, even though VO2 was unchanged...
  67. ncbi request reprint Low vs high positive end-expiratory pressure in the ventilatory management of acute lung injury
    J Villar
    Division of Organ Dysfunction Research Instituto Canario de Investigación Biomédica ICIB, Las Palmas de Gran Canaria and Santa Cruz de Tenerife, Canary Islands, Spain
    Minerva Anestesiol 72:357-62. 2006
    ..In this article I will review the basic mechanisms of PEEP and the current knowledge of the effects of PEEP on the evolution and outcome of ALI/ARDS...
  68. ncbi request reprint The use of positive end-expiratory pressure in the management of the acute respiratory distress syndrome
    J Villar
    Research Institute, Hospital Universitario N S de Candelaria, Tenerife, Canary Islands, Spain
    Minerva Anestesiol 71:265-72. 2005
    ....
  69. ncbi request reprint Ventilator or physician-induced lung injury?
    J Villar
    Research Institute, Hospital Universitario N S of Candelaria, Tenerife, Canary Islands, Spain
    Minerva Anestesiol 71:255-8. 2005
    ....
  70. ncbi request reprint From ventilator-induced lung injury to physician-induced lung injury: why the reluctance to use small tidal volumes?
    J Villar
    Hospital Universitario N S de Candelaria, Tenerife, Canary Islands, Spain
    Acta Anaesthesiol Scand 48:267-71. 2004