Marcel Wolbers

Summary

Affiliation: Ho Chi Minh City
Country: Vietnam

Publications

  1. pmc JC virus-specific immune responses in human immunodeficiency virus type 1 patients with progressive multifocal leukoencephalopathy
    Nina Khanna
    Division of Infectious Diseases and Hospital Epidemiology, University Hospital Basel, CH 4031 Basel, Switzerland
    J Virol 83:4404-11. 2009
  2. doi request reprint Prognostic models with competing risks: methods and application to coronary risk prediction
    Marcel Wolbers
    Basel Institute for Clinical Epidemiology and Biostatistics, University Hospital Basel, Basel, Switzerland
    Epidemiology 20:555-61. 2009
  3. pmc Sample size requirements for separating out the effects of combination treatments: randomised controlled trials of combination therapy vs. standard treatment compared to factorial designs for patients with tuberculous meningitis
    Marcel Wolbers
    Hospital for Tropical Diseases, Wellcome Trust Major Overseas Programme and Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam
    Trials 12:26. 2011
  4. pmc CryptoDex: a randomised, double-blind, placebo-controlled phase III trial of adjunctive dexamethasone in HIV-infected adults with cryptococcal meningitis: study protocol for a randomised control trial
    Jeremy Day
    Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Programme Vietnam, Ho Chi Minh City, Vietnam
    Trials 15:441. 2014
  5. pmc Competing risks analyses: objectives and approaches
    Marcel Wolbers
    Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Wellcome Trust Major Overseas Programme, Ho Chi Minh City, Vietnam Centre for Tropical Medicine, Nuffield Department of Medicine, University of Oxford, Oxford, UK
    Eur Heart J 35:2936-41. 2014
  6. pmc Concordance for prognostic models with competing risks
    Marcel Wolbers
    Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Programme, Ho Chi Minh City, Viet Nam and Centre for Tropical Medicine, Nuffield Department of Medicine, University of Oxford, Oxford, OX3 7FZ, UK
    Biostatistics 15:526-39. 2014
  7. pmc Lovastatin for adult patients with dengue: protocol for a randomised controlled trial
    James Whitehorn
    Department of Clinical Research, London School of Hygiene and Tropical Medicine, London, UK
    Trials 13:203. 2012
  8. pmc Studying the effectiveness of activated carbon R95 respirators in reducing the inhalation of combustion by-products in Hanoi, Vietnam: a demonstration study
    Heiman F L Wertheim
    Oxford University Clinical Research Unit and Wellcome Trust Major Overseas Programme, Hanoi, Vietnam
    Environ Health 11:72. 2012
  9. pmc Evaluation of microscopic observation drug susceptibility assay for diagnosis of multidrug-resistant tuberculosis in Viet Nam
    Thi Minh Ha Dang
    Pham Ngoc Thach Hospital, 120 Hung Vuong, District 5, Ho Chi Minh City, Viet Nam
    BMC Infect Dis 12:49. 2012
  10. pmc Pretreatment CD4 cell slope and progression to AIDS or death in HIV-infected patients initiating antiretroviral therapy--the CASCADE collaboration: a collaboration of 23 cohort studies
    Marcel Wolbers
    Basel Institute for Clinical Epidemiology and Biostatistics, University Hospital Basel, Basel, Switzerland
    PLoS Med 7:e1000239. 2010

Detail Information

Publications63

  1. pmc JC virus-specific immune responses in human immunodeficiency virus type 1 patients with progressive multifocal leukoencephalopathy
    Nina Khanna
    Division of Infectious Diseases and Hospital Epidemiology, University Hospital Basel, CH 4031 Basel, Switzerland
    J Virol 83:4404-11. 2009
    ..JCV-specific T-cell and IgG responses may serve as prognostic markers for patients at risk...
  2. doi request reprint Prognostic models with competing risks: methods and application to coronary risk prediction
    Marcel Wolbers
    Basel Institute for Clinical Epidemiology and Biostatistics, University Hospital Basel, Basel, Switzerland
    Epidemiology 20:555-61. 2009
    ..We conclude that competing risks have to be considered explicitly in frail populations such as the elderly...
  3. pmc Sample size requirements for separating out the effects of combination treatments: randomised controlled trials of combination therapy vs. standard treatment compared to factorial designs for patients with tuberculous meningitis
    Marcel Wolbers
    Hospital for Tropical Diseases, Wellcome Trust Major Overseas Programme and Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam
    Trials 12:26. 2011
    ..This can either be tested with a simple randomized trial of combination versus standard treatment or with a 2 x 2 factorial design...
  4. pmc CryptoDex: a randomised, double-blind, placebo-controlled phase III trial of adjunctive dexamethasone in HIV-infected adults with cryptococcal meningitis: study protocol for a randomised control trial
    Jeremy Day
    Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Programme Vietnam, Ho Chi Minh City, Vietnam
    Trials 15:441. 2014
    ..The principal research question posed by this study is as follows: does adding dexamethasone to standard antifungal therapy for CM reduce mortality? Dexamethasone is a cheap, readily available, and practicable intervention...
  5. pmc Competing risks analyses: objectives and approaches
    Marcel Wolbers
    Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Wellcome Trust Major Overseas Programme, Ho Chi Minh City, Vietnam Centre for Tropical Medicine, Nuffield Department of Medicine, University of Oxford, Oxford, UK
    Eur Heart J 35:2936-41. 2014
    ..We stress the importance of choosing statistical methods that are appropriate if competing risks are present. We also clarify the role of competing risks for the analysis of composite endpoints. ..
  6. pmc Concordance for prognostic models with competing risks
    Marcel Wolbers
    Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Programme, Ho Chi Minh City, Viet Nam and Centre for Tropical Medicine, Nuffield Department of Medicine, University of Oxford, Oxford, OX3 7FZ, UK
    Biostatistics 15:526-39. 2014
    ..We further illustrate the methods by computing the concordance probability for a prognostic model of coronary heart disease (CHD) events in the presence of the competing risk of non-CHD death. ..
  7. pmc Lovastatin for adult patients with dengue: protocol for a randomised controlled trial
    James Whitehorn
    Department of Clinical Research, London School of Hygiene and Tropical Medicine, London, UK
    Trials 13:203. 2012
    ..This paper describes the protocol for a randomised controlled trial investigating a short course of lovastatin therapy in adult patients with dengue...
  8. pmc Studying the effectiveness of activated carbon R95 respirators in reducing the inhalation of combustion by-products in Hanoi, Vietnam: a demonstration study
    Heiman F L Wertheim
    Oxford University Clinical Research Unit and Wellcome Trust Major Overseas Programme, Hanoi, Vietnam
    Environ Health 11:72. 2012
    ..In this demonstration study we set out to establish methods to assess whether wearing an R95 activated carbon respirator could reduce intake of polycyclic aromatic hydrocarbons (PAH) in street workers in Hanoi, Vietnam...
  9. pmc Evaluation of microscopic observation drug susceptibility assay for diagnosis of multidrug-resistant tuberculosis in Viet Nam
    Thi Minh Ha Dang
    Pham Ngoc Thach Hospital, 120 Hung Vuong, District 5, Ho Chi Minh City, Viet Nam
    BMC Infect Dis 12:49. 2012
    ..We evaluated the microscopic observation drug susceptibility (MODS) assay as a direct rapid drug susceptibility testing (DST) method for MDR-TB screening in sputum samples..
  10. pmc Pretreatment CD4 cell slope and progression to AIDS or death in HIV-infected patients initiating antiretroviral therapy--the CASCADE collaboration: a collaboration of 23 cohort studies
    Marcel Wolbers
    Basel Institute for Clinical Epidemiology and Biostatistics, University Hospital Basel, Basel, Switzerland
    PLoS Med 7:e1000239. 2010
    ..It is not known whether the rate of CD4 cell decline prior to therapy is related to prognosis and should, therefore, influence the decision on when to initiate cART...
  11. pmc Evaluation of GeneXpert MTB/RIF for diagnosis of tuberculous meningitis
    Nguyen Thi Quynh Nhu
    Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Wellcome Trust Major Overseas Programme, Ho Chi Minh City, Vietnam
    J Clin Microbiol 52:226-33. 2014
    ..The Xpert MTB/RIF represents a significant advance in the early diagnosis of this devastating condition. ..
  12. ncbi request reprint Predictors of optimal viral suppression in patients switched to abacavir, lamivudine, and zidovudine: the Swiss HIV Cohort Study
    Marcel Wolbers
    Basel Institute for Clinical Epidemiology, University Hospital Basel, Switzerland
    AIDS 21:2201-7. 2007
    ....
  13. doi request reprint Guidance of antibiotic therapy with procalcitonin in lower respiratory tract infections: insights into the ProHOSP study
    Philipp Schuetz
    Department of Internal Medicine, Division of Endocrinology, Diabetes and Clinical Nutrition, University Hospital Basel, Basel, Switzerland
    Virulence 1:88-92. 2010
    ..In lower respiratory tract infections, PCT guidance had a differential effect on antibiotic exposure depending on the underlying type and severity of respiratory tract infection...
  14. pmc Influence of antituberculosis drug resistance and Mycobacterium tuberculosis lineage on outcome in HIV-associated tuberculous meningitis
    Dau Quang Tho
    Oxford University Clinical Research Unit Vietnam, Wellcome Trust Major Overseas Programme, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam
    Antimicrob Agents Chemother 56:3074-9. 2012
    ..tuberculosis lineage are important determinants of mortality in patients with HIV-associated TBM. Interventions which target these factors may help reduce the unacceptably high mortality in patients with TBM...
  15. pmc Intensified treatment with high dose rifampicin and levofloxacin compared to standard treatment for adult patients with tuberculous meningitis (TBM-IT): protocol for a randomized controlled trial
    Dorothee Heemskerk
    Hospital for Tropical Diseases Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Programme 190 Ben Ham Tu, District 5, Ho Chi Minh City, Vietnam
    Trials 12:25. 2011
    ....
  16. pmc Prospective evaluation of GeneXpert for the diagnosis of HIV- negative pediatric TB cases
    Do Chau Giang
    Pham Ngoc Thach Hospital, Ho Chi Minh City, Vietnam
    BMC Infect Dis 15:70. 2015
    ..The GeneXpertMTB/RIF (Xpert) assay is now recommended by WHO for diagnosis of tuberculosis (TB) in children but evaluation data is limited...
  17. pmc A Prognostic Model for Development of Profound Shock among Children Presenting with Dengue Shock Syndrome
    Phung Khanh Lam
    Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Viet Nam
    PLoS ONE 10:e0126134. 2015
    ..To identify risk factors and develop a prediction model for the development of profound and recurrent shock amongst children presenting with dengue shock syndrome (DSS)...
  18. pmc Hemagglutination inhibiting antibodies and protection against seasonal and pandemic influenza infection
    Annette Fox
    Oxford University Clinical Research Unit and Wellcome Trust Major Overseas Programme, Viet Nam Center for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK The University of Melbourne, Peter Doherty Institute for Infection and Immunity, Department of Microbiology and Immunology, Parkville, Victoria, Australia Electronic address
    J Infect 70:187-96. 2015
    ..Hemagglutination inhibiting (HI) antibodies correlate with influenza vaccine protection but their association with protection induced by natural infection has received less attention and was studied here...
  19. pmc Development and validation of a coronary risk prediction model for older U.S. and European persons in the Cardiovascular Health Study and the Rotterdam Study
    Michael T Koller
    University Hospital Basel, Basel, Switzerland
    Ann Intern Med 157:389-97. 2012
    ..Risk scores for prediction of coronary heart disease (CHD) in older adults are needed...
  20. pmc Clinical features of dengue in a large Vietnamese cohort: intrinsically lower platelet counts and greater risk for bleeding in adults than children
    Dinh The Trung
    Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam
    PLoS Negl Trop Dis 6:e1679. 2012
    ....
  21. doi request reprint Long-term safety and effectiveness of lopinavir/ritonavir in antiretroviral-experienced HIV-1-infected children
    Christoph Rudin
    Division of Infectious Diseases, University Children s Hospital, Basel, Switzerland
    Arch Dis Child 95:478-81. 2010
    ..To evaluate the long-term safety and effectiveness of lopinavir/ritonavir (LPV/r) in a population-based cohort of HIV-1-infected children...
  22. pmc Clinical presentations, diagnosis, mortality and prognostic markers of tuberculous meningitis in Vietnamese children: a prospective descriptive study
    Nguyen Duc Bang
    Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Programme, 764 Vo Van Kiet, Quan 5, Ho Chi Minh City, Vietnam
    BMC Infect Dis 16:573. 2016
    ..We present a prospective descriptive study of Vietnamese children with TBM to define the presentation, course and characteristics associated with poor outcome...
  23. pmc A randomized, double-blind placebo controlled trial of balapiravir, a polymerase inhibitor, in adult dengue patients
    Nguyet Minh Nguyen
    Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam
    J Infect Dis 207:1442-50. 2013
    ..Dengue is the most common arboviral infection of humans. There are currently no specific treatments for dengue. Balapiravir is a prodrug of a nucleoside analogue (called R1479) and an inhibitor of hepatitis C virus replication in vivo...
  24. pmc Host and viral features of human dengue cases shape the population of infected and infectious Aedes aegypti mosquitoes
    Minh Nguyen Nguyet
    Oxford University Clinical Research Unit, District 5, Ho Chi Minh City, Vietnam
    Proc Natl Acad Sci U S A 110:9072-7. 2013
    ..These data define serotype-specific viremia levels that vaccines or drugs must inhibit to prevent DENV transmission...
  25. pmc Dengue virus infections and maternal antibody decay in a prospective birth cohort study of Vietnamese infants
    Tran Nguyen Bich Chau
    Oxford University Clinical Research Unit, Hong Vuong Hospital, Ho Chi Minh City, Vietnam
    J Infect Dis 200:1893-900. 2009
    ..These results suggest that whereas DENV infection in infants is frequently subclinical, there is a window between 4 and 12 months of age where virion-binding but nonneutralizing IgG could facilitate antibody-dependent enhancement...
  26. pmc A Randomized Comparison of Chloroquine Versus Dihydroartemisinin-Piperaquine for the Treatment of Plasmodium vivax Infection in Vietnam
    Phung Duc Thuan
    Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam Institute of Malaria Parasitology Entomology, Ho Chi Minh City, Vietnam Oxford University Global Health MSc Program, Oxford University, Oxford, United Kingdom Centre for Tropical Medicine and Global Health, Oxford University, Oxford, United Kingdom Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Am J Trop Med Hyg 94:879-85. 2016
    ..Chloroquine thus remains efficacious for the treatment of P. vivax malaria in southern Vietnam, but DHA-PPQ provides more rapid symptomatic and parasitological recovery...
  27. pmc Households as foci for dengue transmission in highly urban Vietnam
    Katherine L Anders
    Oxford University Clinical Research Unit Wellcome Trust Major Overseas Programme, Ho Chi Minh City, Vietnam Centre for Tropical Medicine, University of Oxford, Oxford, United Kingdom Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia
    PLoS Negl Trop Dis 9:e0003528. 2015
    ..We conducted a prospective study of dengue clustering around households in highly urban Ho Chi Minh City, Vietnam...
  28. pmc LTA4H genotype is associated with susceptibility to bacterial meningitis but is not a critical determinant of outcome
    Sarah J Dunstan
    Oxford University Clinical Research Unit, Ho Chi Minh City, District 5, Vietnam Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, Oxford University, Oxford, OX3 7LJ, United Kingdom Nossal Institute of Global Health, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, 3010, Australia
    PLoS ONE 10:e0118789. 2015
    ..01, OR 1.27 95% confidence interval [CI] 1.05-1.54) but did not influence clinical presentation, disease severity or survival following dexamethasone treatment. ..
  29. doi request reprint Prospective evaluation of GeneXpert for the diagnosis of HIV- negative pediatric TB cases
    Do Chau Giang
    Pham Ngoc Thach Hospital, Ho Chi Minh City, Vietnam
    BMC Infect Dis 15:814. 2015
    ..The GeneXpertMTB/RIF (Xpert) assay is now recommended by WHO for diagnosis of tuberculosis (TB) in children but evaluation data is limited...
  30. doi request reprint Death without prior appropriate implantable cardioverter-defibrillator therapy: a competing risk study
    Michael T Koller
    University Hospital Basel, Basel Institute for Clinical Epidemiology, CH 4031 Basel, Switzerland
    Circulation 117:1918-26. 2008
    ..Competing death without prior appropriate ICD therapy might preclude benefit from ICD implantation in a less selected routine-care population...
  31. pmc Corticosteroids for dengue - why don't they work?
    Thi Hanh Tien Nguyen
    Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Viet Nam
    PLoS Negl Trop Dis 7:e2592. 2013
    ..Dysregulated immune responses may contribute to the clinical complications that occur in some patients with dengue...
  32. pmc Evaluation of Xpert MTB/RIF and MODS assay for the diagnosis of pediatric tuberculosis
    Nguyen Thi Quynh Nhu
    Oxford University Clinical Research Unit, Hospital for Tropical Diseases, 764 Vo Van Kiet, District 5, Ho Chi Minh City, Vietnam
    BMC Infect Dis 13:31. 2013
    ....
  33. pmc Assessment of microalbuminuria for early diagnosis and risk prediction in dengue infections
    Nguyen Thi Hanh Tien
    Oxford University Clinical Research Unit, Hospital for Tropical Diseases, District 5, Ho Chi Minh City, Vietnam
    PLoS ONE 8:e54538. 2013
    ....
  34. doi request reprint Procalcitonin levels predict bacteremia in patients with community-acquired pneumonia: a prospective cohort trial
    Fabian Müller
    Department of Internal Medicine, Division of Endocrinology, Diabetes and Clinical Nutrition, University Hospital Basel, Basel, Switzerland
    Chest 138:121-9. 2010
    ..However, the yield of true-positive results is low. We investigated the benefit of procalcitonin (PCT) on hospital admission to predict blood culture positivity in CAP...
  35. ncbi request reprint Validity of the Framingham point scores in the elderly: results from the Rotterdam study
    Michael T Koller
    Basel Institute for Clinical Epidemiology, Basel, Switzerland
    Am Heart J 154:87-93. 2007
    ..Individuals with a risk >20% are classified as high risk and are candidates for preventive intervention. We aimed to validate the FPS in a European population of elderly subjects...
  36. pmc Sensitivity and specificity of a novel classifier for the early diagnosis of dengue
    Nguyen Minh Tuan
    Children s Hospital No 1, Ho Chi Minh City, Vietnam
    PLoS Negl Trop Dis 9:e0003638. 2015
    ..An early and accurate diagnosis of dengue can support clinical management, surveillance and disease control and is central to achieving the World Health Organisation target of a 50% reduction in dengue case mortality by 2020...
  37. pmc Measuring the association between artemisinin-based case management and malaria incidence in southern Vietnam, 1991-2010
    Corey M Peak
    Center for Communicable Disease Dynamics, Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts Institute for Malariology, Parasitology, and Entomology, Ho Chi Minh City, Vietnam Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Programme, Ho Chi Minh City, Vietnam Department of Global Health and Population, Harvard School of Public Health, Boston, Massachusetts Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, United Kingdom
    Am J Trop Med Hyg 92:811-7. 2015
    ..Our findings suggest that including an artemisinin component in malaria drug regimens was strongly associated with reduced malaria incidence in southern Vietnam, whereas changes in urbanization and coverage with ITN or IRS were not. ..
  38. pmc The epidemiology of interpandemic and pandemic influenza in Vietnam, 2007-2010: the Ha Nam household cohort study I
    Peter Horby
    Oxford University Clinical Research Unit, National Hospital of Tropical Diseases, 78 Giai Phong Street, Dong Da District, Hanoi, Vietnam
    Am J Epidemiol 175:1062-74. 2012
    ..These heterogeneities could influence the impact of school closure and childhood vaccination on influenza transmission in tropical areas, such as Vietnam...
  39. pmc Clinical characteristics of Dengue shock syndrome in Vietnamese children: a 10-year prospective study in a single hospital
    Phung Khanh Lam
    Oxford University Clinical Research Unit, Hospital for Tropical Diseases
    Clin Infect Dis 57:1577-86. 2013
    ..Despite its increasing global importance, there are no prospective studies describing the clinical characteristics, management, or outcomes of DSS...
  40. pmc An oral preparation of Lactobacillus acidophilus for the treatment of uncomplicated acute watery diarrhoea in Vietnamese children: study protocol for a multicentre, randomised, placebo-controlled trial
    Marion Eliëtte Kolader
    The Hospital for Tropical Diseases, Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam
    Trials 14:27. 2013
    ..We have designed a RCT to test the hypothesis that an oral preparation of Lactobacillus acidophilus is superior to placebo in the treatment of acute watery diarrhoea in Vietnamese children...
  41. pmc Risk factors of Streptococcus suis infection in Vietnam. A case-control study
    Ho Dang Trung Nghia
    Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Programme, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam
    PLoS ONE 6:e17604. 2011
    ..Little is known of the risk factors underlying the disease...
  42. pmc A multi-center randomized trial to assess the efficacy of gatifloxacin versus ciprofloxacin for the treatment of shigellosis in Vietnamese children
    Ha Vinh
    The Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam
    PLoS Negl Trop Dis 5:e1264. 2011
    ..We aimed to assess the efficacy of gatifloxacin versus ciprofloxacin in the treatment of uncomplicated shigellosis in children...
  43. ncbi request reprint CD4+ T-cell count increase in HIV-1-infected patients with suppressed viral load within 1 year after start of antiretroviral therapy
    Marcel Wolbers
    Basel Institute for Clinical Epidemiology, University Hospital Basel, Switzerland
    Antivir Ther 12:889-97. 2007
    ..This study aimed to identify predictive factors for long-term CD4+ T-cell increase in treatment-naive patients starting combination antiretroviral therapy (cART)...
  44. pmc Microscopic observation drug susceptibility assay (MODS) for early diagnosis of tuberculosis in children
    Dang Thi Minh Ha
    TB Department, Pham Ngoc Thach Hospital, Ho Chi Minh City, Vietnam
    PLoS ONE 4:e8341. 2009
    ..001 and P = 0.04), respectively. MODS is a rapid and sensitive alternative method for the isolation of M.tuberculosis from children...
  45. pmc Adjunctive Dexamethasone in HIV-Associated Cryptococcal Meningitis
    Justin Beardsley
    From the Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Programme Vietnam J B, M W, J F, L M, G T, J N D, Hospital for Tropical Diseases N T K C, N V V C, Cho Ray Hospital T Q B, L P, Ho Chi Minh City, and the National Hospital for Tropical Diseases N V K and Bach Mai Hospital P T T, Hanoi all in Vietnam Nuffield Department of Clinical Medicine, Centre for Tropical Medicine and Global Health, University of Oxford, Oxford J B, M W, J F, L M, G T, M M, D D, J N D, University College London, London R H, and Liverpool School of Tropical Medicine, Liverpool D G L all in the United Kingdom MRC UVRI Uganda Research Unit on AIDS, Entebbe, Uganda F M K, A B M G, A K Mahidol Oxford Tropical Medicine Research Unit, Mahidol University, Department of Physiology
    N Engl J Med 374:542-54. 2016
    ..The use of adjuvant glucocorticoids reduces mortality among patients with other forms of meningitis in some populations, but their use is untested in patients with cryptococcal meningitis...
  46. pmc Clinical implications of reduced susceptibility to fluoroquinolones in paediatric Shigella sonnei and Shigella flexneri infections
    Corinne N Thompson
    Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Programme, The Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam Centre for Tropical Medicine, Oxford University, Oxford, UK The London School of Hygiene and Tropical Medicine, London, UK
    J Antimicrob Chemother 71:807-15. 2016
    ..Such information is important to inform therapeutic management for infections caused by this increasingly drug-resistant pathogen, responsible for high morbidity and mortality in young children globally...
  47. pmc Kinetics of plasma viremia and soluble nonstructural protein 1 concentrations in dengue: differential effects according to serotype and immune status
    Huynh T L Duyen
    Oxford University Clinical Research Unit, Churchill Hospital, Oxford, UK
    J Infect Dis 203:1292-300. 2011
    ..Our findings identify clear serotype and immune-status related effects on the dynamics of dengue viremia and sNS1 responses, together with associations with important clinical parameters...
  48. pmc Appropriateness of antibiotic treatment in intravenous drug users, a retrospective analysis
    Dominik Mertz
    Division of Infectious Diseases and Hospital Epidemiology, University Hospital Basel, Switzerland
    BMC Infect Dis 8:42. 2008
    ..Infectious disease is often the reason for intravenous drug users being seen in a clinical setting. The objective of this study was to evaluate the appropriateness of treatment and outcomes for this patient population in a hospital setting...
  49. pmc Diagnosis of pulmonary tuberculosis in HIV-positive patients by microscopic observation drug susceptibility assay
    Dang Thi Minh Ha
    Pham Ngoc Thach Hospital, and Wellcome Trust Mamor Overseas Programme, Oxford University Clinical Research Unit, 120 Hung Vuong, District 5, Ho Chi Minh City, Vietnam
    J Clin Microbiol 48:4573-9. 2010
    ..7%. In conclusion, MODS is a sensitive, specific, and rapid test that is appropriate for the detection of HIV-associated TB; its cost and ease of use make it particularly useful in resource-limited settings...
  50. pmc Rapid decline in the susceptibility of Plasmodium falciparum to dihydroartemisinin-piperaquine in the south of Vietnam
    Ngo Viet Thanh
    Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Programme, 764 Vo Van Kiet street, Ward 1, District 5, Ho Chi Minh City, Vietnam
    Malar J 16:27. 2017
    ..The relationship of artemisinin resistance to treatment failure has been unclear...
  51. pmc Immunological and viral determinants of dengue severity in hospitalized adults in Ha Noi, Viet Nam
    Annette Fox
    Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Programme, Hanoi, Socialist Republic of Vietnam
    PLoS Negl Trop Dis 5:e967. 2011
    ..This cross-sectional study examined these interactions in adult patients hospitalized with dengue in Ha Noi...
  52. pmc In vivo susceptibility of Plasmodium falciparum to artesunate in Binh Phuoc Province, Vietnam
    Tran Tinh Hien
    Wellcome Trust Major Overseas Programme MOP, Oxford University Clinical Research Unit OUCRU, Ho Chi Minh City, Vietnam
    Malar J 11:355. 2012
    ..Therefore, there is an urgent need to investigate whether there is any evidence of a change in the parasitological response to the artemisinin derivatives in Vietnam...
  53. pmc Competing risks and the clinical community: irrelevance or ignorance?
    Michael T Koller
    Basel Institute for Clinical Epidemiology and Biostatistics, University Hospital Basel, Switzerland
    Stat Med 31:1089-97. 2012
    ..Better recognition of issues related to competing risks and of statistical methods that deal with competing risks in accordance with the aim of the study is needed...
  54. doi request reprint Two-stage randomization designs in drug development
    Marcel Wolbers
    Basel Institute for Clinical Epidemiology and Biostatistics, University Hospital Basel, Basel, Switzerland
    Stat Med 27:4161-74. 2008
    ..We present a simulation study, which compares TSRDs to several strategies based on SRDs in terms of total sample size and time to reach clinical decisions...
  55. pmc Weighted analysis of composite endpoints with simultaneous inference for flexible weight constraints
    Anh Nguyen Duc
    Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Programme, Ho Chi Minh City, Vietnam
    Stat Med . 2016
    ..2016 The Authors. Statistics in Medicine Published by John Wiley & Sons Ltd...
  56. pmc Combination antifungal therapy for cryptococcal meningitis
    Jeremy N Day
    Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Programme Vietnam, Ho Chi Minh City, Vietnam
    N Engl J Med 368:1291-302. 2013
    ..We performed a randomized, controlled trial to determine whether combining flucytosine or high-dose fluconazole with high-dose amphotericin B improved survival at 14 and 70 days...
  57. pmc Epidemiology, seasonality, and predictors of outcome of AIDS-associated Penicillium marneffei infection in Ho Chi Minh City, Viet Nam
    Thuy Le
    Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Ho Chi Minh City, Viet Nam
    Clin Infect Dis 52:945-52. 2011
    ..Penicillium marneffei is an important human immunodeficiency virus (HIV)-associated opportunistic pathogen in Southeast Asia. The epidemiology and the predictors of penicilliosis outcome are poorly understood...
  58. pmc Clinical validation of a point-of-care multiplexed in vitro immunoassay using monoclonal antibodies (the MSD influenza test) in four hospitals in Vietnam
    H Rogier van Doorn
    South East Asian Infectious Diseases Clinical Research Network, Ho Chi Minh City, Vietnam
    J Clin Microbiol 50:1621-5. 2012
    ..Drawbacks to the technology include the requirement for a dedicated reader instrument and the need for continual updating of subtyping antibodies within the test array...
  59. pmc The antimicrobial resistance patterns and associated determinants in Streptococcus suis isolated from humans in southern Vietnam, 1997-2008
    Ngo T Hoa
    Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam
    BMC Infect Dis 11:6. 2011
    ..suis strains isolated from human cases are lacking. We studied antimicrobial resistance and associated resistance determinants in S. suis isolated from patients with meningitis in southern Vietnam...
  60. pmc Prohormones for prediction of adverse medical outcome in community-acquired pneumonia and lower respiratory tract infections
    Philipp Schuetz
    Department of Internal Medicine, Division of Endocrinology, Diabetes and Clinical Nutrition, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland
    Crit Care 14:R106. 2010
    ..Measurement of prohormones representing different pathophysiological pathways could enhance risk stratification in patients with community-acquired pneumonia (CAP) and other lower respiratory tract infections (LRTI)...
  61. pmc Early pandemic influenza (2009 H1N1) in Ho Chi Minh City, Vietnam: a clinical virological and epidemiological analysis
    Tran Tinh Hien
    Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Program, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam
    PLoS Med 7:e1000277. 2010
    ..In addition, we present detailed systematic viral clearance data on 292 isolated and treated patients and the first three cases of selection of resistant virus during treatment in Vietnam...
  62. pmc Immunological and biochemical correlates of adjunctive dexamethasone in Vietnamese adults with bacterial meningitis
    Nguyen Thi Hoang Mai
    Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam
    Clin Infect Dis 49:1387-92. 2009
    ....
  63. pmc HIV patients developing primary CNS lymphoma lack EBV-specific CD4+ T cell function irrespective of absolute CD4+ T cell counts
    Olivier Gasser
    Immunobiology Laboratory, Department of Research, University Hospital Basel, Basel, Switzerland
    PLoS Med 4:e96. 2007
    ....