Sarah J Dunstan

Summary

Affiliation: Ho Chi Minh City
Country: Vietnam

Publications

  1. ncbi Host susceptibility and clinical outcomes in toll-like receptor 5-deficient patients with typhoid fever in Vietnam
    Sarah J Dunstan
    Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam
    J Infect Dis 191:1068-71. 2005
  2. pmc Toll-like receptor 4 (TLR4) and typhoid fever in Vietnam
    Thi Hue Nguyen
    Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam
    PLoS ONE 4:e4800. 2009
  3. pmc Identification of tuberculosis susceptibility genes with human macrophage gene expression profiles
    Nguyen Thuy Thuong Thuong
    Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam
    PLoS Pathog 4:e1000229. 2008
  4. pmc LTA4H genotype is associated with susceptibility to bacterial meningitis but is not a critical determinant of outcome
    Sarah J Dunstan
    Oxford University Clinical Research Unit, Ho Chi Minh City, District 5, Vietnam Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, Oxford University, Oxford, OX3 7LJ, United Kingdom Nossal Institute of Global Health, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, 3010, Australia
    PLoS ONE 10:e0118789. 2015
  5. pmc Glucose-6-phosphate dehydrogenase (G6PD) mutations and haemoglobinuria syndrome in the Vietnamese population
    Nguyen Thi Hue
    Oxford University Clinical Research Unit, Hospital for Tropical Diseases, 190 Ben Ham Tu, District 5, Ho Chi Minh City, Vietnam
    Malar J 8:152. 2009
  6. pmc A TNF region haplotype offers protection from typhoid fever in Vietnamese patients
    Sarah J Dunstan
    Oxford University Clinical Research Unit, Hospital for Tropical Diseases, 190 Ben Ham Tu, Quan 5, District 5, Ho Chi Minh City, Vietnam
    Hum Genet 122:51-61. 2007
  7. ncbi A common human TLR1 polymorphism regulates the innate immune response to lipopeptides
    Thomas R Hawn
    Department of Medicine, University of Washington School of Medicine, Seattle, WA 98195, USA, and Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam
    Eur J Immunol 37:2280-9. 2007
  8. pmc High prevalence of PI resistance in patients failing second-line ART in Vietnam
    Vu Phuong Thao
    Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam
    J Antimicrob Chemother 71:762-74. 2016
  9. doi HIV-1 drug resistance in antiretroviral-naive individuals with HIV-1-associated tuberculous meningitis initiating antiretroviral therapy in Vietnam
    Vu P Thao
    Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam
    Antivir Ther 17:905-13. 2012
  10. doi An updated systematic review of the role of host genetics in susceptibility to influenza
    Peter Horby
    Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Programme, Vietnam
    Influenza Other Respir Viruses 7:37-41. 2013

Collaborators

Detail Information

Publications12

  1. ncbi Host susceptibility and clinical outcomes in toll-like receptor 5-deficient patients with typhoid fever in Vietnam
    Sarah J Dunstan
    Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam
    J Infect Dis 191:1068-71. 2005
    ..TLR5 may not play an important role in TLR-stimulated innate immune responses to human infection with Salmonella enterica serovar Typhi. Initiation of these responses may rely on other TLRs that recognize different bacterial ligands...
  2. pmc Toll-like receptor 4 (TLR4) and typhoid fever in Vietnam
    Thi Hue Nguyen
    Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam
    PLoS ONE 4:e4800. 2009
    ..Here we determined the extent of genetic variation within TLR4 in a Vietnamese population and suggest that TLR4 may be involved in defense against typhoid fever in this population...
  3. pmc Identification of tuberculosis susceptibility genes with human macrophage gene expression profiles
    Nguyen Thuy Thuong Thuong
    Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam
    PLoS Pathog 4:e1000229. 2008
    ....
  4. pmc LTA4H genotype is associated with susceptibility to bacterial meningitis but is not a critical determinant of outcome
    Sarah J Dunstan
    Oxford University Clinical Research Unit, Ho Chi Minh City, District 5, Vietnam Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, Oxford University, Oxford, OX3 7LJ, United Kingdom Nossal Institute of Global Health, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, 3010, Australia
    PLoS ONE 10:e0118789. 2015
    ..01, OR 1.27 95% confidence interval [CI] 1.05-1.54) but did not influence clinical presentation, disease severity or survival following dexamethasone treatment. ..
  5. pmc Glucose-6-phosphate dehydrogenase (G6PD) mutations and haemoglobinuria syndrome in the Vietnamese population
    Nguyen Thi Hue
    Oxford University Clinical Research Unit, Hospital for Tropical Diseases, 190 Ben Ham Tu, District 5, Ho Chi Minh City, Vietnam
    Malar J 8:152. 2009
    ..The G6PD variants within the Vietnamese Kinh contributing to the disease risk in this population, and more generally to haemoglobinuria, are currently unknown...
  6. pmc A TNF region haplotype offers protection from typhoid fever in Vietnamese patients
    Sarah J Dunstan
    Oxford University Clinical Research Unit, Hospital for Tropical Diseases, 190 Ben Ham Tu, Quan 5, District 5, Ho Chi Minh City, Vietnam
    Hum Genet 122:51-61. 2007
    ..Finally, individuals that carry the typhoid fever protective haplotype *12122*1111 also produce a relatively low TNF-alpha response to LPS...
  7. ncbi A common human TLR1 polymorphism regulates the innate immune response to lipopeptides
    Thomas R Hawn
    Department of Medicine, University of Washington School of Medicine, Seattle, WA 98195, USA, and Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam
    Eur J Immunol 37:2280-9. 2007
    ....
  8. pmc High prevalence of PI resistance in patients failing second-line ART in Vietnam
    Vu Phuong Thao
    Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam
    J Antimicrob Chemother 71:762-74. 2016
    ..There are limited data from resource-limited settings on antiretroviral resistance mutations that develop in patients failing second-line PI ART...
  9. doi HIV-1 drug resistance in antiretroviral-naive individuals with HIV-1-associated tuberculous meningitis initiating antiretroviral therapy in Vietnam
    Vu P Thao
    Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam
    Antivir Ther 17:905-13. 2012
    ..Access to antiretroviral therapy (ART) for HIV-infected individuals in Vietnam is rapidly expanding, but there are limited data on HIV drug resistance (HIVDR) to guide ART strategies...
  10. doi An updated systematic review of the role of host genetics in susceptibility to influenza
    Peter Horby
    Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Programme, Vietnam
    Influenza Other Respir Viruses 7:37-41. 2013
    ..One study does however present convincing functional evidence for an important role for IFITM3 in susceptibility to severe influenza in mice, and some evidence that this may also be important in human A/H1N1/pdm2009 infection. ..
  11. pmc A multi-center randomised controlled trial of gatifloxacin versus azithromycin for the treatment of uncomplicated typhoid fever in children and adults in Vietnam
    Christiane Dolecek
    Oxford University Clinical Research Unit, The Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam
    PLoS ONE 3:e2188. 2008
    ..Drug resistant typhoid fever is a major clinical problem globally. Many of the first line antibiotics, including the older generation fluoroquinolones, ciprofloxacin and ofloxacin, are failing...
  12. pmc A polymorphism in Toll-interleukin 1 receptor domain containing adaptor protein is associated with susceptibility to meningeal tuberculosis
    Thomas R Hawn
    Department of Medicine, University of Washington School of Medicine, Seattle WA 98195, USA
    J Infect Dis 194:1127-34. 2006
    ....