Xavier Verhelst

Summary

Publications

  1. ncbi request reprint Acute hepatitis after treatment for hair loss with oral green tea extracts (Camellia Sinensis)
    X Verhelst
    Department of Gastroenterology, AZ Maria Middelares, Ghent, Belgium
    Acta Gastroenterol Belg 72:262-4. 2009
  2. ncbi request reprint Subfulminant hepatitis B during treatment with adalimumab in a patient with rheumatoid arthritis and chronic hepatitis B
    Xavier Verhelst
    Department of Gastroenterology and Hepatology, Ghent University Hospital, De Pintelaan 185, Ghent B 9000, Belgium
    Eur J Gastroenterol Hepatol 22:494-9. 2010
  3. doi request reprint Progressive multifocal leukoencephalopathy in liver transplant recipients: a case report and review of the literature
    Xavier Verhelst
    Department of Gastroenterology and Hepatology, AZ St Jan AV Brugge, Belgium
    Transpl Int 24:e30-4. 2011
  4. doi request reprint Combination of tauroursodeoxycholic acid and N-acetylcysteine exceeds standard treatment for acetaminophen intoxication
    Annelies Paridaens
    Department of Hepatology and Gastroenterology, Ghent University, Ghent, Belgium
    Liver Int . 2016
  5. pmc Placental growth factor inhibition modulates the interplay between hypoxia and unfolded protein response in hepatocellular carcinoma
    Yves Paul Vandewynckel
    Department of Hepatology and Gastroenterology, Ghent University Hospital, De Pintelaan 185, 1K12IE, B 9000, Ghent, Belgium
    BMC Cancer 16:9. 2016
  6. pmc Tauroursodeoxycholic acid dampens oncogenic apoptosis induced by endoplasmic reticulum stress during hepatocarcinogen exposure
    Yves Paul Vandewynckel
    Department of Hepatology and Gastroenterology, Ghent University, Ghent, Belgium
    Oncotarget 6:28011-25. 2015
  7. pmc Time-dependent effect of hypoxia on tumor progression and liver progenitor cell markers in primary liver tumors
    Eliene Bogaerts
    Gastro enterology and hepatology, Ghent University, Ghent, Belgium
    PLoS ONE 10:e0119555. 2015
  8. pmc Next-generation proteasome inhibitor oprozomib synergizes with modulators of the unfolded protein response to suppress hepatocellular carcinoma
    Yves Paul Vandewynckel
    Department of Hepatology and Gastroenterology, Ghent University, Ghent, Belgium
    Oncotarget 7:34988-5000. 2016
  9. pmc Modulation of the unfolded protein response impedes tumor cell adaptation to proteotoxic stress: a PERK for hepatocellular carcinoma therapy
    Yves Paul Vandewynckel
    Department of Hepatology and Gastroenterology, Ghent University, De Pintelaan 185, 1K12 IE, 9000 Ghent, Belgium
    Hepatol Int 9:93-104. 2015
  10. doi request reprint Therapeutic effects of artesunate in hepatocellular carcinoma: repurposing an ancient antimalarial agent
    Yves Paul Vandewynckel
    aDepartment of Hepatology and Gastroenterology bInfinity Imaging Lab, MEDISIP, iMinds cDepartment of Respiratory Medicine dGROUP ID Consortium, Ghent University eDepartment of Pathology, Ghent University Hospital fUnit Immunoregulation and Mucosal Immunology, VIB Inflammation Research Center, Ghent, Belgium
    Eur J Gastroenterol Hepatol 26:861-70. 2014

Collaborators

Detail Information

Publications18

  1. ncbi request reprint Acute hepatitis after treatment for hair loss with oral green tea extracts (Camellia Sinensis)
    X Verhelst
    Department of Gastroenterology, AZ Maria Middelares, Ghent, Belgium
    Acta Gastroenterol Belg 72:262-4. 2009
    ..We raise concern about the safety of nutritional additives with few proven beneficial effects and want to emphasize the importance of accurate and thorough history taking, with attention for over the counter drugs and herbal products...
  2. ncbi request reprint Subfulminant hepatitis B during treatment with adalimumab in a patient with rheumatoid arthritis and chronic hepatitis B
    Xavier Verhelst
    Department of Gastroenterology and Hepatology, Ghent University Hospital, De Pintelaan 185, Ghent B 9000, Belgium
    Eur J Gastroenterol Hepatol 22:494-9. 2010
    ..Administration of antiviral prophylaxis proves beneficial in prevention of reactivation in hepatitis B surface antigen positive patients...
  3. doi request reprint Progressive multifocal leukoencephalopathy in liver transplant recipients: a case report and review of the literature
    Xavier Verhelst
    Department of Gastroenterology and Hepatology, AZ St Jan AV Brugge, Belgium
    Transpl Int 24:e30-4. 2011
    ..The prognosis remains, however, extremely poor regardless of treatment...
  4. doi request reprint Combination of tauroursodeoxycholic acid and N-acetylcysteine exceeds standard treatment for acetaminophen intoxication
    Annelies Paridaens
    Department of Hepatology and Gastroenterology, Ghent University, Ghent, Belgium
    Liver Int . 2016
    ....
  5. pmc Placental growth factor inhibition modulates the interplay between hypoxia and unfolded protein response in hepatocellular carcinoma
    Yves Paul Vandewynckel
    Department of Hepatology and Gastroenterology, Ghent University Hospital, De Pintelaan 185, 1K12IE, B 9000, Ghent, Belgium
    BMC Cancer 16:9. 2016
    ..Because hypoxia and endoplasmic reticulum stress, which activates the unfolded protein response (UPR), have been implicated in HCC progression, we assessed the interactions between PlGF and these microenvironmental stresses...
  6. pmc Tauroursodeoxycholic acid dampens oncogenic apoptosis induced by endoplasmic reticulum stress during hepatocarcinogen exposure
    Yves Paul Vandewynckel
    Department of Hepatology and Gastroenterology, Ghent University, Ghent, Belgium
    Oncotarget 6:28011-25. 2015
    ..Therefore, this chemical chaperone could represent a novel chemopreventive agent. ..
  7. pmc Time-dependent effect of hypoxia on tumor progression and liver progenitor cell markers in primary liver tumors
    Eliene Bogaerts
    Gastro enterology and hepatology, Ghent University, Ghent, Belgium
    PLoS ONE 10:e0119555. 2015
    ..Our aim was to elucidate the time-dependent effects of hypoxia on the LPC niche in hepatocellular carcinoma which could aid in determining a safe time frame for use of hypoxia inducing therapies...
  8. pmc Next-generation proteasome inhibitor oprozomib synergizes with modulators of the unfolded protein response to suppress hepatocellular carcinoma
    Yves Paul Vandewynckel
    Department of Hepatology and Gastroenterology, Ghent University, Ghent, Belgium
    Oncotarget 7:34988-5000. 2016
    ..This finding can be exploited to enhance the antitumor efficacy by combining oprozomib with clinically applicable UPR activators. ..
  9. pmc Modulation of the unfolded protein response impedes tumor cell adaptation to proteotoxic stress: a PERK for hepatocellular carcinoma therapy
    Yves Paul Vandewynckel
    Department of Hepatology and Gastroenterology, Ghent University, De Pintelaan 185, 1K12 IE, 9000 Ghent, Belgium
    Hepatol Int 9:93-104. 2015
    ..In human hepatocellular carcinoma (HCC), the UPR is shown to be activated; however, little is known about the UPR kinetics and effects of UPR modulation in HCC...
  10. doi request reprint Therapeutic effects of artesunate in hepatocellular carcinoma: repurposing an ancient antimalarial agent
    Yves Paul Vandewynckel
    aDepartment of Hepatology and Gastroenterology bInfinity Imaging Lab, MEDISIP, iMinds cDepartment of Respiratory Medicine dGROUP ID Consortium, Ghent University eDepartment of Pathology, Ghent University Hospital fUnit Immunoregulation and Mucosal Immunology, VIB Inflammation Research Center, Ghent, Belgium
    Eur J Gastroenterol Hepatol 26:861-70. 2014
    ..We evaluated the effects of artesunate, a semisynthetic derivative of artemisinin, on tumor growth, angiogenesis, the unfolded protein response, and chemoresistance in hepatocellular carcinoma...
  11. pmc Quality of life after liver transplantation: State of the art
    Louis Onghena
    Louis Onghena, Wouter Develtere, Anja Geerts, Hans Van Vlierberghe, Xavier Verhelst, Department of Hepatology and Gastroenterology, Ghent University Hospital, 9000 Ghent, East Flanders, Belgium
    World J Hepatol 8:749-56. 2016
    ..Opportunities for further research are the use of dedicated questionnaires and identification of influencing factors for QoL. ..
  12. doi request reprint Hypoxia-regulated mechanisms in the pathogenesis of obesity and non-alcoholic fatty liver disease
    Sander Lefere
    Department of Gastroenterology and Hepatology, Ghent University Hospital, De Pintelaan 185, 1K12IE, 9000, Ghent, Belgium
    Cell Mol Life Sci 73:3419-31. 2016
    ..This review summarizes the molecular mechanisms through which the hypoxia adaptive response affects adipocyte and hepatic metabolism, and the therapeutic possibilities of modulating HIFs and PHDs in obesity and fatty liver disease. ..
  13. doi request reprint Hepatopulmonary syndrome and portopulmonary hypertension: recent knowledge in pathogenesis and overview of clinical assessment
    Sarah Raevens
    Department of Gastroenterology and Hepatology, Ghent University Hospital, Ghent, Belgium
    Liver Int 35:1646-60. 2015
    ..The aim of is this review is to provide an overview on the hepatopulmonary syndrome and portopulmonary hypertension with primary focus on diagnosis and recent knowledge regarding pathogenesis and therapeutic targets...
  14. doi request reprint Role of angiogenic factors/cell adhesion markers in serum of cirrhotic patients with hepatopulmonary syndrome
    Sarah Raevens
    Department of Gastroenterology and Hepatology, Ghent University Hospital, Ghent, Belgium
    Liver Int 35:1499-507. 2015
    ..Aims of this study were to identify angiogenic factors in serum of patients with hepatopulmonary syndrome and to study the possibility to predict its presence by these factors...
  15. doi request reprint Refractory subacute steatohepatitis after biliopancreatic diversion
    Sander Lefere
    Department of Gastroenterology and Hepatology, Ghent University Hospital, Ghent, Belgium
    Hepatology . 2017
    ..We present a case of fatal recurrent steatohepatitis post-PBD despite repeated liver transplantations. This article is protected by copyright. All rights reserved...
  16. doi request reprint Oral vasodilator therapy in patients with moderate to severe portopulmonary hypertension as a bridge to liver transplantation
    Sarah Raevens
    Department of Hepatology and Gastroenterology, Ghent University Hospital, 185 9000 Ghent, Belgium
    Eur J Gastroenterol Hepatol 25:495-502. 2013
    ....
  17. doi request reprint Longitudinal Transient Elastography Measurements Used in Follow-up for Patients with Cystic Fibrosis
    Stephanie Van Biervliet
    Cystic fibrosis Centre Ghent, Ghent University Hospital, Ghent, Belgium Department of Pediatric Gastroenterology and Hepatology, Ghent University Hospital, Ghent, Belgium Electronic address
    Ultrasound Med Biol 42:848-54. 2016
    ..6% and a negative predictive value of 86.9%, increasing to 91.7% and 98%, respectively, in patients at risk (<14 y) for developing CFLD. Patients with developing CFLD had progressively increasing consecutive TE measurements. ..
  18. ncbi request reprint The paradox of the unfolded protein response in cancer
    Yves Paul Vandewynckel
    Department of Hepatology and Gastroenterology, Ghent University, De Pintelaan 185, 9000 Ghent, Belgium
    Anticancer Res 33:4683-94. 2013
    ..In this review, we aim to elucidate the paradoxical role of the UPR in apoptosis and cancer. ..