Tian Xu

Summary

Affiliation: Yale University
Country: USA

Publications

  1. pmc Ablation of vacuole protein sorting 18 (Vps18) gene leads to neurodegeneration and impaired neuronal migration by disrupting multiple vesicle transport pathways to lysosomes
    Chao Peng
    Institute of Developmental Biology and Molecular Medicine, Fudan University, Shanghai 200433, China
    J Biol Chem 287:32861-73. 2012
  2. pmc piggyBac as a high-capacity transgenesis and gene-therapy vector in human cells and mice
    Rongbo Li
    State Key Laboratory of Genetic Engineering and Institute of Developmental Biology and Molecular Medicine, Fudan Yale Biomedical Research Center, School of Life Sciences, Fudan University, Shanghai 200433, China
    Dis Model Mech 6:828-33. 2013
  3. pmc Characterization of fluorescent eye markers for mammalian transgenic studies
    Jonathan C Cornett
    Department of Genetics, Boyer Center for Molecular Medicine, Yale University School of Medicine, Howard Hughes Medical Institute, New Haven, Connecticut, USA
    PLoS ONE 6:e29486. 2011
  4. pmc piggyBac transposon somatic mutagenesis with an activated reporter and tracker (PB-SMART) for genetic screens in mice
    Sean F Landrette
    Department of Genetics, Yale University School of Medicine, Boyer Center for Molecular Medicine, Howard Hughes Medical Institute, New Haven, Connecticut, United States of America
    PLoS ONE 6:e26650. 2011
  5. pmc Somatic genetics empowers the mouse for modeling and interrogating developmental and disease processes
    Sean F Landrette
    Department of Genetics, Howard Hughes Medical Institute, Yale University School of Medicine, Boyer Center for Molecular Medicine, New Haven, Connecticut, United States of America
    PLoS Genet 7:e1002110. 2011
  6. pmc Interaction between Ras(V12) and scribbled clones induces tumour growth and invasion
    Ming Wu
    Howard Hughes Medical Institute, Department of Genetics, Yale University School of Medicine, 295 Congress Avenue, New Haven, Connecticut 06519, USA
    Nature 463:545-8. 2010
  7. pmc The effort to make mosaic analysis a household tool
    Tian Xu
    Department of Genetics, Howard Hughes Medical Institute, Yale University School of Medicine, Boyer Center for Molecular Medicine, 295 Congress Avenue, New Haven, CT 06510, USA
    Development 139:4501-3. 2012
  8. pmc Ras promotes cell survival by antagonizing both JNK and Hid signals in the Drosophila eye
    Yue Wu
    Institute of Developmental Biology and Molecular Medicine and School of Life Science, Fudan University, Shanghai, PR China
    BMC Dev Biol 9:53. 2009
  9. pmc SUN1/2 and Syne/Nesprin-1/2 complexes connect centrosome to the nucleus during neurogenesis and neuronal migration in mice
    Xiaochang Zhang
    Institute of Developmental Biology and Molecular Medicine, School of Life Science, Fudan University, Shanghai, China
    Neuron 64:173-87. 2009
  10. ncbi request reprint Loss of cell polarity drives tumor growth and invasion through JNK activation in Drosophila
    Tatsushi Igaki
    Howard Hughes Medical Institute, Department of Genetics, Yale University School of Medicine, Boyer Center for Molecular Medicine, 295 Congress Avenue, New Haven, Connecticut 06536, USA
    Curr Biol 16:1139-46. 2006

Collaborators

Detail Information

Publications55

  1. pmc Ablation of vacuole protein sorting 18 (Vps18) gene leads to neurodegeneration and impaired neuronal migration by disrupting multiple vesicle transport pathways to lysosomes
    Chao Peng
    Institute of Developmental Biology and Molecular Medicine, Fudan University, Shanghai 200433, China
    J Biol Chem 287:32861-73. 2012
    ..Our results demonstrate important roles of Vps18 in neuron survival and migration, which are disrupted in multiple neural disorders...
  2. pmc piggyBac as a high-capacity transgenesis and gene-therapy vector in human cells and mice
    Rongbo Li
    State Key Laboratory of Genetic Engineering and Institute of Developmental Biology and Molecular Medicine, Fudan Yale Biomedical Research Center, School of Life Sciences, Fudan University, Shanghai 200433, China
    Dis Model Mech 6:828-33. 2013
    ..These results indicate that PB could serve as an effective high-capacity vector for functional analysis of the mammalian genome and for gene therapy in human cells...
  3. pmc Characterization of fluorescent eye markers for mammalian transgenic studies
    Jonathan C Cornett
    Department of Genetics, Boyer Center for Molecular Medicine, Yale University School of Medicine, Howard Hughes Medical Institute, New Haven, Connecticut, USA
    PLoS ONE 6:e29486. 2011
    ..Taken together, these eye markers dramatically reduce the time and cost of genotyping transgenics and empower analysis of genetic interaction...
  4. pmc piggyBac transposon somatic mutagenesis with an activated reporter and tracker (PB-SMART) for genetic screens in mice
    Sean F Landrette
    Department of Genetics, Yale University School of Medicine, Boyer Center for Molecular Medicine, Howard Hughes Medical Institute, New Haven, Connecticut, United States of America
    PLoS ONE 6:e26650. 2011
    ..With these features, PB-SMART provides an integrated platform for individual investigators to harness the power of somatic mutagenesis and phenotypic screens to decipher the genetic basis of mammalian biology and disease...
  5. pmc Somatic genetics empowers the mouse for modeling and interrogating developmental and disease processes
    Sean F Landrette
    Department of Genetics, Howard Hughes Medical Institute, Yale University School of Medicine, Boyer Center for Molecular Medicine, New Haven, Connecticut, United States of America
    PLoS Genet 7:e1002110. 2011
    ..In this review, we briefly outline the current advances in somatic mutagenesis and discuss how these new tools, especially the piggyBac transposon system, can be applied to decipher human biology and disease...
  6. pmc Interaction between Ras(V12) and scribbled clones induces tumour growth and invasion
    Ming Wu
    Howard Hughes Medical Institute, Department of Genetics, Yale University School of Medicine, 295 Congress Avenue, New Haven, Connecticut 06519, USA
    Nature 463:545-8. 2010
    ..Given the conservation of the pathways examined here, similar cooperative mechanisms could have a role in the development of human cancers...
  7. pmc The effort to make mosaic analysis a household tool
    Tian Xu
    Department of Genetics, Howard Hughes Medical Institute, Yale University School of Medicine, Boyer Center for Molecular Medicine, 295 Congress Avenue, New Haven, CT 06510, USA
    Development 139:4501-3. 2012
    ..In 1990, we set out to improve the methods used to make genetic mosaics in Drosophila by taking advantage of recently developed approaches for genome engineering. These efforts led to the work described in our 1993 Development paper...
  8. pmc Ras promotes cell survival by antagonizing both JNK and Hid signals in the Drosophila eye
    Yue Wu
    Institute of Developmental Biology and Molecular Medicine and School of Life Science, Fudan University, Shanghai, PR China
    BMC Dev Biol 9:53. 2009
    ..Ras is known to mediate anti-apoptotic signals by inhibiting Hid activity in the Drosophila eye. Here we report the isolation of a new loss-of-function ras allele, rasKP, which causes excessive apoptosis in the Drosophila eye...
  9. pmc SUN1/2 and Syne/Nesprin-1/2 complexes connect centrosome to the nucleus during neurogenesis and neuronal migration in mice
    Xiaochang Zhang
    Institute of Developmental Biology and Molecular Medicine, School of Life Science, Fudan University, Shanghai, China
    Neuron 64:173-87. 2009
    ..Syne-2 mutants also display severe defects in learning and memory. These results fill an important gap in our understanding of the mechanism of nuclear movement during brain development...
  10. ncbi request reprint Loss of cell polarity drives tumor growth and invasion through JNK activation in Drosophila
    Tatsushi Igaki
    Howard Hughes Medical Institute, Department of Genetics, Yale University School of Medicine, Boyer Center for Molecular Medicine, 295 Congress Avenue, New Haven, Connecticut 06536, USA
    Curr Biol 16:1139-46. 2006
    ..Similar oncogenic cooperation mediated through these evolutionarily conserved signaling pathways could contribute to human cancer progression...
  11. ncbi request reprint Tumor suppressor CYLD regulates JNK-induced cell death in Drosophila
    Lei Xue
    Howard Hughes Medical Institute, Department of Genetics, Yale University School of Medicine, New Haven, CT 06536, USA
    Dev Cell 13:446-54. 2007
    ..These data provide a molecular mechanism for the tumor suppressor function of this evolutionary conserved molecule by indicating that dCYLD plays a critical role in modulating TNF-JNK-mediated cell death...
  12. pmc KASH protein Syne-2/Nesprin-2 and SUN proteins SUN1/2 mediate nuclear migration during mammalian retinal development
    Juehua Yu
    Institute of Developmental Biology and Molecular Medicine, School of Life Science, Fudan University, Shanghai 200433, China
    Hum Mol Genet 20:1061-73. 2011
    ..These key retinal developmental signaling results will advance our understanding of the mechanism of nuclear migration in the mammalian retina...
  13. pmc Disruption of lysosome function promotes tumor growth and metastasis in Drosophila
    Congwu Chi
    Institute of Developmental Biology and Molecular Medicine, Fudan Yale Center for Biomedical Research, School of Life Science, Fudan University, Shanghai 200433, China
    J Biol Chem 285:21817-23. 2010
    ..Taken together, our data provide evidence for a causative role of lysosome dysfunction in tumor growth and invasion and indicate that members of the Class C VPS complex behave as tumor suppressors...
  14. doi request reprint C-terminal deletion of the atrophin-1 protein results in growth retardation but not neurodegeneration in mice
    Juehua Yu
    Institute of Developmental Biology and Molecular Medicine, School of Life Sciences, Fudan University, Shanghai, China
    Dev Dyn 238:2471-8. 2009
    ..These results support the model that poly-Q expanded Atrophin-1 proteins cause DRPLA in a manner independent of any functional interaction with wild-type Atrophin-1 proteins...
  15. pmc An innate immune response of blood cells to tumors and tissue damage in Drosophila
    Jose Carlos Pastor-Pareja
    Howard Hughes Medical Institute, Department of Genetics, Yale University School of Medicine, 295 Congress Avenue, New Haven, CT 06519, USA
    Dis Model Mech 1:144-54; discussion 153. 2008
    ..Our findings reveal common mechanisms in the response to tumors and wounds in flies. A similar innate reaction may underlie the response to tumors and tissue damage in vertebrates and humans...
  16. pmc SUN1 and SUN2 play critical but partially redundant roles in anchoring nuclei in skeletal muscle cells in mice
    Kai Lei
    Institute of Developmental Biology and Molecular Medicine, School of Life Science, Fudan University, Shanghai, China
    Proc Natl Acad Sci U S A 106:10207-12. 2009
    ..These results clearly indicate that SUN1 and SUN2 function critically in skeletal muscle cells for Syne-1 localization at the NE, which is essential for proper myonuclear positioning...
  17. pmc Intrinsic tumor suppression and epithelial maintenance by endocytic activation of Eiger/TNF signaling in Drosophila
    Tatsushi Igaki
    Howard Hughes Medical Institute, Department of Genetics, Yale University School of Medicine, Boyer Center for Molecular Medicine, 295 Congress Avenue, New Haven, CT 06536, USA
    Dev Cell 16:458-65. 2009
    ..Our data indicate that TNF signaling and the endocytic machinery could be components of an evolutionarily conserved fail-safe mechanism by which animals protect against neoplastic development...
  18. ncbi request reprint A genetic screen in Drosophila for metastatic behavior
    Raymond A Pagliarini
    Howard Hughes Medical Institute, Department of Genetics, Yale University School of Medicine, Boyer Center for Molecular Medicine, 295 Congress Avenue, New Haven, CT 06536, USA
    Science 302:1227-31. 2003
    ..These findings suggest that the oncogenic background of tissues makes a distinct contribution toward metastatic development...
  19. pmc Basement membrane remodeling is essential for Drosophila disc eversion and tumor invasion
    Ajay Srivastava
    Department of Genetics and Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06510, USA
    Proc Natl Acad Sci U S A 104:2721-6. 2007
    ..Finally, although past efforts using MMP inhibitors have not yielded much success, our results strongly argue that BM modulation could be a critical target for cancer therapy...
  20. doi request reprint A large-scale functional approach to uncover human genes and pathways in Drosophila
    Rong Xu
    Institute of Developmental Biology and Molecular Medicine and School of Life Science, Fudan University, Shanghai 200433, China
    Cell Res 18:1114-27. 2008
    ..In summary, the functions of many human genes appear to be highly conserved, and the ability to identify them in Drosophila represents a powerful genetic tool for large-scale analysis of human transcripts in vivo...
  21. pmc Shaping cells and organs in Drosophila by opposing roles of fat body-secreted Collagen IV and perlecan
    Jose Carlos Pastor-Pareja
    Howard Hughes Medical Institute, Department of Genetics, Yale University School of Medicine, 295 Congress Avenue, New Haven, CT 06519, USA
    Dev Cell 21:245-56. 2011
    ..Our results uncover incorporation of Collagen IV and Perlecan into BMs as a major determinant of organ shape and animal form...
  22. ncbi request reprint Drosophila Src-family kinases function with Csk to regulate cell proliferation and apoptosis
    Laura G Pedraza
    Department of Genetics, Howard Hughes Medical Institute, Yale University School of Medicine, Boyer Center for Molecular Medicine, 295 Congress Avenue, PO Box 9812, New Haven, CT 06536 0812, USA
    Oncogene 23:4754-62. 2004
    ....
  23. doi request reprint Adam10 is essential for early embryonic cardiovascular development
    Chi Zhang
    Institute of Developmental Biology and Molecular Medicine, School of Life Sciences, Fudan University, Shanghai, China
    Dev Dyn 239:2594-602. 2010
    ..Finally, we provide experimental evidence to support that Adam10 functions in a cell autonomous manner during mammalian cardiac development...
  24. ncbi request reprint Sodium butyrate ameliorates histone hypoacetylation and neurodegenerative phenotypes in a mouse model for DRPLA
    Mingyao Ying
    Institute of Developmental Biology and Molecular Medicine, Morgan Tan International Center for Life Sciences, Fudan University, Shanghai 200433, China
    J Biol Chem 281:12580-6. 2006
    ....
  25. ncbi request reprint SUN1 is required for telomere attachment to nuclear envelope and gametogenesis in mice
    Xu Ding
    Institute of Developmental Biology and Molecular Medicine and School of Life Science, Fudan University, Shanghai 200433, China
    Dev Cell 12:863-72. 2007
    ..This study provides genetic evidence that SUN1-telomere interaction is essential for telomere dynamic movement and is required for efficient homologous chromosome pairing/synapsis during mammalian gametogenesis...
  26. pmc Inner nuclear envelope proteins SUN1 and SUN2 play a prominent role in the DNA damage response
    Kai Lei
    Institute of Developmental Biology and Molecular Medicine, School of Life Science, Fudan University, Shanghai 200433, China
    Curr Biol 22:1609-15. 2012
    ..SUN1 and SUN2 could affect DDR by localizing certain nuclear factors to the NE or by mediating communication between nuclear and cytoplasmic events...
  27. ncbi request reprint Efficient transposition of the piggyBac (PB) transposon in mammalian cells and mice
    Sheng Ding
    Institute of Developmental Biology and Molecular Medicine, School of Life Sciences, Fudan University, 220 Handan Road, Shanghai 200433, China
    Cell 122:473-83. 2005
    ..These data provide a first and critical step toward a highly efficient transposon system for a variety of genetic manipulations including transgenesis and insertional mutagenesis in mice and other vertebrates...
  28. ncbi request reprint Syne-1 and Syne-2 play crucial roles in myonuclear anchorage and motor neuron innervation
    Xiaochang Zhang
    Institute of Developmental Biology and Molecular Medicine, School of Life Science, Fudan University, Shanghai, 200433, China
    Development 134:901-8. 2007
    ..These results suggest that the KASH-domain-containing proteins Syne-1 and Syne-2 play crucial roles in anchoring both synaptic and non-synaptic myonuclei that are important for proper motor neuron innervation and respiration...
  29. pmc Endothelial SUR-8 acts in an ERK-independent pathway during atrioventricular cushion development
    Jing Yi
    Institute of Developmental Biology and Molecular Medicine, School of Life Sciences, Fudan University, Shanghai, PR China
    Dev Dyn 239:2005-13. 2010
    ..However, ERK activation did not appear to be affected in mutant ECs, suggesting that SUR-8 may act in an ERK-independent pathway to regulate AVC development...
  30. pmc Mst1 and mst2 are essential regulators of trophoblast differentiation and placenta morphogenesis
    Xingrong Du
    State Key Laboratory of Genetic Engineering and National Center for International Research of Development and Disease, Institute of Developmental Biology and Molecular Medicine, School of Life Sciences, Fudan University, Shanghai, China
    PLoS ONE 9:e90701. 2014
    ..Thus, our studies have defined novel roles of Mst1/2 in mouse placental development. ..
  31. pmc A mitotic recombination system for mouse chromosome 17
    Lei Sun
    Institute of Developmental Biology and Molecular Medicine, School of Life Science, Fudan University, Shanghai 200433, China
    Proc Natl Acad Sci U S A 105:4237-41. 2008
    ....
  32. ncbi request reprint Muscle atrophy in transgenic mice expressing a human TSC1 transgene
    Min Wan
    Institute of Developmental Biology and Molecular Medicine, Morgan Tan International Center for Life Sciences, School of Life Sciences, Fudan University, 220 Handan Road, Shanghai 200433, China
    FEBS Lett 580:5621-7. 2006
    ..This study suggests that an increase in the steady state level of resident TSC1-TSC2 complex is sufficient to reduce muscle mass and cause atrophy...
  33. doi request reprint ADAM10 is essential for proteolytic activation of Notch during thymocyte development
    Lei Tian
    Institute of Developmental Biology and Molecular Medicine, School of Life Sciences, Fudan University, Shanghai 200433, China
    Int Immunol 20:1181-7. 2008
    ..Our study demonstrates a T cell intrinsic role for Adam10 in activation of Notch1 during thymocyte development...
  34. pmc Low-copy piggyBac transposon mutagenesis in mice identifies genes driving melanoma
    Thomas K Ni
    Department of Genetics, Howard Hughes Medical Institute, and Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, CT 06510
    Proc Natl Acad Sci U S A 110:E3640-9. 2013
    ....
  35. doi request reprint Histone methyltransferase Ash1l suppresses interleukin-6 production and inflammatory autoimmune diseases by inducing the ubiquitin-editing enzyme A20
    Meng Xia
    Institute of Immunology, Zhejiang University School of Medicine, Hangzhou 310057, China National Key Laboratory of Medical Immunology and Institute of Immunology, Second Military Medical University, Shanghai 200433, China
    Immunity 39:470-81. 2013
    ....
  36. doi request reprint Vps18 deficiency inhibits dendritogenesis in Purkinje cells by blocking the lysosomal degradation of Lysyl Oxidase
    Chao Peng
    Institute of Developmental Biology and Molecular Medicine, Fudan University, Shanghai 200433, China
    Biochem Biophys Res Commun 423:715-20. 2012
    ..Our results suggest that lysosome regulates dendritogenesis of Purkinje cells though degrading Lox...
  37. ncbi request reprint Analyzing the function of tumor suppressor genes using a Drosophila model
    Raymond A Pagliarini
    Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, CT, USA
    Methods Mol Biol 223:349-82. 2003
  38. doi request reprint A cell-intrinsic role for Mst1 in regulating thymocyte egress
    Yongli Dong
    Institute of Developmental Biology and Molecular Medicine, School of Life Science, Fudan University, Shanghai, China
    J Immunol 183:3865-72. 2009
    ..T lineage-specific knockout of the Mst1 gene demonstrates a cell-intrinsic role for Mst1 in regulating T cell development. Our study indicates that Mst1 is crucial in controlling lymphocyte chemotaxis and thymocyte emigration...
  39. ncbi request reprint LATS1 tumour suppressor affects cytokinesis by inhibiting LIMK1
    Xiaolong Yang
    Howard Hughes Medical Institute, and Department of Genetics, Yale University School of Medicine, Boyer Center for Molecular Medicine, 295 Congress Avenue, New Haven, CT 06536 0812, USA
    Nat Cell Biol 6:609-17. 2004
    ..Our findings indicate that LATS1 is a novel cytoskeleton regulator that affects cytokinesis by regulating actin polymerization through negative modulation of LIMK1...
  40. ncbi request reprint The KASH domain protein MSP-300 plays an essential role in nuclear anchoring during Drosophila oogenesis
    Juehua Yu
    Institute of Developmental Biology and Molecular Medicine, Morgan Tan International Center for Life Sciences, School of Life Science, Fudan University, Shanghai, China
    Dev Biol 289:336-45. 2006
    ..These results indicate that maternal MSP-300 plays an important role in actin-dependent nuclear anchorage during cytoplasmic transport...
  41. pmc Dlic1 deficiency impairs ciliogenesis of photoreceptors by destabilizing dynein
    Shanshan Kong
    State Key Laboratory of Genetic Engineering and Institute of Developmental Biology and Molecular Medicine, School of Life Science, Fudan University, Shanghai 200433, China
    Cell Res 23:835-50. 2013
    ..The Dlic1(-/-) mice also provide a new mouse model to study human retinal degeneration...
  42. doi request reprint Mst1/Mst2 regulate development and function of regulatory T cells through modulation of Foxo1/Foxo3 stability in autoimmune disease
    Xingrong Du
    State Key Laboratory of Genetic Engineering and Institute of Developmental Biology and Molecular Medicine, National Center for International Research of Development and Diseases, School of Life Sciences, Fudan University, Shanghai 200433, China
    J Immunol 192:1525-35. 2014
    ....
  43. ncbi request reprint Akt regulates growth by directly phosphorylating Tsc2
    Christopher J Potter
    Howard Hughes Medical Institute, Department of Genetics, Yale University School of Medicine, Boyer Center for Molecular Medicine, 295 Congress Avenue, New Haven, CT 06536 0812, USA
    Nat Cell Biol 4:658-65. 2002
    ..Furthermore, all Akt/PKB growth signals are blocked by expression of a Tsc2 mutant lacking Akt phosphorylation sites. Thus, Tsc2 seems to be the critical target of Akt in mediating growth signals for the insulin signalling pathway...
  44. pmc Generation of Dhx9-deficient clones in T-cell development with a mitotic recombination technique
    Yi Zhu
    Institute of Developmental Biology and Molecular Medicine, School of Life Science, Fudan University, Shanghai, China
    Genesis 50:543-51. 2012
    ..Mosaic analysis revealed a stage-specific role for Dhx9 during T-cell maturation. Thus, the experimental system described in this study offers a practical means for mosaic analysis of germline mutations in the hematopoietic system...
  45. ncbi request reprint A genetic screen for modifiers of the lats tumor suppressor gene identifies C-terminal Src kinase as a regulator of cell proliferation in Drosophila
    Rodney Anderson Stewart
    Department of Genetics, Howard Hughes Medical Institute, Yale University School of Medicine, Boyer Center for Molecular Medicine, 295 Congress Avenue, PO Box 9812, New Haven, CT 06536 0812, USA
    Oncogene 22:6436-44. 2003
    ..Taken together, these results demonstrate a role for dCSK in regulating cell numbers during development by inhibiting cell proliferation and suggest that lats is one of the mediators of the dcsk phenotype...
  46. ncbi request reprint Hypermutability in a Drosophila model for multiple endocrine neoplasia type 1
    Valeria Busygina
    Department of Genetics, Yale University School of Medicine, New Haven, CT 06520 8005, USA
    Hum Mol Genet 13:2399-408. 2004
    ..Our data indicate that Mnn1 is a novel member of the class of autosomal dominant cancer genes that function in maintenance of genomic integrity, similar to the BRCA and HNPCC genes...
  47. ncbi request reprint Ubiquitous expression of mRFP1 in transgenic mice
    Huaxing Zhu
    Institute of Developmental Biology and Molecular Medicine, School of Life Sciences, Fudan University, Shanghai, P R China
    Genesis 42:86-90. 2005
    ..The intensity of mRFP1 signals can be used to distinguish homozygous and heterozygous transgenic mice. Together, these features make mRFP1 an attractive marker for broad applications in transgenic research...
  48. doi request reprint A piggyBac insertion disrupts Foxl2 expression that mimics BPES syndrome in mice
    Fubiao Shi
    State Key Laboratory of Genetic Engineering and National Center for International Research of Development and Disease, Institute of Developmental Biology and Molecular Medicine, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, Shanghai 200433, China
    Hum Mol Genet 23:3792-800. 2014
    ..Therefore, this mutant presents an excellent animal model for mechanistic study of BPES and regulation of Foxl2. ..
  49. pmc Modeling Sjögren's syndrome with Id3 conditional knockout mice
    Zengli Guo
    Institute of Developmental Biology and Molecular Medicine, School of Life Sciences, Fudan University, Shanghai 200433, China
    Immunol Lett 135:34-42. 2011
    ..Our observation provides an experimental case that autoimmune disease may be induced by acquired mutation in developing T cells...
  50. pmc PBmice: an integrated database system of piggyBac (PB) insertional mutations and their characterizations in mice
    Ling V Sun
    Institute of Developmental Biology and Molecular Medicine, School of Life Sciences, Fudan University, Shanghai 200433, Shanghai Center for Bioinformation Technology, Shanghai 200235, China
    Nucleic Acids Res 36:D729-34. 2008
    ..PBmice is freely available at http://www.idmshanghai.cn/PBmice or http://www.scbit.org/PBmice/...
  51. pmc Rhomboid domain-containing protein 3 is a negative regulator of TLR3-triggered natural killer cell activation
    Juan Liu
    National Key Laboratory of Medical Immunology and Institute of Immunology, Second Military Medical University, Shanghai 200433, China
    Proc Natl Acad Sci U S A 110:7814-9. 2013
    ..Our study outlines a mechanism for the negative regulation of NK cell activation and also provides clues for the function of the rhomboid proteins in immunity...
  52. pmc The expanding role of mouse genetics for understanding human biology and disease
    Duc Nguyen
    Howard Hughes Medical Institute, Department of Genetics, Yale University School of Medicine, 295 Congress Avenue, New Haven, CT 06510, USA
    Dis Model Mech 1:56-66. 2008
    ....
  53. doi request reprint Generation of genetically engineered mice by the piggyBac transposon system
    Sheng Ding
    State Key Laboratory of Genetic Engineering and Institute of Developmental Biology and Molecular Medicine, Fudan Yale Biomedical Research Center, School of Life Sciences, Fudan University, Shanghai, 200433, China
    Methods Mol Biol 1194:171-85. 2014
    ..Given that PB can transpose in a broad spectrum of eukaryotic hosts, the protocols described here could be adapted for other species in the future. ..
  54. ncbi request reprint Drosophila atrophin homolog functions as a transcriptional corepressor in multiple developmental processes
    Sheng Zhang
    Howard Hughes Medical Institute, Department of Genetics, Yale University School of Medicine, 295 Congress Avenue, New Haven, CT 06535, USA
    Cell 108:45-56. 2002
    ..We propose that Atrophin proteins function as versatile transcriptional corepressors and discuss a model that deregulation of transcription may contribute to the pathogenesis of neurodegeneration...
  55. ncbi request reprint Karyotype-phenotype insights from 11q14.1-q23.2 interstitial deletions: FZD4 haploinsufficiency and exudative vitreoretinopathy in a patient with a complex chromosome rearrangement
    Peining Li
    Department of Genetics, Yale University School of Medicine, New Haven, Connecticut, USA
    Am J Med Genet A 140:2721-9. 2006
    ..These results provide insight into karyotype-phenotype correlations and prompt a rational analytic approach to cases with interstitial deletions of the 11q14-q23 region...