Mario Strazzabosco

Summary

Affiliation: Yale University
Country: USA

Publications

  1. pmc Development of the bile ducts: essentials for the clinical hepatologist
    Mario Strazzabosco
    Section of Digestive Diseases, Yale University, New Haven, CT, USA
    J Hepatol 56:1159-70. 2012
  2. pmc Differentially expressed adenylyl cyclase isoforms mediate secretory functions in cholangiocyte subpopulation
    Mario Strazzabosco
    Section of Digestive Diseases, Department of Internal Medicine, Yale University School of Medicine and Liver Center, New Haven, CT 06520, USA
    Hepatology 50:244-52. 2009
  3. pmc Functional anatomy of normal bile ducts
    Mario Strazzabosco
    Department of Internal Medicine, Yale University, New Haven 06504, Connecticut, USA
    Anat Rec (Hoboken) 291:653-60. 2008
  4. pmc Foxa1 and Foxa2 regulate bile duct development in mice
    Mario Strazzabosco
    Liver Center and Department of Internal Medicine, Yale University, USA
    J Hepatol 52:765-7. 2010
  5. pmc Polycystic liver diseases: congenital disorders of cholangiocyte signaling
    Mario Strazzabosco
    Liver Center and Section of Digestive Diseases, Department of Internal Medicine, School of Medicine, Yale University, New Haven, Connecticut 06520, USA
    Gastroenterology 140:1855-9, 1859.e1. 2011
  6. pmc Cyclic AMP/PKA-dependent paradoxical activation of Raf/MEK/ERK signaling in polycystin-2 defective mice treated with sorafenib
    Carlo Spirli
    Liver Center and Section of Digestive Diseases, Department of Internal Medicine, Yale University, New Haven, CT 06520, USA
    Hepatology 56:2363-74. 2012
  7. pmc Mammalian target of rapamycin regulates vascular endothelial growth factor-dependent liver cyst growth in polycystin-2-defective mice
    Carlo Spirli
    Section of Digestive Diseases, Department of Internal Medicine, Yale University, New Haven, CT 06520, USA
    Hepatology 51:1778-88. 2010
  8. pmc Altered store operated calcium entry increases cyclic 3',5'-adenosine monophosphate production and extracellular signal-regulated kinases 1 and 2 phosphorylation in polycystin-2-defective cholangiocytes
    Carlo Spirli
    Department of Internal Medicine, Liver Center and Digestive Diseases Section, Yale University, New Haven, CT 06520, USA
    Hepatology 55:856-68. 2012
  9. pmc ERK1/2-dependent vascular endothelial growth factor signaling sustains cyst growth in polycystin-2 defective mice
    Carlo Spirli
    Section of Digestive Diseases, Department of Internal Medicine, Yale University, New Haven, Connecticut 06520, USA
    Gastroenterology 138:360-371.e7. 2010
  10. pmc Loss of CFTR affects biliary epithelium innate immunity and causes TLR4-NF-κB-mediated inflammatory response in mice
    Romina Fiorotto
    Section of Digestive Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Gastroenterology 141:1498-508, 1508.e1-5. 2011

Collaborators

  • Gianfranco Alpini
  • Tullio Pozzan
  • Heather Francis
  • Michael Trauner
  • Jason N Rogart
  • Shannon S Glaser
  • T Roskams
  • L Libbrecht
  • E Gaudio
  • D Alvaro
  • Fabio Marra
  • E Ierardi
  • James M Neuberger
  • Alberto Grassi
  • Maria Guido
  • Carlo Spirli
  • Romina Fiorotto
  • Luca Fabris
  • Massimiliano Cadamuro
  • Roberto Scirpo
  • Ambra Villani
  • Lajos Okolicsanyi
  • Carola M Morell
  • Luigi Locatelli
  • Aurelio Sonzogni
  • Stefano Okolicsanyi
  • Saida Melero
  • Valeria Mariotti
  • Mariangela Amenduni
  • Stefan Somlo
  • Silvia Lecchi
  • Xin Tian
  • Giorgio Ballardini
  • Marzia Montalbano
  • Michele Colledan
  • Ruth E Joplin
  • Michele Barone
  • Antonis Kourtidis
  • Panos Z Anastasiadis
  • Simone Brivio
  • Peter J Geibel
  • Elena Duner
  • Barbara Torsello
  • Stuart D Morton
  • Aileen Raizner
  • Amy K Kim
  • Cecilia Ferrero
  • Rafaz Hoque
  • Frederic Lemaigre
  • Peggy Raynaud
  • Giuseppe Remuzzi
  • Daniele Alberti
  • Luisa Pasulo
  • Giuliano Torre
  • Loretta Rocchi
  • Marina de Bernard
  • Maria Pia Vairetti
  • Sara Masier
  • Joseph Santos-Sacchi
  • Lei Song
  • Alfredo Di Leo
  • Anna Maria Valentini
  • Eugenio Maiorano
  • Roberta Ladisa
  • Maria Lucia Caruso
  • Antonio Francavilla
  • Pasquale Berloco
  • Antonia Pece
  • Nicholas F Larusso
  • Paolo Groff
  • Juan F Medina
  • Daniela Zauli
  • Antonino Cavallari
  • Francesco Bianco Bianchi
  • Sabrina Ghetti
  • Jesus Prieto
  • Emilio De Raffele
  • Gianluca Grazi
  • Roberto Bellusci
  • Akos Zsembery
  • Micaela Susca
  • Rosa Maria Iemmolo
  • Massimo Zuin
  • Paulette Bioulac-Sage

Detail Information

Publications30

  1. pmc Development of the bile ducts: essentials for the clinical hepatologist
    Mario Strazzabosco
    Section of Digestive Diseases, Yale University, New Haven, CT, USA
    J Hepatol 56:1159-70. 2012
    ..Finally, we discuss the pathogenic aspects of the most important primary cholangiopathies related to altered biliary development, i.e. polycystic and fibropolycystic liver diseases, Alagille syndrome...
  2. pmc Differentially expressed adenylyl cyclase isoforms mediate secretory functions in cholangiocyte subpopulation
    Mario Strazzabosco
    Section of Digestive Diseases, Department of Internal Medicine, Yale University School of Medicine and Liver Center, New Haven, CT 06520, USA
    Hepatology 50:244-52. 2009
    ..Treatment with lipopolysaccharide or alpha-naphthylisothiocyanate increased expression of AC7 and sAC but decreased expression of the other ACs...
  3. pmc Functional anatomy of normal bile ducts
    Mario Strazzabosco
    Department of Internal Medicine, Yale University, New Haven 06504, Connecticut, USA
    Anat Rec (Hoboken) 291:653-60. 2008
    ..Functional interactions with other branching systems, such as nerve and vascular structures, are crucial in the modulation of the different cholangiocyte functions...
  4. pmc Foxa1 and Foxa2 regulate bile duct development in mice
    Mario Strazzabosco
    Liver Center and Department of Internal Medicine, Yale University, USA
    J Hepatol 52:765-7. 2010
    ..Our data suggest that Foxa1/2 function as terminators of bile duct expansion in the adult liver through inhibition of IL-6 expression...
  5. pmc Polycystic liver diseases: congenital disorders of cholangiocyte signaling
    Mario Strazzabosco
    Liver Center and Section of Digestive Diseases, Department of Internal Medicine, School of Medicine, Yale University, New Haven, Connecticut 06520, USA
    Gastroenterology 140:1855-9, 1859.e1. 2011
    ..Each pathway represents a potential target for therapies aimed at reducing disease progression...
  6. pmc Cyclic AMP/PKA-dependent paradoxical activation of Raf/MEK/ERK signaling in polycystin-2 defective mice treated with sorafenib
    Carlo Spirli
    Liver Center and Section of Digestive Diseases, Department of Internal Medicine, Yale University, New Haven, CT 06520, USA
    Hepatology 56:2363-74. 2012
    ....
  7. pmc Mammalian target of rapamycin regulates vascular endothelial growth factor-dependent liver cyst growth in polycystin-2-defective mice
    Carlo Spirli
    Section of Digestive Diseases, Department of Internal Medicine, Yale University, New Haven, CT 06520, USA
    Hepatology 51:1778-88. 2010
    ..Phosphorylation of the mTOR-dependent kinase P70S6K was significantly reduced by PKA inhibitor 14-22 amide and by the mitogen signal-regulated kinase inhibitor U1026...
  8. pmc Altered store operated calcium entry increases cyclic 3',5'-adenosine monophosphate production and extracellular signal-regulated kinases 1 and 2 phosphorylation in polycystin-2-defective cholangiocytes
    Carlo Spirli
    Department of Internal Medicine, Liver Center and Digestive Diseases Section, Yale University, New Haven, CT 06520, USA
    Hepatology 55:856-68. 2012
    ..g., the Orai1 channel) are unchanged. In Pkd2KO cells, ER-Ca(2+) depletion increases cAMP and PKA-dependent ERK1/2 activation and both are inhibited by STIM1 inhibitors or by silencing of adenylyl cyclase type 6 (AC6)...
  9. pmc ERK1/2-dependent vascular endothelial growth factor signaling sustains cyst growth in polycystin-2 defective mice
    Carlo Spirli
    Section of Digestive Diseases, Department of Internal Medicine, Yale University, New Haven, Connecticut 06520, USA
    Gastroenterology 138:360-371.e7. 2010
    ..We investigated the effects of VEGF on liver cyst growth and autocrine VEGF signaling in mice with Pkd1 and Pkd2 conditional knockouts...
  10. pmc Loss of CFTR affects biliary epithelium innate immunity and causes TLR4-NF-κB-mediated inflammatory response in mice
    Romina Fiorotto
    Section of Digestive Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Gastroenterology 141:1498-508, 1508.e1-5. 2011
    ..We studied the effects of CFTR deficiency on Toll-like receptor 4 (TLR4)-mediated responses of the biliary epithelium to endotoxins...
  11. pmc Protein kinase A-dependent pSer(675) -β-catenin, a novel signaling defect in a mouse model of congenital hepatic fibrosis
    Carlo Spirli
    Liver Center and Section of Digestive Diseases, Department of Internal Medicine, Yale University, New Haven, CT, USA
    Hepatology 58:1713-23. 2013
    ..Cell migration (Boyden chambers) was significantly higher in cholangiocytes obtained from Pkhd1(del4/del4) and was inhibited by: (1) PKI, (2) silencing β-catenin (siRNA), and (3) the Rac-1 inhibitor NSC 23766...
  12. pmc Notch signaling regulates tubular morphogenesis during repair from biliary damage in mice
    Romina Fiorotto
    Liver Center and Section of Digestive Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    J Hepatol 59:124-30. 2013
    ..We hypothesized that the morphogenetic role of Notch signaling is maintained during the repair process and have addressed this hypothesis using pharmacologic and genetic models of defective Notch signaling...
  13. pmc The cystic fibrosis transmembrane conductance regulator controls biliary epithelial inflammation and permeability by regulating Src tyrosine kinase activity
    Romina Fiorotto
    Section of Digestive Diseases, Liver Center, Yale University, New Haven, CT
    Hepatology 64:2118-2134. 2016
    ....
  14. doi request reprint Adenylyl Cyclase 5 links changes in calcium homeostasis to cAMP-dependent cyst growth in Polycystic Liver Disease
    Carlo Spirli
    Section of Digestive Diseases, Yale University, New Haven, Connecticut, USA
    J Hepatol . 2016
    ....
  15. pmc Posttranslational regulation of polycystin-2 protein expression as a novel mechanism of cholangiocyte reaction and repair from biliary damage
    Carlo Spirli
    Section of Digestive Diseases, Yale University, New Haven, CT
    Hepatology 62:1828-39. 2015
    ..Treatment of 3,5-diethoxycarbonyl-1,4-dihydrocollidine mice and of Mdr2(-/-) mice with the proteasome inhibitor bortezomib restored PC2 expression and significantly reduced the ductular reaction, fibrosis, and phosphorylated ERK1/2...
  16. pmc Type I autoimmune hepatitis presenting with acute liver failure in the setting of wild mushroom ingestion
    Jason N Rogart
    Department of Medicine, Section of Digestive, Yale University School of Medicine, New Haven, CT 06520 8019
    J Clin Gastroenterol 42:662-6. 2008
    ..Here, we report the unusual case of a woman in her seventh decade who presented with acute liver failure as her initial manifestation of autoimmune hepatitis, and who had been a long-time ingestor of hand-picked, wild mushrooms...
  17. pmc Stimulation of nuclear receptor peroxisome proliferator-activated receptor-γ limits NF-κB-dependent inflammation in mouse cystic fibrosis biliary epithelium
    Roberto Scirpo
    Section of Digestive Diseases, Liver Center, Yale University, New Haven, CT
    Hepatology 62:1551-62. 2015
    ..Stimulation of PPAR-γ in vivo (rosiglitazone) significantly attenuates biliary damage and inflammation in Cftr-knockout mice exposed to a dextran sodium sulfate-induced portal endotoxemia...
  18. pmc Revisiting Epithelial-to-Mesenchymal Transition in Liver Fibrosis: Clues for a Better Understanding of the "Reactive" Biliary Epithelial Phenotype
    Luca Fabris
    Department of Molecular Medicine, University of Padua School of Medicine, Viale G Colombo 3, 35131 Padua, Italy Liver Center, Section of Digestive Diseases, Yale University, TAC Building, 333 Cedar Street, New Haven, CT 06520, USA
    Stem Cells Int 2016:2953727. 2016
    ..Understanding microenvironmental cues and signaling perturbations promoting these changes in DRC may help to identify potential targets for new antifibrotic therapies in cholangiopathies. ..
  19. ncbi request reprint Ursodeoxycholic acid stimulates cholangiocyte fluid secretion in mice via CFTR-dependent ATP secretion
    Romina Fiorotto
    Department of Internal Medicine, Section of Digestive Diseases, Yale University School of Medicine and Liver Center, New Haven, Connecticut, USA
    Gastroenterology 133:1603-13. 2007
    ..Ursodeoxycholic acid (UDCA) is widely used for cholangiopathy treatment, but its effects on cholangiocyte secretory functions remain unclear and are the subject of this study...
  20. ncbi request reprint Epithelial expression of angiogenic growth factors modulate arterial vasculogenesis in human liver development
    Luca Fabris
    CeLiveR, Center for Liver Research, Ospedali Riuniti di Bergamo, Bergamo, Italy
    Hepatology 47:719-28. 2008
    ..In early postnatal Hnf6(-/-) mice, VEGF-expressing ductal plates failed to incorporate into the portal mesenchyma, resulting in severely altered arterial vasculogenesis...
  21. ncbi request reprint Defective regulation of cholangiocyte Cl-/HCO3(-) and Na+/H+ exchanger activities in primary biliary cirrhosis
    Saida Melero
    Division of Hepatology and Gene Therapy, University of Navarra, Pamplona, Spain
    Hepatology 35:1513-21. 2002
    ....
  22. ncbi request reprint Cytokine-stimulated nitric oxide production inhibits adenylyl cyclase and cAMP-dependent secretion in cholangiocytes
    Carlo Spirli
    Department of Medical and Surgical Sciences, University of Padova, Italy
    Gastroenterology 124:737-53. 2003
    ..The biliary epithelium is involved both in bile production and in the inflammatory/reparative response to liver damage. Recent data indicate that inflammatory aggression to intrahepatic bile ducts results in chronic progressive cholestasis...
  23. ncbi request reprint Ursodeoxycholate further increases bile-duct cell proliferative response induced by partial bile-duct ligation in rats
    Michele Barone
    Section of Gastroenterology, D E T O, University of Bari, Italy
    Virchows Arch 444:554-60. 2004
    ....
  24. ncbi request reprint Glibenclamide stimulates fluid secretion in rodent cholangiocytes through a cystic fibrosis transmembrane conductance regulator-independent mechanism
    Carlo Spirli
    Department of Meidcal and Surgical Sciences, University of Padova, Italy
    Gastroenterology 129:220-33. 2005
    ..We studied the molecular mechanisms underlying this effect and whether glibenclamide could restore cholangiocyte secretion in cystic fibrosis...
  25. pmc Thiazolidinedione treatment inhibits bile duct proliferation and fibrosis in a rat model of chronic cholestasis
    Fabio Marra
    Dipartimento di Medicina Interna, University of Florence, Viale Morgagni 85, Florence I 50134, Italy
    World J Gastroenterol 11:4931-8. 2005
    ....
  26. ncbi request reprint Effects of angiogenic factor overexpression by human and rodent cholangiocytes in polycystic liver diseases
    Luca Fabris
    Center for Liver Research, Gastroenterology Division, Ospedali Riuniti, Bergamo, Italy
    Hepatology 43:1001-12. 2006
    ..Supplementary material for this article can be found on the HEPATOLOGY website (http://interscience.wiley.com/jpages/0270-9139/suppmat/index.html)...
  27. ncbi request reprint Treatment with pegylated interferon and ribavirin for hepatitis C virus-associated severe cryoglobulinemia in a liver/kidney transplant recipient
    Marzia Montalbano
    Section of Gastroenterology and CeLiverR, Ospedali Riuniti di Bergamo, Bergamo, Italy
    J Clin Gastroenterol 41:216-20. 2007
    ..Treatment with pegylated-IFN-alpha2b and RBV for 12 months cured the cryoglobulinemic vasculitis and allowed the sustained eradication of HCV with no significant changes in kidney function...
  28. pmc Analysis of liver repair mechanisms in Alagille syndrome and biliary atresia reveals a role for notch signaling
    Luca Fabris
    CeLiveR, Gastroenterology and Liver Transplant Unit, Ospedali Riuniti di Bergamo, Bergamo, Italy
    Am J Pathol 171:641-53. 2007
    ....
  29. pmc Morphological and functional features of hepatic cyst epithelium in autosomal dominant polycystic kidney disease
    Domenico Alvaro
    Department of Clinical Medicine, University of Rome Sapienza, via R Rossellini 51, 00137 Rome, Italy
    Am J Pathol 172:321-32. 2008
    ..Our findings could explain the role of estrogens in accelerating the progression of ADPKD and may suggest a potential benefit of therapeutic strategies based on estrogen antagonism...
  30. ncbi request reprint Timing of reinfection and mechanisms of hepatocellular damage in transplanted hepatitis C virus-reinfected liver
    Giorgio Ballardini
    Department of Internal Medicine, Azienda Ospedaliera and University of Bologna, Bologna, Italy
    Liver Transpl 8:10-20. 2002
    ....