Affiliation: Yale University
- Roles of microRNAs and their targets in cancerGiovanni Stefani
Yale University, Department of Molecular, Cellular and Developmental Biology, 266 Whitney Avenue, New Haven, CT 06520, USA
Expert Opin Biol Ther 7:1833-40. 2007..Furthermore, the variations in the abundance of miRNAs in different tissues and cancers offer a specific 'signature' that can be useful in diagnosis...
- Small non-coding RNAs in animal developmentGiovanni Stefani
Department of Molecular, Cellular and Developmental Biology, Yale University, 266 Whitney Avenue, New Haven, Connecticut 06520, USA
Nat Rev Mol Cell Biol 9:219-30. 2008..These studies show that miRNAs are key regulators of animal development and are potential human disease loci...
- A novel mechanism of LIN-28 regulation of let-7 microRNA expression revealed by in vivo HITS-CLIP in C. elegansGiovanni Stefani
Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, Connecticut 06405, USA Centre for Integrative Biology CIBIO, University of Trento, 38123 Povo Tn, Italy
RNA 21:985-96. 2015..Furthermore, our data show that LIN-28 regulates the expression of the let-7 microRNA by binding its primary transcript in a previously unknown region, revealing a novel regulatory mechanism. ..
- The let-7 microRNA target gene, Mlin41/Trim71 is required for mouse embryonic survival and neural tube closureBetsy R Maller Schulman
Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, Connecticut, USA
Cell Cycle 7:3935-42. 2008..Since Mlin41 is required for neural tube closure and survival it points to human lin-41 (HLIN41/TRIM71) as a potential human development and disease gene...
- Characterization of Xenopus Phox2a and Phox2b defines expression domains within the embryonic nervous system and early heart fieldMarja Talikka
Laboratory of Developmental Neurobiology, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
Gene Expr Patterns 4:601-7. 2004....
- Fragile X mental retardation protein is associated with translating polyribosomes in neuronal cellsGiovanni Stefani
Howard Hughes Medical Institute and Laboratory of Molecular Neuro Oncology, The Rockefeller University, New York, New York 10021, USA
J Neurosci 24:7272-6. 2004..These data indicate that FMRP associates with functional polyribosomes in neurons...
- Nova autoregulation reveals dual functions in neuronal splicingB Kate Dredge
Laboratory of Molecular Neuro Oncology, Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10021, USA
EMBO J 24:1608-20. 2005..These studies demonstrate that in addition to its previously described role as a splicing activator, Nova autoregulates its own expression by acting as a splicing repressor...
- The let-7 microRNA represses cell proliferation pathways in human cellsCharles D Johnson
Asuragen, Inc, Texas, USA
Cancer Res 67:7713-22. 2007..This work reveals the let-7 microRNA to be a master regulator of cell proliferation pathways...