Steven G Shimada

Summary

Affiliation: Yale University
Country: USA

Publications

  1. ncbi request reprint Scratching behavior in mice induced by the proteinase-activated receptor-2 agonist, SLIGRL-NH2
    Steven G Shimada
    Department of Anesthesiology, Yale University School of Medicine, P O Box 208051, 333 Cedar Street, New Haven, CT 06520 8051, USA
    Eur J Pharmacol 530:281-3. 2006
  2. pmc Behavioral differentiation between itch and pain in mouse
    Steven G Shimada
    Department of Anesthesiology, Yale University School of Medicine, New Haven, Connecticut 06520 8051, USA
    Pain 139:681-7. 2008
  3. pmc Chronic Compression of the Dorsal Root Ganglion Enhances Mechanically Evoked Pain Behavior and the Activity of Cutaneous Nociceptors in Mice
    Tao Wang
    Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Neuroscience Center, Department of Anatomy, Histology and Embryology, Beijing, China Department of Anesthesiology, Yale University School of Medicine, New Haven, Connecticut, United States of America
    PLoS ONE 10:e0137512. 2015
  4. pmc Enhanced excitability of MRGPRA3- and MRGPRD-positive nociceptors in a model of inflammatory itch and pain
    Lintao Qu
    1 Department of Anaesthesiology, Yale University School of Medicine, New Haven, CT, 06520, USA
    Brain 137:1039-50. 2014
  5. pmc Sensory responses to injection and punctate application of capsaicin and histamine to the skin
    Parul Sikand
    Department of Anesthesiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Pain 152:2485-94. 2011
  6. pmc Similar itch and nociceptive sensations evoked by punctate cutaneous application of capsaicin, histamine and cowhage
    Parul Sikand
    Department of Anesthesiology, Yale University School of Medicine, P O Box 208051, 333 Cedar Street, New Haven, CT 06520 8051, USA
    Pain 144:66-75. 2009
  7. pmc Mouse models of acute, chemical itch and pain in humans
    Robert H LaMotte
    Department of Anesthesiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Exp Dermatol 20:778-82. 2011
  8. pmc CXCR3 chemokine receptor signaling mediates itch in experimental allergic contact dermatitis
    Lintao Qu
    aDepartment of Anesthesiology, Yale University School of Medicine, New Haven, CT, USA bDepartment of Neurosurgery, Neurosurgery Pain Research Institute, Johns Hopkins School of Medicine, Baltimore, MD, USA cDepartment of Genetics, Yale University School of Medicine, New Haven, CT, USA
    Pain 156:1737-46. 2015
  9. pmc Enhanced scratching elicited by a pruritogen and an algogen in a mouse model of contact hypersensitivity
    Kai Fu
    Department of Anesthesiology, Yale University School of Medicine, New Haven, CT 06520, USA Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou 510632, Guangdong, China
    Neurosci Lett 579:190-4. 2014

Collaborators

  • Chao Ma
  • Tao Wang
  • Robert H LaMotte
  • Lintao Qu
  • Parul Sikand
  • Kai Fu
  • Barry G Green
  • Jennifer Yang
  • Hong Nie
  • Yingdi Wang
  • Xinzhong Dong
  • Ni Fan
  • Liang Han

Detail Information

Publications9

  1. ncbi request reprint Scratching behavior in mice induced by the proteinase-activated receptor-2 agonist, SLIGRL-NH2
    Steven G Shimada
    Department of Anesthesiology, Yale University School of Medicine, P O Box 208051, 333 Cedar Street, New Haven, CT 06520 8051, USA
    Eur J Pharmacol 530:281-3. 2006
    ..Pretreatment of animals with a histamine H1 receptor antagonist, pyrilamine, blocked histamine induced scratching, but it had little effect on SLIGRL scratching. Our study suggests that PAR2 mediates histamine independent itch...
  2. pmc Behavioral differentiation between itch and pain in mouse
    Steven G Shimada
    Department of Anesthesiology, Yale University School of Medicine, New Haven, Connecticut 06520 8051, USA
    Pain 139:681-7. 2008
    ..That is, the model provides a behavioral differentiation between itch and pain in the mouse...
  3. pmc Chronic Compression of the Dorsal Root Ganglion Enhances Mechanically Evoked Pain Behavior and the Activity of Cutaneous Nociceptors in Mice
    Tao Wang
    Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Neuroscience Center, Department of Anatomy, Histology and Embryology, Beijing, China Department of Anesthesiology, Yale University School of Medicine, New Haven, Connecticut, United States of America
    PLoS ONE 10:e0137512. 2015
    ..We conclude that CCD produced both a behavioral hyperalgesia and an enhanced response of cutaneous C-nociceptors to aversive punctate mechanical stimuli. ..
  4. pmc Enhanced excitability of MRGPRA3- and MRGPRD-positive nociceptors in a model of inflammatory itch and pain
    Lintao Qu
    1 Department of Anaesthesiology, Yale University School of Medicine, New Haven, CT, 06520, USA
    Brain 137:1039-50. 2014
    ....
  5. pmc Sensory responses to injection and punctate application of capsaicin and histamine to the skin
    Parul Sikand
    Department of Anesthesiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Pain 152:2485-94. 2011
    ....
  6. pmc Similar itch and nociceptive sensations evoked by punctate cutaneous application of capsaicin, histamine and cowhage
    Parul Sikand
    Department of Anesthesiology, Yale University School of Medicine, P O Box 208051, 333 Cedar Street, New Haven, CT 06520 8051, USA
    Pain 144:66-75. 2009
    ..These results suggest the possibility that capsaicin, histamine and cowhage activate common peripheral or central neural mechanisms that mediate pruritic sensations and associated dysesthesias...
  7. pmc Mouse models of acute, chemical itch and pain in humans
    Robert H LaMotte
    Department of Anesthesiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Exp Dermatol 20:778-82. 2011
    ..Here, we review to what extent mice behaviourally differentiate chemicals that elicit itch versus pain in humans...
  8. pmc CXCR3 chemokine receptor signaling mediates itch in experimental allergic contact dermatitis
    Lintao Qu
    aDepartment of Anesthesiology, Yale University School of Medicine, New Haven, CT, USA bDepartment of Neurosurgery, Neurosurgery Pain Research Institute, Johns Hopkins School of Medicine, Baltimore, MD, USA cDepartment of Genetics, Yale University School of Medicine, New Haven, CT, USA
    Pain 156:1737-46. 2015
    ..Thus, upregulation of CXCL10/CXCR3 signaling in sensory neurons may contribute to itch associated with ACD. Targeting the CXCL10/CXCR3 signaling might be beneficial for the treatment of allergic itch. ..
  9. pmc Enhanced scratching elicited by a pruritogen and an algogen in a mouse model of contact hypersensitivity
    Kai Fu
    Department of Anesthesiology, Yale University School of Medicine, New Haven, CT 06520, USA Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou 510632, Guangdong, China
    Neurosci Lett 579:190-4. 2014
    ..Thus, within an area of CHS, histamine-independent itch is enhanced and chemically evoked pain is accompanied by itch. ..