Xingguang Luo

Summary

Affiliation: Yale University
Country: USA

Publications

  1. pmc Personality traits of agreeableness and extraversion are associated with ADH4 variation
    Xingguang Luo
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
    Biol Psychiatry 61:599-608. 2007
  2. pmc Multiple OPR genes influence personality traits in substance dependent and healthy subjects in two American populations
    Xingguang Luo
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06516, USA
    Am J Med Genet B Neuropsychiatr Genet 147:1028-39. 2008
  3. pmc ADH7 variation modulates extraversion and conscientiousness in substance-dependent subjects
    Xingguang Luo
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
    Am J Med Genet B Neuropsychiatr Genet 147:179-86. 2008
  4. pmc Multiple ADH genes modulate risk for drug dependence in both African- and European-Americans
    Xingguang Luo
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06516, USA
    Hum Mol Genet 16:380-90. 2007
  5. pmc Haplotypic variants in DRD2, ANKK1, TTC12, and NCAM1 are associated with comorbid alcohol and drug dependence
    Bao zhu Yang
    Department of Psychiatry, Division of Human Genetics, Yale University School of Medicine, New Haven, Connecticut 06516, USA
    Alcohol Clin Exp Res 32:2117-27. 2008
  6. pmc Association between common alcohol dehydrogenase gene (ADH) variants and schizophrenia and autism
    Lingjun Zuo
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06516, USA
    Hum Genet 132:735-43. 2013
  7. pmc Genome-wide search for replicable risk gene regions in alcohol and nicotine co-dependence
    Lingjun Zuo
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Am J Med Genet B Neuropsychiatr Genet 159:437-44. 2012
  8. ncbi request reprint Mutation screen of the GAD2 gene and association study of alcoholism in three populations
    Jaakko Lappalainen
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
    Am J Med Genet B Neuropsychiatr Genet 144:183-92. 2007
  9. pmc ADH1A variation predisposes to personality traits and substance dependence
    Lingjun Zuo
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06516, USA
    Am J Med Genet B Neuropsychiatr Genet 153:376-86. 2010
  10. ncbi request reprint ADH4 gene variation is associated with alcohol dependence and drug dependence in European Americans: results from HWD tests and case-control association studies
    Xingguang Luo
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06516, USA
    Neuropsychopharmacology 31:1085-95. 2006

Detail Information

Publications50

  1. pmc Personality traits of agreeableness and extraversion are associated with ADH4 variation
    Xingguang Luo
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
    Biol Psychiatry 61:599-608. 2007
    ..Strong associations between ADH4 variation and SD have been reported. We aimed to investigate the relationship between ADH4 variation and personality traits in the present study...
  2. pmc Multiple OPR genes influence personality traits in substance dependent and healthy subjects in two American populations
    Xingguang Luo
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06516, USA
    Am J Med Genet B Neuropsychiatr Genet 147:1028-39. 2008
    ..Further, the three OPR genes have significant interaction effects on personality traits. This work provides additional evidence that personality traits and SD have a partially overlapping genetic basis...
  3. pmc ADH7 variation modulates extraversion and conscientiousness in substance-dependent subjects
    Xingguang Luo
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
    Am J Med Genet B Neuropsychiatr Genet 147:179-86. 2008
    ..The present study demonstrated that the ADH7 variation may contribute to the genetic component of variation in personality traits, with the risk for SD and personality traits being partially shared...
  4. pmc Multiple ADH genes modulate risk for drug dependence in both African- and European-Americans
    Xingguang Luo
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06516, USA
    Hum Mol Genet 16:380-90. 2007
    ..These findings, obtained using a series of powerful and reliable analytic methods, may also help to explain the high rate of co-morbidity between AD and DD...
  5. pmc Haplotypic variants in DRD2, ANKK1, TTC12, and NCAM1 are associated with comorbid alcohol and drug dependence
    Bao zhu Yang
    Department of Psychiatry, Division of Human Genetics, Yale University School of Medicine, New Haven, Connecticut 06516, USA
    Alcohol Clin Exp Res 32:2117-27. 2008
    ..Because comorbid AD with DD (AD+DD) is common, we hypothesized that heterogeneity of the SD diagnoses studied might have contributed to the inconsistency of prior results...
  6. pmc Association between common alcohol dehydrogenase gene (ADH) variants and schizophrenia and autism
    Lingjun Zuo
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06516, USA
    Hum Genet 132:735-43. 2013
    ..We concluded that common ADH variants conferred risk for both schizophrenia in African-Americans and autism in European-Americans...
  7. pmc Genome-wide search for replicable risk gene regions in alcohol and nicotine co-dependence
    Lingjun Zuo
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Am J Med Genet B Neuropsychiatr Genet 159:437-44. 2012
    ..We concluded that the SH3BP5-NR2C2 region on Chromosome 3 might harbor causal loci for alcohol and nicotine co-dependence...
  8. ncbi request reprint Mutation screen of the GAD2 gene and association study of alcoholism in three populations
    Jaakko Lappalainen
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
    Am J Med Genet B Neuropsychiatr Genet 144:183-92. 2007
    ..The functional promoter GAD2 -243 A > G variant may influence risk for AD in some populations, or its role may be limited to susceptibility to severe AD...
  9. pmc ADH1A variation predisposes to personality traits and substance dependence
    Lingjun Zuo
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06516, USA
    Am J Med Genet B Neuropsychiatr Genet 153:376-86. 2010
    ..008 <or= P <or= 0.060). The present study demonstrates that the ADH1A variation may contribute to the genetic component of variation in personality traits and SD...
  10. ncbi request reprint ADH4 gene variation is associated with alcohol dependence and drug dependence in European Americans: results from HWD tests and case-control association studies
    Xingguang Luo
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06516, USA
    Neuropsychopharmacology 31:1085-95. 2006
    ..SNP2 or SNP6 was the marker genetically closest to the functional risk loci for both alcohol dependence and drug dependence...
  11. ncbi request reprint CHRM2 variation predisposes to personality traits of agreeableness and conscientiousness
    Xingguang Luo
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Hum Mol Genet 16:1557-68. 2007
    ..002). CHRM2 variation may contribute to the genetic component of variation in personality traits. Personality traits might substantially underlie the heritable component of SD...
  12. pmc Interaction between two independent CNR1 variants increases risk for cocaine dependence in European Americans: a replication study in family-based sample and population-based sample
    Lingjun Zuo
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Neuropsychopharmacology 34:1504-13. 2009
    ..019). We conclude that two independent CNR1 variants have significant interaction effects on risk for CD in EAs; they may also have effects on risk for CD in AAs...
  13. pmc Genome-wide significant association signals in IPO11-HTR1A region specific for alcohol and nicotine codependence
    Lingjun Zuo
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06511, USA
    Alcohol Clin Exp Res 37:730-9. 2013
    ..Alcohol and nicotine codependence can be considered as a more severe subtype of alcohol dependence. A portion of its risk may be attributable to genetic factors...
  14. pmc Association study of DTNBP1 with schizophrenia in a US sample
    Lingjun Zuo
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06516, USA
    Psychiatr Genet 19:292-304. 2009
    ..This study aimed to test the association in two common US populations by using powerful analytic methods...
  15. pmc Genome-wide association study of alcohol dependence implicates KIAA0040 on chromosome 1q
    Lingjun Zuo
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06516, USA
    Neuropsychopharmacology 37:557-66. 2012
    ..TNN is involved in neurite outgrowth and cell migration in hippocampal explants, and TNR is an extracellular matrix protein expressed primarily in the central nervous system...
  16. ncbi request reprint ADH4 gene variation is associated with alcohol and drug dependence: results from family controlled and population-structured association studies
    Xingguang Luo
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
    Pharmacogenet Genomics 15:755-68. 2005
    ..Using rigorous study designs that account for possible population stratification, these findings confirm and extend our original observations indicating that variation at ADH4 predisposes to alcohol and drug dependence...
  17. ncbi request reprint CNR1 variation modulates risk for drug and alcohol dependence
    Lingjun Zuo
    Department of Psychiatry, Yale University School of Medicine, 950 Campbell Avenue, New Haven, CT 06516, USA
    Biol Psychiatry 62:616-26. 2007
    ..Following initial reports of association of CNR1 with SD, we studied multiple markers at this locus in a large case-control sample...
  18. pmc Rare ADH variant constellations are specific for alcohol dependence
    Lingjun Zuo
    Department of Psychiatry, Yale University School of Medicine, West Haven, CT 06516, USA
    Alcohol Alcohol 48:9-14. 2013
    ..In the present study, we comprehensively examined the associations between rare ADH variants [minor allele frequency (MAF) <0.05] and alcohol dependence, with several other neuropsychiatric and neurological disorders as reference...
  19. pmc Association between two mu-opioid receptor gene (OPRM1) haplotype blocks and drug or alcohol dependence
    Huiping Zhang
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Hum Mol Genet 15:807-19. 2006
    ..These findings suggest that OPRM1 intronic variants play a role in susceptibility to AD and DD in populations of European ancestry...
  20. pmc Population admixture modulates risk for alcohol dependence
    Lingjun Zuo
    Department of Psychiatry, Yale University School of Medicine, VA Psychiatry 116A2, West Haven, CT 06516, USA
    Hum Genet 125:605-13. 2009
    ..We cannot exclude the possibility that the results might have been influenced by selection bias due to the multisite nature of the study...
  21. ncbi request reprint CALCYON gene variation, schizophrenia, and cocaine dependence
    Xingguang Luo
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
    Am J Med Genet B Neuropsychiatr Genet 125:25-30. 2004
    ..Furthermore, these findings begin to establish a haplotype map for this gene in the AA and EA populations...
  22. pmc Rare SERINC2 variants are specific for alcohol dependence in individuals of European descent
    Lingjun Zuo
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06516, USA
    Pharmacogenet Genomics 23:395-402. 2013
    ..In the present study, we comprehensively examined the rare variants [minor allele frequency (MAF)<0.05] in the NKAIN1-SERINC2 region to confirm our previous finding...
  23. pmc Pro-opiomelanocortin gene variation related to alcohol or drug dependence: evidence and replications across family- and population-based studies
    Huiping Zhang
    Division of Human Genetics, Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06516, USA
    Biol Psychiatry 66:128-36. 2009
    ..The pro-opiomelanocortin gene (POMC) encodes several peptides important for endogenous opioidergic neurotransmission. We tested whether POMC genetic variation affects risk for substance dependence...
  24. pmc Diplotype trend regression analysis of the ADH gene cluster and the ALDH2 gene: multiple significant associations with alcohol dependence
    Xingguang Luo
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06516, USA
    Am J Hum Genet 78:973-87. 2006
    ..We also found that several ADH genes and the ALDH2 gene were susceptibility loci for AD, and the associations were best explained by several independent risk genes...
  25. pmc NKAIN1-SERINC2 is a functional, replicable and genome-wide significant risk gene region specific for alcohol dependence in subjects of European descent
    Lingjun Zuo
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06516, USA
    Drug Alcohol Depend 129:254-64. 2013
    ..We aimed to identify novel, functional, replicable and genome-wide significant risk regions specific for alcohol dependence using genome-wide association studies (GWASs)...
  26. ncbi request reprint Haplotypes at the OPRM1 locus are associated with susceptibility to substance dependence in European-Americans
    Xingguang Luo
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06516, USA
    Am J Med Genet B Neuropsychiatr Genet 120:97-108. 2003
    ..These findings suggest that OPRM1 may play a role in the pathophysiology of substance dependence and this role is population- and diagnosis-specific...
  27. ncbi request reprint Association of haplotypic variants in DRD2, ANKK1, TTC12 and NCAM1 to alcohol dependence in independent case control and family samples
    Bao zhu Yang
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Hum Mol Genet 16:2844-53. 2007
    ..The complexity of these relationships, many of which replicate between our independent samples, may explain prior inconsistent results...
  28. ncbi request reprint CHRM2 gene predisposes to alcohol dependence, drug dependence and affective disorders: results from an extended case-control structured association study
    Xingguang Luo
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Hum Mol Genet 14:2421-34. 2005
    ..In addition, a specific diplotype might inversely affect risk for AD and DD and risk for affective disorders...
  29. doi request reprint Associations of rare nicotinic cholinergic receptor gene variants to nicotine and alcohol dependence
    Lingjun Zuo
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut
    Am J Med Genet B Neuropsychiatr Genet 171:1057-1071. 2016
    ..We conclude that CHRNs are associated with ND (mainly) and AD, supporting the hypothesis that the full catalog of ND/AD risk genes may contain most neuronal nAChRs-encoding genes. © 2016 Wiley Periodicals, Inc...
  30. pmc Sex chromosome-wide association analysis suggested male-specific risk genes for alcohol dependence
    Lingjun Zuo
    Departments of aPsychiatry and bGenetics, Yale University School of Medicine cDepartment of Genetics, Yale Center for Genome Analysis, Yale University School of Medicine dDepartment of Biostatistics, Yale University School of Public Health, New Haven, Connecticut eDepartment of Biostatistics and Epidemiology, College of Public Health, East Tennessee State University, Johnson City, Tennessee fMenninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, Texas, USA
    Psychiatr Genet 23:233-8. 2013
    ..In the present study, we scanned the entire Y chromosome and its homologs on the X chromosome in men to identify male-specific risk genes for alcohol dependence...
  31. pmc Significant association between rare IPO11-HTR1A variants and attention deficit hyperactivity disorder in Caucasians
    Lingjun Zuo
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut
    Am J Med Genet B Neuropsychiatr Genet 168:544-56. 2015
    ..5 × 10(-17) ≤P < 0.002) in human brain or peripheral blood mononuclear cell tissues. We concluded that IPO11-HTR1A was a significant risk gene region for ADHD in Caucasians...
  32. pmc Genome-wide association discoveries of alcohol dependence
    Lingjun Zuo
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut
    Am J Addict 23:526-39. 2014
    ..To report the genome-wide significant and/or replicable risk variants for alcohol dependence and explore their potential biological functions...
  33. pmc Common PTP4A1-PHF3-EYS variants are specific for alcohol dependence
    Lingjun Zuo
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut
    Am J Addict 23:411-4. 2014
    ..In the present study, we significantly increased the marker density within this region and examined the specificity of the associations of common variants for alcohol dependence...
  34. pmc The efficacies of clozapine and haloperidol in refractory schizophrenia are related to DTNBP1 variation
    Lingjun Zuo
    Departments of Psychiatry, West Haven Campus, Connecticut, USA
    Pharmacogenet Genomics 19:437-46. 2009
    ..We hypothesized that DTNBP1 might also influence the response to antipsychotic treatments. This study aimed to investigate the relationship between the DTNBP1 and the effects of clozapine and haloperidol on refractory schizophrenia...
  35. doi request reprint A New Genomewide Association Meta-Analysis of Alcohol Dependence
    Lingjun Zuo
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut
    Alcohol Clin Exp Res 39:1388-95. 2015
    ..In this study, we introduced a new meta-analysis for 4 genomewide association studies on alcohol dependence that integrated the information of putative causal variants...
  36. pmc Exome-wide association study of replicable nonsynonymous variants conferring risk for alcohol dependence
    Lingjun Zuo
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06516, USA
    J Stud Alcohol Drugs 74:622-5. 2013
    ..In the present study, we scanned the whole exome in three independent samples to search for replicable risk nonsynonymous (ns) variants (ns single-nucleotide polymorphisms [nsSNPs]) for alcohol dependence...
  37. pmc A novel, functional and replicable risk gene region for alcohol dependence identified by genome-wide association study
    Lingjun Zuo
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, United States of America
    PLoS ONE 6:e26726. 2011
    ..We conclude that the PHF3-PTP4A1 region appears to harbor a causal locus for alcohol dependence, and proteins encoded by PHF3 and/or PTP4A1 might play a functional role in the disorder...
  38. ncbi request reprint NOTCH4 gene haplotype is associated with schizophrenia in African Americans
    Xingguang Luo
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
    Biol Psychiatry 55:112-7. 2004
    ..The goal of this study was to investigate the relationship between the NOTCH4 gene and schizophrenia in African American (AA) and European American (EA) subjects...
  39. pmc Sex difference of autosomal alleles in populations of European and African descent
    Lingjun Zuo
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA VA Connecticut Healthcare System, West Haven Campus, CT, USA
    Genes Genomics 37:1007-1016. 2015
    ..The most robust finding was rs7740449 at SYNE1, next to ESR1. We conclude that there are many sex-different markers on autosomes. These markers may be informative in differentiating females and males...
  40. pmc Recessive genetic mode of an ADH4 variant in substance dependence in African-Americans: A model of utility of the HWD test
    Xingguang Luo
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Behav Brain Funct 4:42. 2008
    ....
  41. pmc Long noncoding RNAs in psychiatric disorders
    Lingjun Zuo
    Departments of aPsychiatry bCellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut cDepartment of Biostatistics and Epidemiology, College of Public Health, East Tennessee State University, Johnson City, Tennessee dDepartment of Psychiatry and Behavioral Sciences, Harris County Psychiatric Center, The University of Texas Health Science Center at Houston, Houston, Texas eDepartment of Psychology, Nevada Institute of Personalized Medicine, University of Nevada, Las Vegas, Neveda, USA fBiological Psychiatry Research Center, Beijing Huilongguan Hospital, Beijing, China
    Psychiatr Genet 26:109-16. 2016
    ..We also discuss the potential roles of lncRNAs in the etiological processes of psychiatric disorders and the implications for clinical diagnosis and treatment...
  42. pmc Meta-analysis of 15 genome-wide linkage scans of smoking behavior
    Shizhong Han
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06516, USA
    Biol Psychiatry 67:12-9. 2010
    ..Numerous putative susceptibility loci have been identified, but only a few of these were replicated in independent studies...
  43. pmc Variation at APOE and STH loci and Alzheimer's disease
    Lingjun Zuo
    Division of Human Genetics, Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Behav Brain Funct 2:13. 2006
    ..The present study aimed to elucidate the association between APOE and AD, and between STH and AD in our sample...
  44. pmc piRNAs and Their Functions in the Brain
    Lingjun Zuo
    Division of Human Genetics, Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Int J Hum Genet 16:53-60. 2016
    ..This paper reviewed the common features, biogenesis, functions, and distributions of piRNAs and summarized their specific functions in the brain. This review may provide new insights and research direction for brain disorders...
  45. pmc Replicated Risk Nicotinic Cholinergic Receptor Genes for Nicotine Dependence
    Lingjun Zuo
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06510, USA
    Genes (Basel) 7:. 2016
    ..We conclude that the replicated associations between CHRNB3-A6, CHRNA5-A3-B4,CHRNA4 and ND/CPD are very robust. More research is needed to examine how these genetic variants contribute to the risk for ND/CPD...
  46. ncbi request reprint Association between the cortisol response to opioid blockade and the Asn40Asp polymorphism at the mu-opioid receptor locus (OPRM1)
    Carlos A Hernandez-Avila
    Department of Psychiatry, Alcohol Research Center, University of Connecticut School of Medicine, Farmington, CT 06030 2103, USA
    Am J Med Genet B Neuropsychiatr Genet 118:60-5. 2003
    ..The polymorphism occurs commonly in European Americans and some other population groups, underscoring its potential phenotypic significance...
  47. doi request reprint Intestinal microbiome and digoxin inactivation: meal plan for digoxin users?
    Lingeng Lu
    Department of Chronic Disease Epidemiology, Yale School of Public Health, Yale University, 60 College Street, New Haven, CT, 06520 8034, USA
    World J Microbiol Biotechnol 30:791-9. 2014
    ..We also discuss several issues yet to be addressed in the future, making better strategies in the application of dietary arginine supplements for digoxin users. ..
  48. ncbi request reprint Genomic regions controlling corticosterone levels in rats
    Marc N Potenza
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06519, USA
    Biol Psychiatry 55:634-41. 2004
    ..The identification of genetic factors controlling stress-responsiveness should advance the understanding of susceptibility to psychiatric illness...
  49. ncbi request reprint Resting-State Functional Connectivity of the Basal Nucleus of Meynert in Cigarette Smokers: Dependence Level and Gender Differences
    Sheng Zhang
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT
    Nicotine Tob Res . 2016
    ..However, no studies have examined how this cholinergic system is influenced by cigarette smoking. Here, we addressed this gap of research...
  50. ncbi request reprint Response to Dr. Kopke's comments on haplotypes at the OPRM1 locus
    Xingguang Luo
    Am J Med Genet B Neuropsychiatr Genet 135:102. 2005

Research Grants1

  1. Fine-mapping the risk loci for alcoholism in ADH gene cluster and ALDH2 gene
    Xingguang Luo; Fiscal Year: 2010
    ..In a word, this study will identify some risk genes for alcohol dependence, helping us better understand the etiology of alcohol dependence and provide potential targets for new drugs. ..